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The establishment of the first livestock communities in the eastern Iberian Peninsula during the 6 th millennium cal BCE marked a significant transition in the region’s economic system. The research of early animal management practices provides crucial valuable understanding into feeding and pastoral strategies, revealing insights into the social organization of landscapes and their resources. Using stable carbon (δ 13 C) and nitrogen (δ 15 N) isotopic analyses of faunal remains this study investigates the interplay between environmental conditions, animal management practices, and dietary habits in Neolithic herds from Mas d’Is and Niuet sites in the Serpis Valley. The landscape of the area, characterized by Mediterranean forests and marshes, provided a variety of plant resources. Although most of the valley is covered by C 3 types of plants, there were some clusters of C 4 vegetation. The isotopic analyses prove that the local herds can be disaggregated in two groups: some animals with a diet based on C 3 , some feeding on C 4 plants. These results reveal diverse feeding strategies and, by default, spatialized management practices. In addition, the animals presenting a C 3 signature, have, as well, strong nitrogen values and marks on the bones that indicate they were part of the agricultural cycle as traction force. This complex organisational strategy, with two herds that show different levels of husbandry intensification, might reflect broader socio-economic systems, where the landscape may have been managed with a mosaic of different property regimes: where marginal areas might have been considered as communal or open-access resources, while more fertile areas nearby settlements, might have been used as crop fields, and individually or household managed. The integration of livestock into agricultural systems and the selective use of landscape resources highlight an adaptive and dynamic approach to animal husbandry in response to environmental and social factors during the Neolithic in the Serpis Valley.

Purpose In metastatic neuroblastoma (NB) patients, accurate risk stratification and disease monitoring would reduce relapse probabilities. This study aims to evaluate the independent prognostic significance of detecting tyrosine hydroxylase ( TH ) and doublecortin ( DCX ) mRNAs by reverse transcriptase quantitative polymerase chain reaction (RT-qPCR) in peripheral blood (PB) and bone marrow (BM) samples from metastatic NB patients. Procedures RT-qPCR was performed on PB and BM samples from metastatic NB patients at diagnosis, post-induction therapy and at the end of treatment for TH and DCX mRNAs detection. Results High levels of TH and DCX mRNAs when detected in PB and BM at diagnosis independently predicted worse outcome in a cohort of 162 metastatic NB. In the subgroup of high-risk metastatic NB, TH mRNA detected in PB remained as independent predictor of EFS and OS at diagnosis. After the induction therapy, high levels of TH mRNA in PB and DCX mRNA in BM independently predicted poor EFS and OS. Furthermore TH mRNA when detected in BM predicted worse EFS. TH mRNA in PB samples at the end of treatment is an independent predictor of worse outcome. Conclusion TH and DCX mRNAs levels in PB and BM assessed by RT-qPCR should be considered in new pre-treatment risk stratification strategies to reliable estimate outcome differences in metastatic NB patients. In those high-risk metastatic NB, TH and DCX mRNA quantification could be used for the assessment of response to treatment and for early detection of progressive disease or relapses.

Desde un marco de estudios feministas, en este artículo se analiza Alberto el jugador. Novela de costumbres, de Rosario Orrego, como un texto en el que la regeneración nacional se entrelaza con una compleja agenda feminista de reforma sociofamiliar. Las propuestas reformistas se basan en una política sexual que privilegia las cosmovisiones femeninas. A partir del estudio de las negociaciones, ajustes, tensiones y desobediencias que las tres protagonistas articulan respecto al patriarcado al que pertenecen, es posible desvelar su poder interpretativo. Es con el conjunto de estas visiones femeninas que Orrego logra diseñar con esta novela una audaz agenda feminista de reforma sociofamiliar.

In recent years, ultrasonography has gained unmatched importance in medical practice. After the initial use for central vascular access placement and regional anaesthesia, its application has expanded to airway, ocular, abdominal, lung and cardiac ultrasound, with the concept of point of care ultrasound (POCUS) gaining acceptability and applicability in the most diverse situations. In fact, it has recently been acclaimed as the fifth pillar to bedside evaluation [1]. Performing a POCUS-guided eva­luation has proved to be of value in emergency medicine, with studies demonstrating improved diagnosis and better outcomes [2]. Similarly, in critical care, systematic ultrasound evaluation has been shown to decrease the use of conventional diagnostic imaging tools and time on mechanical ventilation and improve the management of fluid therapy [3]. Recognition of the benefit of ultrasound evaluation in the perioperative period has been increasing. In fact, the need to master clinical ultrasound evaluation has led the Canadian anaesthesiology academic centres to issue recommendations regarding the scope of practice and required training for perioperative POCUS [4].

