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Since we aim to test new options to find medication for cognitive disorders, we have begun to assess the effect of semaglutide and to conduct a review gathering studies that have attempted this purpose. This systematic review focuses on the cognitive effects of semaglutide, a glucagon-like peptide 1 receptor agonist (GLP-1 RA), in the context of neurological and cognitive impairment. Semaglutide, a synthetic GLP-1 analog, showcased neuroprotective effects beyond metabolic regulation. It mitigated apoptosis and improved cognitive dysfunction in cerebrovascular disease, suggesting broader implications for neurological well-being. Also, studies highlighted GLP-1 RAs’ positive impact on olfactory function in obese individuals with type 2 diabetes, on neurodegenerative disorders, multiple sclerosis, and endotoxemia. In order to analyze current studies that assess the impact of semaglutide on cognitive function, a literature search was conducted up to February 2024 on two online databases, MEDLINE (via PubMed) and Web of Science Core Collection, as well as various websites. Fifteen studies on mice populations and two studies on cell lines were included, analyzed, and assessed with bias-specific tools. The neuroprotective and anti-apoptotic properties of GLP-1 and its analogs were emphasized, with animal models and cell line studies demonstrating enhanced cognitive function. While promising, limitations include fewer studies, highlighting the need for extensive research, particularly in the human population. Even though this medication seems promising, there are significant limitations, one of which is the lack of studies on human subjects. Therefore, this review aims to gather current evidence.

Background: Advanced-stage ovarian cancer presents a significant therapeutic challenge, with primary cytoreductive surgery (PCS) followed by chemotherapy and neoadjuvant chemotherapy (NACT) with interval debulking surgery (IDS) as the two main treatment modalities. This study aims to compare the clinical outcomes, surgical complexity, and survival rates between these approaches and to assess the impact of molecular markers such as BRCA and HRD status. Methods: This retrospective, single-center observational study included 100 patients diagnosed with stage III-IV high-grade serous ovarian cancer. The patients were divided into two cohorts based on their treatment strategy: PCS followed by adjuvant chemotherapy or NACT followed by IDS. Clinical outcomes, recurrence-free survival (RFS), progression-free survival (PFS), and overall survival (OS) were analyzed, along with the impact of genetic biomarkers. Results: No statistically significant differences were observed in OS and PFS between the two treatment approaches. Patients who underwent NACT followed by IDS had lower surgical complexity scores and reduced perioperative morbidity. The HRD-positive patients exhibited improved responses to PARP inhibitors, reinforcing the significance of molecular profiling in therapeutic decision-making. The KELIM scores demonstrated prognostic relevance, particularly in the patients receiving neoadjuvant chemotherapy. Conclusion: Both PCS and NACT-IDS are viable treatment options for advanced ovarian cancer, with similar survival outcomes. The choice between strategies should be tailored based on patient-specific factors, including tumor burden, performance status, and molecular profile. The integration of biomarkers such as BRCA mutations and HRD status into clinical practice can further refine treatment selection and improve personalized management strategies.

Type 2 diabetes (T2D) represents a major public health challenge, being associated with significant metabolic and cardiovascular complications. Evidence-based nutritional interventions are essential for the prevention and management of the disease. Dietary fibers, particularly soluble fibers such as psyllium, β-glucan, inulin, and fermentable fiber blends, have demonstrated beneficial effects on glycemia, glycated hemoglobin (HbA1c), lipid profile, body weight, and medication requirements. This narrative review synthesizes the results of recent clinical trials and meta-analyses, highlighting the underlying physiological mechanisms, including colonic fermentation and short-chain fatty acid (SCFA) production, as well as the impact on gut microbiota composition. The findings support the integration of soluble fibers into a personalized dietary plan as part of a multidimensional strategy for T2D management. Further long-term randomized studies are warranted to standardize doses and assess the metabolic and microbiota-mediated effects of dietary fibers.

Endometrial cancer affects the uterus and is becoming increasingly common and deadly. Although surgery and adjuvant pelvic radiotherapy can often cure the disease when it is contained in the uterus, patients with metastatic or recurrent disease have limited response rates to chemotherapy, targeted agents, and hormonal therapy. To address this unmet clinical need, innovative treatment strategies are needed, and a growing focus on the immunomodulation of the tumor microenvironment has arisen. Current data suggest that active and/or passive immunotherapy may be promising for the treatment of endometrial cancer.

Background/Aim: Currently, the impact of diabetes mellitus (DM) on rectal cancer patients is complex and just partly elucidated. The purpose of this study was to investigate the impact of diabetes mellitus on rectal cancer patients focusing on tumor differentiation grade, neoadjuvant chemoradiotherapy (NACRT) response, disease-free (DFS) and overall (OS) survival. Patients and Methods: Our study’s population consisted of a group of 53 patients diagnosed with locally advanced rectal cancer, who underwent NACRT, followed by radical oncological surgery. This patient population was further divided into two groups according to diabetes presence. Results: Downstaging rates, local control, DFS, and OS were lower in the DM subgroup compared to the non-DM locally advanced rectal cancer patients. Conclusion: The presence of DM at the time of diagnosis of locally advanced rectal cancer patients may be a negative predictive factor for response to neoadjuvant therapy, distant metastases, and local recurrences rates.

