Explore the vast range of titles available.

We use two CORDEX-Africa simulations performed with the regional model RegCM4 to characterize the projected changes in extremes and hydroclimatic regimes associated with the West African Monsoon (WAM). RegCM4 was driven for the period 1970–2100 by the HadGEM2-ES and the MPI-ESM Global Climate Models (GCMs) under the RCP8.5 greenhouse gas concentration pathway. RegCM4 accurately simulates the WAM characteristics in terms of seasonal mean, seasonal cycle, interannual variability and extreme events of rainfall. Overall, both RegCM4 experiments are able to reproduce the large-scale atmospheric circulation for the reference period (i.e. present-day), and in fact show improved performance compared to the driving GCMs in terms of precipitation mean climatology and extreme events, although different shortcomings in the various models are still evident. Precipitation is projected to decrease (increase) over western (eastern) Sahel, although with different spatial detail between RegCM4 and the corresponding driving GCMs. Changes in extreme precipitation events show patterns in line with those of the mean change. The models project different changes in water budget over the Sahel region, where the MPI projects an increased deficit in local moisture supply (E < P) whereas the rest of models project a local surplus (E > P). The E–P change is primarily precipitation driven. The precipitation increases over the eastern and/or central Sahel are attributed to the increase of moisture convergence due to increased water vapor in the boundary layer air column and surface evaporation. On the other hand, the projected dry conditions over the western Sahel are associated with the strengthening of moisture divergence in the upper level (850–300 hPa) combined to both a southward migration of the African Easterly Jet (AEJ) and a weakening of rising motion between the core of the AEJ and the Tropical Easterly Jet.

We analyze the relationship between total precipitation change and change in occurrence and intensity of wet days across West Africa using simulations from the Coupled Model Intercomparison Project Phase 6 (CMIP6). While both changes in the intensity and occurrence of wet days contribute to the projected decrease of total precipitation over the West Sahel, there is a larger contribution from changes in the number of wet days, associated with a shorter precipitation season. The projected increase of total precipitation over the Central‐Eastern Sahel is connected primarily with changes in the intensity of wet days. Over the Guinean Coast, models disagree in how total precipitation will change, since they tend to show a decrease in the number of wet days combined with an increase in intensity of wet days. Evaluation of the models during the historical period shows they do not reproduce several key features of the observed relationships.

Africa is disproportionately exposed to catastrophic climate, hydrological and meteorological risks. Well-funded weather monitoring, nowcasting and early-warning systems must become a priority. Africa is disproportionately exposed to catastrophic climate, hydrological and meteorological risks. Well-funded weather monitoring, nowcasting and early-warning systems must become a priority. Aerial view of debris and destroyed buildings caused by Cyclone Idai

We investigate the atmospheric response to seasonal variations in sea surface temperature (SST) in the eastern tropical Atlantic during the boreal summer, using the Weather Research and Forecasting (WRF) regional atmospheric model. Three ensembles of 11 simulations each are produced with different SST forcings: the control ensemble (CTL) uses the observed climatology of the SST in 2000–2009, while the Frozen North (FzN) and Frozen South (FzS) experiments block the seasonal warming or cooling of the SST from June onwards in a region confined to the eastern tropical Atlantic. The result is a cold SST anomaly in the northeastern tropical Atlantic off the coasts of Senegal and Mauritania in FzN, and a warm anomaly in the southeastern region (Gulf of Guinea and the cold tongue zone in the equatorial Atlantic) in FzS. Comparison with CTL reveals significant impacts of these SST anomalies on the position and intensity of the marine intertropical convergence zone (ITCZ) and on West African rainfall during July and August. Over the ocean, the cold anomaly in NETA suppresses convection on the northern side of the ITCZ (north of 10 ∘ N), while the warm anomaly in the Gulf of Guinea strengthens convection on its southern flank. The latter is also leading to a sharp increase in precipitation in the coastal regions to the northeast of the Gulf of Guinea. These changes are clearly due to variations in surface pressure gradients and the divergence of low-level moisture in response to SST anomalies, which in turn induce changes in deep atmospheric convection through thermodynamic feedback. On the continent, a substantial reduction in precipitation is observed in the western Sahel (particularly Senegal) following the cold anomaly in NETA, and in the eastern Sahel following the warm anomaly in the Gulf of Guinea: both are explained by a positive anomaly in the divergence of moisture transport in the upper troposphere, associated with an acceleration of the African easterly jet along its southern edge. However, the mechanism by which the SST anomalies create this acceleration in both experiments remains to be elucidated.

