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• Effective defense of Arabidopsis against filamentous pathogens requires two mechanisms, both of which involve biosynthesis of tryptophan (Trp)-derived metabolites. Extracellular resistance involves products of PEN2-dependent metabolism of indole glucosinolates (IGs). Restriction of further fungal growth requires PAD3-dependent camalexin and other, as yet uncharacterized, indolics. • This study focuses on the function of CYP71A12 monooxygenase in pathogen-triggered Trp metabolism, including the biosynthesis of indole-3-carboxylic acid (ICA). Moreover, to investigate the contribution of CYP71A12 and its products to Arabidopsis immunity, we analyzed infection phenotypes of multiple mutant lines combining pen2 with pad3, cyp71A12, cyp71A13 or cyp82C2. • Metabolite profiling of cyp71A12 lines revealed a reduction in ICA accumulation. Additionally, analysis of mutant plants showed that low amounts of ICA can form during an immune response by CYP71B6/AAO1-dependent metabolism of indole acetonitrile, but not via IG hydrolysis. Infection assays with Plectosphaerella cucumerina and Colletotrichum tropicale, two pathogens with different lifestyles, revealed cyp71A12-, cyp71A13- and cyp82C2-associated defects associated with Arabidopsis immunity. • Our results indicate that CYP71A12, but not CYP71A13, is the major enzyme responsible for the accumulation of ICA in Arabidopsis in response to pathogen ingression. We also show that both enzymes are key players in the resistance of Arabidopsis against selected filamentous pathogens after they invade.

Immune responses in plants can be triggered by damage/microbe-associated molecular patterns (DAMPs/MAMPs) upon recognition by plant pattern recognition receptors (PRRs). DAMPs are signaling molecules synthesized by plants or released from host cellular structures (e.g., plant cell walls) upon pathogen infection or wounding. Despite the hypothesized important role of plant cell wall-derived DAMPs in plant-pathogen interactions, a very limited number of these DAMPs are well characterized. Recent work demonstrated that pectin-enriched cell wall fractions extracted from the cell wall mutant impaired in ( ), that showed altered disease resistance to several pathogens, triggered more intense immune responses than those activated by similar cell wall fractions from wild-type plants. It was hypothesized that cell wall fractions could be differentially enriched in DAMPs. In this work, we describe the characterization of the previous immune-active fractions of showing the highest triggering capacities upon further fractionation by chromatographic means. These analyses pointed to a role of pentose-based oligosaccharides triggering plant immune responses. The characterization of several pentose-based oligosaccharide structures revealed that β-1,4-xylooligosaccharides of specific degrees of polymerization and carrying arabinose decorations are sensed as DAMPs by plants. Moreover, the pentasaccharide 3 -α-L-arabinofuranosyl-xylotetraose (XA3XX) was found as a highly active DAMP structure triggering strong immune responses in and enhancing crop disease resistance.

Purpose The aim of this review is to establish the efficacy of aquatic therapeutic exercise in female breast cancer survivors for improving fatigue, pain, lymphedema, and quality of life. Methods A systematic literature review was conducted in PubMed, Web of Science, and Cochrane Library databases for articles published in the last 10 years. The review focuses on aquatic exercise-based rehabilitation in female breast cancer survivors, according to the PRISMA statement and using the PEDRO and Jadad scales. Results Ten randomized controlled trials with 606 participants were included. Two studies showed aquatic therapeutic exercise to be effective in reducing fatigue, three in reducing pain, and four in improving quality of life after intervention. Three of five studies obtained significant immediate changes in lymphedema volume, although this improvement was only maintained at 3 months in a single study. The methodological quality of all the studies was ≥ 7 on the PEDro scale and ≥ 3 on the Jadad scale. Conclusion Aquatic therapeutic exercise is an effective strategy for improving fatigue, pain, and quality of life in breast cancer survivors, although the effects on lymphedema remain uncertain. Participants showed high adherence to treatment and no adverse effects after intervention were reported.

