Explore the vast range of titles available.

الكتاب دليل علمي، ينقل عمل فريق قيادة التغيير في جامعة هارفارد إلى جمهور أوسع نطاقا، وهو العمل الذي استغرق خمس سنوات ؛ رغبة في إصلاح المدارس، و هو يتضمن شروحا واضحة وحلولا عملية، ويقدم إطارا لتحليل التغيير داخل المدارس، وما يواجه المربين من تحديات. كما أنه يرشد إلى تحسين نوعية التدريس إذا كنت قائدا في مجال التدريس، أو معنيا بهذا الشأن، وتضمن أدوات تشخيصية وتمارين ووصلا بمواد إضافية لزيادة الفهم، ويستخدم أمثله من الواقع المعيش.

The Cloud–Aerosol Lidar with Orthogonal Polarization (CALIOP) on board the Cloud–Aerosol Lidar Infrared Pathfinder Satellite Observations (CALIPSO) satellite has been making near-global height-resolved measurements of cloud and aerosol layers since mid-June 2006. Version 4.10 (V4) of the CALIOP data products, released in November 2016, introduces extensive upgrades to the algorithms used to retrieve the spatial and optical properties of these layers, and thus there are both obvious and subtle differences between V4 and previous data releases. This paper describes the improvements made to the extinction retrieval algorithms and illustrates the impacts of these changes on the extinction and optical depth estimates reported in the CALIPSO lidar level 2 data products. The lidar ratios for both aerosols and ice clouds are generally higher than in previous data releases, resulting in generally higher extinction coefficients and optical depths in V4. A newly implemented algorithm for retrieving extinction coefficients in opaque layers is described and its impact examined. Precise lidar ratio estimates are also retrieved in these opaque layers. For semi-transparent cirrus clouds, comparisons between CALIOP V4 optical depths and the optical depths reported by MODIS collection 6 show substantial improvements relative to earlier comparisons between CALIOP version 3 and MODIS collection 5.

Because of their broad-spectrum bactericidal activity, amoxicillin (AMX) and third-generation cephalosporins (TGC) are widely used for the prophylaxis and treatment of established infections. They are considered relatively safe, but several recent reports have suggested substantial nephrotoxicity, especially with AMX use. Considering the importance of AMX and TGC for clinical practice, we conducted this up-to-date review, using the PubMed database, which focuses specifically on the nephrotoxicity of these molecules. We also briefly review the pharmacology of AMX and TGC. Nephrotoxicity of AMX may be driven by several pathophysiological mechanisms, such as a type IV hypersensitivity reaction, anaphylaxis, or intratubular and/or urinary tract drug precipitation. In this review, we focused on the two main renal adverse effects of AMX, namely acute interstitial nephritis and crystal nephropathy. We summarize the current knowledge in terms of incidence, pathogenesis, factors, clinical features, and diagnosis. The purpose of this review is also to underline the probable underestimation of AMX nephrotoxicity and to educate clinicians about the recent increased incidence and severe renal prognosis associated with crystal nephropathy. We also suggest some key elements on the management of these complications to avoid inappropriate use and to limit the risk of nephrotoxicity. While renal injury appears to be rarer with TGC, several patterns of nephrotoxicity have been reported in the literature, such as nephrolithiasis, immune-mediated hemolytic anemia, or acute interstitial nephropathy, which we detail in the second part of this review.

A new satellite remote sensing method is described whereby the sensitivity of thermal infrared wave resonance absorption to small ice crystals is exploited to estimate cirrus cloud ice-particle number concentration N, effective diameter De and ice water content IWC. This method uses co-located observations from the Infrared Imaging Radiometer (IIR) and from the CALIOP (Cloud and Aerosol Lidar with Orthogonal Polarization) lidar aboard the CALIPSO (Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observation) polar orbiting satellite, employing IIR channels at 10.6 and 12.05 µm. Using particle size distributions measured over many flights of the TC4 (Tropical Composition, Cloud and Climate Coupling) and the mid-latitude SPARTICUS (Small Particles in Cirrus) field campaigns, we show for the first time that N∕IWC is tightly related to βeff; the ratio of effective absorption optical depths at 12.05 and 10.6 µm. Relationships developed from in situ aircraft measurements are applied to βeff derived from IIR measurements to retrieve N. This satellite remote sensing method is constrained by measurements of βeff from the IIR and is by essence sensitive to the smallest ice crystals. Retrieval uncertainties are discussed, including uncertainties related to in situ measurement of small ice crystals (D<15 µm), which are studied through comparisons with IIR βeff. The method is applied here to single-layered semi-transparent clouds having a visible optical depth between about 0.3 and 3, where cloud base temperature is ≤235 K. CALIPSO data taken over 2 years have been analyzed for the years 2008 and 2013, with the dependence of cirrus cloud N and De on altitude, temperature, latitude, season (winter vs. summer) and topography (land vs. ocean) described. The results for the mid-latitudes show a considerable dependence on season. In the high latitudes, N tends to be highest and De smallest, whereas the opposite is true for the tropics. The frequency of occurrence of these relatively thick cirrus clouds exhibited a strong seasonal dependence in the high latitudes, with the occurrence frequency during Arctic winter being at least twice that of any other season. Processes that could potentially explain some of these micro- and macroscopic cloud phenomena are discussed.

