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ObjectiveTo assess the neurodevelopmental outcomes of preterm neonates who received inhaled nitric oxide (iNO) in the first week of age for hypoxaemic respiratory failure (HRF).MethodsIn this retrospective cohort study, we included neonates born at <29 weeks gestational age (GA) between January 2010 and December 2018 who had a neurodevelopmental assessment at 18–24 months corrected age (CA) at one of the Canadian Neonatal Follow-Up Network clinics. The primary outcome was neurodevelopmental impairment (NDI). We performed propensity score-matched analysis to compare the outcomes of those who received and did not receive iNO.ResultsOf the 5612 eligible neonates, 460 (8.2%) received iNO in the first week of age. Maternal age, receipt of antenatal corticosteroids, GA and birth weight were lower in the iNO group compared with the no-iNO group. Neonates in the iNO group had higher illness severity scores and higher rates of preterm prolonged rupture of membranes and were small for GA. Severe brain injury, bronchopulmonary dysplasia and mortality were higher in the iNO group. Of the 4889 survivors, 3754 (77%) neonates had follow-up data at 18–24 months CA. After propensity score matching, surviving infants who received rescue iNO were not associated with higher odds of NDI (adjusted OR 1.34; 95% CI 0.85 to 2.12).ConclusionsIn preterm neonates <29 weeks GA with HRF, rescue iNO use was not associated with worse neurodevelopmental outcomes among survivors who were assessed at 18–24 months CA.

ObjectiveTo assess the association between time of birth and mortality among preterm infants.Study designPopulation-based study of infants born 22–36 weeks gestation (GA) in Canada from 2010 to 2015 (n = 173 789). Multivariable logistic regression models assessed associations between timing of birth and mortality.ResultAmong infants 22–27 weeks GA, evening birth was associated with higher mortality than daytime birth (adjusted odds ratio [AOR] 1.14, 95% CI 1.01–1.29). Among infants 28–32 weeks GA and 33–36 weeks GA, night birth was associated with lower mortality than daytime birth (AOR 0.75, 95% CI 0.59–0.95; AOR 0.78, 95% CI 0.62–0.99, respectively). Sensitivity analysis excluding infants with major congenital anomaly revealed that associations between hour of birth and mortality among infants born 28–32 and 33–36 weeks GA decreased or were not statistically significant.ConclusionHigher mortality among extremely preterm infants during off-peak hours may suggest variations in available resources based on time of day.

We present near-infrared scattered-light observations of the disks around two stars of the Corona Australis star-forming region, V721 CrA, and BN CrA, obtained with VLT/SPHERE, in the H band, as part of the DESTINYS large programme. Our objective is to analyse the morphology of these disks, and highlight their main properties. We adopt an analytical axisymmetric disk model to fit the observations and perform a regression on key disk parameters, namely the dust mass, the height profile, and the inclination. We use RADMC-3D code to produce synthetic observations of the analytical models, with full polarised scattering treatment. Both stars show resolved and extended disks with substructures in the near-IR. The disk of V721 CrA is vertically thicker, radially smaller (120 au), and brighter than BN CrA (190 au). It also shows spiral arms in the inner regions. The disk of BN CrA shows a dark circular lane, which could be either an intrinsic dust gap or a self-cast shadow, and a brightness enhancement along the disk minor axis. Both disks are compatible with the evolutionary stage of their parent subgroup within the CrA region: V721 CrA belongs to the \"on-cloud\" part of CrA, which is dustier, denser and younger, whereas BN CrA is found on the outskirts of the older \"off-cloud\" group.