While previous research has shown the potential links between taste perception pathways and brain-related conditions, the area involving Alzheimer’s disease remains incompletely understood. Taste perception involves neurotransmitter signaling, including serotonin, glutamate, and dopamine. Disruptions in these pathways are implicated in neurodegenerative diseases. The integration of olfactory and taste signals in flavor perception may impact brain health, evident in olfactory dysfunction as an early symptom in neurodegenerative conditions. Shared immune response and inflammatory pathways may contribute to the association between altered taste perception and conditions like neurodegeneration, present in Alzheimer’s disease. This study consists of an exploration of expression-quantitative trait loci (eQTL), utilizing whole-blood transcriptome profiles, of 28 taste perception genes, from a combined cohort of 475 African American subjects. This comprehensive dataset was subsequently intersected with single-nucleotide polymorphisms (SNPs) identified in Genome-Wide Association Studies (GWAS) of Alzheimer’s Disease (AD). Finally, the investigation delved into assessing the association between eQTLs reported in GWAS of AD and the profiles of 741 proteins from the Olink Neurological Panel. The eQTL analysis unveiled 3,547 statistically significant SNP-Gene associations, involving 412 distinct SNPs that spanned all 28 taste genes. In 17 GWAS studies encompassing various traits, a total of 14 SNPs associated with 12 genes were identified, with three SNPs consistently linked to Alzheimer’s disease across four GWAS studies. All three SNPs demonstrated significant associations with the down-regulation of TAS2R41, and two of them were additionally associated with the down-regulation of TAS2R60 . In the subsequent pQTL analysis, two of the SNPs linked to TAS2R41 and TAS2R60 genes (rs117771145 and rs10228407) were correlated with the upregulation of two proteins, namely EPHB6 and ADGRB3. Our investigation introduces a new perspective to the understanding of Alzheimer's disease, emphasizing the significance of bitter taste receptor genes in its pathogenesis. These discoveries set the stage for subsequent research to delve into these receptors as promising avenues for both intervention and diagnosis. Nevertheless, the translation of these genetic insights into clinical practice requires a more profound understanding of the implicated pathways and their pertinence to the disease's progression across diverse populations.

As climate model uncertainties remain very large for future rainfall in the Sahel, a multi-centennial perspective is required to assess the situation of current Sahel climate in the context of global warming. We present here the first record of hydroclimatic variability over the past 1600 years in Senegal, obtained from stable oxygen isotope analyses (δ18O) in archaeological shell middens from the Saloum Delta. During the preindustrial period, the region was relatively humid, with maximum humidity reached during the period from AD 1500 to AD 1800, referred to as the Little Ice Age. A significant negative link is observed at the centennial scale between global temperature and humidity in the Sahel that is at odds with the expected effects of latitudinal shifts of the intertropical convergence zone during the last millennium. In the context of the past 1600 years, the Western Sahel appears to be experiencing today unprecedented drought conditions. The rapid aridification that started ca. AD 1800 and the recent emergence of Sahel drought from the natural variability point to an anthropogenic forcing of Sahel drying trend. This new long-term perspective suggests that the recovery of Sahel rainfall in the last decade may only result from short-term internal variability, and supports climate models that predict an increase of Sahel drought under future greenhouse climate.

Intra-seasonal drought episodes (extreme dry spells) are strongly linked to crop yield loss in the West African Sahel, especially when they occur at crop critical stages such as juvenile or flowering stage. This paper seeks to expose potentially predictable features in the sub-seasonal to inter-annual occurrence of “extreme dry spells” (extDS) through their links to sea surface temperature anomalies (SSTAs). We consider two kinds of extreme dry spells: more than 2 weeks of consecutive dry days following a rain event (often found at the beginning of the rainy season, after the first rain events) and more than a week (observed towards the end of the rainy season, before the last rain events). We extract dry spells from daily rainfall data at 43 stations (31 stations in Senegal over 1950–2010 and 12 stations in Niger over 1960–2000) to identify the intra-seasonal distribution of extDS and their significant correlation with local rainfall deficits. Seasonality of distribution and high spatial coherence are found in the timing and the frequency of occurrence of extDS in different rainfall regions over Niger and Senegal. The correlation between the regional occurrence index (ROI), necessary to capture the spatial extent of extDS, and observed global sea surface temperature anomalies (SSTAs) sheds light on the influence of the external factors on the decadal, interannual and sub-seasonal variability of extDS over the West African Sahel. When the global tropics and the Atlantic are warmer than normal, more coherent and delayed June–July extDS are observed after onset of rainy season, as well as early cessation type in August–September. When the Indo-Pacific is cooler and the equatorial south Atlantic is warmer than normal little to no extDS are found in the onset sub-period of the monsoon season. Mostly late types of extDS occur in October as a result of late cessation. These results show potential predictability of extreme dry spells after onset and before cessation of monsoonal rain based on global patterns of sea surface temperature anomalies.

