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Edible electronics and robotics are emerging areas intimately bridging food science and engineering to deliver technology using food‐derived materials. Edible devices offer unprecedented opportunities thanks to features such as bioresorbability, nutritional value, associated taste, minimal toxicity, and sustainability. However, several challenges need to be addressed to bring edible devices closer to reality. Although prototypal edible sensors are available, rotation sensors—an essential component for orientation perception—are still missing. Integrating sensors, actuators, and structural components into an edible system also remains a challenge due to the lack of processes and standardization. Here the first edible tilt sensor is presented. Starting from a commercial nonedible bistable tilt sensor, each material is replaced with edible equivalents using simple and straightforward fabrication approaches. Its functionality is validated in the first implementation of an autonomous and partly edible rolling robot, which has a nutritional value of 807.5 kcal and integrates gelatin actuators, an array of tilt sensors, and an edible wheeled frame. The robot works in closed loop, perceiving its orientation and input for actuation from the sensors. These findings may pave the way to novel edible technologies, from drug delivery for wild animals to health applications. The first edible tilt sensor is implemented using only food‐derived materials and validated in the first autonomous partly‐edible rolling robot, integrating gelatin actuators, tilt sensors, and an edible wheel. The robot has a nutritional value of 807.5 kcal and works in closed loop, perceiving its orientation from the sensors and actuating the suitable actuator to sustain the rolling motion.

Edible electronics leverages the electronic properties of food‐derived materials to deliver safer technologies that can be degraded (or digested) in the environment (or body) at the end‐of‐life. Sensors will be central to future smart edible robots, and edible strain sensors are particularly interesting as they can transduce deformation, providing real time feedback of the movement. Yet, to date edible strain sensors have been limited to the use of ionic conductive hydrogels, resulting in sensors not directly suitable for direct current operation and therefore not compatible with existing edible batteries. Here, the first edible strain sensor based on electronic conduction made of a novel conductive ink sprayed over an edible substrate is presented. The ink formulation consists of activated carbon (conductor), Haribo gummy bears (binder), and water−ethanol mixture (dispersant). The ink, deposited on multiple substrates by spray deposition, produces edible electrically conductive composite coatings with resistivity of ≈50 Ω cm. The coatings were used as a piezoresistive layer to fabricate strain sensors with gauge factors of 19−92 suitable for direct current operation. As a proof‐of‐concept of future edible systems, the sensor is validated by integrating it within a gelatin actuator to produce a sensorized gripper powered by an edible battery. A sprayable electrically conductive coating with resistivity of ≈50 Ω cm is formulated using only food‐derived materials (activated carbon, Haribo gummy bears, water, and ethanol) and exploited as piezoresistive layer for edible strain sensors compatible with batteries. As a proof‐of‐concept of future edible systems, the edible coating is integrated with a gelatin actuator to produce a sensorized gripper powered by an edible battery.

Edible electronics leverages the electronic properties of food‐grade materials to create non‐toxic technologies that can be either environmentally degraded or digested by the body after the completion of their function. Various edible electronic components have been recently proposed, and their integration into more complex circuits and systems is urgently needed for point‐of‐care devices. In this context, developing a safe technology for interconnecting edible components is crucial. To this aim, here an edible electrically conductive adhesive made from zein, an edible protein derived from corn, and activated carbon, a food additive, are reported. Different formulations are proposed depending on the ratio between adhesive binder (zein) and electrically conductive filler (activated carbon), evidencing a trade‐off between resistivity and adhesion, passing from a 3 × 103 Ω cm resistivity and 2 MPa lap shear adhesion strength to 5 × 102 Ω cm and 0.5 MPa values upon increasing the filler content. As a proof‐of‐concept, the conductive adhesive is validated in different applications relevant to edible electronics, such as mounting devices on top of innovative edible substrates, interconnecting state‐of‐the‐art edible batteries, and conforming highly adhesive electrodes for fruit monitoring. An electrically conductive glue is formulated using only food‐grade materials (zein from corn and activated carbon) for the development of complex circuits in the field of edible electronics. As a proof‐of‐concept, the edible glue is applied in different examples, such as device‐mounting on edible substrates, interconnection of edible batteries, and impedance analysis electrodes for fruit.

