Explore the vast range of titles available.

A bstract A proper understanding of the physics of medium-induced gluon emissions is known to be of critical importance to describe the properties of strongly interacting matter under extreme conditions. In this regard, many theoretical efforts have been directed towards obtaining analytical calculations which might help us discerning the underlying physical picture and the dominant dynamics for different regimes. These analytical approaches rely on approximations whose validity is analyzed here by comparing their results with a recently developed numerical evaluation which includes all-order resummation of multiple scatterings. More specifically, by quantitatively comparing the energy spectrum and rates, we observe that three different regimes — each with its corresponding physical picture — emerge naturally from the equations: the high-energy regime where the emission process is dominated by a single hard scattering, the intermediate-energy regime where coherence effects among multiple scatterings become fundamental, and the low-energy regime where the dynamics is again dominated by a single scattering but where one must include the suppression factor due to the probability of not having any further scatterings (which is obtained through the resummation of virtual terms).

A bstract The recent discovery of the potential of jet quenching observables to constrain the initial stages after a heavy-ion collision makes imperative to have a better understanding of the process of medium-induced radiation before the formation of the quark-gluon plasma (QGP) and its impact on observables at high- p T . In this work, we generalize the BDMPS-Z framework for medium-induced radiation to account for additional emissions occurring before the creation of the QGP. For simplicity, we assume that during the pre-hydrodynamics phase the hard parton propagates as in vacuum. This set-up, allows us to isolate the contribution from the additional initial radiation by comparing with the usual scenarios in which the emitter is created inside the medium but with different starting points. Using both a numerical implementation of the fully resummed emission spectrum and the usual analytical approximations, we find that replacing an initial slab of the medium by vacuum yields to a significant reduction of the emission spectrum for low radiated gluon energies, while the high-energy tails remain largely unmodified. Finally, we assess the effect of replacing the initial medium by vacuum propagation on the single-inclusive particle suppression R AA and high- p T azimuthal asymmetry v 2 . Our findings indicate that considering vacuum propagation prior to hydrodynamization leads to an increase in the v 2 , thus corroborating the importance of the treatment of jet quenching in the initial stages for the correct description of both observables.

A bstract Over the past years, there has been a sustained effort to systematically enhance our understanding of medium-induced emissions occurring in the quark-gluon plasma, driven by the ultimate goal of advancing our comprehension of jet quenching phenomena. To ensure meaningful comparisons between these new calculations and experimental data, it becomes crucial to model the interplay between the radiation process and the evolution of the medium parameters, typically described by a hydrodynamical simulation. This step presents particular challenges when dealing with calculations involving the resummation of multiple scatterings, which have been shown to be necessary for achieving an accurate description of the in-medium emission process. In this paper, we extend our numerical calculations of the fully-resummed gluon spectrum to account for longitudinally expanding media. This new implementation allows us to quantitatively assess the accuracy of previously proposed scaling laws that establish a correspondence between an expanding medium and a “static equivalent”. Additionally, we show that such scaling laws yield significantly improved results when the static reference case is replaced by an expanding medium with the temperature following a simple power-law decay. Such correspondence will enable the application of numerical calculations of medium-induced energy loss in realistic evolving media for a broader range of phenomenological studies.

To collect evidence on the possibility that patients with depression experience self-stigmatization based on label information for medications. We developed a discrete-choice experiment (DCE) survey instrument that asked respondents to make choices between hypothetical treatments for major depressive disorder (MDD). We also included treatment type (antidepressants versus antipsychotics) and approved indications for the medication. The choice questions mimicked the information presented in product inserts and required systematic tradeoffs between treatment efficacy, treatment type, and indication. We calculated how many patients were willing to forgo efficacy to avoid treatments with information associated with self-stigmatization, and how much efficacy they were willing to forgo. We also evaluated the impact of contextualizing the treatment information to reduce self-stigmatization by randomizing respondents who received additional context. A total of 501 patients with MDD were recruited to complete the DCE survey. Respondents had well-defined preferences for treatment outcomes. Over 60% (63.4%) of respondents were found to be significantly affected by treatment indication. These respondents were willing to forgo about 2.5 percentage points in the chance of treatment efficacy to avoid treatments indicated for schizophrenia. We also find that some level of contextualization of the treatment details could help reduce the negative impact of treatment type and indications. Product-label treatment indication can potentially lead to patient self-stigmatization as shown by patients' avoidance of treatments that are also used to treat schizophrenia. While the effect appears to be relatively small, results suggests that the issue is likely pervasive.

