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The coastal ocean environment off California is largely determined by wind‐driven coastal upwelling, with an ecosystem that is tightly coupled to seasonality in this upwelling. Three decades of data measured over the California shelf at NOAA buoys are used to describe the seasonal variability of the winds that force upwelling and the response of the coastal ocean in terms of sea temperature. Moreover, seasonal patterns in surface chlorophyll and alongshore currents are determined from one decade of data. In addition to clear seasonality, all these data exhibit distinct spatial and non‐seasonal temporal variability in upwelling. Based on alongshore wind stress characteristics in central and north California, three seasons are defined: Upwelling Season (April‐June) with strong upwelling‐favorable winds and large standard deviation due to frequent reversals; Relaxation Season (July‐September) with weak equatorward winds and low variability; and Storm Season (December‐February) characterized by weak mean wind stress but large variability. The remaining months are transitional, falling into one or other season in different years. In addition to large‐scale latitudinal differences in wind stress, spatial differences are associated with coastal topography ‐ specifically the acceleration of wind downstream of capes. Latitudinal differences in sea surface temperature depend on wind stress, both local and large‐scale, but also on surface heating and offshore influences. Intra‐annual and inter‐annual anomalies in wind and sea surface temperature are associated with variability in coastal winds, large‐scale winds, and offshore basin‐scale ocean conditions. Satellite chlorophyll concentration shows an optimal window relation with upwelling forcing, allowing maximum concentrations during moderate winds and minimal during poor or strong winds. Key Points Three seasons defined from coastal winds: upwelling, relaxation, and storm Coastal winds driven by large‐scale winds and modified by local topography Upwelling variability associated to winds and basin‐scale ocean conditions

Alongshore wind speed and sea surface temperature (SST) from coastal National Data Buoy Center buoys are used to study the variability of wind‐driven coastal upwelling from 1982 to 2008. A long‐term increase in upwelling is observed in central California (35°N–39°N) with stronger upwelling‐favorable winds, colder water, and more frequent occurrences of upwelling days during the upwelling season (March–July). Further, a longer upwelling season is observed in the same region, starting earlier in the spring and persisting later in the fall. These interannual changes in upwelling strength and seasonal duration are investigated in this study. Changes in alongshore wind (forcing of upwelling) are poorly correlated with the El Niño–Southern Oscillation or the Pacific Decadal Oscillation, but the Northern Oscillation and the North Pacific Gyre Oscillation correlate with the geostrophic upwelling‐favorable winds in the region. However, changes in SST (an upwelling response) are correlated with both changes in wind (upwelling forcing) and the climate indices. Although this short record cannot differentiate between multidecadal cycles and persistent trends, this data‐based result does corroborate model‐based projections of increased upwelling in this region due to global climate change. This increase in upwelling is understood to be a response to the strengthening of large‐scale pressure gradient fields partially due to global‐scale climate change. Farther north and farther south in California, other processes also have a significant influence on coastal conditions, such that the tendency for increased upwelling is not evident in the same way.

In answer to the question “Should ethnobiology and ethnomedicine more decisively foster hypothesis-driven forefront research able to turn findings into policy and abandon more classical folkloric studies? ”, in this essay I argue that a major strength of ethnobiology and ethnomedicine is their ability to bridge theories and methods from the natural sciences, the social sciences, and the humanities. Hypothesis-driven research is a powerful way to structure thinking that can lead to forefront research findings. But hypothesis-driven research is not the only way to structure thinking and is not a necessary condition to impact policymaking. To increase policy impact, ethnobiology and ethnomedicine should continue nurturing a mixture of complementary methods and inclusive approaches as fragmentation through opposing different approaches might weaken the discipline. Moreover, with the aim to play a fundamental role in building bridges between different knowledge systems and co-producing solutions towards sustainability, the discipline could benefit from enlarging its epistemological grounds through more collaborative research. Ethnobiologists' research findings, hypothesis-driven, descriptive, or co-constructed can become leverage points to transform knowledge into actionable outcomes in different levels of decision-making.

