Explore the vast range of titles available.

This study investigates the application of the Keyhole–Tungsten Inert Gas Welding (K-TIG) hot-wire filling welding technique with mechanical arc oscillation to weld a 95 mm-thick Ti-6Al-4V titanium alloy plate. The root layer thickness achieved with this technique reaches up to 17 mm, with an average filling thickness of 2.5 mm. The weld bead displays a smooth, shiny appearance, and no significant welding defects are observed in the cross-section of the welded joint. Experimental results show that the welded joint consists of the α phase in different forms, as well as fine α+β microstructures. Compared to the base material, both the weld metal and the heat-affected zone exhibit a lower crystallographic texture strength, with more complex texture types. The impact toughness of the welded joint is excellent, with no significant weaknesses. The impact toughness of the weld metal significantly surpasses that of both the base material and the heat-affected zone. The engagement strengthening effect induced by high-current filling plays a crucial role in enhancing the impact toughness of the weld metal.

In this work, the effect of Mo on the microstructure and properties of Ni-Mo-Al2O3 coatings by cold spraying was studied. The microstructure, composition, hardness, wear resistance and chlorine salt corrosion resistance of the coatings were analyzed by a scanning electron microscope, EDS, X-ray diffractometer, 3D profilometer, microhardness tester and friction wear tester. The results show that the coatings have low porosity and a uniform structure. The addition of Mo can improve the hardness, electrical conductivity, wear resistance and chlorine salt corrosion resistance of the coating but reduce the deposition efficiency of the powder. In general, the 80Ni-10Mo-10Al2O3 coating has the best comprehensive performance, with a hardness of 270.17 HV, friction coefficient of 0.4171 and corrosion rate of 0.287 g/m2·h in molten chloride.

In this work, the effect of Mo on the microstructure and properties of Ni-Mo-Al[sub.2]O[sub.3] coatings by cold spraying was studied. The microstructure, composition, hardness, wear resistance and chlorine salt corrosion resistance of the coatings were analyzed by a scanning electron microscope, EDS, X-ray diffractometer, 3D profilometer, microhardness tester and friction wear tester. The results show that the coatings have low porosity and a uniform structure. The addition of Mo can improve the hardness, electrical conductivity, wear resistance and chlorine salt corrosion resistance of the coating but reduce the deposition efficiency of the powder. In general, the 80Ni-10Mo-10Al[sub.2]O[sub.3] coating has the best comprehensive performance, with a hardness of 270.17 HV, friction coefficient of 0.4171 and corrosion rate of 0.287 g/m[sup.2]·h in molten chloride.

Hepatic fibrosis represents a pivotal transitional stage between hepatitis and cirrhosis or hepatocellular carcinoma, predominantly mediated by hepatic stellate cells (HSCs) activation, dysregulated extracellular matrix (ECM) deposition, and oxidative stress. Metal-based nanomaterials (MNMs) exhibit dualistic effects in liver fibrosis progression, owing to their high specific surface area, tunable morphology, surface functionalization potential, and quantum properties. On the one hand, MNMs hold substantial therapeutic and diagnostic potential: they enable precise targeted drug delivery (passive/active targeting to HSCs or hepatocytes), synergize with natural products to enhance bioavailability and multifaceted antifibrotic efficacy, remodel the fibrotic microenvironment via nanozyme-mediated reactive oxygen species (ROS) scavenging and hypoxia alleviation, and serve as core components of integrated theranostic platforms for noninvasive imaging and real-time treatment monitoring. Specifically, pure metals (Au, Pt), metal oxides (CeO , Fe O , MnO ), metal sulfide/ selenide/ telluride (MoS ), and metal composites (ZIF-8) have demonstrated promising preclinical outcomes in inhibiting HSCs activation, reducing ECM deposition, and improving fibrosis staging accuracy. While demonstrating therapeutic potential, MNMs present significant fibrogenic risks. Inappropriate physicochemical characteristics (eg, non-biodegradable cores, excessive particle size, cationic surface charges) or improper administration routes may induce hepatic injury through multiple mechanisms, including oxidative stress-mediated damage, inflammatory responses, dysregulated apoptosis/autophagy, and impaired lipid metabolism. These effects ultimately exacerbate fibrosis via multiple signaling pathways, notably the TGF-β1/Smad and MAPK/Akt-FoxO3 cascades. In conclusion, MNMs present a dualistic role in hepatic fibrosis management. While their therapeutic potential is well-established when properly engineered to optimize targeting specificity, biodegradability, and biocompatibility, their fibrogenic risks require systematic mitigation through rational design and comprehensive safety assessments. Future progress will depend on achieving optimal balance between these opposing effects to facilitate clinical translation, thereby enabling novel precision medicine approaches for fibrosis diagnosis and treatment.