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Effective conservation of large carnivores requires reliable estimates of population density, often obtained through capture–recapture analysis, in order to prioritize investments and assess conservation intervention effectiveness. Recent statistical advances and development of user-friendly software for spatially explicit capture–recapture (SECR) circumvent the difficulties in estimating effective survey area, and hence density, from capture–recapture data. We conducted a camera-trapping study on leopards (Panthera pardus) in Mondulkiri Protected Forest, Cambodia. We compared density estimates using SECR with those obtained from conventional approaches in which the effective survey area is estimated using a boundary strip width based on observed animal movements. Density estimates from Chao heterogeneity models (3.8 ± SE 1.9 individuals/100 km²) and Pledger heterogeneity models and models accounting for gender-specific capture and recapture rates (model-averaged density 3.9 = SE 2.9 individuals/100 km²) were similar to those from SECR in program DENSITY (3.6 ± SE 1.0/100 km²) but higher than estimates from Jack-knife heterogeneity models (2.9 ± SE 0.9 individuals/100 km²). Capture probabilities differed between male and female leopards probably resulting from differences in the use of human-made trails between sexes. Given that there are a number of biologically plausible reasons to expect gender-specific variation in capture probabilities of large carnivores, we recommend exploratory analysis of data using models in which gender can be included as a covariate affecting capture probabilities particularly given the demographic importance of breeding females for population recovery of threatened carnivores.

Introduction Routine drain placement is still widely used in both sleeve gastrectomy (SG) and Roux en Y gastric bypass (REYGB). There is mounting evidence that drains may increase complication risk without preventing reoperation or other complications. Methods Data from 2017 Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) Participant Use File was evaluated for drain use during laparoscopic REYGB and SG. Primary outcomes were superficial and deep surgical site infections (SSI), reintervention/reoperation, and readmission. Preoperative patient risk factors were also compared to evaluate for association with drain placement. Results A total of 148 260 patients fit the inclusion criteria. Drains were used in 23 190 (15.6%) cases and not used in 125 070 (84.4%). Drain placement during surgery was associated with increased odds of superficial SSI, deep incisional SSI, and organ space SSI. Patients with drains were found to have increased odds of requiring at least 1 reoperation or intervention within 30 days of surgery. Preoperative risk factors associated with drain placement included diabetes mellitus, a history of chronic obstructive pulmonary disease, and oxygen dependence. Smokers were slightly less likely to have a drain placed. There was no significant association with chronic steroid and immunosuppressant usage. Conclusion There is mounting data against drain placement during bariatric surgery. Prior studies using MBSAQIP data have shown an increased complication rate with drains, and our data set supports the idea that drains may increase complications after surgery. While no randomized prospective trials have been performed looking at drain usage in bariatric surgery, the growing retrospective data certainly inform against the regular use of drains.

You know how to code in Elixir; now learn to think in it. Learn to design libraries with intelligent layers that shape the right data structures, flow from one function into the next, and present the right APIs. Embrace the same OTP that's kept our telephone systems reliable and fast for over 30 years. Move beyond understanding the OTP functions to knowing what's happening under the hood, and why that matters. Using that knowledge, instinctively know how to design systems that deliver fast and resilient services to your users, all with an Elixir focus.Elixir is gaining mindshare as the programming language you can use to keep you software running forever, even in the face of unexpected errors and an ever growing need to use more processors. This power comes from an effective programming language, an excellent foundation for concurrency and its inheritance of a battle-tested framework called the OTP.If you're using frameworks like Phoenix or Nerves, you're already experiencing the features that make Elixir an excellent language for today's demands. This book shows you how to go beyond simple programming to designing, and that means building the right layers. Embrace those data structures that work best in functional programs and use them to build functions that perform and compose well, layer by layer, across processes. Test your code at the right place using the right techniques. Layer your code into pieces that are easy to understand and heal themselves when errors strike.Of all Elixir's boons, the most important one is that it guides us to design our programs in a way to most benefit from the architecture that they run on. The experts do it and now you can learn to design programs that do the same.What You Need:Elixir Version 1.7 or greater.

