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The purpose of this article is to investigate how decolonial studies can contribute to an agenda of southern criminology and in particular, but not exclusively, to our research on gender and gender violence. To do so, the path chosen was to first present the common lines between these ways of theorising. Then, the entanglements of race and capitalism and of race and gender in the decolonial perspective are presented. With this done, it is possible to think about how decoloniality and punishment are related and to, from then on, think of a decolonial agenda for criminology that involves taking the colonial hypothesis seriously and always thinking and seeking to listen, read and research the ways of resistance from those dehumanised by the criminal justice system.

This study aimed to compare the effect of conventional irrigation (CI) and passive ultrasonic irrigation (PUI) with 17% EDTA and QMiX on the maximum depth and percentage of sealer penetration into the dentinal tubules by confocal laser scanning microscopy (CLSM) and to describe the cleaning of root canal walls by scanning electron microscopy (SEM). Eighty single-rooted human mandibular premolars were instrumented and randomly assigned to four groups (n = 20): EDTA + CI, QMiX + CI, EDTA + PUI, and QMiX + PUI. Ten samples from each group were examined by SEM (2,000×) and the remaining 40 roots were filled with a single gutta-percha cone and AH Plus sealer mixed with 0.1% rhodamine B for analysis by CLSM (10×). Images were assessed at distances of 2 mm (apical), 5 mm (middle), and 8 mm (coronal) from the apex with the Leica Application Suite V4.10 software. The EDTA + PUI and QMiX + PUI protocols presented higher rates of debris/smear layer removal in the apical and middle thirds. The PUI was superior to CI in the maximum depth of sealer penetration at the middle third. The QMiX + PUI group had a higher percentage of sealer penetration at the apical third. The PUI and QMiX protocol improved debris/smear layer removal and tubular dentin sealer penetration.

The ratio between lengths of digit II and IV (digit ratio 2D:4D) is a morphological feature that likely affects tetrapod locomotor performances in different microhabitats. Modifications of this trait may be triggered by changes in steroids concentrations during embryo development, which might reflect direct selection acting on digit ratio or be solely a consequence of hormonal differences related for example to body size. Here we apply both conventional and phylogenetic analyses on morphological data from 25 lizard species of 3 families of Iguania (Iguanidae, Polychrotidae, and Tropiduridae), in order to verify whether selective pressures related to locomotion in different microhabitats could override the prenatal developmental cues imposed on the digit ratio 2D:4D by differences in body size between males and females. Data suggest that this trait evolved in association with ecological divergence in the species studied, despite the clear effect of body size on the digit ratio 2D:4D. The ecological associations of size-corrected digit ratios were restricted to one sex, and females of species that often use perches exhibited small digit ratios in the front limbs, which translated into larger sexual dimorphism indexes of arboreal species. The results, together with the subsequent discussion, provide outlines for further investigation about possible developmental mechanisms related to the evolution of adaptive changes in digit lengths that may have occurred during the evolution of ecological divergence in squamates.

This Special Issue 'Policing and preventing gender violence in the global south', is the product of a workshop on innovations in policing and preventing gender violence in the Global South, hosted by Queensland University of Technology (QUT) Centre for Justice, 3-4 December 2019. The event was attended by scholars from Brazil, Pacific Island communities, Bangladesh, Argentina, and several Australian jurisdictions. Hence the articles in this special issue reflect the diverse nationalities present at the event. A central aim of the workshop realised in this Special Issue is the stimulation of innovation in understanding the policing and prevention of gender violence through novel international collaborations and cross-fertilisation. It reverses the assumptions that underpin the epistemic injustice of the social sciences, that innovations generally flow only from the Global North to the Global South. This Special Issue shows that it can be the other way round.

