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Background: The endothelial activation and stress index (EASIX), derived from the serum lactate dehydrogenase, creatinine, and platelet counts, is a composite biomarker for endothelial dysfunction and systemic stress. It has been developed to predict clinical outcomes in hematologic malignancies. This study aimed to investigate the EASIX’s predictive role in contrast-induced nephropathy (CIN) and in-hospital mortality in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 1552 patients with STEMI who underwent primary PCI were retrospectively included. The patients were divided into two groups: CIN (+) and CIN (−). Baseline demographic, laboratory, clinic, and procedural variables were compared between the two groups. Logistic regression analysis was performed to identify independent predictors of CIN and in-hospital mortality, while receiver operating characteristic (ROC) curves were used to determine the optimal EASIX cut-off values. Results: CIN developed in 7.6% (n = 118) of the study population, and these patients had significantly increased EASIX scores. Those with CIN were older and exhibited higher rates of diabetes mellitus, chronic kidney disease (CKD), and decreased left ventricular ejection fraction (LVEF) (all p < 0.001). In multivariable analysis, age (OR 1.053), CKD (OR 1.338), reduced LVEF (OR 0.965), and EASIX (OR 2.467) independently predicted CIN. EASIX > 0.93 demonstrated strong discriminatory ability (AUC 0.785; sensitivity 72% and specificity 72%). EASIX also independently predicted in-hospital mortality (OR 3.592), with an optimal cut-off > 0.88 (AUC 0.774). Conclusions: By integrating markers of renal function, endothelial activation, and systemic stress, EASIX may serve as a useful and reliable indicator for predicting CIN development and in-hospital mortality in STEMI patients undergoing primary PCI.

This study aimed to investigate the anticancer, potential antiepileptic agents, and antioxidant potentials of 10 methyl-substituted halogenated and methoxy conduritols, which had been previously synthesized and characterized. The presence of active functional groups within their structures suggested their potential as bioactive molecules. Both in vitro and in silico approaches were employed to assess their biological activities and therapeutic relevance. Anticancer activity was tested using the MCF-7 breast cancer cell line and the L929 fibroblast cell line, with IC values calculated to evaluate cytotoxicity. Antioxidant activity was determined using DPPH, FRAP, and TAS assays. The effects of methyl-substituted mono- and dimethoxy halogenated conduritol derivatives (A and B forms) on the activities of carbonic anhydrase isoenzymes hCA I and hCA II were examined spectrophotometrically. Additionally, molecular docking studies were performed against hCA I (PDB ID: 3LXE), hCA II (PDB ID: 5AML), and breast cancer proteins (PDB ID: 1JNX, 1A52). ADME/T properties of the compounds were also evaluated to predict their pharmacokinetic and safety profiles. Among the synthesized derivatives, only compound 6 demonstrated notable anticancer activity, with an IC₅₀ of 20.22  M against MCF-7 cells and moderate selectivity over healthy fibroblasts. The other compounds were largely inactive at the tested concentrations. Antioxidant assays demonstrated considerable free radical scavenging and reducing power. The synthesized conduritols showed strong inhibition of carbonic anhydrase isoenzymes, with Ki values ranging from 0.2083 ± 0.11 to 1.4944 ± 1.06  M for hCA I and 0.0857 ± 0.06 to 2.2098 ± 0.68  M for hCA II, outperforming standard inhibitors. Docking studies confirmed strong binding affinities to the investigated proteins, while ADME/T analysis suggested favorable pharmacokinetic properties. The findings indicate that methyl-substituted halogenated and methoxy conduritols possess anticancer, potential antiepileptic agents, and antioxidant potentials. Their strong carbonic anhydrase inhibitory activities highlight their promise as potential therapeutic agents for epilepsy and glaucoma. Overall, these compounds demonstrate considerable potential as multifunctional bioactive molecules and represent promising candidates for further preclinical studies.