Explore the vast range of titles available.

In 1972, when James Lovelock first proposed the Gaia hypothesis--the idea that the Earth is a living organism that maintains conditions suitable for life--he was ridiculed by the scientific establishment. Today Lovelock's revolutionary insight, though still extremely controversial, is recognized as one of the most creative, provocative, and captivating scientific ideas of our time. James Lovelock tells for the first time the whole story of this maverick scientist's life and how it served as a unique preparation for the idea of Gaia. Drawing on in-depth interviews with Lovelock himself and unprecedented access to his private papers, John and Mary Gribbin paint an intimate and fascinating portrait of a restless, uniquely gifted freethinker. In a lifetime spanning almost a century, Lovelock has followed a career path that led him from chemistry, to medicine, to engineering, to space science. He worked for the British secret service and contributed to the success of the D-Day landings in World War II. He was a medical experimenter and an accomplished inventor. And he was working with NASA on methods for finding possible life on Mars when he struck upon the idea of Gaia, conceiving of the Earth as a vast, living, self-regulating system. Deftly framed within the context of today's mounting global-warming crisis, James Lovelock traces the intertwining trajectories of Lovelock's life and the famous idea it brought forth, which continues to provoke passionate debate about the nature and future of life on our planet.

Who are the most important men and women whose notions and theories have changed the world? When Isaac Newton claimed that he only saw further because he stood on the shoulders of giants, he alluded to the long list of geniuses that came before him. The history of science is the story of great discoveries, flashes of intuition that have changed the way people see the world, hard work and arduous calculation in the laboratory. The Britannica Guide to 100 Most Influential Scientistsis a celebration of the lives and work of the men and women who have changed the way we look at the world, the universe, and ourselves. Includes contributions from top name scientists and writers such James Gleick on Richard Feynman; Michio Kaky on Einstein and Sir Harold Kroton on the Fulleriene (for which he won an Nobel Prize). TheBritannica Guide to 100 Most Influential Scientistsis introduced by John Gribbin. He is the author of nearly 100 popular science books, including the best-sellingIN SEARCH OF SCHRODINGER'S CAT. He has received awards for his writing both in the United States and in Britain. The holder of a PhD in astrophysics from the University of Cambridge, he still maintains links with research as a Visiting Fellow in Astronomy at the University of Sussex, and was a member of a team there that measured the age of the Universe. While still a student, he received the prestigious Annual Award of the Gravity Research Foundation in the United States, the only student, and the first Englishman working in England, ever to receive this award.

In this ... new book, Gribbin argues that the very existence of intelligent life anywhere in the cosmos is, from an astrophysicist's point of view, a miracle. So why is there life on Earth and (seemingly) nowhere else? What happened to make this planet special? Taking us back some 600 million years, Gribbin lets you experience the series of unique cosmic events that were responsible for our unique form of life within the Milky Way Galaxy.\"--Provided by the publisher.ular science

THE explanation by G A Barber for the anthropic coincidences that make the universe propitious for life (Letters, April 27) will just not do.

Placenta accreta/percreta is a leading cause of third trimester hemorrhage and postpartum maternal death. The current treatment for third trimester hemorrhage due to placenta accreta/percreta is cesarean hysterectomy, which may be complicated by large volume blood loss. To determine what role, if any, prophylactic temporary balloon occlusion and transcatheter embolization of the anterior division of the internal iliac arteries plays in the management of patients with placenta accreta/percreta. The records of 28 consecutive patients with a diagnosis of placenta accreta/percreta were retrospectively reviewed. Patients were divided into two groups. Six patients underwent prophylactic temporary balloon occlusion, followed by cesarean section, transcatheter embolization of the anterior division of the internal iliac arteries and cesarean hysterectomy (n = 5) or uterine curettage (n = 1). Twenty-two patients underwent cesarean hysterectomy without endovascular intervention. The following parameters were compared in the two groups: patient age, gravidity, parity, gestational age at delivery, days in the intensive care unit after delivery, total hospital days, volume of transfused blood products, volume of fluid replacement intraoperatively, operating room time, estimated blood loss, and postoperative morbidity and mortality. Patients in the embolization group had more frequent episodes of third trimester bleeding requiring admission and bedrest prior to delivery (16.7 days vs. 2.9 days), resulting in significantly more hospitalization time in the embolization group (23 days vs. 8.8 days) and delivery at an earlier gestational age than in those in the surgical group (32.5 weeks). There was no statistical difference in mean estimated blood loss, volume of replaced blood products, fluid replacement needs, operating room time or postoperative recovery time. Our findings do not support the contention that in patients with placenta accreta/percreta, prophylactic temporary balloon occlusion and embolization prior to hysterectomy diminishes intraoperative blood loss.

