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We employ several X-ray based techniques, including X-ray diffraction, absorption and resonant inelastic scattering, to disentangle the contributions of individual chemical species to the structural, electronic and magnetic properties of high-entropy oxides. In the benchmark compound Mg0.2Co0.2Ni0.2Cu0.2Zn0.2O and related systems, we unambiguously resolve a sizable Jahn-Teller distortion at the Cu sites, more pronounced in the absence of Ni2+ and Mg2+, suggesting that these ions promote positional order, whereas Cu2+ ions act to destabilize it. Moreover, we detect magnetic excitations and estimate the strength of the interactions between pairs of different magnetic elements. Our results provide valuable insights into the role of the various chemical species in shaping the physical properties of high-entropy oxides.

We report on the optical properties from terahertz (THz) to Near-Infrared (NIR) of the layered magnetic compound CrI 3 at various temperatures, both in the paramagnetic and ferromagnetic phase. In the NIR spectral range, we observe an insulating electronic gap around 1.1 eV which strongly hardens with decreasing temperature. The blue shift observed represents a record in insulating materials and it is a fingerprint of a strong electron-phonon interaction. Moreover, a further gap hardening is observed below the Curie temperature, indicating the establishment of an effective interaction between electrons and magnetic degrees of freedom in the ferromagnetic phase. Similar interactions are confirmed by the disappearance of some phonon modes in the same phase, as expected from a spin-lattice interaction theory. Therefore, the optical properties of CrI 3 reveal a complex interaction among electronic, phononic and magnetic degrees of freedom, opening many possibilities for its use in 2-Dimensional heterostructures.

Fingolimod, the first oral, disease-modifying therapy for MS, has been recently proposed to modulate glutamate transmission in the central nervous system (CNS) of mice suffering from Experimental Autoimmune Encephalomyelitis (EAE) and in MS patients. Our study aims at investigating whether oral fingolimod recovers presynaptic defects that occur at different stages of disease in the CNS of EAE mice. In vivo prophylactic (0.3 mg/kg for 14 days, from the 7th day post immunization, d.p.i, the drug dissolved in the drinking water) fingolimod significantly reduced the clinical symptoms and the anxiety-related behaviour in EAE mice. Spinal cord inflammation, demyelination and glial cell activation are markers of EAE progression. These signs were ameliorated following oral fingolimod administration. Glutamate exocytosis was shown to be impaired in cortical and spinal cord terminals isolated from EAE mice at 21 ± 1 d.p.i., while GABA alteration emerged only at the spinal cord level. Prophylactic fingolimod recovered these presynaptic defects, restoring altered glutamate and GABA release efficiency. The beneficial effect occurred in a dose-dependent, region-specific manner, since lower (0.1-0.03 mg/kg) doses restored, although to a different extent, synaptic defects in cortical but not spinal cord terminals. A delayed reduction of glutamate, but not of GABA, exocytosis was observed in hippocampal terminals of EAE mice at 35 d.p.i. Therapeutic (0.3 mg/kg, from 21 d.p.i. for 14 days) fingolimod restored glutamate exocytosis in the cortex and in the hippocampus of EAE mice at 35 ± 1 d.p.i. but not in the spinal cord, where also GABAergic defects remained unmodified. These results improve our knowledge of the molecular events accounting for the beneficial effects elicited by fingolimod in demyelinating disorders.

Academic, government, and private organizations from around the globe have established High Frequency radar (hereinafter, HFR) networks at regional or national levels. Partnerships have been established to coordinate and collaborate on a single global HFR network (http://global-hfradar.org/ ). These partnerships were established in 2012 as part of the Group on Earth Observations (GEO) to promote HFR technology and increase data sharing among operators and users. The main product of HFR networks are continuous maps of ocean surface currents within 200 km of the coast at high spatial (1-6 km) and temporal resolution (hourly or higher). Cutting-edge remote sensing technologies are becoming a standard component for ocean observing systems, contributing to the paradigm shift towards ocean monitoring. In 2017 the Global HFR Network was recognized by the Joint Technical WMO-IOC Commission for Oceanography and Marine Meteorology (JCOMM) as an observing network of the Global Ocean Observing System (GOOS). In this paper we will discuss the development of the network as well as establishing goals for the future. The U.S. High Frequency Radar Network (HFRNet) has been in operation for over thirteen years, with radar data being ingested from 31 organizations including measurements from Canada and Mexico. HFRNet currently holds a collection from over 150 radar installations totaling millions of records of surface ocean velocity measurements. During the past 10 years in Europe, HFR networks have been showing steady growth with over 60 stations currently deployed and many in the planning stage. In Asia and Oceania countries, more than 110 radar stations are in operation. HFR technology can be found in a wide range of applications: for marine safety, oil spill response, tsunami warning, pollution assessment, coastal zone management, tracking environmental change, numerical model simulation of 3-dimensional circulation, and research to generate new understanding of coastal ocean dynamics, depending mainly on each country’s coastal sea characteristics. These radar networks are examples of national inter-agency and inter-institutional partnerships for improving oceanographic research and operations. As global partnerships grow, these collaborations and improved data sharing enhances our ability to respond to regional, national, and global environmental and management issues.

