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Complete coverage path planning requires that the mobile robot traverse all reachable positions in the environmental map. Aiming at the problems of local optimal path and high path coverage ratio in the complete coverage path planning of the traditional biologically inspired neural network algorithm, a complete coverage path planning algorithm based on Q-learning is proposed. The global environment information is introduced by the reinforcement learning method in the proposed algorithm. In addition, the Q-learning method is used for path planning at the positions where the accessible path points are changed, which optimizes the path planning strategy of the original algorithm near these obstacles. Simulation results show that the algorithm can automatically generate an orderly path in the environmental map, and achieve 100% coverage with a lower path repetition ratio.

Conjugated polymer photocatalysts for hydrogen production have the advantages of an adjustable structure, strong response in the visible light region, adjustable energy levels, and easy functionalization. Using an atom- and step-economic direct C–H arylation method, dibromocyanostilbene was polymerized with thiophene, dithiophene, terthiophene, and fused thienothiophene and dithienothiophene, respectively, to produce donor–acceptor (D-A)-type linear conjugated polymers containing different thiophene derivatives with different conjugation lengths. Among them, the D-A polymer photocatalyst constructed from dithienothiophene could significantly broaden the spectral response, with a hydrogen evolution rate up to 12.15 mmol h−1 g−1. The results showed that the increase in the number of fused rings on thiophene building blocks was beneficial to the photocatalytic hydrogen production of cyanostyrylphene-based linear polymers. For the unfused dithiophene and terthiophene, the increase in the number of thiophene rings enabled more rotation freedom between the thiophene rings and reduced the intrinsic charge mobility, resulting in lower hydrogen production performance accordingly. This study provides a suitable process for the design of electron donors for D-A polymer photocatalysts.

The kinesin superfamily (KIF) is a group of proteins that share a highly conserved motor domain. Except for some members, many KIF proteins have adenosine triphosphatase activity and microtubule‐dependent plus‐end motion ability. Kinesins participate in several essential cellular functions, including mitosis, meiosis and the transport of macromolecules. Increasing evidence indicates kinesin proteins play critical roles in the genesis and development of human cancers. Some kinesin proteins are associated with maligancy as well as drug resistance of solid tumor. Thus, targeting KIF therapy seems to be a promising anticancer strategy. Inhibitors of KIF such as kinesin spindle protein (KSP/Eg5) have entered clinical trials for monotherapy or in combination with other drugs, and kinesins other than Eg5 with various potential anticancer target characteristics are also constantly being discovered and studied. Here, we summarize the oncogenic roles of kinesin proteins and potential cancer therapy strategies that target KIF.

HighlightsSynthesis strategies of layered double hydroxides (LDHs) were summarized with classifications of traditional coprecipitation, homogeneous precipitation, and newly developed topochemical oxidation.Diverse approaches of structural modulation and hybridization to enhance the electrocatalytic activity of LDHs were systematically reviewed.Layered double hydroxides (LDHs) have attracted tremendous research interest in widely spreading applications. Most notably, transition-metal-bearing LDHs are expected to serve as highly active electrocatalysts for oxygen evolution reaction (OER) due to their layered structure combined with versatile compositions. Furthermore, reducing the thickness of platelet LDH crystals to nanometer or even molecular scale via cleavage or delamination provides an important clue to enhance the activity. In this review, recent progresses on rational design of LDH nanosheets are reviewed, including direct synthesis via traditional coprecipitation, homogeneous precipitation, and newly developed topochemical oxidation as well as chemical exfoliation of parent LDH crystals. In addition, diverse strategies are introduced to modulate their electrochemical activity by tuning the composition of host metal cations and intercalated counter-anions, and incorporating dopants, cavities, and single atoms. In particular, hybridizing LDHs with conductive components or in situ growing them on conductive substrates to produce freestanding electrodes can further enhance their intrinsic catalytic activity. A brief discussion on future research directions and prospects is also summarized.

