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The last rhinos : my battle to save one of the world's greatest creatures
A conservationist traces his efforts to save the endangered White Rhino, describing the brutal region where the last fifteen were struggling to survive, the bureaucratic forces the author navigated to establish protections, and his work as a chief negotiator between the violent Lord's Resistance Army and the Ugandan government.
Book
The Evolution of Selective Dorsal Rhizotomy for the Management of Spasticity
Selective dorsal rhizotomy is a key technique in the surgical management of spasticity in patients with cerebral palsy. The technique evolved from the late 1800s when pioneers like Dana and Abbe performed dorsal rhizotomy in their treatment of refractory pain. These surgeons noted a reduction in muscle tone associated with the operation. When Sherrington then published his Nobel prize-winning work on the corticospinal tract and its role in the neuromuscular system in the 1890s, the course was set for modifying spasticity by aiming surgery at the dorsal roots. This procedure underwent multiple modifications through the next century and today it is, arguably, the most commonly performed operation to treat cerebral palsy children with spasticity. Selective dorsal rhizotomy is a technique that still teaches us a great deal about neurophysiology on a daily basis and it is thanks to the pioneers, described in this article, that we have this tool in our armamentarium.
Journal Article
The fixed period
Trollope's only science fiction novel, written in 1880, is set in the year 1980 on an island near New Zealand where euthanasia for citizens over the age of 67 is compulsory.
Resampling Techniques Study on Class Imbalance Problem in Credit Risk Prediction
Credit risk prediction heavily relies on historical data provided by financial institutions. The goal is to identify commonalities among defaulting users based on existing information. However, data on defaulters is often limited, leading to a concentration of credit data where positive samples (defaults) are significantly fewer than negative samples (nondefaults). It poses a serious challenge known as the class imbalance problem, which can substantially impact data quality and predictive model effectiveness. To address the problem, various resampling techniques have been proposed and studied extensively. However, despite ongoing research, there is no consensus on the most effective technique. The choice of resampling technique is closely related to the dataset size and imbalance ratio, and its effectiveness varies across different classifiers. Moreover, there is a notable gap in research concerning suitable techniques for extremely imbalanced datasets. Therefore, this study aims to compare popular resampling techniques across different datasets and classifiers while also proposing a novel hybrid sampling method tailored for extremely imbalanced datasets. Our experimental results demonstrate that this new technique significantly enhances classifier predictive performance, shedding light on effective strategies for managing the class imbalance problem in credit risk prediction.
Journal Article
The Origin of the Parathyroid Gland
It has long been held that the parathyroid glands and parathyroid hormone evolved with the emergence of the tetrapods, reflecting a need for new controls on calcium homeostasis in terrestrial, rather than aquatic, environments. Developmentally, the parathyroid gland is derived from the pharyngeal pouch endoderm, and studies in mice have shown that its formation is under the control of a key regulatory gene, Gcm-2. We have used a phylogenetic analysis of Gcm-2 to probe the evolutionary origins of the parathyroid gland. We show that in chicks, as in mice, Gcm-2 is expressed in the pharyngeal pouches and the forming parathyroid gland. We find that Gcm-2 is present not only in tetrapods but also in teleosts and chondrichthyans, and that in these species, Gcm-2 is expressed within the pharyngeal pouches and internal gill buds that derive from them in zebrafish (Danio rerio), a teleost, and dogfish (Scyliorhinus canicula), a chondrichthyan. We further demonstrate that Gcm-2 is required for the formation of the internal gill buds in zebrafish. We also have identified parathyroid hormone 1/2-encoding genes in fish and show that these genes are expressed by the gills. We further show that the gills express the calcium-sensing receptor, which is used in tetrapods to monitor serum calcium levels. These results indicate that the tetrapod parathyroid gland and the gills of fish are evolutionarily related structures, and that the parathyroid likely came into being as a result of the transformation of the gills during tetrapod evolution.
