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Both Ralph Waldo Emerson and Zhuangzi lived in eras of profound social transformation. They both reconstruct virtue to respond to the meaning crisis in this social transformation. However, for the reason that their metaphysical foundations of virtue differ, there is a significant difference between them. Emerson’s concept of virtue promotes aesthetic appreciation of nature. Emerson regards nature as the best meaning of life. Meanwhile, Zhuangzi’s concept of virtue promotes the aesthetic appreciation of harmony between humanity and the Dao. He does not have Emerson’s sense of aesthetic appreciation of nature, including wilderness. In this paper, I will conduct a comparative study between Emerson and Zhuangzi based on the core categories in research on meaning in life, which are self-transcendence, value, and power. I aim to reconstruct Zhuangzi’s virtue through intercultural dialogue by absorbing Emerson’s virtue. Through this dialogue, we can deepen our understanding of Emerson and Zhuangzi in their efforts in the reconstruction of the self and value through virtue, which gives them enormous spiritual power to cope with the meaning crisis in their lifetimes. The new virtue is an integrated environmental virtue, which will give us a new understanding of the self, value, and power. The new self is an ecological aesthetic self, which is integrated with value in nature. The new self and value have the potential to shape new practices in the era of new transformation, which is generated by AI.

Age‐associated obesity and muscle atrophy (sarcopenia) are intimately connected and are reciprocally regulated by adipose tissue and skeletal muscle dysfunction. During ageing, adipose inflammation leads to the redistribution of fat to the intra‐abdominal area (visceral fat) and fatty infiltrations in skeletal muscles, resulting in decreased overall strength and functionality. Lipids and their derivatives accumulate both within and between muscle cells, inducing mitochondrial dysfunction, disturbing β‐oxidation of fatty acids, and enhancing reactive oxygen species (ROS) production, leading to lipotoxicity and insulin resistance, as well as enhanced secretion of some pro‐inflammatory cytokines. In turn, these muscle‐secreted cytokines may exacerbate adipose tissue atrophy, support chronic low‐grade inflammation, and establish a vicious cycle of local hyperlipidaemia, insulin resistance, and inflammation that spreads systemically, thus promoting the development of sarcopenic obesity (SO). We call this the metabaging cycle. Patients with SO show an increased risk of systemic insulin resistance, systemic inflammation, associated chronic diseases, and the subsequent progression to full‐blown sarcopenia and even cachexia. Meanwhile in many cardiometabolic diseases, the ostensibly protective effect of obesity in extremely elderly subjects, also known as the ‘obesity paradox’, could possibly be explained by our theory that many elderly subjects with normal body mass index might actually harbour SO to various degrees, before it progresses to full‐blown severe sarcopenia. Our review outlines current knowledge concerning the possible chain of causation between sarcopenia and obesity, proposes a solution to the obesity paradox, and the role of fat mass in ageing.

Very rich scholarly works have been produced to perform a comparative study between Emerson and Zhuang Zi. Many scholars in their comparative research have tried to find how Emerson and the transcendentalists such as Thoreau borrow ideas from Daoism. In this article, I will take a different approach. I aim to find how Emerson and Zhuang Zi’s pursuit of spirituality in nature shapes different types of sense of place. The concept of spirituality is related to the pursuit of meaning in life and self-transcendence. This concept has gradually gained attention from the branches of religion, philosophy, geography, and psychology since, currently, due to the fast urbanization process, more people are separated from their land and move into cities. I will make a comparison between Emerson and Zhuang Zi from the concepts of spirituality, nature, and place. This perspective will shed light on the question of the conservation of various places due to their value and meaning, although I will not discuss conservation issues in this paper. In this article, I will first give a brief introduction to the meaning of spirituality by focusing on the three dimensions of this concept, which include meaning, self-transcendence, and spiritual practices. Then, I will discuss how the concept of nature in Emerson and Zhuang Zi’s works is related to these three dimensions. Finally, I will examine why Emerson and Zhuang Zi treat wilderness and agricultural land, respectively, as a place.

Diabetes nephropathy (DN) is the most common chronic complication of diabetes and has become an important cause of end-stage renal failure. Oxidative stress and inflammatory response play important driving roles in the occurrence and development of diabetic nephropathy. As a key gene of DN, C3AR1 has been shown to mediate oxidative stress and inflammation. However, its potential mechanism in DN is still unclear. Here, we found that C3AR1 was upregulated in high glucose (HG)-treated human renal tubular epithelial cells (HK-2) and kidney tissues of DN rats. Interference with C3AR1 protected HK-2 cells from HG-mediated oxidative stress injury. Co-Immunoprecipitation (Co-IP) analysis showed that C3AR1 interacted with ITGB2 and promoted the expression of ITGB2. Overexpression of ITGB2 reversed the inhibition of C3AR1 interference on oxidative stress, apoptosis, and inflammatory response in HG-treated HK-2 cells. The rat DN model was established by unilateral nephrectomy and one-time intraperitoneal injection of 60 mg/kg streptozotocin (STZ), followed by the tail vein injection of the C3AR1 lentivirus interference plasmid. The results showed that interfering with C3AR1 reduced the level of inflammatory markers in the serum and weakened the oxidative stress and pathological damage of kidney tissues in DN rats. This study showed that C3AR1 may contribute to DN by upregulating ITGB2 protein levels to mediate oxidative stress.

