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ObjectivesTo compare serum ferritin and RET-He values among extremely low gestational age neonates ELGANs with other markers of iron-deficient erythropoiesis.Study DesignThis is a secondary analysis of the NICHD Darbepoetin Trial. Study data from placebo recipients who had a serum ferritin, a RET-He, and a mean corpuscular volume (MCV) measurement within a 24-hour period were analyzed for correlation.ResultsMixed linear regression models showed no association between ferritin and RET-He at both early (β = 0.0016, p = 0.40) and late (β = −0.0001, p = 0.96) time points. Positive associations were observed between RET-He and MCV at baseline, early, and late time points (p < 0.01, =0.01, <0.001, respectively), while ferritin was not associated with MCV at any time point.ConclusionsOur study shows that RET-He is better correlated with MCV as a marker of iron-limited erythropoiesis than ferritin. The results suggest that ferritin is limited as a marker of iron sufficiency in premature infants.Study IdentificationFDA IND Number 100138; ClinicalTrials.gov number NCT03169881; NRN ID number NICHD-NRN-0058 (Darbe).

HIP 9618 (HD 12572, TOI-1471, TIC 306263608) is a bright (\\(G=9.0\\) mag) solar analogue. TESS photometry revealed the star to have two candidate planets with radii of \\(3.9 \\pm 0.044\\) \\(R_\\oplus\\) (HIP 9618 b) and \\(3.343 \\pm 0.039\\) \\(R_\\oplus\\) (HIP 9618 c). While the 20.77291 day period of HIP 9618 b was measured unambiguously, HIP 9618 c showed only two transits separated by a 680-day gap in the time series, leaving many possibilities for the period. To solve this issue, CHEOPS performed targeted photometry of period aliases to attempt to recover the true period of planet c, and successfully determined the true period to be 52.56349 d. High-resolution spectroscopy with HARPS-N, SOPHIE and CAFE revealed a mass of \\(10.0 \\pm 3.1 M_\\oplus\\) for HIP 9618 b, which, according to our interior structure models, corresponds to a \\(6.8\\pm1.4\\%\\) gas fraction. HIP 9618 c appears to have a lower mass than HIP 9618 b, with a 3-sigma upper limit of \\(< 18M_\\oplus\\). Follow-up and archival RV measurements also reveal a clear long-term trend which, when combined with imaging and astrometric information, reveal a low-mass companion (\\(0.08^{+0.12}_{-0.05} M_\\odot\\)) orbiting at \\(26^{+19}_{-11}\\) au. This detection makes HIP 9618 one of only five bright (\\(K<8\\) mag) transiting multi-planet systems known to host a planet with \\(P>50\\) d, opening the door for the atmospheric characterisation of warm (\\(T_{\\rm eq}<750\\) K) sub-Neptunes.