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By the year 2050, the world’s population is predicted to have grown to around 9–10 billion people. The food demand in many countries continues to increase with population growth. Various abiotic stresses such as temperature, soil salinity and moisture all have an impact on plant growth and development at all levels of plant growth, including the overall plant, tissue cell, and even sub-cellular level. These abiotic stresses directly harm plants by causing protein denaturation and aggregation as well as increased fluidity of membrane lipids. In addition to direct effects, indirect damage also includes protein synthesis inhibition, protein breakdown, and membranous loss in chloroplasts and mitochondria. Abiotic stress during the reproductive stage results in flower drop, pollen sterility, pollen tube deformation, ovule abortion, and reduced yield. Plant nutrition is one of the most effective ways of reducing abiotic stress in agricultural crops. In this paper, we have discussed the effectiveness of different nutrients for alleviating abiotic stress. The roles of primary nutrients (nitrogen, phosphorous and potassium), secondary nutrients (calcium, magnesium and sulphur), micronutrients (zinc, boron, iron and copper), and beneficial nutrients (cobalt, selenium and silicon) in alleviating abiotic stress in crop plants are discussed.

The crop residues generated in agricultural fields are mostly considered a burden due to their disposal issues. This study attempts to effectively use pigeon pea stalk (PPS) for biochar production, a promising source as a soil amendment for carbon sequestration and alternative fuel source. PPS was pyrolyzed at different loads and reaction times to optimize the kiln temperature (350–400 °C and 450–500 °C) and changes in physicochemical properties, higher heating value (HHV) and yield were assessed. The results indicated that biochar yield, volatile matter, bulk density, O/C and H/C atomic ratios decreased, whereas fixed carbon, ash content and total porosity increased with increasing kiln temperature across all loads. Biochar produced at 450–500 °C (18 kg load kiln−1) had higher total carbon, nitrogen, phosphorous, recovered total carbon and total nitrogen, total potential carbon and CO2 reduction potential. Biochar produced at 350–400 °C had the maximum cation exchange capability (43.0 cmol kg−1). Biochar has estimated O/C and H/C atomic ratios of 0.07–0.15 and 0.35–0.50, respectively. Biochar exhibited good agronomic characteristics and fulfilled key quality criteria of H/C < 0.7 and O/C < 0.4 for soil carbon sequestration, as described by the European Biochar Certificate and the International Biochar Initiative. The estimated mean residence time and the mass fraction of carbon that would remain after 100 years were consistently greater than 1000 years and 80%, respectively. The biochar produced at 450–500 °C (at 18.0 kg kiln−1) from PPS had higher fixed carbon (65.3%), energy density (1.51), energetic retention efficiency (53%), fuel ratio (4.88), and HHV (25.01 MJ kg−1), as well as lower H/C and O/C ratios, implying that it is suitable for use as an alternative solid fuel.

The nomenclature and classification of pseudomyxoma peritonei (PMP) is confusing and controversial. Numerous classification systems have been proposed, none of which are easily reproducible or a useful guide for treatment. Patients with PMP of appendiceal origin were identified from our institution's database. Kaplan-Meier analyses were performed based on a proposed new PMP classification, a three-tiered grading system designated PMP1, PMP2, and PMP3. These results were compared with the established schemes by Ronnett and Bradley et al. There were 211 patients included in the analysis with a mean age of 51 ± 12 years at diagnosis. For PMP1, 86 patients (40.8%) included cases with abundant extracellular mucin and columnar non-stratified epithelium without dysplasia or atypia. For PMP3, 50 patients (23.7%) consisted of PMP with any percentage of signet ring cells (SRCs), For PMP2, 75 patients (35.5%) included all other patients. The mean age (± standard deviation) for PMP 1, 2, and 3 were 51 ± 12, 51 ± 12, and 51 ± 10 years, respectively ( P = 0.90). The three groups had similar sex distribution ( P = 0.24) and resection status ( P = 0.47). Kaplan-Meier analyses showed median survivals of 120, 88, and 40 months and 5-year survival rates of 85.7, 63.05, and 32.2 per cent ( P < 0.0001) for PMP 1, 2, and 3, respectively. Three distinct categories, PMP1, 2, and 3, were identified, which provide better stratification in terms of overall survival and represent differences in tumor biology that may impact treatment recommendations.

