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Historically, emerging and reemerging infectious diseases have caused large, deadly, and expensive multinational outbreaks. Often outbreak investigations aim to identify who infected whom by reconstructing the outbreak transmission tree, which visualizes transmission between individuals as a network with nodes representing individuals and branches representing transmission from person to person. We compiled a database, called OutbreakTrees, of 382 published, standardized transmission trees consisting of 16 directly transmitted diseases ranging in size from 2 to 286 cases. For each tree and disease, we calculated several key statistics, such as tree size, average number of secondary infections, the dispersion parameter, and the proportion of cases considered superspreaders, and examined how these statistics varied over the course of each outbreak and under different assumptions about the completeness of outbreak investigations. We demonstrated the potential utility of the database through 2 short analyses addressing questions about superspreader epidemiology for a variety of diseases, including Coronavirus Disease 2019 (COVID-19). First, we found that our transmission trees were consistent with theory predicting that intermediate dispersion parameters give rise to the highest proportion of cases causing superspreading events. Additionally, we investigated patterns in how superspreaders are infected. Across trees with more than 1 superspreader, we found preliminary support for the theory that superspreaders generate other superspreaders. In sum, our findings put the role of superspreading in COVID-19 transmission in perspective with that of other diseases and suggest an approach to further research regarding the generation of superspreaders. These data have been made openly available to encourage reuse and further scientific inquiry.

\"The 2011 Arab uprisings precipitated the relatively quick collapse of a number of Middle Eastern states once perceived as invincible. The Tunisian and Egyptian states succumbed to revolutionary upheavals early on, followed by that of Qadhafi's Libya. Yemen's President Saleh was also eventually forced to give up power. A bloody civil war continues to rage in Syria. These uprisings highlighted weaknesses in the capacity and legitimacy of states across the Arab Middle East. This book provides a comprehensive study of state weakness-or of 'weak states'-across the Greater Middle East. No other book examines the subject of weak states in the Middle East. Fragile Politics begins with laying the theoretical framework for the study of weak states, examining the theoretical controversies surrounding the topic, the causes and characteristics of weak states, and their consequences for the Middle East. It then looks at a series of case studies, examining various themes within the study of weak states in relation to each case study.\" -- Publisher's description

Trajectories of Education in the Arab World gives a broad yet detailed historical and geographical overview of education in Arab countries. Drawing on pre-modern and modern educational concepts, systems, and practices in the Arab world, this book examines the impact of Western cultural influence, the opportunities for reform and the sustainability of current initiatives. The contributors bring together analyses and case studies of educational standards and structures in the Arab world, from the classical Islamic period to contemporary local and international efforts to re-define the changing needs and purposes of Arab education in the contexts of modernization, multiculturalism, and globalization. Taking a thematic and chronological approach, the first section contrasts the traditional notions, approaches, and standards of education with the changes that were initiated or imposed by European influences in the nineteenth century. The chapters then focus on the role of modern state-based educational systems in constructing and preserving national identities, cultures, and citizenries and concentrates on the role of education in state-formation and the reproduction of socio-political hierarchies. The success of educational reforms and policy-making is then assessed, offering perspectives on future trends and prospects for generating institutional and organizational change. This book will be of interest to graduate and postgraduate students and scholars of education, history, Arab and Islamic history and the Middle East and North Africa. Osama Abi-Mershed is Assistant Professor of History at Georgetown University, where he currently teaches classes on the medieval and modern histories of the Middle East, North Africa and the Western Mediterranean world. His current research focuses on the processes of cultural transformation in colonial Algeria. Introduction: The Politics of Arab Educational Reforms Osama Abi-Mershed Part I: Historical Perspectives 1. The Principles of Instruction are the Grounds of Our Knowledge: Al-Farabi’s Philosophical and al-Ghazali’s spiritual approaches to learning Sebastian Günther 2. Between the Golden Age and the Renaissance: Islamic Higher Education in Eighteenth-Century Damascus Stephen Tamari 3. \"If the Devil Taught French\": Strategies of Language and Learning in French Mandate Beirut Nadya Sbaiti 4. \"According to a Logic Befitting the Arab Soul\": Cultural Policy and Popular Education in Morocco Since 1912 Spencer Segalla Part II: Education and the Post-Colonial State 5. Public Institutions of Religious Education in Egypt and Tunisia: Contrasting the Post-Colonial Reforms of Al-Azhar and the Zaytuna Malika Zeghal 6. Palestinian Education in a Virtual State Nubar Hovsepian 7. Language-in-Education Policies in Contemporary Lebanon: Youth Perspective Zeena Zakharia 8. Education as a Humanitarian Response as Applied to the Arab World, With Special Reference to the Palestinian Case Colin Brock and Lala Demirdjian Part III: Education and Socio-Political Development: Reform, Policy and Practice 9. Naming the Imaginary:”Building an Arab Knowledge Society” and the Contested Terrain of educational Reforms for development Andre Elias Mazawi 10. An Introduction to Qatar’s Primary and Secondary Education Reform Dominic Brewer 11. Observations from the Edge of the deluge: Are we going too far too fast in our Educational Transformation in the Arab World? Munir Bashshur