Background Few studies have examined the association between gender-differentiated patient–physician interactions and antimicrobial prescription (AP) patterns. We analyzed gender-specific differences in AP in relation to the sex and age of general practitioners (GPs), drawing on data from a comprehensive regional database in Tuscany, Italy. Methods We extracted data on primary care APs for 2023 using a population sample of 3,022,332 patients and 2,311 GPs. We used defined daily doses per 1,000 population per day (DDD/1000 population/day), the percentage of subjects with at least one antimicrobial prescription (AP prevalence), and the percentage of Access AP according to Access, Watch and Reserve (AwaRE) classification as indicators. We fitted regression models for each indicator with patient-physician gender dyads and other covariates. Adjusted indicators and average marginal effects (AMEs) of having a female GP separately for the female and male patients are reported together with the difference between the above AMEs. Results A total of 1,583,893 female patients (52.4%) and 1,104 female GPs (54.1%) were included. Same-sex care was observed for 774,411 female patients (48.9%) and 815,887 male patients (56.7%). Female GPs prescribed fewer antibiotics—in terms of both DDD/1000 population/day and prevalence of AP—and were more likely to prescribe Access antibiotics. These differences were more pronounced among male patients. Among male patients, having a female GP was associated with an adjusted AME of -0.78 DDD/1000 population/day (95% CI -1.09 to -0.47), -0.21% in AP prevalence (95% CI -1.74 to -0.69), and + 0.73% in proportion of Access AP (95% CI -0.10 to 1.56). Among female patients with a female GP, the adjusted AME was − 0.51 DDD/1000 population/day (95% CI -0.86 to -0.15), -0.59% in AP prevalence (95% CI -1.18 to -0.004), and + 0.24% in proportion of Access AP (95% CI -0.52 to 0.99). When the patient-GP gender dyad and GP age were included, male GPs under 40 years of age showed consistently lower antibiotic prescription—both in DDD/1000 population/day and AP prevalence—and a higher proportion of Access AP compared with female GPs, particularly among female patients. In this subgroup, the adjusted AME of having a female GP was + 0.87 DDD/1000 population/day (95% CI 0.06 to 1.69), + 1.86% in AP prevalence (95% CI 0.52 to 3.2), and − 1.44% in Access AP (95% CI -3.01 to 0.13). Conclusions In our analysis of a large administrative dataset, we observed that the gender-differentiated interaction between physician and patient was associated with antimicrobial prescription. Overall, female GPs showed lower AP rates. However, among physicians under 40 years of age, male GPs had lower prescription indicators than their female counterparts, especially for male patients. The differences highlighted in our study could be the target of stewardship interventions.

[This corrects the article DOI: 10.1371/journal.pone.0170825.].[This corrects the article DOI: 10.1371/journal.pone.0170825.].

•Cardiac magnetic resonance (CMR) should be repeated every 2 years in patients with hypertrophic cardiomyopathy because the extent of late gadolinium enhancement (LGE) may increase rapidly in a relevant percentage of patients.•In hypertrophic cardiomyopathy, LGE extent ≥15% of the left ventricular mass is considered a marker of risk of sudden cardiac death; however, some patients with a lower extent of LGE at baseline CMR may present a ≥15% extent at the follow-up examination.•The finding of an LGE extent ≥15% of the left ventricular mass at the follow-up CMR allows a significant reclassification of the risk of major arrhythmic events compared with the same finding at baseline CMR.•The high rate of progression of LGE, defined as the increase of LGE extent >0.07 g/month between 2 consecutive CMR examinations, is the best independent predictor of major arrhythmic events. In hypertrophic cardiomyopathy (HCM), late gadolinium enhancement (LGE) extent ≥15% of left ventricular mass is considered a prognostic risk factor. LGE extent increases over time and the clinical role of the progression of LGE over time (LGE rate) was not prospectively evaluated. We sought to evaluate the prognostic role of the LGE rate in HCM. We enrolled 105 patients with HCM who underwent cardiac magnetic resonance (CMR) at baseline (CMR-I) and after ≥2 years of follow-up (CMR-II). LGE rate was defined as the ratio between the increase of LGE extent (grams) and the time interval (months) between examinations. A combined end point of sudden cardiac death, resuscitated cardiac arrest, appropriate Implanted Cardioverter Defibrillator (ICD) intervention, and sustained ventricular tachycardia was used (hard events). The percentage of patients with LGE extent ≥15% increased from 9% to 20% from CMR-I to CMR-II (p = 0.03). During a median follow-up of 52 months, 25 hard events were recorded. The presence of LGE ≥15% at CMR-II allowed a significant reclassification of the risk of patients than at LGE ≥15% at CMR-I (net reclassification improvement 0.21, p = 0.046). On the MaxStat analysis, the optimal prognostic cut point for LGE rate was >0.07 g/month. On the Kaplan–Meier curve, patients with LGE rate >0.07 had worse prognosis than those without (p <0.0001). LGE rate >0.07 allowed a significant reclassification of the risk compared with LGE ≥15% at CMR-I and at CMR-II (net reclassification improvement 0.49, p = 0.003). In the multivariable models, LGE rate >0.07 was the best independent predictor of hard events. In conclusion, CMR should be repeated after 2 years to reclassify the risk for sudden death of those patients. A high LGE rate may be considered a novel prognostic factor in HCM.

