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EP3.4, e-Poster Terminal 3, September 4, 2025, 11:35 - 13:00 Aim Mis- and disinformation about migration are increasingly being used to disrupt and create divisions in communities. Responses to information are shaped by personal, emotional, social and cultural influences and trust in the data source. The arts play an important role in regulating our responses to experiences and information. Music is biologically important for interpersonal attunement and is effective in developing social bonds and building trust. Its ability to engage, beyond the limits of language, makes it a valuable tool to support the health and well-being of multi-ethic communities. The aim of this study is to explore the potential of innovative, interdisciplinary and participatory research methods to combat disinformation and increase social inclusion in multi-ethnic communities. Methods This feasibility study recruited participants from multi-ethnic communities to a co-designed, 12-week intercultural song exchange and data literacy programme. Participants committed to learning about each other through song and data. Social inclusion and confidence in ability to recognise disinformation about migration were measured at baseline and at the end of the study. Evaluation was carried out using surveys and interviews and the study ended with a community-based performance of singing and data storytelling. Results Thirty-six participants from four continents, speaking 17 different languages, were recruited to the study. At baseline, one in five (21%) were not confident in their ability to recognise disinformation about migration which decreased to 8% by the end of the study. A quarter (24%) described themselves as not feeling settled and part of the community which decreased to 12% by the end of the study. Conclusions This study has demonstrated the innovative use of participatory, interdisciplinary research methods, combining the arts and data literacy, to combat disinformation and increase social inclusion in multi-ethnic communities. Further research is needed to explore the scalability of this project.

PTH 8: Miscellaneous 1, B304 (FCSH), September 5, 2025, 11:30 - 12:30 Introduction The World Health Organisation calls for evidence-based policy and practice about the specific health needs of refugees and migrants. Refugees and migrants need to be meaningfully involved as partners in the co-production of that evidence. However, there are challenges that inhibit partnership development e.g., linguistic barriers, mistrust. Culturally attuned methods, such as arts-based methods, support trust-building in intercultural social groups and, thus, may create participatory spaces that facilitate new inter-sectoral research partnerships. Aims Explore inter-sectoral, inter-cultural partnership development for refugee and migrant health research using an arts-based method known as the Irish World Music Cafe. Methods Following the principles of purposeful sample, twenty-five participants from the community (n = 9), health (n = 4) and arts or health academic sectors (n = 12) were recruited for five 2 hour music cafes (four on-line and one in-person). A questionnaire administered at the end of each music café evaluated participants’ enjoyment of the music cafes and their networking opportunities. These data were analysed using frequency analysis and social network analysis to see if health, community or academic sector actors were most central in the participant group. Semi-structured interviews were conducted after the cafes ended to complement the quantitative date. These were analysed using inductive, thematic analysis. Results The overall rates of enjoyment of music cafes were very high. Participants from the health sector were most central in the network at the first two music cafes. However, their centrality decreased and migrants from community-based organisations emerged as the more central actors in the network by the end of the fifth music café. Participants described several examples of how specific characteristics of music and singing shaped interactions and partnership building in the music cafes. Conclusions Music cafes as arts-based methods warrant further investigation as methods to optimise inter-sectoral, inter-cultural partnership development for refugee and migrant health research.

Do you know how many adventures are available tor your Atari? Even if you have played quite a lot, there will be many on this list that you may not have even heard of. They are all genuine adventures that have been, or are, available. Finding some of these, though, could be an adventure itself! The adventures are the standard 'text' adventures and so do not include arcade adventures and the like. Where graphics are available I have indicated by using 'Illustrated'.

Capelin are a focal forage species in the Northwest Atlantic ecosystem as they act as an energy conduit from lower to higher trophic levels. Fisheries and Oceans Canada determined that the Newfoundland capelin stock (Northwest Atlantic Fisheries Organization Divisions 2J3KL) suffered an order of magnitude decline in biomass in 1990–1991. This collapse was concomitant with drastic changes observed in the ecosystem during the late 1980s and early 1990s. While the results of more than a dozen studies have supported the capelin stock collapse hypothesis, an alternative non-collapse hypothesis proposed that rather than collapsing in 1990–1991, the capelin stock either (1) changed its migratory patterns while the timing of the spring capelin acoustic survey remained constant, leading to a spatio-temporal mismatch between the spring acoustic survey and the stock, or (2) became less migratory and remained inshore year-round, therefore being largely underestimated by the offshore spring and fall acoustic surveys. The collapse and non-collapse hypotheses were tested using multiple independent data sets, which included both fishery-dependent (inshore commercial catch) and fishery-independent (spring and fall acoustic and fall bottom-trawl surveys, capelin larval indices, aerial surveys, predator diet and behavior) data, and diverse statistical methods. The weight of evidence approach led us to reject the non-collapse hypothesis and conclude that the Newfoundland capelin stock did collapse in 1990–1991 with minimal recovery over the subsequent 3 decades.

