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According to an ecological perspective in psychology and in line with social cognitive theory, smoking behaviour is determined by different social contexts (for example, peers, family and school) providing adolescents with important role models. This paper investigates the effects of personal characteristics as well as family, peer and school context variables on youth smoking behaviour. We hypothesize that school smoking policy variables predict adolescents' smoking in addition to other context variables. Data were obtained from a self-report survey administered to 3364 students in 40 secondary schools in Bavaria, Germany. For both younger (10-15 years) and older (16-21 years) students, strong associations were found between smoking behaviour and (i) smoking best friends and friends in general, (ii) other substance use and (iii) school performance. In the younger age group, the non-existence of smoking bans for students was associated with an increased risk of being smoker. For the older students, a positive association was found between the presence of smoking teachers on school grounds and smoking behaviour. Results are discussed considering methodological aspects and public health concerns.

Smokers with smoking-related diseases who are hospitalized in rehabilitation centers should be offered smoking cessation. This is the first study evaluating whether telephone booster sessions after intensive inpatient treatment are an effective strategy. The present study was conducted in 13 rehabilitation centers for somatic disorders as a prospective multicenter study with a randomized treatment–control group design. We compared abstinence rates after hospital discharge from treatment that included a group smoking cessation program with (treatment group) and without telephone booster sessions (control group). Data from 290 smokers were analyzed. After 6 and 12 months the treatment group achieved abstinence rates twice as high as those of the control group. Men profited more from telephone booster sessions than did women. Results indicated that telephone booster sessions were highly effective (even) after an inherently intensive group program during a hospital stay. Further research should focus on the special needs of women receiving telephone counseling.

Inclusive doubly differential cross sections d 2 σ pA / dx F   dp T 2 as a function of Feynman-x ( x F ) and transverse momentum ( p T ) for the production of K S 0 , Λ and in proton-nucleus interactions at 920 GeV are presented. The measurements were performed by HERA-B in the negative x F range (−0.12< x F <0.0) and for transverse momenta up to p T =1.6 GeV/ c . Results for three target materials: carbon, titanium and tungsten are given. The ratios of production cross sections are presented and discussed. The Cronin effect is clearly observed for all three V 0 species. The atomic number dependence is parameterized as σ pA = σ pN ⋅ A α where σ pN is the proton-nucleon cross section. The measured values of α are all near one. The results are compared with EPOS 1.67 and PYTHIA 6.3. EPOS reproduces the data to within ≈20% except at very low transverse momentum.

The results of five years of development of the inner tracking system of the HERA-B experiment and first experience from the data taking period of the year 2000 are reported. The system contains 184 chambers, covering a sensitive area of about 20 * 20 cm2 each. The detector is based on microstrip gas counters (MSGCs) with diamond like coated (DLC) glass wafers and gas electron multipliers (GEMs). The main problems in the development phase were gas discharges in intense hadron beams and aging in a high radiation dose environment. The observation of gas discharges which damage the electrode structure of the MSGC led to the addition of the GEM as a first amplification step. Spurious sparking at the GEM cannot be avoided completely. It does not affect the GEM itself but can produce secondary damage of the MSGC if the electric field between the GEM and the MSGC is above a threshold depending on operation conditions. We observed that aging does not only depend on the dose but also on the spot size of the irradiated area. Ar-DME mixtures had to be abandoned whereas a mixture of 70% Ar and 30% CO2 showed no serious aging effects up to about 40 mC/cm deposited charge on the anodes. X-ray measurements indicate that the DLC of the MSGC is deteriorated by the gas amplification process. As a consequence, long term gain variations are expected. The Inner Tracker has successfully participated in the data taking at HERA-B during summer 2000.

Inclusive differential cross sections $d\\sigma_{pA}/dx_F$ and $d\\sigma_{pA}/dp_t^2$ for the production of \\kzeros, \\lambdazero, and \\antilambda particles are measured at HERA in proton-induced reactions on C, Al, Ti, and W targets. The incident beam energy is 920 GeV, corresponding to $\\sqrt {s} = 41.6$ GeV in the proton-nucleon system. The ratios of differential cross sections \\rklpa and \\rllpa are measured to be $6.2\\pm 0.5$ and $0.66\\pm 0.07$, respectively, for \\xf $\\approx-0.06$. No significant dependence upon the target material is observed. Within errors, the slopes of the transverse momentum distributions $d\\sigma_{pA}/dp_t^2$ also show no significant dependence upon the target material. The dependence of the extrapolated total cross sections $\\sigma_{pA}$ on the atomic mass $A$ of the target material is discussed, and the deduced cross sections per nucleon $\\sigma_{pN}$ are compared with results obtained at other energies.

