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We present the results from a litter translocation experiment along a 2800-m elevation gradient in Peruvian tropical forests. The understanding of the environmental factors controlling litter decomposition is important in the description of the carbon and nutrient cycles of tropical ecosystems, and in predicting their response to long-term increases in temperature. Samples of litter from 15 species were transplanted across all five sites in the study, and decomposition was tracked over 448 d. Species' type had a large influence on the decomposition rate (k), most probably through its influence on leaf quality and morphology. When samples were pooled across species and elevations, soil temperature explained 95% of the variation in the decomposition rate, but no direct relationship was observed with either soil moisture or rainfall. The sensitivity of the decay rate to temperature (𝒦 T ) varied seven-fold across species, between 0.024 and 0.169°C⁻¹, with a mean value of 0.118 ± 0.009°C⁻¹ (SE). This is equivalent to a temperature sensitivity parameter (Q₁₀) for litter decay of 3.06 ± 0.28, higher than that frequently assumed for heterotrophic processes. Our results suggest that the warming of approx. 0.9°C experienced in the region in recent decades may have increased decomposition and nutrient mineralization rates by c. 10%.

The shift from a hunting and gathering economy to a productive economy, based on the domestication of plants and animals, is one of the most important changes in human history. This change, which manifested itself in different forms and at different times in different areas of the Old and New Worlds, is still a subject of debate and discussion today. How and why does such a profound change occur in the relationship with the environment and the land? Could the arrival of foreign settlers with a mature and structured Neolithic cultural heritage be the cause of this change in the Mediterranean? The archaeological excavations conducted at the settlement of La Marmotta (Anguillara Sabazia, Rome, Italy), today submerged under the waters of Lake Bracciano, represents one of the most relevant Neolithic villages of the entire Mediterranean. The exceptional nature of this site is given by the conservation of the organic remains. Not only are the piles and architectural remains of the houses well preserved at La Marmotta, but so are small finds and fragile artifacts such as spoons, textile crafts, baskets, ropes, sickles and bows. In addition, there are a huge variety of remains of both animal and vegetal nature, such as seeds, spikelets, bundles of wheat and other plants, possible cheese and milk derivatives and other mixtures of foodstuff. This set of materials has an enormous potential for changing and deepening our understanding of the first farming societies, of their technological complexity, their know-hows, their lifestyle and food habits. Thanks to La Marmotta it is truly possible to rewrite the evolution of techniques for processing plants and wood during prehistoric times. Until now, published information on the site is very limited and partial. The main aim of this book is to make visible the extreme richness of the La Marmotta archaeological record and provide insights into Neolithic woodworking, basketry, textile production and other crafting and subsistence activities.

The present paper assesses whether the adoption of Industry 4.0 technologies can be related to backshoring. It does so by -firstly- investigating the implementation of such technologies by industrial firms with foreign production plants, the experiences and intentions of these firms regarding the location of production activities, and -secondly- by analyzing backshoring cases among them.It finds that backshoring is a rare phenomenon, and it is questionable whether there is a correlation, left alone causality, between the adoption of digital technologies in home-based manufacturing sites and backshoring hitherto. And while the future may hold more backshoring movements in store, they may not be primarily due to the adoption of Industry 4.0 technologies at home-based plants. Instead, other (foreign) location-specific factors seem to have greater weight in the decision-making processes around backshoring operations. I.e., deteriorating sales forecasts in offshore places where firms have production activities, increases in institutional uncertainty in such places, rationalization of global production apparatuses, and/or a lack of possibilities to deploy foreign manufacturing activities and output for third markets. Also against the backdrop of events like the outbreak of Covid19 and the uncertainty-raising effect it has on international business, the trade-off between producing off-shore or bringing manufacturing activities back home is not likely to depend on technology adoption levels at home and abroad either.

This article explores the changes that occurred in harvesting technology during the dispersal of the Neolithic in the Mediterranean basin. It does so through technological and use-wear analysis of flaked stone tools from archaeological sites dated between ca. 7000 and 5000 cal BCE, from the Aegean Sea to the westernmost coasts of Portugal. The main goal is to analyse the transformations that occurred in the harvesting toolkit. Our study reveals dynamics of continuity and change in sickles at a Mediterranean scale, resulting from adaptations of the migrant groups to the newly occupied territories and from processes of technological innovation. Adaptations in the production system of the inserts and in their use-pattern occurred in relation to lithic raw material availability and knappers' skills, but also in relation to the scale of production and farming techniques. A major shift took place in the north-western Mediterranean arc with the diffusion of parallel-hafted inserts, probably as a result of heterogeneous phenomena including the diffusion of new groups, technical transfers, establishment of new interaction networks and new systems of lithic production.

The retouching and resharpening of lithic tools during their production and maintenance leads to the production of large numbers of small flakes and chips known as microdebitage. Standard analytical approaches to this material involves the mapping of microartefact densities to identify activity areas, and the creation of techno-typologies to characterise the form of retouch flakes from different types of tools. Whilst use-wear analysis is a common approach to the analysis of tools, it has been applied much less commonly to microdebitage. This paper contends that the use-wear analysis of microdebitage holds great potential for identifying activity areas on archaeological sites, representing a relatively unexplored analytical resource within microartefact assemblages. In order to test the range of factors that affect the identification of use-wear traces on small retouch flakes, a blind test consisting of 40 retouch flakes was conducted. The results show that wear traces can be identified with comparable levels of accuracy to those reported for historic blind tests of standard lithic tools suggesting that the use-wear analysis of retouch flakes can be a useful analytical tool in understanding site function, and in increasing sample sizes in cases where assemblages contain few tools.