Cancer during pregnancy presents considerable challenges that arise from various factors, including the diagnostic, prognostic and therapeutic implications of managing cancer in this unique patient population. There is a crucial need for an integrated approach that aligns medical interventions for both the pregnant patient and the developing embryo or fetus. Furthermore, the distinct characteristics associated with each stage of gestation may significantly influence the treatment protocols that can be proposed. Due to all of these factors, the importance of collaboration among healthcare professionals from different specialties (to ensure that both mother and child receive optimal care throughout the pregnancy) is often neglected. This review is designed to provide a thorough overview of the current standard procedures regarding the diagnosis and treatment options for cancer in pregnant patients in order to ensure the safety of mother and child. Furthermore, the review describes the feasibility of current fertility preservation methods, highlights the psychological effects of cancer during pregnancy and examines the risks and benefits of breastfeeding.

Introduction: A key element for a healthy lifestyle in the formative years of a young adult is a balanced, healthy, individualized diet. Aim: The aim of this study was to analyze the eating behavior and lifestyles of students at a university in Romania, as well as the extent to which the study program interferes with these factors. Methods: A retrospective study was performed, with the data being collected through an online questionnaire via the Google Forms platform; data collection for the current study was carried out in November 2024 during a student session. Results: Out of the total of 501 questionnaires collected, 416 were completed by women and 85 by men. It can be observed that 57.65% of men (49 participants) eat three meals a day compared to 53.13% of women (221 participants). The university program influenced the students’ meal schedules for 59.88% (n = 300) of participants, while 30.94% (n = 155) declared that they never have an ordered meal schedule. For 39.92% of students, the exam period has an influence on the meal schedule, including an increase the intake of sweet foods (59.88%), and some declared that they forget to eat (33.93%). Conclusions: The food and lifestyle behaviors in the studied group show health risk elements, especially an increase in tobacco consumption, a lack of regular meal schedules, and the consumption of an excess of unhealthy snacks. It was found that intensive study schedules may intensify this behavior.

Background: Palliative radiotherapy plays a crucial role in managing symptomatic gynecological cancers (GCs). This article aims to systematically review literature studies on palliative pelvic radiotherapy in cervical, endometrial, ovarian, vaginal, and vulvar cancers. The primary focus is centered around evaluating symptom relief, quality of life (QOL), and toxicity in order to ascertain optimal radiotherapy regimens. Methodology: For this thorough review, we mainly relied on Medline to gather papers published until November 2023. Selected studies specifically detailed symptomatology and QOL responses in palliative pelvic radiotherapy used for GCs. Results: Thirty-one studies, mostly retrospective studies and those lacking standardized outcome measures, showed varied responses. Encouraging outcomes were noted in managing hemorrhage (55%) and pain control (70%). However, comprehensively assessing overall symptom response rates and toxicity remained challenging. Investigations into 10 Gy fractionation revealed benefits in addressing tumor-related bleeding and pain in female genital tract cancers. Conclusions: Palliative pelvic radiotherapy effectively manages symptomatic GCs. Nonetheless, unresolved dosing and fractionation considerations warrant further investigation. Embracing modern therapies alongside radiotherapy offers improved symptom control, emphasizing the importance of selecting suitable patients for successful GC palliation interventions.

The paper presents the production of thermoplastic starch (TPS) mixtures using potato starch and two types of plasticizers: glycerol and sorbitol. The effects of plasticizers, citric acid, organically modified montmorillonite clay nanofiller (OMMT) and an additive based on ultrahigh molecular weight siloxane polymer on the structure and physical–mechanical and thermal properties of TPS samples were analysed. Starch mixtures plasticized with glycerol were obtained, where the starch/glycerol mass ratio was 70:30, as well as starch mixtures plasticized with glycerol and sorbitol, with a starch/glycerol/sorbitol mass ratio of 60:20:20. The starch gelatinization process to obtain TPS was carried out in a Brabender Plasti-Corder internal mixer at 120 °C, with a mixing speed of 30–80 rpm, for 10 min. The obtained results indicate that by adding 2% (weight percentage) of citric acid to the TPS mixtures, there is an improvement in the physical–mechanical properties, as well as structural changes that can indicate both cross-linking reactions by esterification in stages and depolymerisation reactions. The sample of TPS plasticized with glycerol, which contains OMMT, shows an increase in tensile strength by 34.4%, compared to the control sample.

Simulation has become an essential pedagogical tool in health professions education, traditionally valued for its ability to approximate clinical practice. Higher simulation fidelity is often assumed to directly enhance learner engagement and improve educational outcomes; however, this assumption oversimplifies a complex relationship. Fidelity is multidimensional, encompassing physical, emotional, and contextual dimensions, as well as qualitative and quantitative considerations, each influencing learners’ perception of realism in distinct ways. Engagement is shaped not only by these dimensions of fidelity but also by intrinsic factors such as motivation, prior experience, stress, and emotional resilience, and by extrinsic factors including instructional design, facilitation, debriefing, and psychological safety. A central mediator in this process is the fiction contract, an implicit agreement that enables learners to suspend disbelief and engage authentically despite inherent limitations in realism. Technological sophistication alone does not necessarily translate into greater educational impact. Rather, fidelity should be intentionally aligned with learning objectives: advanced patient simulators may support procedural training, standardized patients may enhance communication skills, and task trainers may optimize focused psychomotor practice. This viewpoint advocates for a goal-oriented, multimodal approach that redefines high-fidelity simulation not as the pursuit of maximum realism, but as the deliberate alignment of fidelity with pedagogy to optimize learner engagement and educational effectiveness.