In this work, we report the synthesis of an active material for supercapacitors (SCs), namely α-Fe2O3/carbon composite (C-Fe2O3) made of elongated nanoparticles linearly connected into a worm-like morphology, by means of electrospinning followed by a calcination/carbonization process. The resulting active material powder can be directly processed in the form of slurry to produce SC electrodes with mass loadings higher than 1 mg cm−2 on practical flat current collectors, avoiding the need for bulky porous substrate, as often reported in the literature. In aqueous electrolyte (6 M KOH), the so-produced C-Fe2O3 electrodes display capacity as high as ~140 mAh g−1 at a scan rate of 2 mV s−1, while showing an optimal rate capability (capacity of 32.4 mAh g−1 at a scan rate of 400 mV s−1). Thanks to their poor catalytic activity towards water splitting reactions, the electrode can operate in a wide potential range (−1.6 V–0.3 V vs. Hg/HgO), enabling the realization of performant quasi-symmetric SCs based on electrodes with the same chemical composition (but different active material mass loadings), achieving energy density approaching 10 Wh kg−1 in aqueous electrolytes.

Electrical energy storage is a topic of growing importance. Organic polymer batteries made of earth‐abundant elements are important tools for achieving a sustainable and electrified society. However, organic redox‐active polymers have low conductivity, necessitating conductive additives to be exploited in battery electrodes. To date, most of the organic polymers reported in the literature are mixed with expensive additives, such as graphene and carbon nanotubes. Porous carbons are a sustainable alternative, as they can be obtained from biowaste, and convenient for polymer‐carbon hybrid materials, as they have a high surface area, which can absorb polymers. In order to offer guidelines for achieving batteries with drastically reduced environmental impact while ensuring economic viability, here we review the most important advancements in polymer‐carbon hybrid materials formation. We pay special attention to the choice of porous carbons, as well as to the method of hybrid formation. This perspective is the first guide for the formation of truly sustainable battery electrodes, comprising both sustainable polymer and conductive additives.

ObjectiveTo assess if the use of a V-Y reconstructive flap after excisional radical surgery positively influences the surgical outcomes in patients with vulvar cancer.MethodsThis was a multicenter, retrospective, controlled study. Surgical outcomes and complication rates of women with invasive vulvar cancer who underwent radical surgery and vulvar reconstruction and those who underwent radical surgery without the reconstruction step were compared. Only patients who underwent bilateral or unilateral V-Y advancement fascio-cutaneous flaps were included in the reconstruction group. Univariate and multivariate logistic regression models were used to analyze predicting variables for their association with complication rates.ResultsOverall, 361 patients were included: 190 (52%) underwent the reconstructive step after the excisional radical procedure and were compared with 171 (47.4%) who did not undergo the reconstructive step. At multivariate analysis, body mass index >30 kg/m2 (odds ratio (OR) 3.36, p=0.007) and diabetes (OR 2.62, p<0.022) were independently correlated with wound infection. Moreover, increasing age (OR 1.52, p=0.009), body mass index >30 kg/m2 (OR 3.21, p=0.002,) and International Federation of Gynecology and Obstetrics (FIGO) stages III–IV (OR 2.25, p=0.017) were independent predictors of wound dehiscence. A significant reduction in the incidence of postoperative wound complications among patients who underwent V-Y reconstructive flaps was demonstrated. This was correlated more significantly in women with lesions >4 cm.ConclusionsThe adoption of V-Y flaps in vulvar surgery was correlated with reduced surgical related complications, particularly in vulnerable patients involving large surgical defects following excisional radical procedures.

