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Volunteering in old age plays an important role in addressing feelings of loneliness, but little research has been conducted on the impact of engaging in volunteering activities during the COVID-19 pandemic. This study investigates the longitudinal impact of volunteering on feelings of loneliness. We analyzed data from 31,667 adults aged 50 years and older in the Survey of Health, Ageing and Retirement in Europe (SHARE), across three consecutive waves (one before the pandemic and two during the COVID-19 pandemic). Binary logistic regression analyses were conducted for loneliness, using volunteering and several control variables as independent variables, and found that even after controlling for previous loneliness, volunteering has a protective effect against experiencing feelings of loneliness. Those who participated in volunteering activities before or during the second pandemic period had a lower risk of loneliness during the second pandemic period. Volunteering during the second pandemic period, before and during the second pandemic period, and during all three periods measured in the study was negatively associated with the odds of feeling lonely. Encouraging volunteering among older adults can be a useful strategy to prevent loneliness during future emergency situations like the COVID-19 outbreak.

The HER2-enriched (HER2-E) subtype within HER2-positive (HER2+) breast cancer is highly addicted to the HER2 pathway. However, ∼20–60% of HER2+/HER2-E tumors do not achieve a complete response following anti-HER2 therapies. Here we evaluate gene expression data before, during and after neoadjuvant treatment with lapatinib and trastuzumab in HER2+/HER2-E tumors of the PAMELA trial and breast cancer cell lines. Our results reveal that dual HER2 blockade in HER2-E disease induces a low-proliferative Luminal A phenotype both in patient’s tumors and in vitro models. These biological changes are more evident in hormone receptor-positive (HR+) disease compared to HR-negative disease. Interestingly, increasing the luminal phenotype with anti-HER2 therapy increased sensitivity to CDK4/6 inhibition. Finally, discontinuation of HER2-targeted therapy in vitro, or acquired resistance to anti-HER2 therapy, leads to restoration of the original HER2-E phenotype. Our findings support the use of maintenance anti-HER2 therapy and the therapeutic exploitation of subtype switching with CDK4/6 inhibition. HER2-enriched breast cancers within the HER2-positive subtype are addicted to the HER2 pathway. Here, the authors analyse gene expression before, during, and after treatment with anti-HER2-based therapies in the phase II PAMELA clinical trial, finding phenotypic changes induced by treatment.

Some scales co-exist in the literature to measure prosocial behavior in adolescents. Gender differences in prosocial behavior have been a controversial topic of research. To strengthen future research in the area, the psychometric properties of the most used instruments must be guaranteed, especially its gender non-bias. Our study provides psychometric evidence for the Prosocial Behavior Scale in a sample of adolescents, exploring: (a) its factor structure; (b) reliability; (c) gender-related differential item functioning (DIF); (d) nomological validity. A sample of 512 high school students (mean age = 13.62 (SD = 1.34), 51.6% females) participated in the research. Confirmatory Factor Analysis (CFA) was used to test the factor structure of the scale, which adequately fitted the data (χ2 (35) = 152.224, p < 0.001, Comparative Fit Index (CFI) = 0.905, Root Mean Squared Error of Approximation (RMSEA) = 0.085 90%CI [0.072–0.099], Standardized Root Mean Squared Residual (SRMR) = 0.079). Reliability results were good (α = 0.74, ω = 0.74). Regarding the DIF, five items presented some gender-related bias, generally benefiting females. However, the DIF impact could be considered negligible. Correlations with the subdimensions of the psychological capital offered evidence of the nomological validity of the scale. In conclusion, the scale presented adequate psychometric properties that support its ability to effectively assess prosocial behavior and gender differences in the prosocial behavior samples of adolescents. Additionally, the results obtained imply that gender differences in the manifestations of prosocial behavior require measurements that can fairly sample behaviors characteristic of each gender.

The influence of academic support on students’ academic and personal development has been previously demonstrated. The objective of this study was to present a validation of the Perceived Academic Support Questionnaire (PASQ). This scale has three dimensions: academic support from (1) teachers, (2) family, and (3) peers. For the reliability analysis, we estimated the Cronbach alpha and Composite Reliability Indices (CRIs). Factorial validity was assessed by confirmatory factor analysis (CFA) and external validity was tested via a structural equation model in which the dimensions of academic support predicted academic motivation. The CFA fit indices showed very good fit to the data, supporting the theoretically proposed three-factor structure. The reliability indices, considering Cronbach alpha and CRI, were adequate for all dimensions and the predictive model fit was satisfactory. Teacher and parental academic support had a positive impact on academic motivation. On the contrary, a negative relationship between peer support and academic motivation was found. The evidence provided supports for the use of the PASQ as a brief academic support scale in future research.HighlightsThe development of rigorous instruments for measuring academic support is needed.The Perceived Academic Support Questionnaire (PASQ) has shown adequate psychometric properties in a sample from the Dominican Republic.Significant positive correlations have been found among parental and teacher’s academic support and academic motivation.Significant negative relation was found among peers’ support and academic motivation.

Background: : Suicide behavior represents a major public health problem for the older population. Within the continuum of suicidal behavior, suicidal ideation may lead to a suicide attempts/death. Risk factors for developing suicidal ideation include mobility limitations, lack of social participation and loneliness. However, there is a need for longitudinal studies to examine these relationships over time. Method: : 50423 older people from three waves of the SHARE project formed the sample (60 years in the first wave; ± = 71.49 ± 8.15; 55% female). Results:: A series of nested Cross-Lagged Panel Models (CLPM) of suicidal ideation, mobility limitations, social participation and loneliness were tested. The best fitting model was that with equal autoregressive and cross-lagged effects across waves (( = 1220.56, CFI = .982, RMSEA = .028, SRMR = .024). The autoregressive effects showed high stability across waves. The cross-lagged effects between suicidal ideation and mobility limitations were strong, while the cross-lagged effects between suicidal ideation and social participation were comparatively smaller. In the case of loneliness, statistical significance was not achieved. Conclusions:: These findings highlight the importance of promoting mobility programs and social activities to prevent suicidal ideation among older adults.