TRUST is an acronym for Transition to the Urban Water Services of Tomorrow. Just into its second year, this four-year European Union project consists of a consortium that is split into eight work areas (which in turn are segmented into many work packages), focusing on different aspects of the project. These eight work areas are not islands of expertise working in isolation in different countries in Europe, but cooperating and collaborating team members actively exchanging and sharing information among themselves to ensure that progress toward the end goals is ensured and expedited.

TRUST is an acronym for Transition to the Urban Water Services of Tomorrow. Just into its second year, this four‐year European Union project consists of a consortium that is split into eight work areas (which in turn are segmented into many work packages), focusing on different aspects of the project. These eight work areas are not islands of expertise working in isolation in different countries in Europe, but cooperating and collaborating team members actively exchanging and sharing information among themselves to ensure that progress toward the end goals is ensured and expedited.

Polyhalite-based POLY4, a multi-nutrient source containing potassium, calcium, magnesium, and sulphur, is increasingly recognised for its potential to improve crop yields and soil health in agricultural systems. It is also been considered as a feasible approach for addressing the deficiency in potassium, calcium, and sulphur within a single application source. The present study aimed to investigate the impact of polyhalite-based POLY4 application, either as a complete or partial substitute for traditional potassium fertiliser and gypsum supplement, on the improvement of peanut ( Arachis hypogaea ) growth and soil quality. An extensive field study was conducted from 2021 and 2022, employing ten distinct nutrient management treatments with three replications in a randomised complete block design. The findings of the study indicated that the application of polyhalite (POLY4) in conjunction with only NP fertilisers resulted in a higher yield advantage (approximately 150–200 kg ha -1 ) than in plots treated with NPK + gypsum (at 500 kg ha -1 ) and control plots. The application of polyhalite-based fertiliser (POLY4) at a rate that was 100% equivalent to K along with NP fertilisers resulted in a significant increase in pod yield (5.3–12.8%) over NPK + gypsum and control plots. Thus, the increased crop yield led to an increase in gross returns of 4.88% and in net returns of 4.28% with the application of POLY4 (100%) + NP fertilisers over other treatments. Likewise, variable rates of conventional fertilisers along with POLY4 (100% recommended) + NP + gypsum at 310 kg/ha significantly increased the linoleic acid content (38.5%), oleic acid content, and oil content (48.1%) by reducing palmitic acid (11.96%) content in the groundnut seed. Interestingly, POLY4 use at the 50% recommended rate also resulted in yields that were comparable with those obtained with 100% NPK. Therefore, applying POLY4, a polyhalite fertiliser, in either a 100% or 50% equivalent of essential K can be an effective way of increasing the production of peanut crops and promoting agricultural sustainability.

The challenges of providing services to growing populations multiply, as demonstrated by the trials faced in Norway as it searched for effective ways of addressing a growing wastewater treatment problem.

