Explore the vast range of titles available.

Effective regulation and control of tobacco products require robust laboratory testing capabilities to ensure quality, safety and compliance with relevant standards. Currently, no standardized assessment tool exists globally to evaluate the tobacco testing laboratories. This study aims to address this gap by developing the Tobacco Testing Laboratory Assessment Tool (TTLAT). This tool aligns with the WHO-FCTC on Tobacco Control's Article 9, which calls for the adoption and implementation of effective testing, measuring, and regulation measures. The TTLAT was developed through a systematic literature review and a two-round Delphi technique involving 24 experts. The tool was then validated in four National Tobacco Testing Laboratories in India. Content validity was assessed using the Item-Content Validity Index (I-CVI) and Scale-Content Validity Index (S-CVI). Construct validity was evaluated through exploratory and confirmatory factor analyses. Internal consistency reliability was measured using Cronbach's alpha. The final TTLAT comprises 213 items across 11 critical domains including General Information (17), Documents (37), Organization and Management (10), Human Resources (28), Infrastructure (7), Equipment (23), Consumables and Reagents (10), Sample Handling (17), Tobacco Product Analytes (8), Data Management (36), and Biosafety and Biosecurity (20). Content validity analysis showed excellent results. Exploratory factor analysis identified six factors accounting for 52.5% of the total variance. Confirmatory factor analysis demonstrated good model fit (CFI = 0.91; TLI = 0.90; RMSEA = 0.05; SRMR = 0.06). The tool showed high internal consistency reliability across factors (Cronbach's alpha 0.72-0.92). The TTLAT demonstrates strong psychometric properties and provides a comprehensive, standardised approach for assessing tobacco testing laboratory capacity.

Introduction Tobacco consumption continues to pose a substantial global public health threat, resulting in more than 8 million preventable deaths annually. The WHO Framework Convention on Tobacco Control (FCTC) negotiated as the first global public health treaty under the auspices of the WHO, which serves as a critical instrument in combating the global tobacco epidemic. The WHO FCTC prioritizes a comprehensive approach that addresses both the demand for and supply side interventions for curbing tobacco epidemic globally. Strong evidence demonstrates the efficacy of these measures in safeguarding individuals, regardless of age, from tobacco initiation, and the associated harms. WHO FCTC Article 9 and 10 emphasizes upon testing and disclosure of tobacco product contents. This scoping review aims to explore the Implementation Landscape of WHO FCTC Articles 9 and 10 globally by adopting Consolidated Framework for Implementation Research (CFIR) framework. Methods The planned scoping review will adhere to the methodology outlined by “Arksey and O’Malley and Levac et al.” Through an exhaustive search strategy, relevant literature published from 2013 onwards will be sourced from databases including PubMed, CINAHL, EMBASE, Web of Science, Scopus, government websites, and reports. A predetermined set of criteria for study inclusion and exclusion will be applied independently by four reviewers to assess study eligibility. The findings will be synthesized narratively and qualitatively analyzed, incorporating the Consolidated Framework for Implementation Research (CFIR) framework for discussion and outlining. The review will adhere to the reporting standards outlined in the “Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Review (PRISMA-ScR)” guidelines. Conclusions/discussion Analyzing the implementation of FCTC Articles 9 and 10 across global contexts is expected to offer valuable insights into the need for context-specific adjustments and customized interventions. Understanding regional variations in efforts to regulate tobacco products is crucial for formulating specific strategies that effectively address cultural, economic, and regulatory challenges. This comparative examination has the potential to guide policymakers, public health professionals, and researchers in optimizing tobacco control initiatives to expedite progress toward effective implementation of Articles 9 and 10 in both the WHO-SEAR region and globally. Ethics approval This review will identify the landscape of the implementation of WHO FCTC Article 9 and 10. This review will also identify the best practices, policies, and strategies across the globe. An ethics committee approval was not sought for this since this involve secondary data.

Capacitive micromachined ultrasonic transducers (CMUT) are MEMS-based transducers with advantages over conventional ultrasonic transducers, such as their small size, the ease of integration with semiconductor electronics, and batch fabrication. In this study, the effect of different membrane topologies on the displacement, resonant frequency, and output pressure of the CMUT membrane is investigated in the transmission mode in an air environment. A novel structural-support feature, the rocker stem, is introduced, where the membrane is weakly held to the substrate in order to minimize mechanical constraints. Four different CMUT topologies are designed and assessed to analyze the impacts of topological variations. A new CMUT array configuration is also designed to provide an approach for maximizing CMUT density. This study aims to contribute to efficient CMUT design and the determination of optimum structural parameters for portable applications in air.

Mounting ambitions and capabilities for public and private, non-government sector crewed space exploration bring with them an increasingly diverse set of space travelers, raising new and nontrivial ethical, legal, and medical policy and practice concerns which are still relatively underexplored. In this piece, we lay out several pressing issues related to ethical considerations for selecting space travelers and conducting human subject research on them, especially in the context of non-governmental and commercial/private space operations. New and dynamically changing opportunities for commercial/private and civilian spaceflight raise the need for an examination of how to ethically guide space industry and community. This Perspective explores such considerations with respect to space traveler selection and human subject research.

