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"Gott, Brian"
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Variety : an illustrated history of the world from the most important magazine in Hollywood
\"Variety is not only a fascinating look at the history of entertainment as reported by the world's most highly-regarded commentator of show business news, it is also a history of American popular culture, and a record of the influence and confluence of art, life, and Hollywood. Illustrated with hundreds of front pages, articles, and new and archival photographs spanning Variety's more-than-century old archives, it includes personal anecdotes written exclusively for this book by a host of well-regarded artists. Variety is a decade-by-decade documentation of the seminal moments in history, including how pop culture reflected and responded to such pivotal moments in time as audiences' move from vaudeville houses to movie theaters, the sinking of the Titanic, the invention of the summer blockbuster, global politics, war, the moon landing, technological advances and the ever-changing social mores that were both reflected by and influenced the world\"--Jacket.
Book
An eye-opening look at refugees
In an environment where most have lost family, all have lost home, and a single bite from a mosquito can cause death, each day of life with health is a reward that doesn't go unnoticed. * A people filled with a deep despair; the UNHCR (the U.N. organization charged with managing the camp, and providing shelter and security to its more than 90,000 residents) has a little more than $100 per year (yes, per year) to support each man, woman and child at Kakuma The World Food Programme provides nourishment for these residents, but they face desperate challenges.
Journal Article
The product data management market
Design conferencing, though not itself a product data management (PDM) application, is likely to be useful mainly in close association with PDM. The use of multimedia workstations to support concurrent and collaborative engineering dialogue is possibly the most significant recent computer integrated manufacturing enterprise development and represents the ideal user interface to PDM, which basically is an interactive \"multi-information\" management system.
Journal Article
NOTE FROM PUBLISHER
Variety not only provides our subscribers news, we offer detailed analysis, unique columns, colorful commentary and more than 1 ,200 annual reviews across film, TV, legit and music from around the globe. .
Magazine Article
Implicating ABC Transporters in Insecticide Resistance: Research Strategies and a Decision Framework
Pest insects damage crops, transmit diseases, and are household nuisances. Historically, they have been controlled with insecticides, but overuse often leads to resistance to one or more of these chemicals. Insects gain resistance to insecticides through behavioral, metabolic, genetic, and physical mechanisms. One frequently overlooked strategy is through the use of ATP-binding cassette (ABC) transporters. ABC transporters, present in all domains of life, perform natural excretory functions, thus the exploitation of these transporters to excrete insecticides and contribute to resistance is highly plausible. Previous work has implicated ABC transporters in some cases of insecticide resistance. Proposed herein is a framework meant as a formal guide for more easily incorporating the analysis of ABC transporters into existing resistance monitoring using suggested simple research methods. This framework functions as a simple decision tree and its utility is demonstrated using case examples. Determining a role for ABC transporters in insecticide resistance would help to shape future resistance management plans and guide the design of new insecticides.
Journal Article
Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques
The diverse bacterial communities that colonize the gastrointestinal tract play an essential role in maintaining immune homeostasis through the production of critical metabolites such as short-chain fatty acids (SCFAs) and this can be disrupted by antibiotic use. However, few studies have addressed the effects of specific antibiotics longitudinally on the microbiome and immunity. We evaluated the effects of four specific antibiotics: enrofloxacin, cephalexin, paromomycin, and clindamycin, in healthy female rhesus macaques. All antibiotics disrupted the microbiome, including reduced abundances of fermentative bacteria and increased abundances of potentially pathogenic bacteria, including Enterobacteriaceae in the stool, and decreased Helicobacteraceae in the colon. This was associated with decreased SCFAs, indicating altered bacterial metabolism. Importantly, antibiotic use also substantially altered local immune responses, including increased neutrophils and Th17 cells in the colon. Furthermore, we observed increased soluble CD14 in plasma, indicating microbial translocation. These data provide a longitudinal evaluation of antibiotic-induced changes to the composition and function of colonic bacterial communities associated with specific alterations in mucosal and systemic immunity.
Journal Article
Correction: Antibiotic-induced microbiome perturbations are associated with significant alterations to colonic mucosal immunity in rhesus macaques
An amendment to this paper has been published and can be accessed via a link at the top of the paper.An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Journal Article
Functional verification of the IBM System z10 processor chipset
This paper describes the comprehensive verification effort of the IBM System z10(TM) processor chipset, which consists of the z10(TM) quad-core central processor chip and the companion z10 symmetric multiprocessor (SMP) chip. The z10 processor chipset represented a significant redesign of its predecessor and thus presented a new challenge to ensure complete functional correctness of the product before the construction of actual system hardware. The z10 microprocessor pipeline was completely redesigned to support a doubling of the operating frequency. It also includes new hardware performance features, such as enhanced branch prediction, a reoptimized cache hierarchy, hardware-based prefetching, and a hardware implementation of decimal floating-point arithmetic in IEEE formats. In addition, there were significant hardware changes in the SMP storage hierarchy for optimized data latency performance. These changes include a new system topology, interprocessor book protocol, larger SMP size, and various aggressive cache ownership schemes. Key verification innovations are described, and a direct relationship to improved z10 system quality is provided for most cases. [PUBLICATION ABSTRACT]
Journal Article
RFK Is Criticized By MLS
Major League Soccer Commissioner Doug Logan criticized RFK Stadium management yesterday for its handling of the record-setting crowd at D.C. United's home opener Saturday night.
Newspaper Article