The limited capacity of urban green spaces to equitably satisfy the well-being needs of populations in urbanized areas is a global challenge. However, research on the spatial mismatch between green space equity and residents’ subjective well-being (SWB) remains inadequate. Using Shanghai as a case study, this research integrates social media data with an improved GA2SFCA method to evaluate SWB and UPGS accessibility and analyzes and compares the geographical spatial distribution differences of UPGS accessibility across different travel modes. This study employs machine learning to reveal the potential drivers of the mismatch between SWB and UPGS accessibility (note that this study does not explore causal relationships). The results indicate that: (1) UPGS accessibility in Shanghai exhibits pronounced spatial heterogeneity, the equity results derived from the Lorenz curve and Gini coefficient indicate that public transit (Gini = 0.579) < walking (0.427) < driving (0.149), and community parks effectively mitigating disparities among other urban park types; (2) UPGS accessibility and SWB are spatially correlated (r = 0.013, p < 0.01, z > 2.58), with a distinct High-High clustering pattern identified in the inner-ring region; (3) Road network accessibility (SHAP = 0.9478), housing prices (0.7025), and company agglomeration (0.5695) are the three most influential factors contributing to the spatial mismatch where SWB is higher than accessibility, and they exhibit clear threshold effects. These findings link urban green space equity with residents’ SWB, providing a basis for targeted interventions to enhance social welfare and promote urban sustainability.

Loosening of threaded fasteners is a key failure mode, which is mainly caused by the slippage and friction behaviors on the thread and bearing surfaces, and will affect the integrity and reliability of products. Numerous scholars have conducted research on the loosening of threaded fasteners; however, comprehensive reviews on the loosening of threaded fasteners have been scarce. In this review article, we define loosening as a loss of preload and divide it into non-rotational and rotational loosening. The causes and mechanisms of non-rotational and rotational loosening are summarised. Some essential topics regarding loosening under transverse vibration have also attracted significant attention and have been investigated widely, including the loosening curve, critical condition of loosening, and influencing factors of loosening. The research carried out on these three topics is also summarised in this review. It is believed that our work will not only help new researchers quickly understand the state-of-the-art research on loosening, but also increase the knowledge of engineers on this critical subject. In the future, it is important to conduct more quantitative research on local slippage accumulation, and the relationship between local slippage accumulation and rotational loosening, which will have the potential to comprehensively unravel the loosening mechanism, and effectively guide the anti-loosening design of threaded fasteners.

The Asian cultivated rice consists of two major subspecies: indica and japonica . There are already many reports about the existence of genetic introgression between the two subspecies. They propose some possible introgression-related genes from the comparison of population parameters. This study uses the genome-wide variation data of Asia cultivated rice to investigate their genetic introgression on the whole genome level. We detect a total of 13 significantly high introgression loci between the tropical japonica and indica populations. Two different methods are used to identify the genetic introgression regions. For most of the detected introgression regions, they generally get consistent results. Some previously known introgression genes are detected in the identified introgression loci, such as heat resistance gene TT1 and GLW7 . The biological functions for these genetic introgression regions are annotated by the published QTL mapping results. We find that genetic introgression plays a vital role in the determination of both the phenotype and the domestication process of different groups. Our study also provides useful information and resources for the study of rice gene function and the domestication process.

Conjugated polymers (CPs) have attracted much attention in recent years due to their structural abundance and tunable energy bands. Compared with CP-based materials, the inorganic semiconductor TiO2 has the advantages of low cost, non-toxicity and high photocatalytic hydrogen production (PHP) performance. However, studies on polymeric-inorganic heterojunctions, composed of D-A type CPs and TiO2, for boosting the PHP efficiency are still rare. Herein, an elucidation that the photocatalytic hydrogen evolution activity can actually be improved by forming polymeric-inorganic heterojunctions TFl@TiO2, TS@TiO2 and TSO2@TiO2, facilely synthesized through efficient in situ direct C–H arylation polymerization, is given. The compatible energy levels between virgin TiO2 and polymeric semiconductors enable the resulting functionalized CP@TiO2 heterojunctions to exhibit a considerable photocatalytic hydrogen evolution rate (HER). Especially, the HER of TSO2@TiO2 heterojunction reaches up to 11,220 μmol g−1 h−1, approximately 5.47 and 1260 times higher than that of pristine TSO2 and TiO2 photocatalysts. The intrinsic merits of a donor-acceptor conjugated polymer and the interfacial interaction between CP and TiO2 account for the excellent PHP activity, facilitating the separation of photo-generated excitons. Considering the outstanding PHP behavior, our work discloses that the coupling of inorganic semiconductors and suitable D-A conjugated CPs would play significant roles in the photocatalysis community.

