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Secondary school teachers are one of the occupational groups presenting the highest levels of sick leave due to stress in the workplace. This form of stress can cause burnout syndrome, which is characterised by emotional exhaustion, depersonalisation and low levels of personal accomplishment. Secondary education teachers have received relatively little research attention in this respect. This study addresses the prevalence among secondary school teachers of burnout syndrome, in its three dimensions, and investigates possible differences in the prevalence determined by different measuring instruments. A systematic review and meta-analysis was conducted of the scientific literature in this field. Using the Proquest and Eric electronic databases, 45 articles and 49 independent samples ( N  = 14,410) were obtained. Results show that secondary school teachers are at high risk of burnout syndrome. Moreover, there are statistically significant differences between the different measuring instruments used. Pedagogical programmes should be developed to reduce/prevent its impact.

CONTEXT: Although there is a need to develop a spatially explicit methodological approach that addresses the social importance of cultural ecosystem services for regional planning, few studies have analysed the spatial distribution on the cultural ecosystem services based on social perceptions. OBJECTIVE: The main objective of this study was to identify cultural ecosystem service hot-spots, and factors that characterize such hot-spots and define the spatial associations between cultural ecosystem services in Southern Patagonia (Argentina). METHODS: The study was carried out in Southern Patagonia (243.9 thousand km²) located between 46° and 55° SL with the Andes mountains on the western fringe and the Atlantic Ocean on the eastern fringe of the study area. The study region has a range of different vegetation types (grasslands, shrub-lands, peat-lands and forests) though the cold arid steppe is the main vegetation type. We used geo-tagged digital images that local people and visitors posted in the Panoramio web platform to identify hot-spots of four cultural ecosystem services (aesthetic value, existence value, recreation and local identity) and relate these hot-spots with social and biophysical landscape features. RESULTS: Aesthetic value was the main cultural service tagged by people, followed by the existence value for biodiversity conservation, followed by local identity and then recreational activity. The spatial distribution of these cultural ecosystem services are associated with different social and biophysical characteristics, such as the presence of water bodies, vegetation types, marine and terrestrial fauna, protected areas, urbanization, accessibility and tourism offer. The most important factors are the presence of water in Santa Cruz and tourism offer in Tierra del Fuego. CONCLUSIONS: Our results demonstrate that this methodology is useful for assessing cultural ecosystem services at the regional scale, especially in areas with low data availability and field accessibility, such as Southern Patagonia. We also identify new research challenges that can be addressed in cultural ecosystem services research through the use of this method.

The North Atlantic eddy-driven jet (EDJ) is an essential component of the Euro-Atlantic atmospheric circulation. It has been typically described in terms of latitude and intensity but this is not enough to fully characterize its variability and complex EDJ configurations. Here, we present a set of daily parameters of the EDJ based on low-tropospheric zonal wind data for the 1948–2020 period. They describe the intensity, sharpness, location, edges, tilt and other zonal asymmetries of the EDJ, therefore dissecting its structure beyond the latitudinal regimes. This allows for assessments of specific EDJ aspects and a multi-parametric treatment of EDJ configurations in a manageable way. Overall, variations in EDJ parameters reflect distinctive patterns of eddy forcing and wave breaking, with anticyclonic eddies playing a major role in shaping the EDJ structure. A multimodal behavior of the EDJ is only detected in latitude, which largely influences the longitudinal position of the EDJ. Other aspects of the EDJ are less constrained by the latitude and display a variety of configurations. Four multi-parametric states (northern, central, tilted and split EDJs) provide a satisfactory description of recurrent patterns of the EDJ. They participate in meridional migrations of the EDJ, but yield less dramatic transitions than viewed from the latitudinal perspective. Finally, the EDJ parameters help to better understand the EDJ influence on European climate. In many regions, latitude and intensity contain limited information on near-surface anomalies, and their signals can be masked by the additional effect of other EDJ parameters.