Upwelling processes bring nutrient-rich waters from the deep ocean to the surface. Areas of upwelling are often associated with high productivity, offering great economic value in terms of fisheries. The sensitivity of spring/summer-time coastal upwelling systems to climate change has recently received a lot of attention. Several studies have suggested that their intensity may increase in the future while other authors have shown decreasing intensity in their equatorward portions. Yet, recent observations do not show robust evidence of this intensification. The Senegalo-Mauritanian upwelling system (SMUS) located at the southern edge of the north Atlantic system (12°N–20°N) and most active in winter/spring has been largely excluded from these studies. Here, the seasonal cycle of the SMUS and its response to climate change is investigated in the database of the Coupled Models Inter comparison Project Phase 5 (CMIP5). Upwelling magnitude and surface signature are characterized by several sea surface temperature and wind stress indices. We highlight the ability of the climate models to reproduce the system, as well as their biases. The simulations suggest that the intensity of the SMUS winter/spring upwelling will moderately decrease in the future, primarily because of a reduction of the wind forcing linked to a northward shift of Azores anticyclone and a more regional modulation of the low pressures found over Northwest Africa. The implications of such an upwelling reduction on the ecosystems and local communities exploiting them remains very uncertain.

The impact of desert aerosols on climate, atmospheric processes, and the environment is still debated in the scientific community. The extent of their influence remains to be determined and particularly requires a better understanding of the variability of their distribution. In this work, we studied the variability of these aerosols in western Africa using different types of satellite observations. SeaWiFS (Sea-Viewing Wide Field-of-View Sensor) and OMI (Ozone Monitoring Instrument) data have been used to characterize the spatial distribution of mineral aerosols from their optical and physical properties over the period 2005–2010. In particular, we focused on the variability of the transition between continental western African and the eastern Atlantic Ocean. Data provided by the lidar scrolling CALIOP (Cloud-Aerosol Lidar with Orthogonal Polarization) onboard the satellite CALIPSO (Cloud Aerosol Lidar and Infrared Pathfinder Satellite Observations) for the period 2007–2013 were then used to assess the seasonal variability of the vertical distribution of desert aerosols. We first obtained a good representation of aerosol optical depth (AOD) and single-scattering albedo (SSA) from the satellites SeaWiFS and OMI, respectively, in comparison with AERONET estimates, both above the continent and the ocean. Dust occurrence frequency is higher in spring and boreal summer. In spring, the highest occurrences are located between the surface and 3 km above sea level, while in summer the highest occurrences are between 2 and 5 km altitude. The vertical distribution given by CALIOP also highlights an abrupt change at the coast from spring to fall with a layer of desert aerosols confined in an atmospheric layer uplifted from the surface of the ocean. This uplift of the aerosol layer above the ocean contrasts with the winter season during which mineral aerosols are confined in the atmospheric boundary layer. Radiosondes at Dakar Weather Station (17.5° W, 14.74° N) provide basic thermodynamic variables which partially give a causal relationship between the layering of the atmospheric circulation over western Africa and their aerosol contents throughout the year. A SSA increase is observed in winter and spring at the transition between the continent and the ocean. The analysis of mean NCEP (National Centers for Environmental Prediction) winds at 925 hPa between 2000 and 2012 suggest a significant contribution of coastal sand sources from Mauritania in winter which would increase SSA over the ocean.

Research examining associations between air pollution exposure and respiratory symptoms in adults has generally been inconclusive. This may be related in part to sample size issues, which also preclude analysis in potentially vulnerable subgroups. We estimated associations between air pollution exposures and the prevalence of wheeze and shortness of breath using harmonized baseline data from two very large European cohorts, Lifelines (2006-2013) and UK Biobank (2006-2010). Our aim was also to determine whether the relationship between air pollution and respiratory symptom prevalence differed between individuals with different characteristics. Cross-sectional analyses explored associations between prevalence of self-reported wheeze and shortness of breath and annual mean particulate matter with aerodynamic diameter <2.5μm, 2.5-10μm, and <10μm (PM2.5, PMcoarse, and PM10, respectively) and nitrogen dioxide (NO2) concentrations at place of residence using logistic regression. Subgroup analyses and tests for interaction were performed for age, sex, smoking status, household income, obesity status, and asthma status. All PM exposures were associated with respiratory symptoms based on single-pollutant models, with the largest associations seen for PM2.5 with prevalence of wheezing {odds ratio (OR)=1.16 per 5μg/m³ [95% confidence interval (CI): 1.11, 1.21]} and shortness of breath [OR=1.61 per 5μg/m³ (95% CI: 1.45, 1.78)]. The association between shortness of breath and a 5-μg/m³ increment in PM2.5 was significantly higher for individuals from lower-[OR=1.73 (95% CI: 1.52, 1.97)] versus higher-income households [OR=1.31 (95% CI: 1.11, 1.55); p-interaction=0.005), whereas the association between PM2.5 and wheeze was limited to lower-income participants [OR=1.30 (95% CI: 1.22, 1.38) vs. OR=1.02; (95% CI: 0.96, 1.08); p-interaction<0.001]. Exposure to NO2 also showed positive associations with wheeze and shortness of breath. Exposure to PM and NO2 air pollution was associated with the prevalence of wheeze and shortness of breath in this large study, with stronger associations between PM2.5 and both outcomes among lower- versus higher-income participants. https://doi.org/10.1289/EHP1353.