IntroductionPrevious studies have pointed out that persistent cough is a common complication after pulmonary resection and its occurrence is closely related to inflammatory response. However, there are no clinical studies to date that directly verify that the use of non-steroidal anti-inflammatory drugs (NSAIDs) can reduce the incidence of persistent cough after pulmonary resection (CAP). In view of this, this study aimed to explore and confirm whether exposure to NSAIDs can effectively reduce the incidence of CAP through a prospective cohort study.Methods and analysisWe will conduct a single-centre, prospective cohort comparative study to investigate the impact of NSAIDs use on persistent cough after video-assisted thoracoscopic (VATS) lung resection surgery. The study will include all patients without preoperative cough symptoms who are scheduled for VATS lung resection. These patients will be divided into exposed and non-exposed groups according to whether they used NSAIDs after surgery. The primary outcome measures of this study are the incidence of CAP and the association between NSAIDs exposure and the incidence of CAP in patients undergoing VATS lung resection, while the secondary outcome parameter was set as severity of cough.Ethics and disseminationThis research was approved by the Ethics Committee of the 920th Hospital of the Joint Logistics Support Force of the Chinese People’s Liberation Army (2024-041-01). The study findings will be published in peer-reviewed journals and presented at professional conferences.Trial registration numberNCT06476249.

Objectives To compare the accuracy of coronary calcium quantification of cadaveric specimens imaged from a photon-counting detector (PCD)-CT and an energy-integrating detector (EID)-CT. Methods Excised coronary specimens were scanned on a PCD-CT scanner, using both the PCD and EID subsystems. The scanning and reconstruction parameters for EID-CT and PCD-CT were matched: 120 kV, 9.3–9.4 mGy CTDI vol , and a quantitative kernel (D50). PCD-CT images were also reconstructed using a sharper kernel (D60). Scanning the same specimens using micro-CT served as a reference standard for calcified volumes. Calcifications were segmented with a half-maximum thresholding technique. Segmented calcified volume differences were analyzed using the Friedman test and post hoc pairwise Wilcoxon signed rank test with the Bonferroni correction. Image noise measurements were compared between EID-CT and PCD-CT with a repeated-measures ANOVA test and post hoc pairwise comparison with the Bonferroni correction. A p < 0.05 was considered statistically significant. Results The volume measurements in 12/13 calcifications followed a similar trend: EID-D50 > PCD-D50 > PCD-D60 > micro-CT. The median calcified volumes in EID-D50, PCD-D50, PCD-D60, and micro-CT were 22.1 (IQR 10.2–64.8), 21.0 (IQR 9.0–56.5), 18.2 (IQR 8.3–49.3), and 14.6 (IQR 5.1–42.4) mm 3 , respectively ( p < 0.05 for all pairwise comparisons). The average image noise in EID-D50, PCD-D50, and PCD-D60 was 60.4 (± 3.5), 56.0 (± 4.2), and 113.6 (± 8.5) HU, respectively ( p < 0.01 for all pairwise comparisons). Conclusion The PCT-CT system quantified coronary calcifications more accurately than EID-CT, and a sharp PCD-CT kernel further improved the accuracy. The PCD-CT images exhibited lower noise than the EID-CT images. Key Points • High spatial resolution offered by PCD-CT reduces partial volume averaging and consequently leads to better morphological depiction of coronary calcifications. • Improved quantitative accuracy for coronary calcification volumes could be achieved using high-resolution PCD-CT compared to conventional EID-CT. • PCD-CT images exhibit lower image noise than conventional EID-CT at matched radiation dose and reconstruction kernel.