Navigation in the Mediterranean in the Neolithic is studied here through the boats that were used, the degree of technical specialisation in their construction and, above all, their chronology. After a brief explanation of the exceptional site of La Marmotta, the characteristics and chronology of the five canoes found at the settlement and one of the nautical objects linked to Canoe 1 are discussed. This will allow a reflection on the capability of Neolithic societies for navigation owing to their high technological level. This technology was an essential part in the success of their expansion, bearing in mind that in a few millennia they occupied the whole Mediterranean from Cyprus to the Atlantic seaboard of the Iberian Peninsula.

Oral fluid is easy and safe to collect and allows the detection of drugs of abuse after local exposure by oral, smoked, and/or inhaled intake, or systemic exposure. A routine online solid-phase extraction UPLC-MS/MS method was developed for the simultaneous determination of 33 psychoactive drugs in oral fluid. The selected drugs were fourteen fentanyl analogs and nineteen other abused psychoactive compounds, including classical narcotics, which were analyzed in a run of 10 min. Limits of detection and of quantification ranged from 0.02 to 1 ng/mL and from 0.02 to 5 ng/mL depending on the analyte, respectively. Matrix effect was in the range − 17 to + 15.7% for all analytes having a deuterated analog. Accuracy ranged from 82.7 to 113.4% and precision CV was at worst of 18.6%. Carryover was below 0.8% for all analytes. Recovery from FLOQSwabs™ showed high variability between analytes with THC, D2FF, 4-ANPP, ocfentanil, and valerylfentanyl being recovered below 40%. A stability study performed over 2 weeks on collecting devices loaded with artificial oral fluid showed huge variation between analytes with morphine, BZE, and norfentanyl being the more stable. Storage at 4 °C allowed drug detection for 1 week except for THC and remifentanil. The method was successfully applied to the detection of abused psychoactive compounds in oral fluid samples from 6 patients admitted to an addiction department.

While instream large wood is recognized as vital for healthy river ecosystems, the wood regime remains less understood compared to flow and sediment regimes, primarily due to limited monitoring. Most existing research focuses on unregulated rivers, leaving knowledge gaps in regulated systems. This study addresses that by quantifying the wood regime in the Spöl River, a partially regulated alpine river affected by two dams. Despite regulation, the Spöl still receives sediment and wood from unregulated tributaries and benefits from an experimental flood (e‐flood) program initiated in 2000 to mitigate dam impacts. By July 2023, 23 e‐floods had been released from the Ova Spin Dam. Between 2018 and 2023, five of these were monitored to assess wood entrainment, mobility, and deposition. The study explored how much wood moved, where it was deposited, and what factors controlled its transport. Wood movement, measured by number, volume, and distance, was related to e‐flood hydrograph characteristics. On average, less than 30% of wood was mobilized per flood, and long‐distance transport was limited (mean <300 m), aligning with findings from unregulated rivers. Results showed that flood duration, especially the rising limb duration, better explained wood mobility than flood magnitude. This monitoring effort offers rare insights into the interactions between flow, sediment, and wood in a regulated alpine river, and informs the design and effectiveness of e‐flood programs.

There is a significant number of funerary contexts for the Early Neolithic in the Iberian Peninsula, and the body of information is much larger for the Late Neolithic. In contrast, the archaeological information available for the period in between (ca. 4800-4400/4200 cal BC) is scarce. This period, generally called Middle Neolithic, is the least well-known of the peninsular Neolithic sequence, and at present there is no specific synthesis on this topic at the peninsular scale. In 2017, an exceptional funerary context was discovered at Dehesilla Cave (Sierra de Cádiz, Southern Iberian Peninsula), providing radiocarbon dates which place it at the beginning of this little-known Middle Neolithic period, specifically between ca. 4800-4550 cal BC. Locus 2 is a deposition constituted by two adult human skulls and the skeleton of a very young sheep/goat, associated with stone structures and a hearth, and a number of pots, stone and bone tools and charred plant remains. The objectives of this paper are, firstly, to present the new archaeological context documented at Dehesilla Cave, supported by a wide range of data provided by interdisciplinary methods. The dataset is diverse in nature: stratigraphic, osteological, isotopic, zoological, artifactual, botanical and radiocarbon results are presented together. Secondly, to place this finding within the general context of the contemporaneous sites known in the Iberian Peninsula through a systematic review of the available evidence. This enables not only the formulation of explanations of the singular new context, but also to infer the possible ritual funerary behaviours and practices in the 5.sup.th millennium cal BC in the Iberian Peninsula.

Embryonic development requires the coordinated regulation of apoptosis, survival, autophagy, proliferation and differentiation programs. Senescence has recently joined the cellular processes required to master development, in addition to its well-described roles in cancer and ageing. Here, we show that senescent cells are present in a highly regulated temporal pattern in the developing vertebrate inner ear, first, surrounding the otic pore and, later, in the otocyst at the endolymphatic duct. Cellular senescence is associated with areas of increased apoptosis and reduced proliferation consistent with the induction of the process when the endolymphatic duct is being formed. Modulation of senescence disrupts otic vesicle morphology. Transforming growth factor beta (TGFβ) signaling interacts with signaling pathways elicited by insulin-like growth factor type 1 (IGF-1) to jointly coordinate cellular dynamics required for morphogenesis and differentiation. Taken together, these results show that senescence is a natural occurring process essential for early inner ear development.