IgA nephropathy (IgAN), the most frequent primary glomerulonephritis, affects young patients and is associated with a high risk of progression to end-stage renal disease. Consequently, patients with IgAN constitute an important proportion of candidates for kidney transplantation. Several studies showed a significant risk of IgAN recurrence on kidney graft, but the risks factors for recurrence remain to be accurately evaluated. Indeed, early identification of at risk patients may allow the optimization of treatment and the reduction of recurrence rate on the graft. In the present work, we studied the relationship between post-transplant serum IgA (sIgA) levels and the risk of IgAN recurrence after kidney transplantation. Recipients with IgAN had higher levels of sIgA as compared to patients with other nephropathies (p<0.05). The prevalence of IgAN recurrence was 20.8% during the period of analysis (mean follow-up of 6 ± 3.2 years). Serum IgA levels at M6, M12 and M24 post-transplant were significantly higher in patients with IgAN recurrence as compared to those without (p = 0.009, p = 0.035 and p = 0.029, respectively). Using receiver operating curve (ROC), sIgA at M6 and M12 post-transplant were significantly associated with IgAN recurrence (AUC = 0.771, p = 0.004 and AUC = 0.767, p = 0.016, respectively), while serum creatinine and proteinuria were not. Serum IgA level at month 6 was significantly associated with the occurrence of post-transplant IgA recurrence, whether it was analyzed as a continuous or a categorical variable. After successive adjustment on age, gender and proteinuria, sIgA remained a significant risk factor of post-transplant IgAN recurrence. Finally, survival free of IgAN recurrence was significantly better in patients with sIgA<222 mg/dL at month 6 as compare to IgAN patients with sIgA≥222 mg/dL (p = 0.03). Thus, the present work supports a link between post-transplant sIgA levels and IgAN recurrence and suggests that sIgA may be a valuable predictive biomarker of IgAN recurrence in kidney transplant recipients.

Background Humoral response against sudden acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after two doses of BNT162b2 (Pfizer-BioNTech) has been proven to be less intense in maintenance dialysis patients as compared with healthy subjects, leading the French authorities to recommend a third injection in this population. Here we investigated the response to the third injection in two cohorts of haemodialysis (HD) patients. Methods Data from two prospective observational cohorts were collected. In the first (‘systematic’) cohort, patients from two HD centres (n = 66) received a third injection of BNT162b2, regardless of the response after two injections. In the second (‘conditional’) cohort, the injection was only prescribed to patients (n = 34) with no or low response to the previous two doses. In both cohorts, the third dose was injected 1–2 months after the second dose. Serology was performed after the second and third doses to assess anti-Spike immunoglobulin G (S IgG) antibody titre. Results In the systematic cohort, anti-S IgG was found in 83.3 and 92.4% of patients after the second and third doses of BNT162b2, respectively. In this cohort, 6/11 (54.5%) and 20/21 (95.2%) patients switched from non-responder to low responder and from low responder to high responder, respectively. In low and high responders to two doses, 50/55 (90.9%) at least doubled their anti-S IgG titre. Similar trends were observed in the conditional cohort. Conclusions In maintenance HD patients, humoral response against SARS-CoV-2 was boosted after a third dose of BNT162b2, allowing seroconversion in more than half of non-responders. These data may support an intensified vaccination protocol with a third dose of BNT162b2 in dialysis patients. Graphical Abstract Graphical Abstract

