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Arogyamrita Kwath (AMK) is a polyherbal decoction comprising ten medicinal plants, viz., Albizia lebbeck, Andrographis paniculata, Tinospora cordifolia, Adhatoda vasica, Solanum xanthocarpum, Curcuma longa, Glycyrrhiza glabra, Terminalia bellirica, Withania somnifera and Trachyspermum ammi. The plants of the AMK formulation are traditionally used for the treatment of inflammation and respiratory ailments, but no scientific evidence has been reported so far for this formulation. To evaluate anti-inflammatory activity of AMK formulation in vitro and its fractions and to predict in silico anti-viral activity of identified potential phytoconstituents. The MTT cell cytotoxicity assay, nitric oxide (NO) inhibition assay and cytokines assay were carried out at concentrations 100 and 200 μg/mL. The phytoconstituents were identified by UPLC-PDA and UPLC-HRMS analyses. For pharmacoinformatics study molecular docking and molecular dynamics methods were used. The study revealed that AMK significantly inhibited NO in comparison to dexamethasone (100 μg/mL) and pro-inflammatory cytokines in RAW264.7 cells. The three fractions, n-hexane, EtOAc and n-BuOH prepared from the AMK formulation were non-cytotoxic against RAW264.7 murine macrophage cells during MTT cytotoxicity assay and showed satisfactory results during cytokines assay. Ethyl acetate fraction contains active phytoconstituents in appreciable quantities. 16 phytoconstituents have been identified by UPLC-HRMS analysis in the formulation and four phytocompounds were quantified by UPLC-PDA. Molecular dynamics study helped in identifying two macromolecular targets (viral replicase and the membrane protein), which are relatively more important. In the present study, anti-inflammatory activity of AMK was evaluated and the claimed anti-viral property was re-confirmed by molecular modelling in this work. The results clearly established that AMK showed remarkable anti-inflammatory and anti-viral activities. •AMK formulation is a decoction used for the treatment of respiratory ailments.•Sixteen compounds were identified by UPLC-HRMS analysis in the AMK formulation.•AMK formulation significantly lowered NF-kB and TNF-α levels in concentration-dependent manner.•Quercetin and vasicine, present in AMK showed significant binding affinity against seven viral targets.•MD simulations revealed that viral replicase and membrane protein were found to be the preferred targets for AMK formulation.

Pancytopenia in children with celiac disease (CeD) is postulated to be due to nutritional deficiency such as vitamin B 12 , folate and copper or an autoimmune process resulting in aplastic anemia with hypoplastic marrow. In the present case series, we report the profile and explore the etiology of pancytopenia among children with CeD. There are only a few case reports of pancytopenia in children with CeD. We enrolled newly diagnosed cases of CeD and pancytopenia presenting in the celiac disease clinic over three years. Detailed evaluation was carried out for the cause of pancytopenia. We followed up on the cases for compliance and response to gluten-free diet at three months, six months and 12 months. Twenty patients were eligible for inclusion. They were divided into two groups: one with aplastic anemia with hypoplastic marrow labeled as Gp CeD-AA and the other with megaloblastic/nutritional anemia labeled as Gp CeD-MA. Patients in Gp CeD-MA presented with classical symptoms of CeD as recurrent diarrhea, abdomen distension, pallor and poor weight gain. They had none or just one transfusion requirement and had an early and complete recovery from pancytopenia. Patients in Gp CeD-AA presented with atypical symptoms such as epistaxis, short stature, fever, pallor and weakness. They had a multiple blood transfusion requirement and had delayed and partial recovery from pancytopenia. Pancytopenia is not a disease in itself but is the presentation of an underlying disease. It can occur due to various coexisting disorders in children with CeD, which can be as simple as nutritional deficiencies to as complex as an autoimmune process or malignancy. CeD should be included in the differential diagnosis of aplastic anemia as CeD and aplastic anemia both have a similar pathological process involving T cell destruction of tissues.

Earthquake-resistant design of proposed intake-outlet towers and safety-evaluation of existing towers for future earthquakes require reliable analytical and numerical procedures to predict the earthquake induced forces. The objectives of this work are to develop efficient analytical and numerical techniques for analyzing the earthquake response of intake-outlet towers and investigate how tower-water interaction, and tower-foundation-soil interaction affect the response of the tower. A general analytical procedure, based on the substructure method, is developed to compute the response of intake-outlet towers to arbitrary ground motion including the simultaneous effects of tower-water interaction and tower-foundation-soil interaction. The developed procedure is applicable to towers of arbitrary cross-section having two axes of symmetry. Utilizing the analytical procedure the response of various intake-outlet towers to harmonic and earthquake ground motion is computed for a wide range of basic parameters characterizing the tower geometry, surrounding and inside water, and foundation soil. Based on these response results, the effects of tower-water interaction and tower-foundation-soil interaction on the response of towers are investigated and various parameters controlling these interaction effects are identified. In order to develop a simplified analysis procedure suitable for the preliminary design and safety evaluation of intake-outlet towers, approximate representations of various interaction effects in the response analysis are developed. The hydrodynamic interaction effects are represented by added hydrodynamic mass distributions for surrounding and inside water which are determined from hydrodynamic analyses with the assumption of rigid tower. An equivalent single-degree-of-freedom system is developed that approximately represents the fundamental mode response of intake-outlet towers on flexible foundation soil with or without water. Finally, a simplified analysis procedure for intake-outlet towers, including tower-water and tower-foundation-soil interaction effects, is developed to compute the maximum earthquake forces directly from the earthquake design spectrum. It is demonstrated that this procedure leads to estimates of the earthquake induced forces that are sufficiently accurate for the preliminary phase of design and safety evaluation of intake-outlet towers.

  [...] obesity has become a genetic curse and a prominent factor in most of the chronic diseases such as hypertension, diabetes, arthritis, sleep apnea, high blood pressure, hypercholesterolemia and coronary artery disease. Take the ice cream in a tablespoon rather than in a bowl. 6 If you add aerobic exercise to the regimen, you will change the equation in your favor by increasing the number of calories you burn.

In doing this blood test, the lab will be measuring four values: triglycerides, high- density lipoproteins (HDL), low-density lipoproteins (LDL), and total cholesterol. Avoid tobacco, and though the news reports that wine can be healthy, it is important to note that all studies that show a benefit only do so with moderate drinking (less than one glass per day), and even then the studies currently published do not offer sufficient evidence to merit recommendation.

Acute and subacute sinusitis are usually complications of a cold or viral illness, but can also be caused by a bacterial infection (often secondary to a virus). Chronic sinusitis affects a small proportion of the population and is due to chronic allergies causing obstruction.

Smoking causes more relaxation of the LES and more acid production. 6 Certain medications for blood pressure (beta blockers and calcium channel blockers) cause the LES to relax.

[...] in 2002, an osteopathic journal hypothesized that cracking one's knuckles may actually decrease the occurrence of arthritis in people. First is conservative therapy, which includes medications, rest, heat and support with an Ace bandage or splint if warranted.

In support of prevention of pandemics, New Jersey Health Commissioner Dr. Fred M. Jacobs recently approved requiring flu shots for preschool children.