Background: Corticomotor adaptations are believed to contribute to persistent pain. However, prior reviews have lacked sufficient data to adequately explore these adaptations in lower limb pain. This restricts the generalizability of existing research given the distinct functional and neurophysiological differences between upper and lower limb musculature. This research gap has prompted increasing exploration of corticomotor adaptations in response to lower limb pain. Accordingly, this systematic review aimed to synthesize literature investigating corticomotor changes in response to experimental, acute clinical, and chronic lower limb pain. Methods: A comprehensive search of CINAHL, Ovid MEDLINE, PubMed, Scopus, and Web of Science was conducted. Transcranial magnetic stimulation (TMS) outcomes were separated into single‐site assessments of corticomotor excitability over the motor cortical hotspot, assessments of inhibitory/facilitatory mechanisms, and corticomotor organization (mapping) outcomes. Critical appraisals were performed using the Downs and Black checklist and the TMS methodological checklist. Meta‐analyses employed random effects models. Results: Analyses of 18 studies found no consistent effects of lower limb pain on motor evoked potentials. However, motor threshold data indicated that corticomotor responses may vary by region and diagnosis. Results from TMS mapping studies revealed consistent shifts in CoG for representations of painful lower limb muscles, as well as increased overlap of adjacent representations. Map volume findings differed between experimental and clinical pain, suggesting temporal variation in adaptations. Conclusion: This review highlights emerging evidence that corticomotor adaptations to lower limb pain are dynamic and region‐specific. These findings lay the groundwork for future research into pain‐related motor system plasticity. Motor threshold varied by region and diagnosis. We also observed consistent shifts in the corticomotor representations of painful lower limb muscles. Differences in map volume between experimental and clinical pain may suggest temporal variation in corticomotor responses. Corticomotor adaptations appear dynamic, region‐specific, and influenced by pain duration.

Insight into the mechanisms of organ engraftment and acquired tolerance has made it possible to facilitate these mechanisms, by tailoring the timing and dosage of immunosuppression in accordance with two therapeutic principles: recipient pretreatment, and minimum use of post-transplant immunosuppression. We aimed to apply these principles in recipients of renal and extrarenal organ transplants. 82 patients awaiting kidney, liver, pancreas, or intestinal transplantation were pretreated with about 5 mg/kg of a broadly reacting rabbit antithymocyte globulin during several hours. Post-transplant immunosuppression was restricted to tacrolimus unless additional drugs were needed to treat breakthrough rejection. After 4 months, patients on tacrolimus monotherapy were considered for dose-spacing to every other day or longer intervals. We frequently saw evidence of immune activation in graft biopsy samples, but unless this was associated with graft dysfunction or serious immune destruction, treatment usually was not intensified. Immunosuppression-related morbidity was virtually eliminated. 78 (95%) of 82 patients survived at 1 year and at 13–18 months. Graft survival was 73 (89%) of 82 at 1 year and 72 (88%) of 82 at 13–18 months. Of the 72 recipients with surviving grafts, 43 are on spaced doses of tacrolimus monotherapy: every other day (n=6), three times per week (11), twice per week (15), or once per week (11). The striking ability to wean immunosuppression in these recipients indicates variable induction of tolerance. The simple therapeutic principles are neither drug-specific nor organ-specific. Systematic application of these principles should allow improvements in quality of life and long-term survival after organ transplantation.

A glycosyltransferase, α1,3galactosyltransferase, catalyzes the terminal step in biosynthesis of Galα1,3Galβ1-4GlcNAc-R (αGal), an oligosaccharide cell surface epitope. This epitope or antigenically similar epitopes are widely distributed among the different forms of life. Although abundant in most mammals, αGal is not normally found in catarrhine primates (Old World monkeys and apes, including humans), all of which produce anti-αGal antibodies from infancy onward. Natural selection favoring enhanced resistance to αGal-positive pathogens has been the primary reason offered to account for the loss of αGal in catarrhines. Here, we question the primacy of this immune defense hypothesis with results that elucidate the evolutionary history of GGTA1 gene and pseudogene loci. One such locus, GGTA1P, a processed (intronless) pseudogene (PPG), is present in platyrrhines, i.e., New World monkeys, and catarrhines but not in prosimians. PPG arose in an early ancestor of anthropoids (catarrhines and platyrrhines), and GGTA1 itself became an unprocessed pseudogene in the late catarrhine stem lineage. Strong purifying selection, denoted by low nonsynonymous substitutions per nonsynonymous site/synonymous substitutions per synonymous site values, preserved GGTA1 in noncatarrhine mammals, indicating that the functional gene product is subjected to considerable physiological constraint. Thus, we propose that a pattern of alternative and/or more beneficial glycosyltransferase activity had to first evolve in the stem catarrhines before GGTA1 inactivation could occur. Enhanced defense against αGal-positive pathogens could then have accelerated the replacement of αGal-positive catarrhines by αGal-negative catarrhines. However, we emphasize that positively selected regulatory changes in sugar chain metabolism might well have contributed in a major way to catarrhine origins.