This paper introduces the special feature ofEcology and Societyentitled “Traditional Ecological Knowledge and Global Environmental Change. The special feature addresses two main research themes. The first theme concerns the resilience of Traditional Ecological Knowledge (hereafter TEK) and the conditions that might explain its loss or persistence in the face of global change. The second theme relates to new findings regarding the way in which TEK strengthens community resilience to respond to the multiple stressors of global environmental change. Those themes are analyzed using case studies from Africa, Asia, America and Europe. Theoretical insights and empirical findings from the studies suggest that despite the generalized worldwide trend of TEK erosion, substantial pockets of TEK persist in both developing and developed countries. A common trend on the studies presented here is hybridization, where traditional knowledge, practices, and beliefs are merged with novel forms of knowledge and technologies to create new knowledge systems. The findings also reinforce previous hypotheses pointing at the importance of TEK systems as reservoirs of experiential knowledge that can provide important insights for the design of adaptation and mitigation strategies to cope with global environmental change. Based on the results from papers in this feature, we discuss policy directions that might help to promote maintenance and restoration of living TEK systems as sources of socialecological resilience.

In recent years, ever-increasing scientific knowledge and modern high-tech advancements in micro- and nano-scales fabrication technologies have impacted significantly on various scientific fields. A micro-level approach so-called “microfluidic technology” has rapidly evolved as a powerful tool for numerous applications with special reference to bioengineering and biomedical engineering research. Therefore, a transformative effect has been felt, for instance, in biological sample handling, analyte sensing cell-based assay, tissue engineering, molecular diagnostics, and drug screening, etc. Besides such huge multi-functional potentialities, microfluidic technology also offers the opportunity to mimic different organs to address the complexity of animal-based testing models effectively. The combination of fluid physics along with three-dimensional (3-D) cell compartmentalization has sustained popularity as organ-on-a-chip. In this context, simple humanoid model systems which are important for a wide range of research fields rely on the development of a microfluidic system. The basic idea is to provide an artificial testing subject that resembles the human body in every aspect. For instance, drug testing in the pharma industry is crucial to assure proper function. Development of microfluidic-based technology bridges the gap between in vitro and in vivo models offering new approaches to research in medicine, biology, and pharmacology, among others. This is also because microfluidic-based 3-D niche has enormous potential to accommodate cells/tissues to create a physiologically relevant environment, thus, bridge/fill in the gap between extensively studied animal models and human-based clinical trials. This review highlights principles, fabrication techniques, and recent progress of organs-on-chip research. Herein, we also point out some opportunities for microfluidic technology in the future research which is still infancy to accurately design, address and mimic the in vivo niche.

Despite its relative adaptive capacity and its many values, indigenous and local knowledge (ILK) is rapidly eroding. Over the past decades a myriad of efforts have emerged to prevent this erosion. In this work, we reviewed and systematically coded 138 ILK conservation initiatives published in academic papers in order to explore trends in participation, digitalization, timing, location, and approach of the initiatives. We also explored factors influencing initiative inclusiveness. Our findings reveal that ILK holders are generally absent from most phases of the studied initiatives, although IT-based and in situ initiatives (i.e., education and community based conservation) appear as the exceptions. We also found that ex situ initiatives (i.e., research/documentation and policy/legislation efforts) are predominant, despite the challenges they reportedly face. These findings call for re-formulating the ways in which ex situ ILK conservation is done and for supporting in situ and IT based initiatives, as they offer the potential to lead the participatory turn.

In the face of considerable socioeconomic and environmental challenges, traditional ecological knowledge (TEK) systems around the world continue to be practiced and maintained. This study examines how three traditional pastoral practices, mobile grazing, herd breeding, and herd sharing, persist and change in East Ujimchin Banner, Inner Mongolia, China. Based on nine months of fieldwork, including household surveys, interviews, and participatory mapping workshops, we analyze how these practices have evolved under environmental and socioeconomic pressures. Mapping data from 30 households shows that all continue some form of seasonal or spatial mobility, though the frequency and range of movement have significantly declined because of restricted land access. Survey results from 227 herders show that over 80% recognize 26 out of 31 traditional breeding traits, and more than half still actively use 19 of these traits. Beyond their persistence, these practices are multifunctional, fulfilling diverse ecological, economic, and cultural roles. Our results show that herd sharing is used not only to support families in need, but also to address land shortages, labor constraints, and adaptation to severe climatic events, while simultaneously contributing to the preservation of cultural traditions. Additionally, our results show that these practices serve overlapping functions, particularly regarding climate adaptation. During extreme weather events, mobile grazing enables herders to access more favorable pastures; selective herd breeding ensures livestock are better able to withstand weather conditions; and herd sharing allows herders to redistribute livestock to mitigate potential losses. Together, these practices demonstrate the dynamic adaptability and continuous relevance of TEK in a rapidly changing context.