Ecosystem service assessments have increasingly been used to support environmental management policies, mainly based on biophysical and economic indicators. However, few studies have coped with the social-cultural dimension of ecosystem services, despite being considered a research priority. We examined how ecosystem service bundles and trade-offs emerge from diverging social preferences toward ecosystem services delivered by various types of ecosystems in Spain. We conducted 3,379 direct face-to-face questionnaires in eight different case study sites from 2007 to 2011. Overall, 90.5% of the sampled population recognized the ecosystem's capacity to deliver services. Formal studies, environmental behavior, and gender variables influenced the probability of people recognizing the ecosystem's capacity to provide services. The ecosystem services most frequently perceived by people were regulating services; of those, air purification held the greatest importance. However, statistical analysis showed that socio-cultural factors and the conservation management strategy of ecosystems (i.e., National Park, Natural Park, or a non-protected area) have an effect on social preferences toward ecosystem services. Ecosystem service trade-offs and bundles were identified by analyzing social preferences through multivariate analysis (redundancy analysis and hierarchical cluster analysis). We found a clear trade-off among provisioning services (and recreational hunting) versus regulating services and almost all cultural services. We identified three ecosystem service bundles associated with the conservation management strategy and the rural-urban gradient. We conclude that socio-cultural preferences toward ecosystem services can serve as a tool to identify relevant services for people, the factors underlying these social preferences, and emerging ecosystem service bundles and trade-offs.

Background/Objectives: The Maltese islands, situated in the Sicilian Channel, are known to host two gecko species, Hemidactylus turcicus and Tarentola mauritanica. However, gecko taxonomy is complicated by cryptic lineages within species complexes, requiring molecular approaches for accurate identification. Methods: In this study, we investigated species diversity using opportunistic sampling of 30 dead gecko specimens, including road-killed individuals, from across the Maltese islands. Due to the degraded condition of most samples, morphological identification was limited; therefore, mitochondrial markers (12S, 16S and COI) were employed to assign species identity. Results: Our analyses revealed the first records of the Tarentola fascicularis/deserti complex in Malta. This finding extends the known distribution of this complex and complements records from neighbouring islands in the Sicilian Channel, where T. mauritanica and T. fascicularis/deserti lineages occur in sympatry. Conclusions: Given the greater ecological affinity of the T. fascicularis/deserti complex for arid environments, these findings emphasise the importance of continued monitoring to clarify the dynamics of sympatry, potential ecological displacement, and the long-term effects of climate change and anthropogenic activity on the central Mediterranean herpetofauna.

Fatigue in its many forms of physical, mental, and psychosocial exhaustion is a common symptom of post-COVID-19 condition, also known as “Long COVID.” Persistent fatigue in COVID-19 patients is frequently accompanied by cognitive dysfunction and neuropsychiatric symptoms; however, less is known about the relationships between these components of post-COVID-19 condition and fatigue itself. Consequently, the present study sought to (1) distinguish the types of fatigue experienced by participants, and (2) investigate whether cognitive deficits across various domains and neuropsychiatric conditions predicted these different types of fatigue. The study included 136 COVID-19 patients referred for neuropsychological evaluation due to cognitive complaints 8 months on average after SARS-CoV-2 infection. Measures included self-reported fatigue (physical, cognitive, and psychosocial), neuropsychiatric questionnaires (assessing symptoms of depression, anxiety, apathy, and executive functioning), a comprehensive neuropsychological assessment, and self-reported quality of life and everyday functioning. Results showed that reports of clinical significant fatigue were pervasive in our sample (82.3% of participants), with physical fatigue rated highest on average relative to the subscale maximum. Elevated levels of apathy, anxiety, and executive dysfunction in neuropsychiatric measures along with executive and attentional difficulties on cognitive tests were found to be consistently important predictors among different types of fatigue. This implicates both cognitive and neuropsychiatric symptoms as predictors of fatigue in post-COVID-19 condition, and stresses the importance of a holistic approach in assessing and considering potential treatment for COVID-19 patients experiencing fatigue.