ObjectiveThe objective is to analyze the association between therapeutic adherence and disease activity in SLE patients.MethodsAn observational, prospective study in SLE patients (SLICC/ACR criteria), treated whit subcutaneous Belimumab (200 mg/week) was made. Disease activity was measured by SLEDAI in three consecutive visits, and it was considered clinical worsening an increase of SLEDAI-score of ≥4 point. Persistence and adherence of Belimumab data during the follow-up were collected and were calculated based on the number of drug dispensing. Poor therapeutic adherence was established under the 95%.ResultsThirty-one prescriptions of Belimumab were registered (83.9% women) with a mean age of 48.1 (14.9) years. Time since the diagnosis was 12.5 (6.29) years and treatment period were 2.2 (1.4) years. Fifteen patients were considered as non-adherent (48.4%).Persistence and disease activity data in each group were showed in the table 1.Abstract P149 Table 1Poor adherence was secondary to clinical improvement (66.67%), recurrent infections (13.33%), surgery (6.67%), pregnancy (6.67%) and inability to drug collect due to COVID-19 pandemic (6.67%). Non-adherent group showed worse SLEDAI-score than adherent group in V0, despite of a similar SLEDAI-score at V2 in both groups was observed. There was an association between poor therapeutic adherence and high delta_SLEDAI (p=0.046).ConclusionsWe observed an association between poor therapeutic adherence and delta_SLEDAI. The high SLEDAI-score at the beginning of the study in non-adherent group would be due to clinical manifestations, despite of the similar serological activity in both groups.

ObjectiveWe aimed to analyze the association between inflammatory cytokine levels (IFN-a2, IFN-b, IFN-g, IL10 and BLyS) and disease activity for a 12 months of follow-up in SLE patients.MethodsA longitudinal, observational prospective study with evaluations at baseline and follow-up visits every 3 months in SLE patients (SLICC 2012 criteria) and 65 healthy controls was performed. In SLE patients complete laboratory test, clinical evaluation and SLEDAI score was carried out. We analyzed inflammatory cytokines serum levels by colorimetric methods in all cases.Results45 SLE patients (86.7% female) participated in the study, with a mean age at diagnosis of 32.8 (16.2) years and a mean time of disease evolution of 17.9 (11.4) years. The 28.9% of patients showed SLEDAI>6 at the basal visit. The 66.7% were under glucocorticoid treatment, 44.4% under immunosupressants (methotrexate, azatioprine, belimumab or mycophenolate) and 66.7% under antimalarials. SLEDAI and inflammatory cytokine levels during follow-up is shown in table 1.Abstract P9 Table 1 CONTROLS N=65 Mean (SD) SLE V0 N=45 Mean (SD) SLE V3 N=45 Mean (SD) SLE V6 N=45 Mean (SD) SLE V9 N=45 Mean (SD) SLE V12 N=45 Mean (SD) SLEDAI score --- 6.09 (5.38) 3.53 (3.41) 5.09 (4.06) 3.71 (2.87) 3.64 (2.61) IFN-alpha2 (pg/mL) 85.53 (104.72) 202.59 (608.11) 115.24 (219.33) 170.6 (634.44) 103.21 (194.39) 157.22 (523.12) IFN-beta (pg/mL) 38.49 (35.43) 74.61 (91.24) 72.65 (114.59) 76.2 (101.37) 77.23 (114.21) 74.55 (97.51) IFN-gamma (pg/mL) 150.95 (133.14) 257.18 (413.65) 293.62 (395.65) 334.26 (485.59) 289.19 (354.71) 370.53 (794.94) IL-10 (pg/mL) 5.66 (5.45) 14.35 (21.07) 15.48 (16.92) 11.79 (15.23) 11.02 (11.14) 11.86 (11.76) BLyS (pg/mL) 2576.86 (882.64) 3073.4 (2198.6) 6232.42 (4838.81) 4111.58 (3593.74) 4812.91 (3786.77) 5432.31 (4747.82) Statistical analysis showed significant association between SLEDAI score and IL-10 (P=0.014) and IFNa2 (0.009), as well as a tendency with IFN-beta (P=0.057), independently of the time of follow-up. Regarding to clinical activity biomarkers, we observed an association between high levels of antidsDNA and elevated IFN-beta (P=0.005) and IFN-gamma (P=0.038), and low levels of C3 and an increment in IL-10 (P=0.006).Patients under antimalarials treatment during follow-up exhibit low levels of IL-10 (P=0.012) and those under belimumab treatment showed high levels of BLyS (P<0.001). No influence of age at diagnosis, time of evolution, vitamin D levels, corticoids and tobacco use in cytokine levels was observed.SLE patients were categorized by normal or high level of the five cytokines, based on the cytokine level above 2 SD of the mean in healthy controls. Despite the fact that no specific cytokine profile associated with clinical activity was observed, those patients with high SLEDAI score had increased levels of IL10.ConclusionWe observed an association between IL-10, IFN-alpha2, IFN-beta and IFN-gamma levels with clinical activity, independently of the time of follow-up. IL-10 levels may be influenced by antimalarial treatment and BLyS levels by belimumab treatment.