Journal Article
Neuronal cell biocompatibility and adhesion to modified CMOS electrodes
The use of CMOS (Complementary Metal Oxide Semiconductor) integrated circuits to create electrodes for biosensors, implants and drug-discovery has several potential advantages over passive multi-electrode arrays (MEAs). However, unmodified aluminium CMOS electrodes may corrode in a physiological environment. We have investigated a low-cost electrode design based on the modification of CMOS metallisation to produce a nanoporous alumina electrode as an interface to mammalian neuronal cells and corrosion inhibitor. Using NG108-15 mouse neuroblastoma x rat glioma hybrid cells, results show that porous alumina is biocompatible and that the inter-pore distance (pore pitch) of the alumina has no effect on cell vitality. To establish whether porous alumina and a cell membrane can produce a tight junction required for good electrical coupling between electrode and cell, we devised a novel cell detachment centrifugation assay to assess the long-term adhesion of cells. Results show that porous alumina substrates produced with a large pore pitch of 206 nm present a significantly improved surface compared to the unmodified aluminium control and that small pore-pitches of 17 nm and 69 nm present a less favourable surface for cell adhesion.
Journal Article
A leadership maturity model for implementing Six Sigma in academic institutions – using case studies to build theory
Purpose
The purpose of this paper is to present a maturity model for academic leadership teams to benchmark their ability to deliver a culture of continuous improvement through the use of Lean Six Sigma. Teams will also be able to use this model to develop strategic action plans to improve the culture of continuous improvement within their institution. In addition, this paper explains the journey the authors have taken in creating this model by using a mixture of literature review, questionnaires and case studies to build the model and the use of test cases to refine and improve the model.
Design/methodology/approach
This paper uses a structured approach, focussing first on assessing the state of UK Lean Six Sigma (LSS) implementation and the, through the use of the case study method, the authors have designed a maturity model based on the classic capability maturity matrix approach. The final model has then been tested to refine the model into an improved version.
Findings
Key findings from interviewing the academic institutions that make up this paper highlight the current best practice in the UK and how far they still have to travel to become truly continuous improving organisations.
Research limitations/implications
This paper is limited to only focussing on UK institutions in the design and development of the maturity model. Future research should benchmark UK institutions more formally with international universities from North America and the Far East.
Practical implications
This paper present a final maturity model which can be used by academic leadership teams to both map their maturity at delivering continuous improvement projects and to act as an action plan to move the culture towards a quality-based, continuously improving institution.
Originality/value
To the best of the authors’ knowledge, this is the first such model to be produced focussing on the leadership and sustainability of deploying LSS in academic institutions.
Journal Article
Academic leadership – special or simple
Purpose
Is academic leadership unique? Is it special? Do academic leaders require certain knowledge, skills and behaviours that only a career in academic can develop – or is it fundamentally the same as traditional leadership? This paper explores whether or not academic leadership is special or simple. It starts by defining the context and environment academic leaders find themselves in, moving onto explore characteristics and the overlap with traditional leadership thinking and finally concludes with current trends and a working definition of what academic leadership really is. The purpose of this paper is to explore the uniqueness of academic institutions and whether or not they require certain leadership characteristics which can only be found in academic career progression or could an exceptional individual from outside academia lead academics, researchers, administrators and support staff?
Design/methodology/approach
Based around a literature review of current thinking on academic leadership and then the production of a Venn diagram to compares these current trends with more traditional definitions of leadership.
Findings
The key findings of this paper include a definition of academic leadership, and how it is similar in many ways to traditional leadership thinking. However, there is a uniqueness centred on the culture and politics of an academic institution which many traditional leaders would not need to work within.
Research limitations/implications
This paper is part of a wider research project relating to academic leadership and Lean Six Sigma and thus the author has searched out papers which support both areas of the author’s interest.
Practical implications
Anyone in a position of academic leadership may be interested in how it relates to traditional leadership concepts and where their field differs from others.
Originality/value
No research current exists which overlaps academic leadership with traditional definitions and characteristics and thus this paper is a new view of academic leadership.
Journal Article