Although camelina [Camelina sativa (L.) Crantz] is a good source of protein, antioxidants, and polyunsaturated fatty acids, its antinutritional compounds limit its use in animal feeding. The aim of this study was to verify the effect of feeding laying hens with up to 20% of camelina cake from a breeding line containing a low level of glucosinolates on performance, welfare, and eggshell quality. Two hundred and forty Hy-Line® hens from 18 to 51 weeks of age were divided into three treatments: control (C), camelina cake 10% (CAM10), and camelina cake 20% (CAM20). Egg number was recorded daily, while egg weight, feed consumption, and mortality were recorded weekly. At 24 and 43 weeks of hen age, shell resistance to fracture was measured. Our results demonstrate no detrimental effects for CAM10 and CAM20 diets on feed intake, growth performance, and welfare. No difference in egg production was detected among the diets. The significant (p < 0.05) interaction of diet and age factors suggest that the addition of camelina cake, up to 20%, likely protects the eggshell of older hens. Our findings confirm that camelina cake might be an alternative and sustainable protein source for hens.

The paper presents an integrated methodology to assess psychological and physiological responses of people when exposed to forests, with the main objective of assessing the suitability of different stands for stress recovery on the basis of tree species and density. From the methodological viewpoint, the study applies both a Restoration Outcome Scale (ROS) questionnaire and a neuroscientific technique grounded on electro-encephalographic (EEG) measurement. Results show different outcomes for conifers and broadleaves as well as a statistical significance of density in the evaluation of an individual’s emotional state. A forest with a high density of conifers and low density of broadleaves seems to be the proper combination for stress recovery. The differences among psychological stated preferences and EEG trends highlights potential conflict among “needs” and “wants” of people in the topic of stress relief. Potential applications of the research for health care and territorial marketing operations are suggested.

Objectives The prognostic role of left ventricular (LV) papillary muscle abnormalities in patients with preserved LV systolic ejection fraction (LVEF) is unknown. We sought to evaluate the prognosis role of LV papillary muscle abnormalities by CMR in patients with ventricular arrhythmias, preserved LVEF with no cardiac disease. Methods A total of 391 patients with > 500/24 h premature ventricular complexes and/or with non-sustained ventricular tachycardia (NSVT), preserved LVEF, and no cardiac disease were enrolled. Different features of LV papillary muscles were considered: supernumerary muscles, papillary thickness, the attachment, late gadolinium enhancement (LGE). Dark-Paps was defined as end-systolic signal hypointensity of both papillary muscles in early post-contrast cine CMR images. Mitral valve prolapse, mitral annular disjunction (MAD), and myocardial LGE were considered. Results Dark-Paps was found in 79 (20%) patients and was more frequent in females. It was associated with higher prevalence of mitral valve prolapse and MAD. During a median follow-up of 2534 days, 22 hard cardiac events occurred. At Kaplan-Meier curve analysis, patients with Dark-Paps were at higher risk of events than those without ( p  < 0.0001). Dark-Paps was significantly associated with hard cardiac events in all the multivariate models. Dark-Paps improved prognostic estimation when added to NSVT ( p  = 0.0006), to LGE ( p  = 0.005) and to a model including NSVT+LGE ( p  = 0.014). Dark-Paps allowed a significant net reclassification when added to NSVT (NRI 0.30, p = 0.03), to LGE (NRI 0.25, p = 0.04), and to NSVT + LGE (NRI 0.32, p   = 0.02). Conclusions In LV papillary muscles, Dark-Paps is a novel prognostic marker in patients with ventricular arrhythmias and preserved ejection fraction. Key Points • Papillary muscle abnormalities are seen in patients with ventricular arrhythmias and preserved left ventricular ejection fraction. • Early post-contrast hypointensity of papillary muscles in end-systolic cine images (Dark-Paps) is a novel prognostic marker in patients with ventricular arrhythmias and preserved ejection fraction. • Dark-Paps had an additive prognostic role over late gadolinium enhancement and non-sustained ventricular tachycardia.