Aim This study aims to explore the feasibility of using serial MRI without contrast in the monitoring of Charcot neuroarthropathy to reduce duration of immobilisation of the foot, in order to decide whether a large-scale trial is warranted. Methods A multicentre, randomised, prospective, two arm, open, feasibility study (CADOM) of people with diabetes with a suspected or confirmed diagnosis of Charcot neuroarthropathy. Participants were randomised (1:1) to ‘standard care plus’, including repeated foot temperature measurements and X-rays, or the intervention arm, with additional three-monthly MRI, until remission of Charcot neuroarthropathy or a maximum 12 months (active phase). Participants were then followed-up for a further 6 months, post remission to monitor for relapse of the Charcot neuroarthropathy (follow-up phase). Feasibility outcomes were recruitment, retention, data completeness, adherence to study procedures and safety of the intervention MRI. We also collected clinical efficacy outcomes, this included time in cast/off-loading device which will be the primary outcome of a future definitive trial. Finally, we collected patient reported outcomes, and data on health and social care usage. Results One-hundred and five people were assessed for eligibility at five sites. 64/105 potential participants meet the eligibility criteria to participate in the study. Forty-three participants were randomised: 20 to standard care plus and 23 to MRI intervention. The main reason for ineligibility was a previous episode of Charcot neuroarthropathy. Thirteen participants were withdrawn post-randomisation due to an alternative diagnosis being made. Of the remaining 30 participants, 19 achieved remission, 6 had not gone into remission at the end of the 12 month active phase so exited the study. Five participants were lost to follow-up. Of the MRIs that were not disrupted by COVID-19 pandemic 26/31 (84%) were completed. For the visits that were conducted face-to-face, completion rates of patient-reported outcome measures were between 71 and 100%. There were no safety incidents associated with the intervention MRI. As this was a feasibility study it was not designed to test the effectiveness of serial MRI in diagnosing remission. The time in cast/off-loading device was 235 (±108.3) days for the standard care plus arm compared to 292 (±177.4) days for the intervention arm. There was no statistical difference in the time in cast/off-loading device between the two arms of the study: Hazard Ratio (HR) 0.405 (95% CI 0.140–1.172), p  = 0.096. Discussion The findings support a definitive randomised controlled trial to evaluate the effectiveness of MRI in diagnosing remission in Charcot neuroarthropathy. The rates of recruitment, retention, data, and MRI completeness show that a definitive study is feasible. Study registration ISRCTN, 74101606 . Registered on 6 November 2017.

Humanity has emerged as a major force in the operation of the biosphere, with a significant imprint on the Earth System, challenging social-ecological resilience. This new situation calls for a fundamental shift in perspectives, world views, and institutions. Human development and progress must be reconnected to the capacity of the biosphere and essential ecosystem services to be sustained. Governance challenges include a highly interconnected and faster world, cascading social-ecological interactions and planetary boundaries that create vulnerabilities but also opportunities for social-ecological change and transformation. Tipping points and thresholds highlight the importance of understanding and managing resilience. New modes of flexible governance are emerging. A central challenge is to reconnect these efforts to the changing preconditions for societal development as active stewards of the Earth System. We suggest that the Millennium Development Goals need to be reframed in such a planetary stewardship context combined with a call for a new social contract on global sustainability. The ongoing mind shift in human relations with Earth and its boundaries provides exciting opportunities for societal development in collaboration with the biosphere—a global sustainability agenda for humanity.

Background Prescribing, monitoring and administration of medicines in care homes could be improved. A cluster randomised controlled trial (RCT) is ongoing to evaluate the effectiveness of an independent prescribing pharmacist assuming responsibility for medicines management in care homes compared to usual care. Aims and Objectives To conduct a mixed-methods process evaluation of the RCT, in line with Medical Research Council (MRC) process evaluation guidance, to inform interpretation of main trial findings and if the service is found to be effective and efficient, to inform subsequent implementation. Objectives To describe the intervention as delivered in terms of quality, quantity, adaptations and variations across triads and time. To explore the effects of individual intervention components on the primary outcomes. To investigate the mechanisms of impact. To describe the perceived effectiveness of relevant intervention components [including pharmacist independent prescriber (PIP) training and care home staff training] from participant [general practitioner (GP), care home, PIP and resident/relative] perspectives. To describe the characteristics of GP, care home, PIP and resident participants to assess reach. To estimate the extent to which intervention delivery is normalised among the intervention healthcare professionals and related practice staff. Methods A mix of quantitative (surveys, record reviews) and qualitative (interviews) approaches will be used to collect data on the extent of the delivery of detailed tasks required to implement the new service, to collect data to confirm the mechanism of impact as hypothesised in the logic model, to collect explanatory process and final outcome data, and data on contextual factors which could have facilitated or hindered effective and efficient delivery of the service. Discussion Recruitment is ongoing and the trial should complete in early 2020. The systematic and comprehensive approach that is being adopted will ensure data is captured on all aspects of the study, and allow a full understanding of the implementation of the service and the RCT findings. With so many interrelated factors involved it is important that a process evaluation is undertaken to enable us to identify which elements of the service were deemed to be effective, explain any differences seen, and identify enablers, barriers and future adaptions. Trial registration ISRCTN17847169 . Date registered: 15 December 2017.

