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IntroductionBorderline personality disorder (BPD), also known as emotionally unstable personality disorder is a severe disorder of emotional regulation. In people with BPD, mood swings are extreme, relationships are uncertain, and emotions are difficult to control, suicide and self-destructive behaviors are extremely common. medical treatment can certainly reduce the symptoms and suffering of people with BPD, but it is still not enough. The treatment is mainly based on psychotherapy especially Dialectical behavior therapy (DBT) focuses on the concept of mindfulness, or paying attention to the present emotion.ObjectivesTo assess the current level of evidence for mindfulness in BPD.Methodsa systematic review was performed using the database PubMed / Medline, using the following keywords: “MCBT”; “DBT”; “Mindfulness Therapy”;” BPD”; “Borderline personality”.ResultsResearch shows that the mindfulness therapy approach teaches skills for controlling intense emotions and reducing self-destructive behaviors. Decentering appears to play a crucial role in the treatment as a primary mechanism of action in this therapy.Conclusionsresults suggest that the Mindfulness therapy is a main component for BPD treatment.Disclosure of InterestNone Declared

To search for β β 0 ν decay with unprecedented sensitivity, the R2D2 collaboration is developing a radial time projection chamber with a fiducial mass of half a tonne of 136 Xe at high pressure. The various approaches implemented to eliminate the radioactive background are presented in terms of detector design, topological recognition of interactions, and event energy reconstruction. The developed tools enable the disentangling of the sought-after signal from the background. The projected sensitivity after ten years of data taking yields a half-life limit exceeding 10 27 years, along with a constraint on the effective neutrino mass m β β that could cover a large fraction of the inverted mass hierarchy region, depending on the final experimental background.

As part of the R2D2 (Rare Decays with Radial Detector) R &D, the use of a gas detector with a spherical or cylindrical cathode, equipped with a single anode and operating at high pressure, was studied for the search of rare phenomena such as neutrinoless double-beta decay. The presented measurements were obtained with a cylindrical detector, covering gas pressures ranging from 1 to 10 bar in argon and 1 to 6 bar in xenon, using both a point-like source of 210 Po (5.3 MeV α ) and a diffuse source of 222 Rn (5.5 MeV α ). Analysis and interpretation of the data were developed using the anodic current waveform. Similar detection performances were achieved with both gases, and comparable energy resolutions were measured with both sources. As long as the purity of the gas was sufficient, no significant degradation of the measured energy was observed by increasing the pressure. At the highest operating pressure, an energy resolution better than 1.5% full-width at half-maximum (FWHM) was obtained for both gaseous media, although optimal noise conditions were not reached.

We report the measurement of the two-neutrino double-beta ($2\\nu\\beta\\beta$) decay of $^{100}$Mo to the ground state of $^{100}$Ru using lithium molybdate (\\crystal) scintillating bolometers. The detectors were developed for the CUPID-Mo program and operated at the EDELWEISS-III low background facility in the Modane underground laboratory. From a total exposure of $42.235$ kg$\\times$d, the half-life of $^{100}$Mo is determined to be $T_{1/2}^{2\\nu}=[7.12^{+0.18}_{-0.14}\\,\\mathrm{(stat.)}\\pm0.10\\,\\mathrm{(syst.)}]\\times10^{18}$ years. This is the most accurate determination of the $2\\nu\\beta\\beta$ half-life of $^{100}$Mo to date. We also confirm, with the statistical significance of $>3\\sigma$, that the single-state dominance model of the $2\\nu\\beta\\beta$ decay of $^{100}$Mo is favored over the high-state dominance model.

The CUPID-Mo experiment to search for 0νββ decay in 100Mo has been recently completed after about 1.5 years of operation at Laboratoire Souterrain de Modane (France). It served as a demonstrator for CUPID, a next generation 0νββ decay experiment. CUPID-Mo was comprised of 20 enriched Li2100MoO4 scintillating calorimeters, each with a mass of ∼0.2 kg, operated at ∼20 mK. We present here the final analysis with the full exposure of CUPID-Mo (100Mo exposure of 1.47 kg×year) used to search for lepton number violation via 0νββ decay. We report on various analysis improvements since the previous result on a subset of data, reprocessing all data with these new techniques. We observe zero events in the region of interest and set a new limit on the 100Mo 0νββ decay half-life of T1/20ν>1.8×1024 year (stat. + syst.) at 90% CI. Under the light Majorana neutrino exchange mechanism this corresponds to an effective Majorana neutrino mass of mββ <(0.28-0.49) eV, dependent upon the nuclear matrix element utilized.