The primary objective of this study was to explore the mechanisms and conditions whereby Tension-Type Headache (TTH) presenteeism relates to health-related loss of productivity as a result of both reduced physical and mental health. To this end, Structural Equation Modeling (SEM) was used to conduct a secondary data analysis of a randomized clinical trial involving 78 Tension-type Headache (TTH) patients. The results showed that TTH presenteeism did not directly relate to health-related loss of productivity, either due to physical, or mental health problems. However, through anxiety-state, TTH presenteeism decreased patients' productivity, as consequence of reduced physical and mental health. Moreover, by increasing the severity of the Tension-Type Headache, TTH presenteeism indirectly decreased patients' productivity as consequence of reduced physical health (but not mental health). Finally, our results show that such indirect effects only occur when the cause of TTH is non-mechanical (e.g., hormonal causes, etc.). Our work provides an integrative model that can inform organizational behaviorists and health professionals (e.g., physiotherapists). Implications for organizational health are discussed.

In this study, we aimed to explore the impact of previous history of lateral ankle sprain on the mechanical and viscoelastic properties of the tibialis anterior (TA), peroneus longus (PL) and gastrocnemius lateralis (GL) and medialis (GM) in asymptomatic men. For this purpose, a group of 26 men with previous history of lateral ankle sprain (ASG) and a control group (CG) of 29 healthy counter-parts participated in this study. Tone, stiffness, elasticity and mechanical stress relaxation time were measured using a myotonometer in a single session. Higher tone was noted for TA and GL in ASG as compared to CG (effect size of Cohen’s d = 0.57 [p = 0.04] and 0.59 [p = 0.04], respectively). Further, stiffness was higher in ASG than in CG for TA (d = 0.56; p = 0.04), PL (d = 0.58; p = 0.04) and GL (d = 0.63; p = 0.02). Stress relaxation time was also lower for the ASG compared to the CG for TA (d = 0.61; p = 0.03), PL (d = 0.55; p = 0.04) and GL (d = 0.68; p = 0.02). There were no significant differences between groups in elasticity (p > 0.05). GM experienced no significant changes after ankle sprain in any of the variables (p > 0.05). To conclude, previous history of lateral ankle sprain results in higher TA and GL muscle tone. Likewise, these muscles in addition to PL exhibit less deformation against resistance due to their increased stiffness, thus needing a shorter time to restore to their original shape after deformation.

With the increase in public services offered at the local level and heightened budgetary and financial constraints on local government, new ways of managing local public services must be sought, in order to maximize the efficiency of resource management. Accordingly, local governments have introduced organizational changes, through contracting out, the creation of public agencies, and increased cooperation with other municipalities and private companies. However, previous studies have only examined the relationship between contracting out and efficiency, and no in-depth survey has been made of the relationship between efficiency with other forms of management, nor of the joint impact of these forms of management on efficiency. The main aim of this study is to determine whether New Public Management (NPM) delivery forms do in fact improve the efficiency of Spanish local governments. In this regard, we analyze the particular impact of the global recession. Our results suggest that in general terms the creation of agencies, contracting out, and intermunicipal cooperation reduce cost efficiency. However, these results also lead to the conclusion that during the global recession, some of these NPM delivery forms tended to become more efficient. Thus, empirical evidence suggests that the adoption of mixed firms contributes to higher levels of cost efficiency in the whole period considered, and thus it may be a suitable instrument in periods of crisis.

Background Understanding the functional status of people with Alzheimer Disease (AD), both in a single (ST) and cognitive dual task (DT) activities is essential for identifying signs of early-stage neurodegeneration. This study aims to compare the performance quality of several tasks using sensors embedded in an Android device, among people at different stages of Alzheimer and people without dementia. The secondary aim is to analyze the effect of cognitive task performance on mobility tasks. Methods This is a cross-sectional study including 22 participants in the control group (CG), 18 in the group with mild AD and 22 in the group with moderate AD. They performed two mobility tests , under ST and DT conditions, which were registered using an Android device. Postural control was measured by medial-lateral and anterior-posterior displacements of the COM ( MLDisp and APDisp , respectively) and gait, with the vertical and medial-lateral range of the COM ( Vrange and MLrange ). Further, the sit-to-stand ( PStand ) and turning and sit power ( PTurnSit ), the total time required to complete the test and the reaction time were measured. Results There were no differences between the two AD stages either for ST or DT in any of the variables ( p  > 0.05). Nevertheless, people at both stages showed significantly lower values of PStand and PTurnSit and larger Total time and Reaction time compared to CG ( p  < 0.05). Further, Vrange is also lower in CDR1G than in CG ( p  < 0.05). The DT had a significant deleterious effect on MLDisp in all groups ( p  < 0.05) and on APDisp only in moderate AD for DT. Conclusions Our findings indicate that AD patients present impairments in some key functional abilities, such as gait, turning and sitting, sit to stand, and reaction time, both in mild and moderate AD. Nevertheless, an exclusively cognitive task only influences the postural control in people with AD.

