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"Gong, Chen"
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Strichartz Estimates for Wave Equations with Charge Transfer Hamiltonians
We prove Strichartz estimates (both regular and reversed) for a scattering state to the wave equation with a charge transfer
Hamiltonian in
eBook
Photothermal conversion triggered thermal asymmetric catalysis within metal nanoparticles loaded homochiral covalent organic framework
For seeking high enantiopurity, the previously reported thermal asymmetric catalysis is usually carried out at low temperature sometimes with limited yield, that is, the high enantiomeric excess (ee) usually at the cost of high yield. Thus, the achieving both high stereoselectivity and yield is an enormous challenge. We report herein two metal nanoparticle (M NP)-loaded and porphyrin-containing homochiral covalent organic framework (CCOF)-based composite catalysts, and their application in the thermally-driven asymmetric one-pot Henry and A
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-coupling reactions. All the reactions are conducted at elevated temperatures with both excellent stereoselectivity and yield which resulted from the synergy of CCOF confinement effect and M NP catalytic activation. Notably, the needed thermal energy for the asymmetric reactions herein is derived from the photothermal conversion via porphyrin-based CCOF upon irradiation with visible light. Remarkably, the CCOF confinement effect can be effectively maintained up to 100 °C for the asymmetric one-pot Henry and A
3
-coupling reactions herein.
Achieving both high stereoselectivity and yield is a challenge for conventional asymmetric catalysis. Here, the authors report two metal nanoparticle-loaded and porphyrin-containing homochiral covalent organic framework-based composite catalysts that exhibit high stereoselectivity and yield in the thermally-driven asymmetric reactions.
Journal Article
PTSD, FOMO and fake news beliefs: a cross-sectional study of Wenchuan earthquake survivors
Background
Post-traumatic stress disorder (PTSD) sufferers show problematic patterns of Internet use such as fear of missing out (FOMO) and sharing misinformation and fake news. This study aimed to investigate these associations in survivors of the 2008 earthquake in Wenchuan, China.
Methods
A self-reported survey was completed by 356 survivors of the Wenchuan earthquake. A mediated structural equation model was constructed to test a proposed pattern of associations with FOMO as a mediator of the relationship between PTSD symptoms and belief in fake news, as well as moderators of this pathway.
Results
PTSD was directly associated with believing fake news (β = 0.444, p < .001) and with FOMO (β = 0.347, p < .001). FOMO mediated the association between PTSD and fake news belief (β = 0.373, p < .001). Age moderated the direct (β = 0.148, t = 3.097, p = .002) and indirect (β = 0.145, t = 3.122, p = .002) pathways, with effects more pronounced with increasing age. Gender was also a moderator, with the indirect effect present in females but not in males (β = 0.281, t = 6.737, p < .001).
Conclusion
Those with higher PTSD symptoms are more likely to believe fake news and this is partly explained by FOMO. This effect is present in females and not males and is stronger in older people. Findings extend knowledge of the role of psychological variables in problematic Internet use among those with PTSD.
Journal Article
Piano training enhances the neural processing of pitch and improves speech perception in Mandarin-speaking children
Musical training confers advantages in speech-sound processing, which could play an important role in early childhood education. To understand the mechanisms of this effect, we used eventrelated potential and behavioral measures in a longitudinal design. Seventy-four Mandarin-speaking children aged 4–5 y old were pseudorandomly assigned to piano training, reading training, or a no-contact control group. Six months of piano training improved behavioral auditory word discrimination in general as well as word discrimination based on vowels compared with the controls. The reading group yielded similar trends. However, the piano group demonstrated unique advantages over the reading and control groups in consonant-based word discrimination and in enhanced positive mismatch responses (pMMRs) to lexical tone and musical pitch changes. The improved word discrimination based on consonants correlated with the enhancements in musical pitch pMMRs among the children in the piano group. In contrast, all three groups improved equally on general cognitive measures, including tests of IQ, working memory, and attention. The results suggest strengthened common sound processing across domains as an important mechanism underlying the benefits of musical training on language processing. In addition, although we failed to find far-transfer effects of musical training to general cognition, the near-transfer effects to speech perception establish the potential for musical training to help children improve their language skills. Piano training was not inferior to reading training on direct tests of language function, and it even seemed superior to reading training in enhancing consonant discrimination.