Background Molecular analyses such as whole-genome sequencing have become routine and are expected to be transformational for future healthcare and lifestyle decisions. Population-wide implementation of such analyses is, however, not without challenges, and multiple studies are ongoing to identify what these are and explore how they can be addressed. Methods Defined as a research project, the Personal Genome Project UK (PGP-UK) is part of the global PGP network and focuses on open data sharing and citizen science to advance and accelerate personalized genomics and medicine. Results Here we report our findings on using an open consent recruitment protocol, active participant involvement, open access release of personal genome, methylome and transcriptome data and associated analyses, including 47 new variants predicted to affect gene function and innovative reports based on the analysis of genetic and epigenetic variants. For this pilot study, we recruited 10 participants willing to actively engage as citizen scientists with the project. In addition, we introduce Genome Donation as a novel mechanism for openly sharing previously restricted data and discuss the first three donations received. Lastly, we present GenoME, a free, open-source educational app suitable for the lay public to allow exploration of personal genomes. Conclusions Our findings demonstrate that citizen science-based approaches like PGP-UK have an important role to play in the public awareness, acceptance and implementation of genomics and personalized medicine.

To perform a retrospective outcomes analysis of central venous catheters with peripheral venous access ports, with comparison to published data. One hundred and twelve central venous catheters with peripherally placed access ports were placed under sonographic guidance in 109 patients over a 4-year period. Ports were placed for the administration of chemotherapy, hyperalimentation, long-term antibiotic therapy, gamma-globulin therapy, and frequent blood sampling. A vein in the upper arm was accessed in each case and the catheter was passed to the superior vena cava or right atrium. Povidone iodine skin preparation was used in the first 65 port insertions. A combination of Iodophor solution and povidone iodine solution was used in the last 47 port insertions. Forty patients received low-dose (1 mg) warfarin sodium beginning the day after port insertion. Three patients received higher doses of warfarin sodium for preexistent venous thrombosis. Catheter performance and complications were assessed and compared with published data. Access into the basilic or brachial veins was obtained in all cases. Ports remained functional for a total of 28,936 patient days. The port functioned in 50% of patients until completion of therapy, or the patient's expiration. Ports were removed prior to completion of therapy in 18% of patients. Eleven patients (9.9% of ports placed) suffered an infectious complication (0.38 per thousand catheter-days)-in nine, at the port implantation site, in two along the catheter. In all 11 instances the port was removed. Port pocket infection in the early postoperative period occurred in three patients (4.7%) receiving a Betadine prep vs two patients (4.2%) receiving a standard O.R. prep. This difference was not statistically significant (p = 0.9). Venous thrombosis occurred in three patients (6.8%) receiving warfarin sodium and in two patients (3%) not receiving warfarin sodium. This difference was not statistically significant (p = 0.6). Aspiration occlusion occurred in 13 patients (11.7%). Intracatheter urokinase was infused in eight of these patients and successfully restored catheter function in all but two instances. These complication rates are comparable to or better than those reported with chest ports. Peripheral ports for long-term central venous access placed by interventional radiologists in the interventional radiology suite are as safe and as effective as chest ports.

The mortality experience between 1956 and 1985 of 8977 males employed by Atomic Energy of Canada Limited is reported. A total of 4260 men, 47% of the cohort, were exposed to low doses of external ionizing radiation at low dose rates, with a mean cumulative equivalent dose of 52.1 mSv. For cancers as a whole the excess relative risk, based on 227 deaths, was 0.36% per 10 mSv (90% confidence bounds -0.46, 2.45). This is quite comparable to the corresponding estimate based on the atomic bomb survivors study. There was a positive association between radiation dose and death from leukemia (excluding chronic lymphatic leukemia) P = 0.058. However, this was based on only four deaths and hence cannot sensibly be compared to estimates based on high-dose studies. The present results suggest that, for cancer as a whole, risk estimates based on high-dose studies are unlikely to underestimate risks substantially for low-dose and low-dose-rate exposures.

To evaluate the feasibility and complications of placement of a low-profile venous access port in the chest in children requiring long-term venous access. A low-profile peripheral arm port (PAS port; Sims Deltec, St. Paul, MN, USA) was implanted in the chest in 22 children over a 4-year period. The mean age of the study group was 6 years (range: 9 months to 20 years). Ports were placed for the administration of chemotherapy, hyperalimentation and frequent blood sampling. Sonographic guidance was used to access the internal jugular or subclavian vein in each case. A review of all inpatient and outpatient charts was undertaken to assess catheter performance and complications. Access to the central venous circulation was successfully achieved in each case without complication. Ports remained implanted for 6579 catheter-days (mean: 299 days). Ten ports have been removed. Of three patients (13%) experiencing device-related infections (0.45 infections/1000 catheter days), two (9.1%) were unresponsive to antibiotics and removed (0.3 infections/1000 catheter days). One port was removed because of pain in the shoulder adjacent to the port implantation site. One port was removed because of difficult access. The final port was removed in order to place a dual-lumen catheter prior to bone marrow transplant. Twelve ports remain implanted. Aspiration occlusion occurred in four patients (18%). Deep venous thrombosis did not occur in any patient. Low-profile chest ports placed by interventional radiologists in the interventional radiology suite can be placed in children as safely as traditional chest ports placed in the operating room. The incidence of infection, venous thrombosis and aspiration occlusion is comparable to that of ports placed operatively.