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Loneliness typically refers to the feelings of distress and dysphoria resulting from a discrepancy between a person's desired and achieved levels of social relations, and there is now considerable evidence that loneliness is a risk factor for poor psychological and physical health. Loneliness has traditionally been conceptualized as a uniquely human phenomenon. However, over millions of years of evolution, efficient and manifold neural, hormonal, and molecular mechanisms have evolved for promoting companionship and mutual protection/assistance and for organizing adaptive responses when there is a significant discrepancy between the preferred and realized levels of social connection. We review evidence suggesting that loneliness is not a uniquely human phenomenon, but, instead, as a scientific construct, it represents a generally adaptive predisposition that can be found across phylogeny. Central to this argument is the premise that the brain is the key organ of social connections and processes. Comparative studies and animal models, particularly when integrated with human studies, have much to contribute to the understanding of loneliness and its underlying principles, mechanisms, consequences, and potential treatments.

Research on peer-related loneliness in adolescence has paid insufficient attention to the distinction between intimate loneliness (i.e., in a dyadic relationship with a friend) and relational loneliness (i.e., in the broader peer group). This study examined the correlations among a broad set of loneliness scales. A sample of adolescents from Belgium ( n  = 282; 60% female) completed 8 subscales of 6 established loneliness measures. Results revealed high correlations among these measures. At the same time, confirmatory factor analysis revealed the two expected factors, reflecting intimate and relational loneliness. Furthermore, it was found that boys experienced on average more intimate loneliness than girls, and girls experienced on average more relational loneliness than boys. As different types of loneliness are related to problems in different domains, and adolescents may experience one type of loneliness but not the other, it is essential to know which loneliness measure taps into which type of loneliness. The present study not only provides evidence for the distinction between intimate and relational loneliness, but also shows which type is covered by which of six commonly used loneliness measures. Based on these findings, researchers can now make a more deliberate selection of scales for future research, and can better interpret and integrate findings from previous studies that used different loneliness measures.

Loneliness and attitude towards aloneness have been shown to be associated to depression, anxiety, and other psychiatric disorders in adolescents and they may also increase the vulnerability to Non-Suicidal Self-Injury (NSSI). Therefore, the present study investigated the association between lifetime prevalence and functions of NSSI, parent- and peer-related loneliness, and attitude towards aloneness (positive and negative). Data regarding NSSI, loneliness, and attitude towards aloneness were collected from a sample of 401 high school students from three different high schools located in the Dutch-speaking part of Belgium. Lifetime prevalence of NSSI was found to be 16.5%. Females reported a higher lifetime prevalence of NSSI than males. Higher mean scores for parent-, peer-related loneliness, and positive attitude (i.e., affinity) towards aloneness was observed in adolescents with lifetime NSSI as compared to adolescents without a history of NSSI. Filly, a positive correlation between self-related (i.e., automatic) functions of NSSI and parent- and peer-related loneliness and a positive attitude towards aloneness was also observed.

Based on current theories of depression, reciprocal links between loneliness and depressive symptoms are expected to occur. However, longitudinal studies on adolescent samples are scarce and have yielded conflicting results. The present five-wave longitudinal study from mid- to late adolescence ( N  = 428, M age at T1 = 15.22 years; 47% female) examined the direction of effect between loneliness and depressive symptoms, using cross-lagged path analysis. In addition, the robustness of these prospective associations was tested by examining the role of the Big Five personality traits (i.e., extraversion, conscientiousness, agreeableness, neuroticism, and openness) as explaining factors and moderators. Results indicated that loneliness and depressive symptoms influenced one another reciprocally, and these reciprocal associations were not attributable to their mutual overlap with personality traits. In addition, neuroticism was found to be a moderator, in that the bidirectional effects between loneliness and depressive symptoms were only found in adolescents high in neuroticism. Practical implications are discussed, and suggestions for future research are outlined.

Social anxiety symptoms (SAS) are among the most common mental health problems during adolescence, and it has been shown that parenting influences the adolescent's level of social anxiety. In addition, it is now widely assumed that most mental health problems, including social anxiety, originate from a complex interplay between genes and environment. However, to date, gene-environment (G × E) interactions studies in the field of social anxiety remain limited. In this study, we have examined how 274 genes involved in different neurotransmission pathways interact with five aspects of perceived parenting as environmental exposure (i.e., support, proactive control, psychological control, punitive control, and harsh punitive control) to affect SAS during adolescence. We have applied an analytical technique that allows studying genetic information at the gene level, by aggregating data from multiple single-nucleotide-polymorphisms within the same gene and by taking into account the linkage disequilibrium structure of the gene. All participants were part of the STRATEGIES cohort of 948 Flemish adolescents (mean age = 13.7), a population-based study on the development of problem behaviors in adolescence. Relevant genes were preselected based on prior findings and neurotransmitter-related functional protein networks. The results suggest that genes involved in glutamate (SLC1A1), glutathione neurotransmission (GSTZ1), and oxidative stress (CALCRL), in association with harsh punitive parenting, may contribute to social anxiety in adolescence. Isolated polymorphisms in these genes have been related to anxiety and related disorders in earlier work.Conclusions: Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development. Taken together, these findings provide new insights into possible biological pathways and environmental risk factors involved in the etiology of social anxiety symptoms' development.