Cognitive difficulties are reported as lasting sequelae within post COVID-19 condition. However, the chronicity of these difficulties and related factors of fatigue, mood, and perceived health have yet to be fully determined. To address this, the current longitudinal study aimed to clarify the trends of cognitive test performance and cognitive domain impairment following COVID-19 onset, and whether hospitalization influences outcomes. 57 participants who reported subjective cognitive difficulties after confirmed COVID-19 infection were assessed at baseline (~6 months post COVID-19) and follow-up (~15 months later) visits. Assessments included measures across multiple cognitive domains and self-report questionnaires of fatigue, mood, and overall health. Analyses were conducted in three stages: at the test score level (raw and adjusted scores), at the cognitive domain level, and stratified by hospitalization status during infection. Results at the test-score level indicate that cognitive performance remains relatively stable across assessments at the group level, with no significant improvements in any adjusted test scores at follow-up. Cognitive domain analyses indicate significant reductions in attention and executive functioning impairment, while memory impairment is slower to resolve. On self-report measures, there was a significant improvement in overall health ratings at follow-up. Finally, those hospitalized during infection performed worse on timed cognitive measures across visits and accounted for a larger proportion of cases with short-term and working memory impairment at follow-up. Overall, our findings indicate that cognitive difficulties persist both at test score and cognitive domain levels in many cases of post COVID-19 condition, but evidence suggests some improvement in global measures of attention, executive functioning and overall self-rated health. Furthermore, an effect of hospitalization on cognitive symptoms post COVID-19 may be more discernible over time.

B‐cell chronic lymphocytic leukemia (B‐CLL) is characterized by highly heterogeneous genomic alterations and altered signaling pathways, with limited studies on its proteome. Our study presents a comprehensive analysis of the proteome and phosphoproteome in B‐CLL and CLL‐like monoclonal B‐cell lymphocytosis (MBL) primary cells. Using high‐resolution mass spectrometry, we identified 2970 proteins and 316 phosphoproteins across five tumor samples, including 55 newly identified phosphopeptides (ProteomeXchange‐PXD005997). Our multifaceted approach also integrated protein microarrays and western blotting for further data validation in a new patient cohort of 14 patients. Despite sharing 73% of their proteomes, the phosphoproteomes varied significantly among samples, independent of cytogenetic alterations and immunoglobulin heavy variable cluster (IGHV) mutational status. We identified common functional hallmarks in B‐CLL and MBL phosphoproteomes, notably tonic signaling (low‐level, constitutive signaling) of the B‐cell antigen‐specific receptor (BCR) and nuclear factor NF‐kappa‐B (NF‐kβ)/signal transducer and activator of transcription 3 (STAT3) pathways. Nine phosphoproteins involved in BCR signaling were further validated, showing a high correlation with early disease stages. Our study advances the field by providing a detailed perspective on the proteome and phosphoproteome of B‐CLL cells, revealing signaling pathways crucial for disease development and progression. Integrating diverse proteomics techniques and identifying novel phosphopeptides offers new insights into CLL biology, potentially informing future therapeutic strategies and biomarker development for early diagnosis and personalized treatment. B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease progression, uncovering new pathways and biomarkers for advancing therapeutic and diagnostic strategies.

COVID-19 is characterised by systemic immunological perturbations in the human body, which can lead to multi-organ damage. Many of these processes are considered to be mediated by the blood. Therefore, to better understand the systemic host response to SARS-CoV-2 infection, we performed systematic analyses of the circulating, soluble proteins in the blood through global proteomics by mass-spectrometry (MS) proteomics. Here, we show that a large part of the soluble blood proteome is altered in COVID-19, among them elevated levels of interferon-induced and proteasomal proteins. Some proteins that have alternating levels in human cells after a SARS-CoV-2 infection in vitro and in different organs of COVID-19 patients are deregulated in the blood, suggesting shared infection-related changes.The availability of different public proteomic resources on soluble blood proteome alterations leaves uncertainty about the change of a given protein during COVID-19. Hence, we performed a systematic review and meta-analysis of MS global proteomics studies of soluble blood proteomes, including up to 1706 individuals (1039 COVID-19 patients), to provide concluding estimates for the alteration of 1517 soluble blood proteins in COVID-19. Finally, based on the meta-analysis we developed CoViMAPP, an open-access resource for effect sizes of alterations and diagnostic potential of soluble blood proteins in COVID-19, which is publicly available for the research, clinical, and academic community. Babačić et al . performed systematic analyses of blood proteins in COVID-19 patients through mass-spectrometry proteomics, showing that a large part of the soluble blood proteome is altered. The authors then developed an open-access resource, CoViMAPP, for meta-analysis of MS proteomics studies of COVID-19 patients.