The amount of energy released by a nuclear recoil ionizing the atoms of the active volume of detection appears “quenched” compared to an electron of the same kinetic energy. This different behavior in ionization between electrons and nuclei is described by the Ionization Quenching Factor (IQF) and it plays a crucial role in direct dark matter searches. For low kinetic energies (below 50keV), IQF measurements deviate significantly from common models used for theoretical predictions and simulations. We report measurements of the IQF for proton, an appropriate target for searches of Dark Matter candidates with a mass of approximately 1GeV, with kinetic energies in between 2keV and 13keV in 100mbar of methane. We used the Comimac facility in order to produce the motion of nuclei and electrons of controlled kinetic energy in the active volume, and a NEWS-G SPC to measure the deposited energy. The Comimac electrons are used as a reference to calibrate the detector with 7 energy points. A detailed study of systematic effects led to the final results well fitted by IQF(EK)=EKα/(β+EKα) with α=0.70±0.08 and β=1.32±0.17. In agreement with some previous works in other gas mixtures, we measured less ionization energy than predicted from SRIM simulations, the difference reaching 33% at 2keV.

CUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation 0 ν β β decay experiment, CUPID. It consisted of an array of 20 enriched Li 2 100 MoO 4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the 2 ν β β decay and other processes with high precision. We also measure the radio-purity of the Li 2 100 MoO 4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.7  - 0.8 + 0.9  (stat) - 0.7 + 1.5  (syst)  × 10 - 3  counts/ Δ E FWHM / mol iso / year , the lowest in a bolometric 0 ν β β decay experiment.

A high-salt diet is one of the major risk factors in the development and maintenance of hypertension. Numerous experimental and observational studies have confirmed the association of sodium intake with blood pressure levels. The effects of a high-salt diet are related to the function of the renin-angiotensin system, which is normally suppressed by a high-salt diet. Endothelial dysfunction probably plays an important role in the influence of high sodium intake on blood pressure, although the exact mechanisms remain elusive. Genetic factors are known to be very important, and various consomic and congenic rat strains as animal models have proven to be very useful in bringing us a step closer to understanding the interaction between salt intake and hypertension. In this article, experimental data obtained in studies on animals and humans, as well as epidemiological data are reviewed.

The current experiments searching for neutrinoless double- β ( 0 ν β β ) decay also collect large statistics of Standard Model allowed two-neutrino double- β ( 2 ν β β ) decay events. These can be used to search for Beyond Standard Model (BSM) physics via 2 ν β β decay spectral distortions. 100 Mo has a natural advantage due to its relatively short half-life, allowing higher 2 ν β β decay statistics at equal exposures compared to the other isotopes. We demonstrate the potential of the dual read-out bolometric technique exploiting a 100 Mo exposure of 1.47 kg  ×  years, acquired in the CUPID-Mo experiment at the Modane underground laboratory (France). We set limits on 0 ν β β decays with the emission of one or more Majorons, on 2 ν β β decay with Lorentz violation, and 2 ν β β decay with a sterile neutrino emission. In this analysis, we investigate the systematic uncertainty induced by modeling the 2 ν β β decay spectral shape parameterized through an improved model, an effect never considered before. This work motivates searches for BSM processes in the upcoming CUPID experiment, which will collect the largest amount of 2 ν β β decay events among the next-generation experiments.

CUPID-Mo, located in the Laboratoire Souterrain de Modane (France), was a demonstrator for the next generation$$0\\nu \\beta \\beta $$0 ν β β decay experiment, CUPID. It consisted of an array of 20 enriched Li$$_{2}$$2$$^{100}$$100 MoO$$_4$$4 bolometers and 20 Ge light detectors and has demonstrated that the technology of scintillating bolometers with particle identification capabilities is mature. Furthermore, CUPID-Mo can inform and validate the background prediction for CUPID. In this paper, we present a detailed model of the CUPID-Mo backgrounds. This model is able to describe well the features of the experimental data and enables studies of the$$2\\nu \\beta \\beta $$2 ν β β decay and other processes with high precision. We also measure the radio-purity of the Li$$_{2}$$2$$^{100}$$100 MoO$$_4$$4 crystals which are found to be sufficient for the CUPID goals. Finally, we also obtain a background index in the region of interest of 3.7 $$^{+0.9}_{-0.8}$$- 0.8 + 0.9  (stat)$$^{+1.5}_{-0.7}$$- 0.7 + 1.5  (syst) $$\\times ~10 ^{-3}$$× 10 - 3  counts/$$\\Delta E_{\\text {FWHM}}/\\text {mol}_{\\text {iso}}/\\text {year},$$Δ E FWHM / mol iso / year , the lowest in a bolometric$$0\\nu \\beta \\beta $$0 ν β β decay experiment.