The main goal of this cross-sectional study was to detect whether women with fibromyalgia syndrome (FMS) have altered postural control and to study the sensory contribution to postural control. We also explored the possibility that self-induced anxiety and lower limb strength may be related to postural control. For this purpose, 129 women within an age range of 40 to 70 years were enrolled. Eighty of the enrolled women had FMS. Postural control variables, such as Ellipse, Root mean square (RMS) and Sample entropy (SampEn), in both directions (i.e. mediolateral and anteroposterior), were calculated under five different conditions. A force plate was used to register the center of pressure shifts. Furthermore, isometric lower limb strength was recorded with a portable dynamometer and normalized by lean body mass. The results showed that women with FMS have impaired postural control compared with healthy people, as they presented a significant increase in Ellipse and RMS values (p<0.05) and a significant decrease in SampEn in both directions (p<0.05). Postural control also worsens with the gradual alteration of sensory inputs in this population (p<0.05). Performing a stressor dual task only impacts Ellipse in women with FMS (p>0.05). There were no significant correlations between postural control and lower limb strength (p>0.05). Therefore, women with FMS have impaired postural control that is worse when sensory inputs are altered but is not correlated with their lower limb strength.

Objective To translate and culturally adapt the Parental Expectations and Perceptions of Children's Sibling Relationship Questionnaire (PEPC‐SRQ; Kramer & Baron, 1995) into Spanish and test its psychometric properties. Background Sibling relationships contribute significantly to child development; however, to date, no study has validated an instrument to assess the quality of children's sibling relationships with Spanish samples. Method We conducted two studies. In Study 1, the instrument underwent translation and back‐translation along with the inspection of semantic, linguistic, and contextual equivalence. In Study 2, the validity of the instrument scores was assessed by administering the translated PEPC‐SRQ to 229 mothers in Spain. Results The Exploratory Factor Analysis revealed a two‐factor structure that preserved the original 24 items. Both factors presented good internal consistency and were significantly correlated with other constructs. Conclusion These results support the use of the PEPC‐SRQ in Spain. Implications The Spanish PEPC‐SRQ may now be used as a tool for the early detection of conflictual relationships between siblings and as a tool for assessing the effectiveness of targeted strategies designed to bolster children's sibling relationships. Additionally, this adaptation provides the opportunity to carry out cross‐cultural studies.

Mitogen-activated protein kinases (MAPKs) cascades play essential roles in plants by trans-ducing developmental cues and environmental signals into cellular responses. Among the latter are microbe-associated molecular patterns perceived by pattern recognition receptors (PRRs), which trigger immunity. We found that YODA (YDA) – a MAPK kinase kinase regulating several Arabidopsis developmental processes, like stomatal patterning – also modulates immune responses. Resistance to pathogens is compromised in yda alleles, whereas plants expressing the constitutively active YDA (CA-YDA) protein show broad-spectrum resistance to fungi, bacteria, and oomycetes with different colonization modes. YDA functions in the same pathway as ERECTA (ER) Receptor-Like Kinase, regulating both immunity and stomatal patterning. ER-YDA-mediated immune responses act in parallel to canonical disease resistance pathways regulated by phytohormones and PRRs. CA-YDA plants exhibit altered cell-wall integrity and constitutively express defense-associated genes, including some encoding putative small secreted peptides and PRRs whose impairment resulted in enhanced susceptibility phenotypes. CA-YDA plants show strong reprogramming of their phosphoproteome, which contains protein targets distinct from described MAPKs substrates. Our results suggest that, in addition to stomata development, the ER-YDA pathway regulates an immune surveillance system conferring broad-spectrum disease resistance that is distinct from the canonical pathways mediated by described PRRs and defense hormones.