Purpose While gram negative (GN) periprosthetic joint infections (PJI) have previously been described as difficult to treat pathogens with high rates of reinfection, limited investigations have addressed midterm outcomes and risk of infection persistence by the same pathogen. This study analyzed (1) baseline demographics, treatment strategy, and midterm outcomes of GN PJIs, as well as (2) differences in reinfection and relapse rates compared to gram positive (GP) PJIs. Methods We identified 29 patients that were revised for 30 GN PJIs of total hip arthroplasties (THAs) between 2010 and 2020 using a university-based hip registry. Mean age was 77 years, 63% were females (19), and mean BMI was 27 kg/m 2 . Major causative pathogens included Escherichia coli (12), Klebsiella pneumoniae (5), Pseudomonas aeruginosa (5), and Enterobacter cloacae complex (5). Mean follow-up was 3.5 years. Study outcomes included (1) Kaplan–Meier survivorship analyses of all 30 GN PJIs, and (2) comparison of 18 two-stage exchanges for GN PJIs and 104 two-stage exchanges for GP PJIs, performed during the time from 2013 to 2017. Results (1) The 5-year survivorship free of recurrent PJI was 69%, and there were 7 recurrent PJIs at a mean of 2 years. There were 2 further suprafascial wound infections, resulting in a 61% survivorship free of any infection at 5-years. At a mean of 2 years, there were 7 patients with reinfection by the same GN pathogen (6 PJIs, one wound infection) as at index revision (23%). (2) Following two-stage exchange, the 5-year survivorship free of recurrent PJI (GN: 74%; GP: 91%; p = 0.072), any infection (GN: 61%; GP: 91%; p = 0.001), and reinfection by the same pathogen was significantly lower among GN PJIs (GN: 73%; GP: 98%; p < 0.001). Conclusions Patients revised for GN PJIs are at increased risk of reinfection as opposed to GP infections. Affected patients must be counseled on the exceptionally high risk of infection persistence with one in four developing relapses. Level of evidence Therapeutic Level III.

Global Biodiversity Information Facility's (GBIF) global index of primary biodiversity data is based on contributions from more than 2,200 publishing institutions and over 100,000 datasets. Data originate from a broad variety of fields, from research to citizen science, from eDNA through specimen collections to observations and monitoring projects, across all taxonomic groups, and with a wide range of datasets and data types. Equally variable is the underlying motivation and focus for data collection and digitization. Even within commonly used domain concepts like Kingdom or OccurrenceStatus, the values provided by the original sources can vary greatly. This presents challenges for any system that aims to provide joint search access across all these different resources. The vocabulary server*1 in the GBIF Registry is a tool used to standardize selected fields during data interpretation, thereby increasing the searchability of records across datasets on GBIF.org and other GBIF-hosted websites. The server hosts controlled vocabularies for relevant terms from the Darwin Core standard*2, Global Registry of Scientific Collections (GRSciColl)*3, and specific fields used in GBIF. The vocabulary development is managed in a GitHub repository*4, and both concept development and the mapping of verbatim values to concepts are supported by community participation and expert groups. During this talk, we will present some of the vocabularies implemented on GBIF.org and the work that is going into it. We will also go through the roadmap*5 for future implementations and vocabularies. We value input from the Society for the Preservation of Natural History Collections (SPNCH) and Biodiversity Information Standards (TDWG) communities on terms relevant to controlled vocabulary development in GBIF.

