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Converting an odds ratio to a range of plausible relative risks for better communication of research findings
Odds ratios are a necessary evil in medical research; although used as a measure of effect size from logistic regressions and case-control studies, they are poorly understood. This paper provides practical advice for authors and readers on converting odds ratios to relative risks
Journal Article
Cardiovascular disease risk factors in chronic kidney disease: A systematic review and meta-analysis
Chronic kidney disease (CKD) is a global health burden and is independently associated with increased cardiovascular disease risk. Assessment of cardiovascular risk in the general population using prognostic models based on routinely collected risk factors is embedded in clinical practice. In CKD, prognostic models may misrepresent risk due to the interplay of traditional atherosclerotic and non-traditional risk factors. This systematic review's aim was to identify routinely collected risk factors for inclusion in a CKD-specific cardiovascular prognostic model.
Systematic review and meta-analysis of observational cohort studies and randomized controlled trials. Studies identified from MEDLINE and Embase searches using a pre-defined and registered protocol (PROSPERO ID-2016:CRD42016036187). The main inclusion criteria were individuals ≥18 years of age with non-endstage CKD. Routinely collected risk factors where multi-variable adjustment for established cardiovascular risk factors had occurred were extracted. The primary outcome was fatal and non-fatal cardiovascular events.
The review of 3,232, abstracts identified 29 routinely collected risk factors of which 20 were presented in more than 1 cohort. 21 cohorts were identified in relation to 27,465 individuals and 100,838 person-years. In addition to established traditional general population cardiovascular risk factors, left ventricular hypertrophy, serum albumin, phosphate, urate and hemoglobin were all found to be statistically significant in their association with future cardiovascular events.
These non-traditional risk factors should be assessed in the development of future cardiovascular prognostic models for use in individuals with CKD.
Journal Article
The Role of Tumor Necrosis Factor in Manipulating the Immunological Response of Tumor Microenvironment
The tumor microenvironment (TME) is an intricate system within solid neoplasms. In this review, we aim to provide an updated insight into the TME with a focus on the effects of tumor necrosis factor-α (TNF-α) on its various components and the use of TNF-α to improve the efficiency of drug delivery. The TME comprises the supporting structure of the tumor, such as its extracellular matrix and vasculature. In addition to cancer cells and cancer stem cells, the TME contains various other cell types, including pericytes, tumor-associated fibroblasts, smooth muscle cells, and immune cells. These cells produce signaling molecules such as growth factors, cytokines, hormones, and extracellular matrix proteins. This review summarizes the intricate balance between pro-oncogenic and tumor-suppressive functions that various non-tumor cells within the TME exert. We focused on the interaction between tumor cells and immune cells in the TME that plays an essential role in regulating the immune response, tumorigenesis, invasion, and metastasis. The multifunctional cytokine, TNF-α, plays essential roles in diverse cellular events within the TME. The uses of TNF-α in cancer treatment and to facilitate cancer drug delivery are discussed. The effects of TNF-α on tumor neovasculature and tumor interstitial fluid pressure that improve treatment efficacy are summarized.
Journal Article
The transition to statehood in the New World
This 1982 collection of eight original anthropological essays provides an exciting synthesis of theory and practice in one of the key issues of contemporary cultural evolutionary thought. The contributors ask why complex, highly stratified societies emerged at several locations in the New World at the same point in prehistory.
Book
Queer, Trans, and/or Nonbinary French as a Second Language (FSL) Teachers’ Embodiment of Inclusivity in Their Teaching Practice
Increasingly, scholars are attending to questions of identity and power in French as a second language (FSL) education. An underdeveloped area of research is the experience of queer, trans, and nonbinary FSL teachers in Canada. Understanding how marginalized teachers navigate building inclusive and equitable learning spaces is the focus of this study. To this end, this study used narrative inquiry and photo elicitation methods to understand how—if at all—participants embody inclusivity in their classroom practices. Four themes emerged from this study: (1) (in)visibility of queerness, (2) performing a balancing act, (3) urgency to disrupt, and (4) navigating the teaching of a gendered language. These findings suggest that while participants in this study strive to build inclusive spaces for themselves and their students, external factors, such as fear of opposition and being reprimanded, abound. These findings offer insights into discursive moves to facilitate a meaningfully queered and inclusive FSL learning space, and contributes to the growing body of queer applied linguistics by revealing how queer teachers’ embodied practices can reshape inclusivity in FSL education.
Journal Article
Neuromined : triumphing over technological tyranny
\"When our phones become our keys to access everything, will our lives be more convenient or more at the mercy of whoever can hack into our devices? Will self-driving cars help us maximize our time and get to our destination safely, or will they erode the autonomy and freedom we feel when we drive ourselves? What happens if the government, in the name of public health, gains access to the data in our handy fitness trackers and uses it to reward or limit us? In Neuromined, data sovereignty advocate Robert Edward Grant and prolific technology author Michael Ashley team up to explore significant questions such as these. Each chapter imagines a near-future surveillance dystopia through a riveting fictional tale and provides a companion analysis connecting the story to our present reality. Entertaining and provoking, this book shows readers how the technology that has promised a lifetime of convenience has also constrained a public's individual options and agency. But all hope is not lost. Neuromined, at its core, demonstrates how technology, when viewed through a different ethos and used by a conscientious public, can instead provide greater autonomy and greater access to liberation.\"--Amazon.
BOOK
THE EXPANDING DOMAIN OF STRATEGIC MANAGEMENT RESEARCH AND THE QUEST FOR INTEGRATION
Research summary: This special issue of Strategic Management Journal was motivated by concern that the growing scope and diversity of the strategic management field creates the risk of incoherence and fragmentation and the belief that research reviews could contribute to synthesis and integration. In this introductory essay, we address the expanding domain of strategic management, consider where its boundaries lie, identify the forces engendering fragmentation, and discuss how this special issue—and research reviews in general—can assist convergence within the field of strategy. We conclude by addressing the potential for integration more broadly in relation to the theories we deploy, the phenomena we investigate, and cohesiveness of our scholarly community. Managerial summary: The expanding domain of strategic management reflects the widening range of strategic issues that practising managers face. However, the fragmentation that has accompanied this broadening scope impedes the usefulness of strategic management research in guiding strategic decision making. We argue that reviews of strategic management research, such as those included within this special issue, can support the accumulation of an integrated, empirically-validated knowledge base which is essential to informing management practice.
Journal Article