Youth gangs pose a global challenge, often linked to violence, demanding urgent interventions. This study, using the Delphi method with 27 experts, aims to create a checklist of good practices for public policies on legalizing and pacifying street youth groups (SYG). Results provide a consensus across seven areas, offering essential guidelines to design and evaluate policies. These focus on preventing violence, reducing illicit activities, and promoting social inclusion, fostering a culture of peace through effective, impactful measures.

Introduction: This work represents the first attempt to obtain evidence of the validity of an entrepreneurial intention questionnaire in the adolescent population of a Latin American or Caribbean country. The objectives are to study the factor structure, the reliability, the external validity and to test the gender invariance of the Entrepreneurial Intention Questionnaire, in its adaptation for adolescents. Method: The sample consisted of 708 adolescents from the Dominican Republic with a mean age of 15.49, 65.2% of whom were women and 35.8% were men. Analyses included confirmatory factor analysis, Cronbach’s Alpha and Omega scores for reliability, correlations, and a gender invariance routine. Finally, latent means of females and males are compared. Results: The confirmatory factor analysis showed a good fit to the data and the reliability results were adequate. In addition, the correlations with the Entrepreneurial Attitudes Scale for Students were positive and statistically significant. Also, strict gender invariance was successfully verified. Although males presented a higher subjective norm, females showed higher entrepreneurial intentions. Conclusions: The Entrepreneurial Intention Questionnaire shows adequate psychometric properties and proves useful in conducting research on the promotion of entrepreneurship in early stages.

In order to understand the adequate development of students, direct measures such as their grades, but also indirect measures such as their satisfaction with school, must be taken into account. It is also important to determine which variables promote it and how. This study aims to explore if the mediating effect of school engagement between academic support (from teachers, parents, and peers) and school outcomes (satisfaction with school, and grades) is gender invariant. The sample was 1712 students with a mean age of 14.73 (52.7% female). The model was tested using Structural Equation Modeling and an invariance routine was carried out to test gender moderation. The model satisfactorily fitted the data, with the school engagement mediating the effect of parents, teachers, and peer support on satisfaction with school and grades. Teacher support was the dimension of academic support with the highest impact. The model explained 46% of the variance of satisfaction and 7.8% of grades. The invariance routine revealed no moderation effects due to gender. The proposed model is invariant across boys and girls, being the academic support equally relevant for both correct involvement and performance in school. Implications are discussed.

In addition to neuronal migration, brain development, and adult plasticity, the extracellular matrix protein Reelin has been extensively implicated in human psychiatric disorders such as schizophrenia, bipolar disorder, and autism spectrum disorder. Moreover, heterozygous reeler mice exhibit features reminiscent of these disorders, while overexpression of Reelin protects against its manifestation. However, how Reelin influences the structure and circuits of the striatal complex, a key region for the above-mentioned disorders, is far from being understood, especially when altered Reelin expression levels are found at adult stages. In the present study, we took advantage of complementary conditional gain- and loss-of-function mouse models to investigate how Reelin levels may modify adult brain striatal structure and neuronal composition. Using immunohistochemical techniques, we determined that Reelin does not seem to influence the striatal patch and matrix organization (studied by μ-opioid receptor immunohistochemistry) nor the density of medium spiny neurons (MSNs, studied with DARPP-32). We show that overexpression of Reelin leads to increased numbers of striatal parvalbumin- and cholinergic-interneurons, and to a slight increase in tyrosine hydroxylase-positive projections. We conclude that increased Reelin levels might modulate the numbers of striatal interneurons and the density of the nigrostriatal dopaminergic projections, suggesting that these changes may be involved in the protection of Reelin against neuropsychiatric disorders.

Vegans and vegetarians often consume foods containing photosensitizers capable of triggering phytophotodermatitis. The potential effect of vegan and vegetarian diets on the response of psoriatic patients undergoing phototherapy is not well characterized. We assessed clinical outcomes of vegan, vegetarian and omnivore adult psoriatic patients undergoing band ultraviolet B phototherapy (NB-UVB). In this multicenter prospective observational study, we enrolled 119 adult, psoriatic patients, of whom 40 were omnivores, 41 were vegetarians and 38 were vegans, with phototherapy indication. After determining the minimum erythemal dose (MED), we performed NB-UVB sessions for 8 weeks. The first irradiation dosage was 70.00% of the MED, then increased by 20.00% (no erythema) or by 10.00% (presence of erythema) until a maximum single dose of 3 J/cm2 was reached and constantly maintained. All the enrolled patients completed the 8 weeks of therapy. Severe erythema was present in 16 (42.11%) vegans, 7 (17.07%) vegetarians and 4 (10.00%) omnivores (p < 0.01). MED was lowest among vegans (21.18 ± 4.85 J/m2), followed by vegetarians (28.90 ± 6.66 J/m2) and omnivores (33.63 ± 4.53 J/m2, p < 0.01). Patients with severe erythema were more likely to have a high furocumarin intake (OR 5.67, 95% CI 3.74–8.61, p < 0.01). Vegans consumed the highest amount of furocumarin-rich foods. A model examining erythema, adjusted for gender, age, skin type, MED, phototherapy type, number of phototherapies and furocumarin intake, confirmed that vegans had a lower number of treatments. Vegans had more frequent severe erythema from NB-UVB, even after adjustment of the phototherapy protocol for their lower MED. Assessing diet information and adapting the protocol for vegan patients may be prudent.