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Pharmacists are increasingly expected to deliver medication therapy management (MTM) services, yet many pharmacy students report insufficient confidence and preparedness in executing these complex tasks. This study evaluated a scaffolded MTM instructional series integrated into a second-year pharmacy skills laboratory, aiming to enhance student competence through progressive, structured learning. A mixed-methods design assessed changes in self-reported confidence, performance-based outcomes, and reflective insights among 154 students across three educational tracks. The 14-week intervention included sequential activities such as medication history interviews, drug-related problem (DRP) identification, care plan development, and comprehensive MTM simulations. Pre- and post-intervention surveys revealed statistically significant improvements in all 18 confidence domains, with the greatest gains in therapeutic recommendations and prescriber communication. Effect sizes ranged from small to very large (Cohen’s d 0.33–1.05), indicating gains that were both statistically reliable and educationally meaningful. Performance assessments showed consistent proficiency across MTM components, with average scores ranging from 90% to 96%. Qualitative reflections reinforced these findings, highlighting growth in communication, individualized patient care, and professional identity formation. The scaffolded approach aligns with accreditation standards and instructional design theory, offering a model for pharmacy curricula. Despite limitations such as lack of a comparator group and potential response bias, the study demonstrates that scaffolded MTM instruction effectively supports skill acquisition and confidence, preparing students for real-world clinical practice.

Atypical antipsychotics like olanzapine are more efficacious in treating negative symptoms and have less side effects. Nevertheless, important adverse effects of olanzapine are, for example, weight gain and hyperglycemia. Perazine in combination with carbamazepine has shown satisfying results in several single-schizophrenia patients, leading to the hypothesis of being equal or even superior to atypical antipsychotic monotherapy. The aim of the present study was to survey the hypothesis that perazine in combination with carbamazepine have an outcome and risk of side effects comparable to olanzapine. Eleven patients with DSM-IV schizophrenia received 14.0 ± 5.0 mg/day olanzapine and 12 patients received 360.0 ± 196.0 mg/day perazine in combination with 404.0 ± 229.0 mg/day carbamazepine. Symptoms and neuropsychological state were assessed 3 times (days 0, 7, 21) using the Positive and Negative Syndrome Scale and the Brief Psychiatric Rating Scale. The neuropsychological state was assessed by the following neuropsychological tests: Benton, d2, ZVT, VLMT and MWT-B. Data were analyzed of variance for multiple dependent variables and repeated-measures multivariate analysis of variance. Positive and Negative Syndrome Scale and Brief Psychiatric Rating Scale scores showed superior improvement in the group receiving olanzapine. Olanzapine offers a more favorable response in positive symptoms than does perazine in combination with carbamazepine. The effect on negative symptoms is favorable in both forms of therapy and no significant differences between the groups could be determined. In both groups, treatment was associated with improved performance in cognitive tests; however, no differences were determined in the effects of the drugs. Results suggest that olanzapine offers a better response in positive symptoms than perazine in combination with carbamazepine.

The aim of the COBRA experiment is to prove the existence of neutrinoless double-beta-decay (0νββ-decay) and to measure its half-life. For this purpose a detector array made of cadmium-zinc-telluride (CdZnTe) semiconductor detectors is operated at the Gran Sasso Underground Laboratory (LNGS) in Italy. This setup is used to investigate the experimental issues of operating CdZnTe detectors in low-background mode and to identify potential background components, whilst additional studies are proceeding in surface laboratories. The experiment currently consists of monolithic, calorimetric detectors of coplanar grid design (CPG detectors). These detectors are 1 × 1 × 1 cm3 and are arranged in 4 × 4 detector layers. Ultimately four layers will be installed by the end of 2013, of which two are currently operating. To date 82.3 kg·days of data have been collected. In the region of interest for 116Cd around 2.8 MeV, the median energy resolution is 1.5% FWHM, and a background level near 1 counts/keV/kg/y has been reached. This paper gives an overview of the current status of the experiment and future perspectives.

Measurements of the double-differential π ± production cross-section in the range of momentum 100 MeV/c≤p< 800 MeV/c and angle 0.35 rad ≤θ<  2.15 rad in proton–beryllium, proton–aluminium and proton–lead collisions are presented. The data were taken with the HARP detector in the T9 beam line of the CERN PS. The pions were produced by proton beams in a momentum range from 3 GeV/c to 12.9 GeV/c hitting a target with a thickness of 5% of a nuclear interaction length. The tracking and identification of the produced particles was performed using a small-radius cylindrical time projection chamber (TPC) placed inside a solenoidal magnet. Incident particles were identified by an elaborate system of beam detectors. Results are obtained for the double-differential cross-sections d 2 σ/dpdθ at six incident proton beam momenta (3 GeV/c, 5 GeV/c, 8 GeV/c, 8.9 GeV/c (Be only), 12 GeV/c and 12.9 GeV/c (Al only)) and compared to previously available data.