Objectives Knowledge of Candida spondylodiscitis is limited to case reports and smaller case series. Controversy remains on the most effective diagnostical and therapeutical steps once Candida is suspected. This systematic review summarized all cases of Candida spondylodiscitis reported to date concerning baseline demographics, symptoms, treatment, and prognostic factors. Methods A PRISMA-based search of PubMed, Web of Science, Embase, Scopus, and OVID Medline was performed from database inception to November 30, 2022. Reported cases of Candida spondylodiscitis were included regardless of Candida strain or spinal levels involved. Based on these criteria, 656 studies were analyzed and 72 included for analysis. Kaplan-Meier curves, Fisher’s exact, and Wilcoxon’s rank sum tests were performed. Results In total, 89 patients (67% males) treated for Candida spondylodiscitis were included. Median age was 61 years, 23% were immunocompromised, and 15% IV drug users. Median length of antifungal treatment was six months, and fluconazole (68%) most commonly used. Thirteen percent underwent debridement, 34% discectomy with and 21% without additional instrumentation. Median follow-up was 12 months. The two year survivorship free of death was 80%. The two year survivorship free of revision was 94%. Younger age ( p = 0.042) and longer length of antifungal treatment ( p = 0.061) were predictive of survival. Conclusion Most patients affected by Candida spondylodiscitis were males in their sixties, with one in four being immunocompromised. While one in five patients died within two years of diagnosis, younger age and prolonged antifungal treatment might play a protective role.

Background Vacuum-assisted closure (VAC) temporization is a promising technique to achieve local control in aggressive soft tissue sarcomas. Despite its previously reported efficacy, adoption of VAC temporization remains limited, primarily due to the scarce literature on patient-reported outcomes (PROs) supporting its efficacy. This study compared the postoperative PROs after VAC temporization or single-stage (SS) excision and reconstruction for patients undergoing surgical resection for myxofibrosarcoma management. Methods A retrospective analysis of myxofibrosarcoma patients who underwent surgical resections at our institution from 2016 to 2022 was performed. Postoperative PROs collected prospectively for those treated with VAC temporization or SS excision/reconstruction were compared using a visual analog scale (VAS) for pain and three Patient-Reported Outcomes Measurement Information System (PROMIS) questionnaires: Global Health Short-Form Mental (SF Mental), Global Health Short-Form Physical (SF Physical), and Physical Function Short-Form 10a (SF 10a). Absolute and differential (postoperative minus preoperative) scores at the 1-month, 3-month, 6-month, 1-year, and 2-year time points were compared. Results The analysis included 79 patients (47 treated with VAC temporization and 32 treated with SS excision/reconstruction). All outcomes were similar between the groups except for physical function 1 year after surgery, in which the differential PROMIS SF 10a scores were higher in the SS group ( p = 0.001). All the remaining absolute and differential PROMIS and VAS pain scores were similar between the groups at all time points. Postoperative complications did not differ between the groups. Conclusion The PROs for physical and mental health, physical function, and pain were similar between the myxofibrosarcoma patients who had VAC temporization and those who had SS excision/reconstruction after surgical resection.

Prosthetic joint infection (PJI) is the most common mode of failure of megaprostheses, yet the literature on the topic is scarce, and studies report conflicting data regarding the optimal treatment strategy. Patients with megaprostheses PJI are often immunosuppressed, and surgeons must balance the trade-off between treatment efficacy and morbidity associated with the surgery aiming for infection eradication. Our review on megaprostheses PJI focuses on two axes: (1) risk factors and preventative strategies; and (2) surgical strategies to manage this condition. Risk factors were classified as either unmodifiable or modifiable. Attempts to decrease the risk of PJI should target the latter group. Strategies to prevent PJI include the use of silver-coated implants, timely discontinuation of perioperative antibiotic prophylaxis, and adequate soft tissue coverage to diminish the amount of dead space. Regarding surgical treatment, main strategies include debridement, antibiotics, implant retention (DAIR), DAIR with modular component exchange, stem retention (DAIR plus), one-stage, and two-stage revision. Two-stage revision is the “gold standard” for PJI in conventional implants; however, its success hinges on adequate soft tissue coverage and willingness of patients to tolerate a spacer for a minimum of 6 weeks. DAIR plus and one-stage revisions may be appropriate for a select group of patients who cannot endure the morbidity of two surgeries. Moreover, whenever DAIR is considered, exchange of the modular components should be performed (DAIR plus). Due to the low volume of megaprostheses implanted, studies assessing PJI should be conducted in a multi-institutional fashion. This would allow for more meaningful comparison of groups, with sufficient statistical power. Level of evidence: IV.