Explore the vast range of titles available.

The “microbiome” is colloquially taken to mean the relative abundance of the genera and species that constitute the gut bacteria (“taxonomy”); however, the microbiome in its broadest sense encompasses bacterial taxonomy, gut fungi (“mycobiome”) and viruses (“virome”), and the totality of their functional and metabolic state (2,5,6). Any agent that modifies this ecology can be considered an MBT. [...]we believe that an MBT used for therapeutic intent to treat specific human diseases should be regulated by the US FDA and require an IND before clinical trial. Author Notes Correspondence: Shrinivas Bishu, MD. Email: bishus@med.umich.edu REFERENCES 1.Fan, Y, Pedersen, O. Gut microbiota in human metabolic health and disease.

Colorectal cancer (CRC) continues to be a significant global health issue contributing to a high mortality rate. Despite advancements in treatment, the risk of recurrence remains due to inherent mutations and the rapid turnover of intestinal mucosa. We present an exceptionally rare case of CRC metastasis to the duodenum in a 42‐year‐old female who has been compliant with postsurgical surveillance. Despite previous negative surveillance results, elevated CEA levels and a 3‐cm mesenteric mass were detected, raising concerns for carcinoma, which was later confirmed by biopsy. The tumor board deemed her ineligible for surgery due to vascular involvement, leading to palliative care and an attempt at neoadjuvant therapy. Vigilant monitoring is crucial for early detection and intervention.