Pre-gestational diabetes mellitus (PGDM) has been known to be a risk factor for congenital heart defects (CHDs) for decades. However, the associations between maternal PGDM and gestational diabetes mellitus (GDM) and the risk of specific types of CHDs and congenital anomalies (CAs) in other systems remain under debate. We aimed to investigate type-specific CAs in offspring of women with diabetes and to examine the extent to which types of maternal diabetes are associated with increased risk of CAs in offspring. We searched PubMed and Embase from database inception to 15 October 2021 for population-based studies reporting on type-specific CAs in offspring born to women with PGDM (combined type 1 and 2) or GDM, with no limitation on language. Reviewers extracted data for relevant outcomes and performed random effects meta-analyses, subgroup analyses, and multivariable meta-regression. Risk of bias appraisal was performed using the Cochrane Risk of Bias Tool. This study was registered in PROSPERO (CRD42021229217). Primary outcomes were overall CAs and CHDs. Secondary outcomes were type-specific CAs. Overall, 59 population-based studies published from 1990 to 2021 with 80,437,056 participants met the inclusion criteria. Of the participants, 2,407,862 (3.0%) women had PGDM and 2,353,205 (2.9%) women had GDM. The meta-analyses showed increased risks of overall CAs/CHDs in offspring born to women with PGDM (for overall CAs, relative risk [RR] = 1.99, 95% CI 1.82 to 2.17, P < 0.001; for CHDs, RR = 3.46, 95% CI 2.77 to 4.32, P < 0.001) or GDM (for overall CAs, RR = 1.18, 95% CI 1.13 to 1.23, P < 0.001; for CHDs, RR = 1.50, 95% CI 1.38 to 1.64, P < 0.001). The results of the meta-regression analyses showed significant differences in RRs of CAs/CHDs in PGDM versus GDM (all P < 0.001). Of the 23 CA categories, excluding CHD-related categories, in offspring, maternal PGDM was associated with a significantly increased risk of CAs in 21 categories; the corresponding RRs ranged from 1.57 (for hypospadias, 95% CI 1.22 to 2.02) to 18.18 (for holoprosencephaly, 95% CI 4.03 to 82.06). Maternal GDM was associated with a small but significant increase in the risk of CAs in 9 categories; the corresponding RRs ranged from 1.14 (for limb reduction, 95% CI 1.06 to 1.23) to 5.70 (for heterotaxia, 95% CI 1.09 to 29.92). The main limitation of our analysis is that some high significant heterogeneity still persisted in both subgroup and sensitivity analyses. In this study, we observed an increased rate of CAs in offspring of women with diabetes and noted the differences for PGDM versus GDM. The RRs of overall CAs and CHDs in offspring of women with PGDM were higher than those in offspring of women with GDM. Screening for diabetes in pregnant women may enable better glycemic control, and may enable identification of offspring at risk for CAs.

This analysis provides an up‐to‐date assessment of long‐term (1990–2010) rural ozone trends using all available data in the western (12 sites) and eastern (41 sites) USA. Rather than focus solely on average ozone values or air quality standard violations, we consider the full range of ozone values, reporting trends for the 5th, 50th and 95th percentiles. Domestic ozone precursor emissions decreased strongly during 1990–2010. Accordingly 83%, 66% and 20% of summertime eastern U.S. sites experienced statistically significant ozone decreases in the 95th, 50th and 5th percentiles, respectively. During spring 43% of the eastern sites have statistically significant ozone decreases for the 95th percentile with no sites showing a significant increase. At the 50th percentile there is little overall change in the eastern U.S. In contrast, only 17% (2 sites) and 8% (1 site) of summertime western U.S. sites have statistically significant ozone decreases in the 95th and 50th percentiles, respectively. During spring no western site has a significant decrease, while 50% have a significant median increase. This dichotomy in U.S. ozone trends is discussed in terms of changing anthropogenic and biomass burning emissions. Consideration is given to the concept that increasing baseline ozone flowing into the western U.S. is counteracting ozone reductions due to domestic emission reductions. An update to the springtime free tropospheric ozone trend above western North America shows that ozone has increased significantly from 1995 to 2011 at the rate of 0.41 ± 0.27 ppbv yr−1. Finally, the ozone changes are examined in relation to regional temperature trends. Key Points Median ozone in the eastern US is decreasing in summer but unchanged in spring Half of the western US rural sites have increasing median ozone in spring Increasing western ozone is inconsistent with decreasing US precursor emissions