In the intestinal lumen, excess of oxides and sulfates interfere with the absorption of minerals due to competition from the same absorption site. Amino acids-mineral complexed (AACM) is intended to minimize these problems, which might be absorbed by different absorption sites. Then, a study including Zinc (Zn), Manganese (Mn) and Copper (Cu) from different sources was carried out to evaluate the performance, blood parameters and reproductive organs development of Brown Laying Hens. A total of 800 Lohmann Brown Lite were fed, from one-day-old to 182-days-old, Zn, Mn and Cu from different sources. Measurements were made from 105 to 182-days-old. The laying hens were distributed according to a completely randomized design with 20 replicates and 20 birds per experimental unit. The treatments consisted of a diet supplemented with 70, 70 and 8 mg/kg of Zn, Mn and Cu; respectively, from inorganic sources (IM). The second treatment contained 40, 40 and 2.75 mg/kg of Zn, Mn and Cu, respectively from IM plus 30, 30 and 5.25 mg/kg of Zn, Mn and Cu; respectively, from AACM sources. Performance and reproductive organs development (oviduct and ovary weight), tibia weight, liver weight, egg output and body weight, and blood variables were evaluated. Data were compared by Student's t-test (P < 0.05). Laying hens fed AACM reached 35% of egg output two days earlier and presented heavier tibia bone than the IM group. Those hens also presented greater oviduct weight, greater hematocrit and greater serum concentration of total leukocytes, erythrocytes, eosinophils, monocytes and the hormones T4 and FSH, than the hens fed IM. The supplementation of AACM in laying hens' diets since one-day-old improves the productive performance from the beginning of egg output to peak production, which is justified by better development of bones and oviduct, hormone production and immune system support.

Background Preliminary canal enlargement (glide path preparation) may play a significant role in the development of pain. The aim of this systematic review of randomized clinical trials was to assess the influence of glide path kinematics during endodontic treatment on the occurrence and intensity of intraoperative and postoperative pain. Methods A search was performed in June 2019 in six electronic databases (PubMed, Scopus, LILACS, SciELO, Embase and Web of Science) and two grey literature databases (OpenGrey and OpenThesis). The bibliographic references of the eligible articles were also hand-searched. The included clinical studies assessed the occurrence and intensity of intraoperative and/or postoperative pain after root canal preparation without glide path preparation (WGP) or with glide path preparation using manual (M-GP), continuous rotary (CR-GP), or reciprocating (R-GP) instruments. The primary outcome was the occurrence and intensity of intraoperative and postoperative pain, while analgesic consumption was the secondary outcome. The full texts of the eligible studies were analyzed by two reviewers who performed calibration exercises to verify the risk of bias and quality of the individual studies using the Joanna Briggs Institute Critical Appraisal tool. Results From 1283 identified articles, only six studies were included in the qualitative analysis of the results, with a total sample of 884 patients/teeth. Three studies presented a high risk of bias, while three studies presented a moderate risk. Two studies reported that CR-GP causes lower pain levels than M-GP and WGP, and three studies showed no differences between CR-GP and R-GP. Regarding analgesic consumption, two studies found no differences among glide path kinematics, and one study reported lower consumption for CR-GP than for M-GP. Because of the limited number of studies and methodological differences, no statistical analyses were performed for the glide path kinematics comparisons. Conclusions Compelling evidence indicating a significantly different occurrence and intensity of pain among glide path kinematics is lacking. The systematic review protocol was registered in the PROSPERO database [CRD42020139989].

Oncogenomic studies indicate that copy number variation (CNV) alters genes involved in tumor progression; however, identification of specific driver genes affected by CNV has been difficult, as these rearrangements are often contained in large chromosomal intervals among several bystander genes. Here, we addressed this problem and identified a CNV-targeted oncogene by performing comparative oncogenomics of human and zebrafish melanomas. We determined that the gene encoding growth differentiation factor 6 (GDF6), which is the ligand for the BMP family, is recurrently amplified and transcriptionally upregulated in melanoma. GDF6-induced BMP signaling maintained a trunk neural crest gene signature in melanomas. Additionally, GDF6 repressed the melanocyte differentiation gene MITF and the proapoptotic factor SOX9, thereby preventing differentiation, inhibiting cell death, and promoting tumor growth. GDF6 was specifically expressed in melanomas but not melanocytes. Moreover, GDF6 expression levels in melanomas were inversely correlated with patient survival. Our study has identified a fundamental role for GDF6 and BMP signaling in governing an embryonic cell gene signature to promote melanoma progression, thus providing potential opportunities for targeted therapy to treat GDF6-positive cancers.