Organic agriculture’s economic benefits and widespread adoption are well documented, but its impact on soil C dynamics in rainfed regions of semiarid tropics is less understood. The use of organic amendments in organic farming not only supply nutrients but also have the potential to contribute to soil carbon sequestration. Carbon storage and various soil organic pools are affected differently by various crops and production systems. A study was conducted with three crops (sunflower, pigeonpea, and greengram) under three production systems (control, organic and integrated) to assess the effect on soil C stocks, carbon sequestration potential, and crop yield. After seven years of experiment, pigeonpea (Cajanus cajan L.) cultivation improved soil bulk density, porosity and water holding capacity compared to greengram [Vigna radiata (L) Wilczek] and sunflower (Helianthus annuus L.). Furthermore, plots under pigeonpea cultivation being on par with greengram had 15.6% higher total C (113.52 Mg C ha−1), 14% higher easily oxidizable organic C (17.5 Mg C ha−1) and C sequestration rate of 1.22 Mg C ha−1 yr−1 compared to sunflower. Among the three production systems, plots under organic management had significantly lower bulk density and higher water holding capacity and porosity at all of the profile depths compared to integrated production system and control. Similarly, organic production system being on par with integrated production system improved the easily oxidizable, oxidizable and weakly oxidizable organic C fractions at different soil depths compared to control. The C sequestration rate ranged from 0.21 to 0.85 Mg C ha−1 yr−1 in organic production systems compared to negligible rate (0.01–0.04 Mg ha−1 yr−1) in the plots under control. On average, integrated production system being on par with organic management recorded significantly higher pigeonpea equivalent seed yield (886 kg ha−1) compared to control (792 kg ha−1). These results suggest the potential of organic production system in improving soil properties, C sequestration, and crop yields in semiarid rainfed areas.

Mucinous colorectal adenocarcinomas (MCAs) are clinically and morphologically distinct from nonmucinous colorectal cancers (CRCs), show a distinct spectrum of genetic alterations (higher KRAS mutations, lower p53, high MUC2), exhibit more aggressive behavior (more prone to peritoneal dissemination and lymph node involvement) and are associated with poorer response to chemotherapy with limited treatment options. Here, we report the effectiveness of combinatorial targeting of two KRAS-mediated parallel pathways in reducing MUC2 production and mucinous tumor growth in vitro and in vivo. By knockdown of mutant KRAS we show that, mutant KRAS (a) is necessary for MUC2 production in vitro and (b) synergistically engages PI3K/AKT and MEK/ERK pathways to maintain MUC2 expression in MCA cells. These results define a novel and a previously undescribed role for oncogenic KRAS in mucinous cancers. MCA cells were sensitive to MEK inhibition suggesting cellular dependence ('addiction') of KRAS-mutant MCA cells on hyperactivation of the MEK-driven pathway. Interestingly, MCA cells, though initially sensitive, were later resistant to PI3K single agent inhibition. Our studies suggest that this resistance involves dynamic rewiring of signaling circuits mediated through relief of RTK inhibition and MEK-ERK rebound activation. This resistance however, could be overcome by co-targeting of PI3K and MEK. Our studies thus provide a rational basis for MEK- and PI3K-targeted combination therapy for not only KRAS mutant MCA but also for other related mucinous neoplasms that overproduce MUC2 and have a high rate of KRAS mutations such as pseudomyxoma peritonei.

Sweden aspires to become totally carbon dioxide-neutral by 2045. Indisputably, what is needed is not just a reduction in the emissions of CO2 (greenhouse gases in general) from the technosphere, but also a manipulated diversion of CO2 from the atmosphere to ‘traps’ in the lithosphere, technosphere, hydrosphere, and biosphere. The case study in this paper focused on Stockholm Exergi’s proposed waste-to-energy incineration plant in Lövsta, which is keen on incorporating carbon capture and storage (CCS), but is also interested in understanding the potential of carbon capture, utilization, and storage (CCU/S) in helping it to achieve ‘carbon-dioxide-negativity’. Waste-to-energy incineration plants (in cases where the petro-plastics in the waste mix can be substantially reduced) are a key component of a circular bio-economy, though the circularity here pertains to recovering energy from materials which may or may not be recyclable. CCS (storage in the North Sea) was compared with CCU/S (CO2 sintered into high-quality building blocks made of recycled slag from the steel sector) from techno-economic and environmental perspectives. The comparative analysis shows, inter alia, that a hybridized approach—a combination of CCS and CCU/S—is worth investing in. CCU/S, at the time of writing, is simply a pilot project in Belgium, a possible creatively-destructive technology which may or may not usurp prominence from CCS. The authors believe that political will and support with incentives, subsidies, and tax rebates are indispensable to motivate investments in such ground-breaking technologies and moving away from the easier route of paying carbon taxes or purchasing emission rights.