Electroreduction of carbon dioxide into useful fuels helps to reduce fossil-fuel consumption and carbon dioxide emissions, but activating carbon dioxide requires impractically high overpotentials; here a metal atomic layer combined with its native oxide that requires low overpotentials to reduce carbon dioxide is developed, adapted from an existing cobalt-based catalyst. Efficient electroreduction of CO 2 The production of useful fuels from carbon dioxide through electroreduction would be a clean way of replacing fossil fuels and reducing carbon dioxide emissions. Shan Gao et al . have turned cobalt, a metal generally considered not active for this reaction, into a very efficient electrocatalyst by synthesizing it in the form of four-atom-thick layers. This finding, and the observation that partial oxidation of the surface boosts activity further, points to a general strategy for turning otherwise unreactive metals into efficient electroreduction catalysts. Electroreduction of CO 2 into useful fuels, especially if driven by renewable energy, represents a potentially ‘clean’ strategy for replacing fossil feedstocks and dealing with increasing CO 2 emissions and their adverse effects on climate 1 , 2 , 3 , 4 . The critical bottleneck lies in activating CO 2 into the CO 2 •− radical anion or other intermediates that can be converted further, as the activation usually requires impractically high overpotentials. Recently, electrocatalysts based on oxide-derived metal nanostructures have been shown 5 , 6 , 7 , 8 to enable CO 2 reduction at low overpotentials. However, it remains unclear how the electrocatalytic activity of these metals is influenced by their native oxides, mainly because microstructural features such as interfaces and defects 9 influence CO 2 reduction activity yet are difficult to control. To evaluate the role of the two different catalytic sites, here we fabricate two kinds of four-atom-thick layers: pure cobalt metal, and co-existing domains of cobalt metal and cobalt oxide. Cobalt mainly produces formate (HCOO − ) during CO 2 electroreduction; we find that surface cobalt atoms of the atomically thin layers have higher intrinsic activity and selectivity towards formate production, at lower overpotentials, than do surface cobalt atoms on bulk samples. Partial oxidation of the atomic layers further increases their intrinsic activity, allowing us to realize stable current densities of about 10 milliamperes per square centimetre over 40 hours, with approximately 90 per cent formate selectivity at an overpotential of only 0.24 volts, which outperforms previously reported metal or metal oxide electrodes evaluated under comparable conditions 1 , 2 , 6 , 7 , 10 . The correct morphology and oxidation state can thus transform a material from one considered nearly non-catalytic for the CO 2 electroreduction reaction into an active catalyst. These findings point to new opportunities for manipulating and improving the CO 2 electroreduction properties of metal systems, especially once the influence of both the atomic-scale structure and the presence of oxide are mechanistically better understood.

In 2017, western Canadian wildfires injected smoke into the stratosphere that was detectable by satellites for more than 8 months. The smoke plume rose from 12 to 23 kilometers within 2 months owing to solar heating of black carbon, extending the lifetime and latitudinal spread. Comparisons of model simulations to the rate of observed lofting indicate that 2% of the smoke mass was black carbon. The observed smoke lifetime in the stratosphere was 40% shorter than calculated with a standard model that does not consider photochemical loss of organic carbon. Photochemistry is represented by using an empirical ozone-organics reaction probability that matches the observed smoke decay. The observed rapid plume rise, latitudinal spread, and photochemical reactions provide new insights into potential global climate impacts from nuclear war.

To constrain the behavior of Mg isotopes during deep crustal processes and the Mg isotopic composition of the middle and lower continental crust, 30 composite samples from high-grade metamorphic terranes and 18 granulite xenoliths were investigated. The composites derive from eight different high-grade metamorphic terranes in the two largest Archean cratons of China, including 13 TTG gneisses, 5 amphibolites, 4 felsic, 4 intermediate, and 4 mafic granulites. They have variable bulk compositions with SiO2 ranging from 45.7 to 72.5%, representative of the middle crust beneath eastern China. The δ26Mg values of these samples vary from -0.40 to +0.12 ppm, reflecting heterogeneity of their protoliths, which could involve upper crustal sediments. The granulite xenoliths from the Cenozoic Hannuoba basalts also have a diversity of compositions with MgO ranging from 2.95 to 20.2%. These xenoliths equilibrated under high temperatures of 800-950°C, corresponding to depths of the lower continental crust (>30 km). They yield a large δ26Mg variation of -0.76 to -0.24 ppm. The light Mg isotopic compositions likely result from interactions with isotopically light metamorphic fluids, probably carbonate fluids. Together with previously reported data, the average δ26Mg values of the middle and lower continental crusts are estimated to be -0.21±0.07 ppm and -0.26±0.06 ppm, respectively. The bulk continental crust is estimated to have an average δ26Mg of -0.24±0.07 ppm, which is similar to the average of the mantle. The large Mg isotopic variation in the continental crust reflects the combination of several processes, such as continental weathering, involvement of supracrustal materials in the deep crust, and fluid metasomatism.