ObjectiveSeveral drugs have been implicated in the development of de novo systemic lupus erythematosus (SLE), unmasking of quiescent SLE or causing an exacerbation of previously diagnosed SLE. Our aim is to describe the causative drugs, clinical and serological features of patients diagnosed of Drug-Induced lupus (DIL) in our Rheumatology Department.MethodsA total of 445 patients diagnosed with SLE treated in our Rheumatology Department from 2012 to 2023 were retrospectively screened for the fulfilment of DIL criteria through the search of medical electronic records. Demographic, clinical and laboratory data were summarised using descriptive statistics.ResultsWe identified 18 patients diagnosed with DIL, representing a prevalence of 4% among all SLE patients in our Department. There was a female preponderance and a young age at disease onset. Patients’ clinical and serological characteristics are shown in table 1. Only three drugs (infliximab, adalimumab and sulfasalazine) were identified as causative agents of DIL, anti-TNF being the most common. Most patients were treated for a condition different from a rheumatic disease, mainly inflammatory bowel disease (IBD). Median time to symptom onset after drug initiation ranged from 3 to 194 weeks (median 50.4). Peripheral arthritis and skin rash were the most frequent symptoms, with 4 patients (22%) presenting both at onset. Serologically, only 2 patients were ANA negative, but tested positive for anti-dsDNA. After drug withdrawal, ANA titre showed a slow decreasing trend over time, as well as anti-dsDNA antibodies. However, only 2 patients lost ANA-positivity through follow-up. Remarkably, more than half of the patients tested positive for antiphospholipid antibodies.ConclusionDIL showed a prevalence of 4% in our Rheumatology Department. Anti-TNF agents were the most common drugs causing DIL. ANA tend to decrease over time, but only become undetectable in a few patients. Antiphospholipid antibodies are common in our DIL patients. Age at onset is earlier than previously reported, probably because causative drugs are being used in younger populations.Abstract P28 Table 1Patients’ clinical and serological characteristics Age at onset (median years; IQR) 37.6 ± 19.6 Gender (n,%) Female 14 (78%) Male 4 (22%) Baseline diagnosis Inflammatory Bowel Disease 8 (44%) Inflammatory arthritis 4 (22%) Hidrosadenitis 3 (17%) Psoriasis 2 (11%) Nonspecific Orbital Inflammation 1 (6%) Drug Infliximab 12 (66%) Adalimumab 5 (28%) Sulfasalazine 1 (6%) Time to onset after drug initiation (median weeks, range) 50.4 (3 – 194) Symptoms at onset Peripheral arthritis 9 (50%) Skin rash 4 (22%) Peripheral arthritis AND skin rash 4 (22%) Inflammatory arthralgia 1 (6%) Autoantibodies profile ANA positivity 16 (89%) Median ANA titre 1/320 Low C3 and/or C4 5 (28%) Anti-Ro 1 (6%) Antihistone positivity 0 Anti-La 0 Anti-Sm 0 Antiphospholipid antibodies (AAF) 10 (55.5%) 1 AAF 5 (28%) 2 AAF 4 (22%) 3 AAF 1 (6%)

A través de los estudios que Michel Foucault desarrolla acerca del concepto de discurso como productor de verdad en nuestras sociedades, este artículo analiza La rosa muerta (1914), de Aurora Cáceres, como un texto que desarticula el discurso de la bella muerta del entre siglos hispanoamericano. Para ello se examinan los componentes que constituyen el discurso de la bella muerta, qué función tienen, qué efectos provocan, quién los produce, para qué se producen y qué feminidad deseada producen. En este sentido, la rebeldía de la protagonista, que se niega a ser enmarcada en el discurso de la bella muerta, se estudia en relación a la creación, por parte de la protagonista, de su auto inscripción en un imaginario modernista feminista femenino, donde la enfermedad es el detonante de la crisis existencial. Finalmente, se examina la paradoja que plantea el título de la novela que enfatiza el proyecto político de este texto de Cáceres, ya que pone de manifiesto la importancia de las políticas de nombrar, de inscribir y, con ello, denuncia desde el interior del texto, pero también con su título, esa política que nombra e inscribe las feminidades deseadas desde los discursos masculinos hegemónicos del entre siglos hispanoamericano.

Al conjugar parte de la extensa bibliografía sobre la producción literaria de Clorinda Matto de Turner con un marco ideológico feminista, este artículo examina el ideario de género que se construye con relación a la modernidad, a las políticas de género y a los imaginarios nacionales en dos de sus cuentos: \"Pálida!... pero es ella...! Novela homeopática con pretensiones espiritistas\" y \"Amor de redondel. Cuento a modo de novela\". Dicho ideario, superficialmente, presenta inestabilidades y contradicciones. Sin embargo, es a través de estas aparentes contradicciones que Matto de Turner pudo gestionar su ideario de reforma de políticas de género y de refundación nacional sin aparentemente alterar la norma hegemónica.Palabras clave: Clorinda Matto de Turner; Feminismo; Modernidad; Políticas de género; Nación.