Angiostatin and endostatin are potent endothelial cell growth inhibitors that have been shown to inhibit angiogenesis in vivo and tumor growth in mice. However, tumor shrinkage requires chronic delivery of large doses of these proteins. Here we report synergistic antitumor activity and survival of animals when these factors are delivered in combination to tumors by retroviral gene transfer. We have demonstrated this efficacy in both murine leukemia and melanoma models. Complete loss of tumorigenicity was seen in 40% of the animals receiving tumors transduced by the combination of angiostatin and endostatin in the leukemia model. The synergy was also demonstrated in vitro on human umbilical vein endothelial cell differentiation and this antiangiogenic activity may suggest a mechanism for the antitumor activity in vivo. These findings imply separate pathways by which angiostatin and endostatin mediate their antiangiogenic effects. Together, these data suggest that a combination of antiangiogenic factors delivered by retroviral gene transfer may produce synergistic antitumor effects in both leukemia and solid tumors, thus avoiding long-term administration of recombinant proteins. The data also suggest that novel combinations of antiangiogenic factors delivered into tumors require further investigation as therapeutic modalities.

Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patients alone may improve the treatment of depression in both patients and their carers enhancing the mental wellbeing and quality of life of both. A single blind cluster randomised controlled trial to evaluate whether families after stroke who are treated with the Depression Recognition and Treatment package (DepReT-Stroke) in addition to treatment as usual (TAU) show improved mental well being compared to those families who receive only TAU. We aim to recruit one hundred and twenty-six families (63 in each group). The DepReT-Stroke intervention will help families to consider the various treatment options for depression, make choices about which are likely to fit best with their lives and support them in the use of self-help therapies (e.g. computerised Cognitive Behavioural Therapy or exercise). An essential component of the DepReT-Stroke package will be to help people adhere to their chosen treatment(s). The primary outcome will be the Mental Component Subscale of the SF-36 assessed at baseline and again six months post intervention. Effectiveness of the intervention will be determined using analysis of co-variance; comparing the mean change in MCS scores from baseline to six months follow-up adjusting for the clustering effects of baseline scores and family. An economic evaluation of the intervention will help us determine whether the intervention represents a cost-effective use of resources. Depression both for patients and their carers is common after stroke. Our Depression Recognition and Treatment package (DepReT-stroke) may help clinicians be more effective at detecting and managing a common co-morbidity that limits rehabilitation and recovery. ISRCTN: ISRCTN32451749 Research Ethics Committee Reference Number: 10/H0310/23 Grant Reference Number: (NIHR) PB-PG-0808-17056.

Background Depression occurs in up to 50% of patients after stroke and limits rehabilitation and recovery. Mood disorders are also highly prevalent in carers; their mental health intertwined with the physical and mental wellbeing of the person they are caring for. We argue that working with families, rather than patients alone may improve the treatment of depression in both patients and their carers enhancing the mental wellbeing and quality of life of both. Methods A single blind cluster randomised controlled trial to evaluate whether families after stroke who are treated with the Depression Recognition and Treatment package (DepReT-Stroke) in addition to treatment as usual (TAU) show improved mental well being compared to those families who receive only TAU. We aim to recruit one hundred and twenty-six families (63 in each group). The DepReT-Stroke intervention will help families to consider the various treatment options for depression, make choices about which are likely to fit best with their lives and support them in the use of self-help therapies (e.g. computerised Cognitive Behavioural Therapy or exercise). An essential component of the DepReT-Stroke package will be to help people adhere to their chosen treatment(s). The primary outcome will be the Mental Component Subscale of the SF-36 assessed at baseline and again six months post intervention. Effectiveness of the intervention will be determined using analysis of co-variance; comparing the mean change in MCS scores from baseline to six months follow-up adjusting for the clustering effects of baseline scores and family. An economic evaluation of the intervention will help us determine whether the intervention represents a cost-effective use of resources. Discussion Depression both for patients and their carers is common after stroke. Our Dep ression Re cognition and T reatment package (DepReT-stroke) may help clinicians be more effective at detecting and managing a common co-morbidity that limits rehabilitation and recovery. Trial Registration ISRCTN: ISRCTN32451749 Research Ethics Committee Reference Number: 10/H0310/23 Grant Reference Number: (NIHR) PB-PG-0808-17056