Research has demonstrated consistent positive associations between perceived parental psychological control and adolescents' depressive symptoms, but the direction of influence remains unclear. Using a cross-lagged longitudinal design in two samples of late (Study 1, N = 396) and middle (Study 2, N = 724) adolescents, this study compared three models, that is, a psychological control effects model, an adolescent adjustment effects model, and a reciprocal model. Structural equation modeling analyses generally favored the reciprocal model over each of the unidirectional models. The cross-lagged effects of perceived psychological control remained significant after controlling for two important parenting dimensions (i.e., parental responsiveness and behavioral control; Study 1) and were found in all types of parent-adolescent dyads except for the mother-daughter dyad (Study 2). Implications for the understanding of the mechanisms that underlie the deleterious effects of parents' psychological control on adolescent adjustment are discussed.

Previous research has shown that the rs53576 variant of the oxytocin receptor gene (OXTR) is associated with trait levels of loneliness, but results are inconsistent. The aim of the present study is to examine micro-level effects of the OXTR rs53576 variant on state levels of loneliness in early adolescents. In addition, gene-environment interactions are examined between this OXTR variant and positive and negative perceptions of company. Data were collected in 278 adolescents (58% girls), by means of the Experience Sampling Method (ESM). Sampling periods consisted of six days with nine assessments per day. A relation was found between the OXTR rs53576 variant and state loneliness, in girls only. Girls carrying an A allele had higher levels of state loneliness than girls carrying the GG genotype. In addition, adolescents with an A allele were more affected by negative perceptions of company than GG carriers, on weekend days only. No significant gene-environment interactions were found with positive company. Adolescents carrying an A allele were more susceptible to negative environments during weekend days than GG carriers. Our findings emphasize the importance of operationalizing the phenotype and the environment accurately.

Adolescence and young adulthood are characterized by important changes in personality, changes toward a more stable identity, and the establishment of intimate relationships. We examined the role of personality traits in establishing intimate relationships, the interplay between personality traits and interpersonal identity processes during these relationships, and the role of interpersonal identity processes and personality traits in the dissolution thereof. For this purpose, we used longitudinal data on 424 female college students (mean age at T1 = 18.6 years; Sample 1) and 390 late adolescents drawn from a community sample (56.7 % female; mean age at T1 = 19.7 years; Sample 2). Especially highly extraverted individuals were likely to become involved in a relationship. Neuroticism was associated negatively, and Agreeableness and Conscientiousness were associated positively with a stronger sense of interpersonal identity within intimate relationships. Finally, the importance of interpersonal identity processes was underscored by the fact that these processes, and not so much personality traits, predicted relational breakups. Overall, the present study provides important insights into the role of personality and identity in the initiation, maintenance, and dissolution of intimate relationships in late adolescence and young adulthood.

This study presents a comprehensive 4-factor model of autonomy in middle and late adolescence. Partially overlapping sets of scales on adolescent individuation and family functioning were correlated with each other in 2 independent studies. Data for the first study were taken from a sample of high school students in Grades 9-12 (N D 601), whereas the data for the second study were derived from a sample of 1st-year university students (N D 374). Confirmatory factor analysis on all of the scales and derivative subscales in both studies revealed a model that comprised 4 different but related factors, that is, Connectedness, Separation, Detachment, and Agency, all of which occupy a central place in different theories of adolescent autonomy. Connectedness and Detachment, and to a lesser extent Connectedness and Separation, were inversely related to one another. Correlations between Agency and the 3 other factors were much lower. Results are discussed with respect to the different views on autonomy that exist in the literature, and with respect to the term 'autonomy,' which should be used as an umbrella term only. Implications for the conceptual basis of the Emotional Autonomy Scale are also outlined. [PUBLICATION ABSTRACT].

Repetitive Negative Thinking (RNT) is a well-established predictor in adolescents of emotional problems, such as depression. Surprisingly little research, however, has looked at the relative importance of RNT vs. more interpersonally relevant variables in the context of depression, such as loneliness and lack of social connectedness. The present study, therefore, set out to examine whether RNT is a significant predictor when taking into account the contribution of loneliness and social connectedness. A sample of 135 typically developing adolescents ( = 135; 79.3% girls; = 17.5; range 16-21) completed measures of depressive symptoms, RNT, loneliness and social connectedness at two time points with a 3-month interval. Results showed that above and beyond baseline depressive symptoms, RNT was the only other significant predictor of prospective depressive symptoms. According to these results, RNT seems a relatively more important factor to consider in the context of adolescent depression than factors in the interpersonal or social context. Consequently, targeting RNT might be expected to yield more significant gains in reducing or preventing depressive symptoms in adolescents compared to focusing on feelings of loneliness or social connectedness - a hypothesis that remains to be tested.