Journal Article
Visualizing plating-induced cracking in lithium-anode solid-electrolyte cells
Lithium dendrite (filament) propagation through ceramic electrolytes, leading to short circuits at high rates of charge, is one of the greatest barriers to realizing high-energy-density all-solid-state lithium-anode batteries. Utilizing in situ X-ray computed tomography coupled with spatially mapped X-ray diffraction, the propagation of cracks and the propagation of lithium dendrites through the solid electrolyte have been tracked in a Li/Li
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PS
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Cl/Li cell as a function of the charge passed. On plating, cracking initiates with spallation, conical ‘pothole’-like cracks that form in the ceramic electrolyte near the surface with the plated electrode. The spallations form predominantly at the lithium electrode edges where local fields are high. Transverse cracks then propagate from the spallations across the electrolyte from the plated to the stripped electrode. Lithium ingress drives the propagation of the spallation and transverse cracks by widening the crack from the rear; that is, the crack front propagates ahead of the Li. As a result, cracks traverse the entire electrolyte before the Li arrives at the other electrode, and therefore before a short circuit occurs.
Lithium dendrite propagation through ceramic electrolytes can prevent the realization of high-energy-density all-solid-state lithium-anode batteries. The propagation of cracks and lithium dendrites through a solid electrolyte has now been tracked as a function of charge.
Journal Article
Government R&D Investment, Knowledge Accumulation, and Regional Innovation Capability: Evidence of a Threshold Effect Model from China
Innovation is the primary driving force of development and the strategic support for building a modern economic system. For enterprises, continuous innovation capabilities can effectively deal with uncertainties in the business environment and can enhance business competitiveness. Macropolicies can stimulate economic development and can try to promote enterprise innovation, but there is still widespread debate in academia about whether these policies successfully promote or, in fact, inhibit innovation. Looking at the provincial panel data from China between 2009 and 2018, the authors of this paper explored the complex nonlinear mechanism of government R&D investment in driving regional innovation capabilities from the perspective of knowledge accumulation. The empirical results show that, when the level of knowledge accumulation is used as the threshold variable, there is an obvious threshold effect between government R&D input and regional innovation capabilities. As the level of knowledge accumulation crosses the threshold, the influence of government R&D investment on regional innovation capabilities undergoes a structural mutation, shifting from an insignificant inhibitory effect to a significant promotional effect. The above conclusion has strong robustness. This article provides useful policy enlightenment for China to promote the development of scientific and technological civilization and the construction of an innovative country.
Journal Article
Kinase Inhibitors and Kinase-Targeted Cancer Therapies: Recent Advances and Future Perspectives
Over 120 small-molecule kinase inhibitors (SMKIs) have been approved worldwide for treating various diseases, with nearly 70 FDA approvals specifically for cancer treatment, focusing on targets like the epidermal growth factor receptor (EGFR) family. Kinase-targeted strategies encompass monoclonal antibodies and their derivatives, such as nanobodies and peptides, along with innovative approaches like the use of kinase degraders and protein kinase interaction inhibitors, which have recently demonstrated clinical progress and potential in overcoming resistance. Nevertheless, kinase-targeted strategies encounter significant hurdles, including drug resistance, which greatly impacts the clinical benefits for cancer patients, as well as concerning toxicity when combined with immunotherapy, which restricts the full utilization of current treatment modalities. Despite these challenges, the development of kinase inhibitors remains highly promising. The extensively studied tyrosine kinase family has 70% of its targets in various stages of development, while 30% of the kinase family remains inadequately explored. Computational technologies play a vital role in accelerating the development of novel kinase inhibitors and repurposing existing drugs. Recent FDA-approved SMKIs underscore the importance of blood–brain barrier permeability for long-term patient benefits. This review provides a comprehensive summary of recent FDA-approved SMKIs based on their mechanisms of action and targets. We summarize the latest developments in potential new targets and explore emerging kinase inhibition strategies from a clinical perspective. Lastly, we outline current obstacles and future prospects in kinase inhibition.
Journal Article