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On September 12, 2023, the Centers for Disease Control and Prevention's Advisory Committee on Immunization Practices recommended that all persons aged ≥6 months receive 2023–2024 COVID-19 vaccination. This study examines the relationship between vaccination and COVID-19 symptom frequency, using data from the Increasing Community Access to Testing, Treatment, and Response (ICATT) platform. Among 6966 records of first SARS-CoV-2-positive tests collected from September 21, 2023 through August 22, 2024, individuals who received 2023–2024 COVID-19 vaccination consistently reported lower frequencies of 12 symptoms. The adjusted odds of reporting most symptoms were significantly lower among vaccinated participants, especially recent loss of sense of smell or taste (adjusted odds ratio(aOR): 0.39; 95 %CI: 0.29–0.53) and muscle pain (aOR: 0.49; 95 %CI: 0.41–0.59). These findings indicate that receiving 2023–2024 COVID-19 vaccination was associated with significantly lower odds of reporting most COVID-19 symptoms following SARS-CoV-2 infection, highlighting the importance of receiving recommended COVID-19 vaccination to mitigate symptomatic illness.