There is increasing public and academic interest in local and sustainable foods and food tourism. These interests have been reflected in such diverse elements as the growth of farmers markets, green restaurants, food miles, crabon and sustainability labelling, concerns over food supply and security, Slow Food, Fair Trade, and a desire to buy and 'eat locally'. Food related hospitality and tourism is integral to this process because of the way in which it simultaneously acts to globalise and localise food consumption and create new foodways and commodity chains. This book therefore aims to provide an integrated understanding of the contemporary interest in food and food tourism through the use of an international collection of illustrative case study chapters as well as the provision of a novel integrative framework for the book, a sustainable culinary system. This is the first volume to examine the concept of sustainable culinary systems, particularly with specific reference to tourism and hospitality. Divided into two parts, firstly the notion of the local is explored, reflecting the increased interest in the championing of local food production and consumption. Secondly treatment of sustainability in food and food tourism and hospitality in settings that reach beyond the local in a business and socio-economic sense is reviewed. The book therefore, reflects much of the contemporary public interest in the conscious or ethical consumption and production food, as well as revealing the inherent tensions between local and broader goals in both defining and achieving sustainable culinary systems and the environmental, social and economic implications of food production and consumption. This book provides the reader with an integrated approach to understanding the subject of how culinary systems may be made more sustainable and will be valuable reading to all those interested in sustainable food and food tourism.

The COBRA collaboration operates a demonstrator setup at the underground facility LNGS (Laboratori Nazionali del Gran Sasso, located in Italy) to prove the technological capabilities of this concept for the search for neutrinoless double beta-decay. The setup consists of 64 \\((1\\times\\!1\\times\\!1)\\) cm\\(^{3}\\) CZT detectors in CPG configuration. One purpose of this demonstrator is to test if reliable long-term operation of CZT-CPG detectors in such a setup is possible. The demonstrator has been operated under ultra low-background conditions since more than three years and collected data corresponding to an exposure of 218 kg\\(\\cdot\\)days. The presented study focuses on the long-term stability of CZT detectors by analyzing the intrinsic, fourfold forbidden non-unique \\(^{113}\\)Cd single beta-decay. It can be shown that CZT detectors can be operated stably for long periods of time and that the \\(^{113}\\)Cd single beta-decay can be used as an internal monitor of the detector performance during the runtime of the experiment.

Foraminifera are ubiquitously distributed in marine habitats, playing a major role in marine sediment carbon sequestration and the nitrogen cycle. They exhibit a wide diversity of feeding and behavioural strategies (heterotrophy, autotrophy and mixotrophy), including species with the ability of sequestering intact functional chloroplasts from their microalgal food source (kleptoplastidy), resulting in a mixotrophic lifestyle. The mechanisms by which kleptoplasts are integrated and kept functional inside foraminiferal cytosol are poorly known. In our study, we investigated relationships between feeding strategies, kleptoplast spatial distribution and photosynthetic functionality in two shallow-water benthic foraminifera ( Haynesina germanica and Elphidium williamsoni ), both species feeding on benthic diatoms. We used a combination of observations of foraminiferal feeding behaviour, test morphology, cytological TEM-based observations and HPLC pigment analysis, with non-destructive, single-cell level imaging of kleptoplast spatial distribution and PSII quantum efficiency. The two species showed different feeding strategies, with H. germanica removing diatom content at the foraminifer’s apertural region and E. williamsoni on the dorsal site. All E. williamsoni parameters showed that this species has higher autotrophic capacity albeit both feeding on benthic diatoms. This might represent two different stages in the evolutionary process of establishing a permanent symbiotic relationship, or may reflect different trophic strategies.

An array of sixteen 1 cm^3 CdZnTe semiconductor detectors was operated at the Gran Sasso Underground Laboratory (LNGS) to further investigate the feasibility of double-beta decay searches with such devices. As one of the double-beta decay experiments with the highest granularity the 4 x 4 array accumulated an overall exposure of 18 kg days. The setup and performance of the array is described. Half-life limits for various double-beta decay modes of Cd, Zn and Te isotopes are obtained. No signal has been found, but several limits beyond 10^20 years have been performed. They are an order of magnitude better than those obtained with this technology before and comparable to most other experimental approaches for the isotopes under investigation. An improved limit for the beta^+/EC decay of Te 120 is given.

Atmospheric water vapour tracers (WVTs) are an elegant tool to determine source–sink relations of moisture \"online\" in atmospheric general circulation models (AGCMs). However, it is sometimes desirable to establish such relations \"offline\" based on already existing atmospheric data (e.g. reanalysis data). One simple and frequently applied offline method is 2-D moisture tracing. It makes use of the \"well-mixed\" assumption, which allows for treating the vertical dimension integratively. Here we scrutinise the \"well-mixed\" assumption and 2-D moisture tracing by means of analytical considerations in combination with AGCM-WVT simulations. We find that vertically well-mixed conditions are seldom met. Due to the presence of vertical inhomogeneities, 2-D moisture tracing (i) neglects a significant degree of fast-recycling, and (ii) results in erroneous advection where the direction of the horizontal winds varies vertically. The latter is not so much the case in the extratropics, but in the tropics this can lead to large errors. For example, computed by 2-D moisture tracing, the fraction of precipitation in the western Sahel that originates from beyond the Sahara is ~40%, whereas the fraction that originates from the tropical and Southern Atlantic is only ~4%. According to full (i.e. 3-D) moisture tracing, however, both regions contribute roughly equally, showing that the errors introduced by the 2-D approximation can be substantial.

A search for the 4-fold forbidden beta decay of \\iso{Cd}{113} has been performed with CdZnTe semiconductors. With 0.86 kg \\(\\cdot\\) days of statistics a half-life for the decay of \\(T_{1/2} = (8.2 \\pm 0.2 (stat.) ^{+0.2}_{-1.0} (sys.)) \\cdot 10^{15}\\)yrs has been obtained. This is in good agreement with published values. A comparison of the spectral shape with the one given on the Table of Isotopes Web-page shows a severe deviation.