You know how to code in Elixir; now learn to think in it. Learn to design libraries with intelligent layers that shape the right data structures, flow from one function into the next, and present the right APIs. Embrace the same OTP that's kept our telephone systems reliable and fast for over 30 years. Move beyond understanding the OTP functions to knowing what's happening under the hood, and why that matters. Using that knowledge, instinctively know how to design systems that deliver fast and resilient services to your users, all with an Elixir focus.Elixir is gaining mindshare as the programming language you can use to keep you software running forever, even in the face of unexpected errors and an ever growing need to use more processors. This power comes from an effective programming language, an excellent foundation for concurrency and its inheritance of a battle-tested framework called the OTP.If you're using frameworks like Phoenix or Nerves, you're already experiencing the features that make Elixir an excellent language for today's demands. This book shows you how to go beyond simple programming to designing, and that means building the right layers. Embrace those data structures that work best in functional programs and use them to build functions that perform and compose well, layer by layer, across processes. Test your code at the right place using the right techniques. Layer your code into pieces that are easy to understand and heal themselves when errors strike.Of all Elixir's boons, the most important one is that it guides us to design our programs in a way to most benefit from the architecture that they run on. The experts do it and now you can learn to design programs that do the same.What You Need:Elixir Version 1.7 or greater.

PurposeTo explore the effect of tasting unpleasant salty or bitter solutions on lower limb corticomotor excitability and neuromuscular function.MethodsNine females and eleven males participated (age: 27 ± 7 years, BMI: 25.3 ± 4.0 kg m−2). Unpleasant salty (1 M) and bitter (2 mM quinine) solutions were compared to water, sweetened water, and no solution, which functioned as control conditions. In a non-blinded randomized cross-over order, each solution was mouth rinsed (10 s) and ingested before perceptual responses, instantaneous heart rate (a marker of autonomic nervous system activation), quadricep corticomotor excitability (motor-evoked potential amplitude) and neuromuscular function during a maximal voluntary contraction (maximum voluntary force, resting twitch force, voluntary activation, 0–50 ms impulse, 0–100 impulse, 100–200 ms impulse) were measured.ResultsHedonic value (water: 47 ± 8%, sweet: 23 ± 17%, salt: 71 ± 8%, bitter: 80 ± 10%), taste intensity, unpleasantness and increases in heart rate (no solution: 14 ± 5 bpm, water: 18 ± 5 bpm, sweet: 20 ± 5 bpm, salt: 24 ± 7 bpm, bitter: 23 ± 6 bpm) were significantly higher in the salty and bitter conditions compared to control conditions. Nausea was low in all conditions (< 15%) but was significantly higher in salty and bitter conditions compared to water (water: 3 ± 5%, sweet: 6 ± 13%, salt: 7 ± 9%, bitter: 14 ± 16%). There was no significant difference between conditions in neuromuscular function or corticomotor excitability variables.ConclusionAt rest, unpleasant tastes appear to have no influence on quadricep corticomotor excitability or neuromuscular function. These data question the mechanisms via which unpleasant tastes are proposed to influence exercise performance.

During the course of his short but extraordinary life, John Ledyard (1751-1789) came in contact with some of the most remarkable figures of his era: the British explorer Captain James Cook, American financier Robert Morris, Revolutionary naval commander John Paul Jones, Benjamin Franklin, Thomas Jefferson, and others. Ledyard lived and traveled in remarkable places as well, journeying from the New England backcountry to Tahiti, Hawaii, the American Northwest coast, Alaska, and the Russian Far East. In this engaging biography, the historian Edward Gray offers not only a full account of Ledyard's eventful life but also an illuminating view of the late eighteenth-century world in which he lived.Ledyard was both a product of empire and an agent in its creation, Gray shows, and through this adventurer's life it is possible to discern the many ways empire shaped the lives of nations, peoples, and individuals in the era of the American Revolution, the world's first modern revolt against empire.

A large teaching hospital instituted a major technological change in its intensive care unit (ICU) to deliver superior care to critically ill patients. This paper examines how the decision makers viewed the proposals that were considered in their ante-decision discussions and what they did to minimize their post-decision regrets-minimum regrets would indicate that the changes were successful. In those ante-decision discussions, quality measures were pinpointed by which post-decision analyses would judge success or failure for the changes that were implemented. In addition to statistical measures, the planners also used graphical analyses, including laddering, of the communication and decision networks within the ICU before and after the changes. The results of the quality measures were proof that the new operation of the ICU was a fabulous success. The minimization of regret made the innovation process run far more smoothly and successfully than anyone could have expected, which resulted in universal acceptance of the ICU innovations by all parties affected by the decisions made. This research has applicability to any hospital planning a change in its operations and seeks at the same time to insure its medical, professional, and administrative staffs' support for those changes.