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The HYPEDIA study aimed at evaluating the implementation of the 2018 European guidelines for treating hypertension in primary care. A nationwide prospective non-interventional cross-sectional study was performed in consecutive untreated or treated hypertensives recruited mainly in primary care in Greece. Participants’ characteristics, office blood pressure (BP) (triplicate automated measurements, Microlife BPA3 PC) and treatment changes were recorded on a cloud platform. A total of 3,122 patients (mean age 64 ± 12.5 [SD] years, 52% males) were assessed by 181 doctors and 3 hospital centers. In 772 untreated hypertensives (25%), drug treatment was initiated in the majority, with monotherapy in 53.4%, two-drug combination in 36.3%, and three drugs in 10.3%. Angiotensin receptor blocker (ARB) monotherapy was initiated in 30%, ARB/calcium channel blocker (CCB) 20%, ARB/thiazide 8%, angiotensin converting enzyme inhibitor (ACEi)-based 19%. Of the combinations used, 97% were in single-pill. Among 977 treated hypertensives aged <65 years, 79% had BP ≥ 130/80 mmHg (systolic and/or diastolic), whereas among 1,373 aged ≥65 years, 66% had BP ≥ 140/80 mmHg. ARBs were used in 69% of treated hypertensives, CCBs 47%, ACEis 19%, diuretics 39%, beta-blockers 19%. Treatment modification was decided in 53% of treated hypertensives aged <65 years with BP ≥ 130/80 mmHg and in 62% of those ≥65 years with BP ≥ 140/80 mmHg. Renin-angiotensin system blocker-based therapy constitutes the basis of antihypertensive drug treatment in most patients in primary care, with wide use of single-pill combinations. In almost half of treated uncontrolled hypertensives, treatment was not intensified, suggesting suboptimal implementation of the guidelines and possible physician inertia.

Chatzinikolaou, A, Fatouros, IG, Gourgoulis, V, Avloniti, A, Jamurtas, AZ, Nikolaidis, MG, Douroudos, I, Michailidis, Y, Beneka, A, Malliou, P, Tofas, T, Georgiadis, I, Mandalidis, D, and Taxildaris, K. Time course of changes in performance and inflammatory responses after acute plyometric exercise. J Strength Cond Res 24(5)1389-1398, 2010-The objectives of the present investigation were to study the inflammatory and performance responses after an acute bout of intense plyometric exercise during a prolonged recovery period. Participants were randomly assigned to either an experimental group (P, n = 12) that performed intense plyometric exercises or a control group (C, n = 12) that rested. The delayed onset of muscle soreness (DOMS), knee range of motion (KROM), creatine kinase (CK) and lactate dehydrogenase (LDH) activities, white blood cell count, C reactive protein (CRP), uric acid (UA), cortisol, testosterone, IL-6, IL-1b strength (isometric and isokinetic), and countermovement (CMJ) and static (SJ) jumping performance were measured at rest, immediately postexercise and at 24, 48, 72, 96, and 120 hours of recovery. Lactate was measured at rest and postexercise. Strength remained unchanged throughout recovery, but CMJ and SJ declined (p < 0.05) by 8-20%. P induced a marked rise in DOMS, CK, and LDH (peaked 24-48 hours postexercise) and a KROM decline. An acute-phase inflammatory response consisting of leukocytosis (postexercise and at 24 hours), an IL-6, IL-1b, CRP, and cortisol elevation (during the first 24 hours of recovery) and a delayed increase of UA (peaked at 48 hours) and testosterone (peaked at 72 hours) was observed in P. The results of this investigation indicate that performing an acute bout of intense plyometric exercise may induce a short-term muscle damage and marked but transient inflammatory responses. Jumping performance seems to deteriorate for as long as 72 hours postexercise, whereas strength appears to remain unchanged. The acute-phase inflammatory response after a plyometric exercise protocol appears to follow the same pattern as in other exercise models. These results clearly indicate the need of sufficient recovery between successive plyometric exercise training sessions.

Background: We examined changes in hematological, biochemical, and hormonal biomarkers, along with endurance and explosive performance indices, in amateur soccer players over a 4-week preseason period. Methods: Thirteen players (age: 19.7 ± 2.0 years; body mass: 73.0 ± 6.8 kg; height: 180 ± 0.1 cm; body fat: 8.6 ± 3.5%) were monitored during a 4-week preseason program, which included 21 training days, three friendly matches, and four days of rest. Before and after this period, endurance capacity was evaluated using the Yo-Yo IR1 test, and leg power was assessed using the CMJ. Blood samples were collected for three consecutive days in week 1 and after week 4 to assess hematological and biochemical parameters. Internal load during all weeks was assessed with session RPE (sRPE). Results: There was a 25.5% increase in Yo-Yo IR1 distance (2123 ± 413 vs. 1560 ± 356 m, p = 0.002), with the estimated VO2max and the speed associated with VO2max (vVO2max) improving by 8.7% (49.5 ± 3.0 to 54.2 ± 3.5 mL/kg/min, p = 0.002) and 5.3% (16.0 ± 0.7 to 16.9 ± 0.6 km/h, p = 0.002), respectively. In contrast, CMJ performance in weeks 2–4 declined by 13.4–21.0% relative to baseline, while sRPE peaked during week 3 (4011 ± 440 AU). Hematological variables were mostly stable except for small increases in MCV and MCH (1.5–1.8%, p < 0.001), while there were significant reductions in urea (12%), uric acid (6.2%), and erythropoietin (33%). Conclusions: A 4-week preseason program substantially improved aerobic capacity yet compromised leg power. Changes in biomarker profiles suggest that the training load maintained an appropriate balance between overload and recovery. These findings provide valuable guidance for coaches seeking to optimize training protocols while minimizing the risk of overtraining and preventing injuries during the competitive season.

Greece, along with most of the countries in the Mediterranean basin, is historically linked with forest fires. Wildfires have always occurred, are happening, and will continue to occur, causing serious problems regarding the sustainability of natural resources. Their frequency, however, has shown a noticeable increase during the last decades; according to the most recent projections, the broader Mediterranean region will face significant challenges in the future within the context of climate change. Despite the historical experience of forest fires in Greece, a standardized and up-to-date system for identifying and prioritizing burnt areas, in relation to their restoration needs, has not yet been developed and adopted. In this paper, a systematic methodological approach for decision-making regarding the identification and prioritization of active restoration/reforestation of burnt areas is proposed. This approach is based on critical parameters, such as the regeneration potential of the affected forest species, the “fire history”, and the slope of the affected areas. The proposed methodological approach can be applied in all burnt natural areas in the country in the future, as well as in other areas of the Mediterranean region. The fire impact on Natura 2000 sites is also assessed to highlight the importance of restoration and conservation needs in protected areas. The results from case studies are presented, and future steps and policy recommendations for the post-fire management of natural ecosystems are discussed to enable the sustainable management of forest resources in the burnt areas.

Optimizing path planning for energy efficiency is critical for achieving sustainable vehicular transportation. This paper presents a novel framework for evaluating the impact of path planning algorithms (PPAs) on energy consumption within a simulated environment. We leverage the CARLA simulator to conduct a comparative analysis between the widely used A* and a Hybrid Genetic Algorithm (HGA) across diverse vehicular scenarios. This investigation aims to quantify the influence of PPA selection on vehicle energy expenditure, enabling data-driven optimization for energy minimization. We leverage an offline energy estimation model to further streamline the comparison of the two PPAs. Extensive simulations are employed to demonstrate the efficiency and adaptability of the proposed framework. The findings contribute to the development of energy-efficient path-planning strategies, promoting advancements toward sustainable transportation systems.