Wnt reception at the membrane is complex and not fully understood. CD44 is a major Wnt target gene in the intestine and is essential for Wnt-induced tumor progression in colorectal cancer. Here we show that CD44 acts as a positive regulator of the Wnt receptor complex. Downregulation of CD44 expression decreases, whereas CD44 overexpression increases Wnt activity in a concentration-dependent manner. Epistasis experiments place CD44 function at the level of the Wnt receptor LRP6. Mechanistically, CD44 physically associates with LRP6 upon Wnt treatment and modulates LRP6 membrane localization. Moreover, CD44 regulates Wnt signaling in the developing brain of Xenopus laevis embryos as shown by a decreased expression of Wnt targets tcf-4 and en-2 in CD44 morphants.

Multiprincipal-element alloys are an enabling class of materials owing to their impressive mechanical and oxidation-resistant properties, especially in extreme environments. Here we develop a new oxide-dispersion-strengthened NiCoCr-based alloy using a model-driven alloy design approach and laser-based additive manufacturing. This oxide-dispersion-strengthened alloy, called GRX-810, uses laser powder bed fusion to disperse nanoscale Y2O3 particles throughout the microstructure without the use of resource-intensive processing steps such as mechanical or in situ alloying. We show the successful incorporation and dispersion of nanoscale oxides throughout the GRX-810 build volume via high-resolution characterization of its microstructure. The mechanical results of GRX-810 show a twofold improvement in strength, over 1,000-fold better creep performance and twofold improvement in oxidation resistance compared with the traditional polycrystalline wrought Ni-based alloys used extensively in additive manufacturing at 1,093 °C. The success of this alloy highlights how model-driven alloy designs can provide superior compositions using far fewer resources compared with the ‘trial-and-error’ methods of the past. These results showcase how future alloy development that leverages dispersion strengthening combined with additive manufacturing processing can accelerate the discovery of revolutionary materials.

This study aims to compare the microstructure of 17–4 PH stainless steel (SS) manufactured via laser powder bed fusion (L-PBF) and laser powder directed energy deposition (LP-DED) in non-heat treated (NHT) and heat treated conditions. In addition, the room-temperature tensile behavior of heat-treated L-PBF and LP-DED 17–4 PH SS has been investigated and compared with that of the wrought counterpart with the same heat treatment conditions. The results show that the L-PBF specimens have a finer microstructure (ferrite + lath martensite) than the LP-DED ones (massive ferrite + Widmanstätten ferrite) in NHT condition. Electron backscatter diffraction analysis shows that the L-PBF and LP-DED specimens have twin-based substructure lath martensite after heat treatment. Despite the lower tensile strength of the LP-DED specimens compared with the L-PBF ones, the ductility of peak-aged LP-DED specimens was reduced due to the presence of the δ-ferrite phase having a significant plastic deformation incompatibility with the martensite.

Metal additive manufacturing (AM) encapsulates the myriad of manufacturing processes available to meet industrial needs. Determining which of these AM processes is best for a specific aerospace application can be overwhelming. Based on the application, each of these AM processes has advantages and challenges. The most common metal AM methods in use include Powder Bed Fusion, Directed Energy Deposition, and various solid-state processes. Within each of these processes, there are different energy sources and feedstock requirements. Component requirements heavily affect the process determination, despite existing literature on these AM processes (often inclusive of input parameters and material properties). This article provides an overview of the considerations taken for metal AM process selection for aerospace components based on various attributes. These attributes include geometric considerations, metallurgical characteristics and properties, cost basis, post-processing, and industrialization supply chain maturity. To provide information for trade studies and selection, data on these attributes were compiled through literature reviews, internal NASA studies, as well as academic and industry partner studies and data. These studies include multiple AM components and sample build experiments to evaluate (1) material and geometric variations and constraints within the processes, (2) alloy characterization and mechanical testing, (3) pathfinder component development and hot-fire evaluations, and (4) qualification approaches. This article summarizes these results and is meant to introduce various considerations when designing a metal AM component.