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"Goldstein, Ann"
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Function and Regulation of Tumbleweed (RacGAP50C) in Neuroblast Proliferation and Neuronal Morphogenesis
Drosophila RacGAP50C and its homologues act as part of a complex with a kinesin-like protein (Pavarotti/Zen-4) that is essential for the formation of the central spindle and completion of cytokinesis [Mishima, M., Kaitna, S. & Glotzer, M. (2002) Dev. Cell 2, 41-54; Somers, W. G. & Saint, R. (2003) Dev. Cell 4, 29-39; Jantsch-Plunger et al. (2000) J. Cell Biol. 149, 1391-1404]. We report here that RacGAP50C corresponds to the tumbleweed (tum) gene previously identified based on its defects in dendrite development of sensory neurons [Gao, F. B., Brenman, J. E., Jan, L. Y. & Jan, Y. N. (1999) Genes Dev. 13, 2549-2561]. Using mushroom body neurogenesis and morphogenesis as a model, we show that Tumbleweed (Tum), Pavarotti, and their association are required for neuroblast proliferation. Tum with a mutation predicted to disrupt the GTPase-activating protein (GAP) activity still largely retains its activity in regulating cell division but is impaired in its activity to limit axon growth. We also provide evidence that Tum and Pavarotti regulate the subcellular localization of each other in postmitotic neurons and that cytoplasmic accumulation of both proteins disrupts axon development in a GAP-dependent manner. Taken together with previous studies of RacGAP50C in regulating cytokinesis, we propose that Tum serves as a scaffolding protein in regulating cell division but acts as a GAP to limit axon growth in postmitotic neurons.
Journal Article
A girl returned
\"Told with an immediacy and a rare expressive intensity that has earned it countless adoring readers and one of Italy's most prestigious literary prizes, A Girl Returned marks the English-language debut of an extraordinary literary talent. Set against the stark, beautiful landscape of Abruzzo in central Italy, this is a compelling story about mothers and daughters, about responsibility, siblings, and caregiving. Without warning or explanation, an unnamed 13-year-old girl is sent away from the family she has always thought of as hers to live with her birth family: a large, chaotic assortment of individuals whom she has never met and who seem anything but welcoming. Thus begins a new life, one of struggle, tension, and conflict, especially between the young girl and her mother. But in her relationship with Adriana and Vincenzo, two of her newly acquired siblings, she will find the strength to start again and to build a new and enduring sense of self. \"--Publisher description.
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