Urolithiasis (UL) involves the formation of stones in different parts of the urinary tract. UL is a health problem, and its prevalence has increased considerably in developing countries. Several regions use plants in traditional medicine as an alternative in the treatment or prevention of UL. Mexico has known about the role of traditional medicine in the management of urinary stones. Mexican traditional medicine uses plants such as Argemone mexicana L., Berberis trifoliata Hartw. ex Lindl., Costus mexicanus Liebm, Chenopodium album L., Ammi visnaga (L.) Lam., Eysenhardtia polystachya (Ortega) Sarg., Selaginella lepidophylla (Hook. & Grev.) Spring, and Taraxacum officinale L. These plants contain different bioactive compounds, including polyphenols, flavonoids, phytosterols, saponins, furanochromones, alkaloids, and terpenoids, which could be effective in preventing the process of stone formation. Evidence suggests that their beneficial effects might be associated with litholytic, antispasmodic, and diuretic activities, as well as an inhibitory effect on crystallization, nucleation, and aggregation of crystals. The molecular mechanisms involving these effects could be related to antioxidant, anti-inflammatory, and antimicrobial properties. Thus, the review aims to summarize the preclinical evidence, bioactive compounds, and molecular mechanisms of the plants used in Mexican traditional medicine for the management of UL.

Background Prognosis of patients with glioblastoma multiforme (GBM) remains dismal, with median overall survival (OS) of about 15 months. It is therefore crucial to search alternative strategies that improve these results obtained with conventional treatments. In this context, immunotherapy seems to be a promising therapeutic option. We hypothesized that the addition of tumor lysate-pulsed autologous dendritic cells (DCs) vaccination to maximal safe resection followed by radiotherapy and concomitant and adjuvant temozolomide could improve patients’ survival. Methods We conducted a phase-II clinical trial of autologous DCs vaccination in patients with newly diagnosed patients GBM who were candidates to complete or near complete resection. Candidates were finally included if residual tumor volume was lower than 1 cc on postoperative radiological examination. Autologous DCs were generated from peripheral blood monocytes and pulsed with autologous whole tumor lysate. The vaccination calendar started before radiotherapy and was continued during adjuvant chemotherapy. Progression free survival (PFS) and OS were analyzed with the Kaplan–Meier method. Immune response were assessed in blood samples obtained before each vaccines. Results Thirty-two consecutive patients were screened, one of which was a screening failure due to insufficient resection. Median age was 61 years (range 42–70). Karnofsky performance score (KPS) was 90–100 in 29%, 80 in 35.5% and 60–70 in 35.5% of cases. MGMT (O 6 -methylguanine-DNA-methyltransferase) promoter was methylated in 45.2% of patients. No severe adverse effects related to immunotherapy were registered. Median PFS was 12.7 months (CI 95% 7–16) and median OS was 23.4 months (95% CI 16–33.1). Increase in post-vaccination tumor specific immune response after vaccines (proliferation or cytokine production) was detected in 11/27 evaluated patients. No correlation between immune response and survival was found. Conclusions Our results suggest that the addition of tumor lysate-pulsed autologous DCs vaccination to tumor resection and combined radio-chemotherapy is feasible and safe. A multicenter randomized clinical trial is warranted to evaluate the potential survival benefit of this therapeutic approach. Trial registration This phase-II trial was registered as EudraCT: 2009-009879-35 and ClinicalTrials.gov Identifier: NCT01006044 retrospectively registered

In recent years, ethnobiology has undergone significant transformation. A renewed research framework has emerged that prioritizes an ethics of care—one that emphasizes relationships, interdependence, and responsibility towards both human and non-human others throughout all stages of research. This paradigm shift, led largely by Indigenous scholars and researchers from the Global South, invites European ethnobiologists to critically reflect on how they can engage with, contribute to, and learn from these evolving approaches in light of pressing environmental and social challenges. In this Perspective, we explore the future of European ethnobiology in two main ways. First, we reflect on the specificities of a European lens within global ethnobiology, considering how European ethnobiologists might participate more meaningfully in transdisciplinary and intercultural dialogues. Second, drawing on core principles of the emerging global paradigm, we outline five key avenues for future development: (1) deepening commitments to an ethics of care; (2) responding more directly to contemporary challenges; (3) expanding research contexts; (4) reimagining methodological approaches; and (5) enhancing the societal relevance and applied impact of European ethnobiologists, both within and beyond Europe. We highlight current examples of European ethnobiologists already advancing these directions and underscore the field’s dynamic evolution. We conclude by identifying critical challenges faced by European ethnobiologists, including the need to engage with rapidly evolving digital technologies and to navigate institutional and epistemic barriers that hinder the co-creation of knowledge across diverse worldviews.