Human space exploration poses inherent risks to astronauts’ health, leading to molecular changes that can significantly impact their well-being. These alterations encompass genomic instability, mitochondrial dysfunction, increased inflammation, homeostatic dysregulation, and various epigenomic changes. Remarkably, these changes bear similarities to those observed during the aging process on Earth. However, our understanding of the connection between these molecular shifts and disease development in space remains limited. Frailty syndrome, a clinical syndrome associated with biological aging, has not been comprehensively investigated during spaceflight. To bridge this knowledge gap, we leveraged murine data obtained from NASA’s GeneLab, along with astronaut data gathered from the JAXA and Inspiration4 missions. Our objective was to assess the presence of biological markers and pathways related to frailty, aging, and sarcopenia within the spaceflight context. Through our analysis, we identified notable changes in gene expression patterns that may be indicative of the development of a frailty-like condition during space missions. These findings suggest that the parallels between spaceflight and the aging process may extend to encompass frailty as well. Consequently, further investigations exploring the utility of a frailty index in monitoring astronaut health appear to be warranted.

The snow trout ( Schizothorax richardsonii ) belonging to family Cyprinidae, is an endemic fish of the Himalayan region. The species is tagged as vulnerable species in the IUCN red list of threatened species. The fish thrives well in snowmelt water of several streams and rivers in the region but are occasionally exposed to more than 20 °C during the summer season. Therefore, we have used deep RNA sequencing to decipher the transcriptome of snow trout and characterize the genes and molecular pathways involved in heat shock response. In this study 72,601,298 and 65,428,283 raw reads for heat-shocked and control, respectively, were obtained by Illumina paired-end sequencing technology. The de novo assembled transcriptome was tested for differential gene expression across the treatment groups. The quality of assembly was high with N75 and N50 lengths of 461 and 1274 bases, respectively. A total of 65 unique transcripts were differentially expressed in liver under heat shock and control. Annotated blast matches reveal that differentially expressed transcripts correspond to critical chaperones and molecular pathways, previously shown to be important for thermal stress in other fish species. Eight randomly selected heat-stressed responsive transcripts were also observed to be upregulated during qRT-PCR analysis. This study is the preliminary step to understanding the responses during sudden environmental changes like heat shock. The reference transcriptome database would also aid further studies on biological and physiological aspects of the snow trout under abiotic stresses.

Background: A novel subjective Motivational Value toward Child Gender (MVCG) tool was developed using the theoretical construct of 10 motivational domains described by Shalom H Schwartz. Objective: The study aimed to summarize the pattern of correlations of (MVCG) in women of reproductive age in Himachal Pradesh, India. Methods: A cross-sectional study was conducted from October 2018 to November 2019 among a sample of 355 women. Required data were collected through an interviewer-administered questionnaire. Maximum likelihood exploratory factor analysis (EFA) with oblique rotation was done with Bartlett's test sphericity and Kaiser-Meyer-Olkin test. Results: A total of 28 (53.8%) questions loaded on eight factors explaining maximum variance (68.7%). Reliability analysis of these questions, with high loadings on extracted factors, of the questionnaire, observed with poor Cronbach's alpha of 0.61 and intraclass cluster coefficient (ICC) 0.49. However, selected domains such as tradition, power, achievement, self-direction, and benevolence were observed with a good Cronbach's alpha and ICC. Conclusion: MCVG is novel tool in its kind with well scalable properties in measuring subjective motivational values towards child gender. After EFA, total questions across 10 domains reduced from 52 to 28, across 8 domains, loaded on 8 factors with good reliability and agreement.

Energy harvesting has become a fascinating topic of research. As the world moves towards reducing its dependency on fossil fuels, new and innovative techniques of energy harvesting have been tested and developed. The use of piezoelectric materials to harvest the ambient vibrations from the surroundings is one method that has seen a dramatic rise in use for power harvesting. Remote sensors can be powered by these piezoelectric materials and could potentially act as a continuous source of energy. In space vehicles, energy is generated using solar panels which are bulky, heavy and expensive. Instead piezoelectric harvesters can be used to generate power and are much lighter, compact and relatively cheap when produced in bulk. This paper presents a theoretical study on energy harvesting from structural vibration caused by combustion instability of a solid rocket motor through the motor burnout. Vibration data of tested solid rocket motor was taken as a reference and was inputted as the boundary condition. The 3-D model of the harvester system was designed on Fusion360 and the simulation was performed on COMSOL. Finally, improvements needed in the system to enhance practicality were discussed.

Tumor invasion and metastasis remain the leading causes of mortality for patients with cancer despite current treatment strategies. In some cancer types, recurrence is considered inevitable due to the lack of effective anti-metastatic therapies. Recent studies across many cancer types demonstrate a close relationship between cancer-initiating cells (CICs) and metastasis, as well as general cancer progression. First, this review describes CICs’ contribution to cancer progression. Then we discuss our recent understanding of mechanisms through which CICs promote tumor invasion and metastasis by examining the role of CICs in each stage. Finally, we examine the current understanding of CICs’ contribution to therapeutic resistance and recent developments in CIC-targeting drugs. We believe this understanding is key to advancing anti-CIC clinical therapeutics.

Background: Routine outcome-based monitoring is required to assess the status of consumption of iodized salt as USI strategy. Objective: To assess the extent of recent iodine intake among children from 6 to 15 years of age in the hilly terrain of northern states of India. Methods: A school-based cross-sectional observational study among 227 children attending school was done for assessment of socio-demographic, dietary, salt consumption and urinary iodine concentration (UIC). Results: Mean age of children was about 6 years and 87.7% were consuming salt of >30 and none with <15 ppm iodine content. Median UIC was 138.0 μg/L. Among those assessed, 37.9% had adequate level of UIC, whereas about 20% and 40% participants had less (<99.0 μg/L) and more than adequate to excessive (≥200 μg/L) levels of UIC. Insignificant difference (p = 0.07) was observed for mean log UIC between cabbage eaters (2.3) and non-eaters (1.9) consuming salt >5 grams/day. Conclusion: Recent iodine intake among children observed to be inadequate and effect of cruciferous food items on UIC needs to be studied despite high coverage of iodized salt among children.