People in many African communities live within a series of concentric circles when it comes to language. In a small group, a speaker uses an often unwritten and endangered mother tongue that is rarely used in school. A national indigenous language-written, widespread, sometimes used in school-surrounds it. An international language like French or English, a vestige of colonialism, carries prestige, is used in higher education, and promises mobility-and yet it will not be well known by its users.The essays inLanguages in Africaexplore the layers of African multilingualism as they affect language policy and education. Through case studies ranging across the continent, the contributors consider multilingualism in the classroom as well as in domains ranging from music and film to politics and figurative language. The contributors report on the widespread devaluing and even death of indigenous languages. They also investigate how poor teacher training leads to language-related failures in education. At the same time, they demonstrate that education in a mother tongue can work, linguists can use their expertise to provoke changes in language policies, and linguistic creativity thrives in these multilingual communities.

This volume explores the role of water in the Middle East's current economic, political and environmental transformations, which are set to continue in the near future. In addition to examining water conflict from within the domestic contexts of Iraq, Yemen and Syria - all experiencing high levels of instability today - the contributors shed further light on how conflict over water resources has influenced political relations in the region. They interrogate how competition over water resources may precipitate or affect war in the Middle East, and assess whether or how resource vulnerability impacts fragile states and societies in the region and beyond.

Despite the availability of seasonal vaccines and antiviral medications, influenza virus continues to be a major health concern and pandemic threat due to the continually changing antigenic regions of the major surface glycoprotein, hemagglutinin (HA). One emerging strategy for the development of more efficacious seasonal and universal influenza vaccines is structure-guided design of nanoparticles that display conserved regions of HA, such as the stem. Using the H1 HA subtype to establish proof of concept, we found that tandem copies of an alpha-helical fragment from the conserved stem region (helix-A) can be displayed on the protruding spikes structures of a capsid scaffold. The stem region of HA on these designed chimeric nanoparticles is immunogenic and the nanoparticles are biochemically robust in that heat exposure did not destroy the particles and immunogenicity was retained. Furthermore, mice vaccinated with H1-nanoparticles were protected from lethal challenge with H1N1 influenza virus. By using a nanoparticle library approach with this helix-A nanoparticle design, we show that this vaccine nanoparticle construct design could be applicable to different influenza HA subtypes. Importantly, antibodies elicited by H1, H5, and H7 nanoparticles demonstrated homosubtypic and heterosubtypic cross-reactivity binding to different HA subtypes. Also, helix-A nanoparticle immunizations were used to isolate mouse monoclonal antibodies that demonstrated heterosubtypic cross-reactivity and provided protection to mice from viral challenge via passive-transfer. This tandem helix-A nanoparticle construct represents a novel design to display several hundred copies of non-trimeric conserved HA stem epitopes on vaccine nanoparticles. This design concept provides a new approach to universal influenza vaccine development strategies and opens opportunities for the development of nanoparticles with broad coverage over many antigenically diverse influenza HA subtypes.