The NASA-CNES Cloud-Aerosol Lidar and Infrared Pathfinder Satellite Observations (CALIPSO) mission provided a spaceborne global record of atmospheric aerosol and cloud profiles from June 2006 to June 2023. As an elastic backscatter lidar, the CALIPSO Cloud-Aerosol Lidar with Orthogonal Polarization (CALIOP) typically required an assumption of the aerosol lidar ratio (extinction-to-backscatter ratio; Sa) to retrieve aerosol extinction and column-integrated aerosol optical depth (AOD). In all previous versions of its data products, the CALIPSO extinction algorithms first determine the aerosol types then assign one Sa value globally for each aerosol type (e.g., 23 sr for marine at 532 nm). One of the major changes for the final CALIPSO data products release (Version 5, or V5) is the implementation of regional and seasonal Sa tables for CALIOP-classified “marine” aerosols. In this study, we describe the process of creating the tables using 12 years (June 2006–August 2018) of Aqua Moderate Resolution Imaging Spectroradiometer (MODIS) total column AODs to constrain collocated CALIOP backscatter profiles in a Fernald inversion scheme and infer Sa (at 532 nm), focusing solely on the CALIOP “marine” aerosol type. The Goddard Chemistry Aerosol Radiation and Transport (GOCART) global aerosol model is used to estimate sea salt volume fraction (SSVF) that are collocated with the constrained Sa retrievals. Patterns of smaller SSVF (< 65 %) and larger constrained Sa (> 40 sr) are found near land masses, while larger SSVF (> 95 %) and smaller constrained Sa (< 30 sr) are generally observed in the remote oceans. The inverse empirical relationship found between modeled SSVF and constrained Sa over global oceans yields values of ∼ 21 sr for SSVF of 100 % (i.e., “pure” marine) and ∼ 58 sr for SSVF of 0 % (i.e., the absence of marine aerosol). This relationship is applied to develop regional and seasonal hybrid (retrieval and model-assisted) climatological Sa maps for CALIOP-classified marine aerosols; i.e., when MODIS-constrained results are not available, the model-assisted values are used. These hybrid Sa maps are subsequently used to retrieve new CALIPSO Level 2 (L2) aerosol extinction profiles and column AODs in the V5 release. For a 4-month (January, April, July, and October 2015) analysis, the V5 L2 CALIPSO AODs compared better to CALIPSO Ocean Derived Column Optical Depth (ODCOD) than the CALIPSO Version 4.51 (V4.51) standard AODs in several regions, most notably the Bay of Bengal/Arabian Sea, where smoke/pollution typically mixes with marine aerosols. Also, the V5 CALIPSO AODs likely provide a lower AOD bias and root-mean-square-error than V4.51 AODs relative to coastal and island Aerosol Robotic Network (AERONET) AODs, as found in a validation study using data from June 2006 through October 2022. The technique described in this study contributes to CALIPSO's final V5 data products release and provides critical Sa information for future spaceborne elastic backscatter lidars.

The beta-adrenergic system is a potent stimulus for enhancing cardiac output that may become deleterious when energy metabolism is compromised as in heart failure. We thus examined whether the AMP-activated protein kinase (AMPK) that is activated in response to energy depletion may control the beta-adrenergic pathway. We studied the cardiac response to beta-adrenergic stimulation of AMPKα2-/- mice or to pharmacological AMPK activation on contractile function, calcium current, cAMP content and expression of adenylyl cyclase 5 (AC5), a rate limiting step of the beta-adrenergic pathway. In AMPKα2-/- mice the expression of AC5 (+50%), the dose response curve of left ventricular developed pressure to isoprenaline (p<0.001) or the response to forskolin, an activator of AC (+25%), were significantly increased compared to WT heart. Similarly, the response of L-type calcium current to 3-isobutyl-l-methylxanthine (IBMX), a phosphodiesterase inhibitor was significantly higher in KO (+98%, p<0.01) than WT (+57%) isolated cardiomyocytes. Conversely, pharmacological activation of AMPK by 5-aminoimidazole-4-carboxamide riboside (AICAR) induced a 45% decrease in AC5 expression (p<0.001) and a 40% decrease of cAMP content (P<0.001) as measured by fluorescence resonance energy transfer (FRET) compared to unstimulated rat cardiomyocytes. Finally, in experimental pressure overload-induced cardiac dysfunction, AMPK activation was associated with a decreased expression of AC5 that was blunted in AMPKα2-/- mice. The results show that AMPK activation down-regulates AC5 expression and blunts the beta-adrenergic cascade. This crosstalk between AMPK and beta-adrenergic pathways may participate in a compensatory energy sparing mechanism in dysfunctional myocardium.

Satellite-based measurements of global ice cloud microphysical properties are sampled to develop a novel set of physical parameterizations, relating to cloud layer temperature and effective diameter De , that can be implemented for two separate applications: in numerical weather prediction models and lidar-based cloud radiative forcing studies. Ice cloud optical properties (i.e., spectral scattering and absorption) are estimated based on the effective size and habit mixture of the cloud particles. Historically, the ice cloud De has been parameterized from aircraft in situ measurements. However, aircraft-based parameterizations are opportunistic in that they only represent specific types of clouds (e.g., convective anvil, tropopause-topped cirrus) in the regions in which they were sampled and, in some cases, are limited in fully resolving the entire vertical cloud layer. Breaking away from the aircraft-based parameterization paradigm, this study is the first of its kind to attempt a parameterization of De as a function of temperature, ice water content (IWC), and lidar-derived extinction from satellite-based global oceanic measurements of ice clouds. Data from both active and passive remote sensing sensors from two of NASA’s A-Train satellites, CloudSat and CALIPSO, are collected to guide development of globally robust parameterizations of all ice cloud types and one exclusively for cirrus clouds.