Purpose The purpose of this paper aims to discuss the outreach strategies of higher education institutions (HEIs) to promote the inclusion of refugees, focusing on two case studies of programs in southern Brazil. Design/methodology/approach This paper analyzes two outreach programs of Brazilian universities: the Welcome Program for Immigrants (Programa Acolhida ao Imigrante) of the University of South Santa Catarina, a private higher education institution and the Support Center for Immigrants and Refugees (Núcleo de Apoio ao Imigrantes e Refugiados), sponsored by the Federal University of Santa Catarina, a public university. The activities of the two institutions were compared with the targets of the sustainable development goals to discuss the outreach strategies of HEIs aimed at promoting the inclusion of refugees, through descriptive research, with a qualitative approach based on documentary and bibliographic research. Findings The results show that academic participation in research and outreach programs provides refugees with an education but also represents a social contribution far beyond qualifications and technical training, by mitigating local and global problems. The practice of inclusive education allows a reduction in historically existing inequalities. The findings of this study indicate that the results are much more effective when universities, government and society work together to reduce inequalities. Originality/value This study addressed how universities can and should ensure life quality (SDG 3), including an equitable education and fostering lifelong learning opportunities for everybody (SDG 4) and gender equality (SDG 5), to reduce unemployment (SDG 8) and inequalities among people (SDG 10), through outreach projects.

Apical periodontitis (AP) is a prevalent immunoinflammatory disease affecting adults worldwide, this disease is also often co-occurring with high exposure to cigarette smoke. While the harmful effects of secondhand smoke (ShS) are well-documented, its interaction with AP and systemic health implications remain underexplored. This study investigated the combined effects of ShS and AP on disease progression and lung health in a rat model. Twenty-eight female Wistar rats were assigned to four groups: control (no ShS, no AP), control-AP (AP without ShS), ShS (ShS without AP), and ShS-AP (ShS with AP). ShS exposure involved daily inhalation of smoke from up to four cigarettes for 10 weeks, with AP induced via pulp exposure in the lower first molar. Post-euthanasia, jaws and lung tissues were analyzed. Micro-computed tomography confirmed ShS exposure significantly increased the volume and area of apical lesions. Oxidative stress levels in the lung tissue were highest in the ShS-AP group, along with increased total oxidant activity and reduced antioxidant enzyme activity. AP and ShS together were associated with pronounced alveolar destruction and chronic airway remodeling in the lungs. These findings suggest a synergistic interaction between AP and ShS, exacerbating both local and systemic effects. This underscores the critical need to address the interplay between oral and systemic health, particularly in the context of environmental exposures like ShS.

We investigated three calcium silicate-based sealers with respect to their chemical characterization, cytotoxicity, and attachment to RAW264.7 cells. BioRoot RCS (BR), Bio-C Sealer (BC), and Sealer Plus BC (SPBC) were assessed using Fourier transform infrared spectroscopy (FTIR), X-ray fluorescence spectroscopy (XRF), and energy-dispersive X-ray spectroscopy (EDX) (n = 4) for elemental characterization, and using scanning electron microscopy (SEM) to evaluate cell morphology and adhesion. Cytotoxicity was determined at different dilutions (1:1, 1:2, and 1:5) using the succinate dehydrogenase activity (MTT assay). Statistical analysis was performed for normal distribution using the Shapiro–Wilk test and for homoscedasticity using Levene’s test, and one-way ANOVA, Tukey’s/Dunnett’s post hoc tests for cell viability and XRF (α = 0.05). Calcium silicate hydrate and calcium hydroxide were detected by FTIR in all groups. EDX detected a higher calcium content for BR and SPBC and aluminum only in the premixed sealers. XRF detected the highest calcium release in BR (p < 0.05). The surface morphology showed irregular precipitates for all the sealers. SPBC at a 1:2 dilution resulted in the lowest cell viability compared to BR (p < 0.05) and BC (p < 0.05). The calcium silicate-based sealers produced a statistically significant reduction in cellular viability at a 1:1 dilution compared to the control group (p < 0.0001). All the sealers maintained viability above 70%.