Introduction/BackgroundThe aim of present multicenter retrospective controlled study is to assess the feasibility and safety of the modified V-Y advancement gluteal flap in the vulvo-perineal reconstruction among women operated for vulvar malignancies.MethodologyA multi-institutional retrospective study compared surgical outcomes and complication rates of women with invasive vulvar cancer who underwent radical surgery and vulvar reconstruction with those of a control group of women who underwent radical surgery without the reconstruction step. In the present series, only patients who underwent bilateral or monolateral V-Y advancement fascia-cutaneous flap were included in the reconstruction group. Univariate and multivariate logistic regression model was used to analyze predicting variables for their association with complication rate.ResultsThree hundred sixty-one patients surgically treated for vulvar cancer were evaluated. Overall, 190 (52%) underwent the reconstructive step after the demolition procedure and were compared with 171 (47.4%) patients who did not undergo the reconstructive step. At multivariate analysis, BMI>30 (OR 3.36; p=0.007), diabetes (OR 2.62, p<0.022), were independently correlated with wound infection. Moreover, increasing age (OR 1.52, p=0.009), BMI> 30 (OR 3.21, p=0.002), advanced stage (III-IV FIGO) (OR 2.25, p=0.017) were independent predictors of wound dehiscence. Moreover, a significant reduction in the incidence of post-operative wound complications among patients who underwent reconstructive procedures was demonstrated. This was correlated more significantly in women affected by tumor lesions larger than 4 cm.ConclusionThe rate of vulvar surgical-related morbidity is significantly influenced by the stage at diagnosis, the extent of surgery, and existing medical conditions (BMI and Obesity), including preoperative comorbidities. The adoption of V-Y fascia-cutaneous flaps in vulvar surgery seems to be significantly correlated with a reducing surgical related complication, particularly in vulnerable patient cases involving large surgical defects following demolitive procedures.DisclosuresNone.Abstract 1060 Figure 1

Perforation of the ileum in the antepartum period resulting in meconial peritonitis is a condition that, although rare, is burdened by several complications. In 80–90% of cases, meconial ileus is the first manifestation of a disease, cystic fibrosis. In the remaining 10–20% of cases, it is caused by other situations, such as prematurity. In most cases, the diagnosis of meconial ileus occurs after birth, although in some cases it can be suspected prenatally, with the finding of a hyperechoic intestine on second trimester ultrasound. The prognosis depends on the gestational age, the location of the obstruction and the presence of fetal abnormalities. Mortality is very high and the recovery of intestinal function in the postoperative course is very high risk. In this case series, we describe two meconial peritonitis and our experience at the center.

To assess if the use of a V-Y reconstructive flap after excisional radical surgery positively influences the surgical outcomes in patients with vulvar cancer. This was a multicenter, retrospective, controlled study. Surgical outcomes and complication rates of women with invasive vulvar cancer who underwent radical surgery and vulvar reconstruction and those who underwent radical surgery without the reconstruction step were compared. Only patients who underwent bilateral or unilateral V-Y advancement fascio-cutaneous flaps were included in the reconstruction group. Univariate and multivariate logistic regression models were used to analyze predicting variables for their association with complication rates. Overall, 361 patients were included: 190 (52%) underwent the reconstructive step after the excisional radical procedure and were compared with 171 (47.4%) who did not undergo the reconstructive step. At multivariate analysis, body mass index >30 kg/m (odds ratio (OR) 3.36, p=0.007) and diabetes (OR 2.62, p<0.022) were independently correlated with wound infection. Moreover, increasing age (OR 1.52, p=0.009), body mass index >30 kg/m (OR 3.21, p=0.002,) and International Federation of Gynecology and Obstetrics (FIGO) stages III-IV (OR 2.25, p=0.017) were independent predictors of wound dehiscence. A significant reduction in the incidence of postoperative wound complications among patients who underwent V-Y reconstructive flaps was demonstrated. This was correlated more significantly in women with lesions >4 cm. The adoption of V-Y flaps in vulvar surgery was correlated with reduced surgical related complications, particularly in vulnerable patients involving large surgical defects following excisional radical procedures.

We report the fabrication of the first 24-mode universal photonic processor (UPP) realized through femtosecond laser writing (FLW), marking the most complex UPP demonstrated to date. Optimized for quantum dot emission at 925 nm, the device exhibits total insertion losses averaging only 4.35 dB, enabling its direct application in advanced multi-photon quantum experiments. Leveraging the versatility of FLW, we introduce suspended waveguides and precisely engineered 2D and 3D microstructures, significantly enhancing thermal isolation and minimizing power dissipation. As a result, our processor operates efficiently at less than 10 W, requiring only a simple thermo-electric cooler for stable thermal management. The device exhibits exceptional performance after calibration, implementing Haar-random unitary transformations with an amplitude fidelity of 99.7 %. This work establishes FLW-based integrated photonics as a scalable and robust platform for advancing quantum computing, communication, and sensing technologies.