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In this work, we present the first experimental upper limits on the presence of stochastic gravitational waves in a frequency band with frequencies above 1 THz. We exclude gravitational waves in the frequency bands from 2.7-14×1014 Hz and 5-12×1018 Hz down to a characteristic amplitude of hcmin≈6×10-26 and hcmin≈5×10-28 at 95% confidence level, respectively. To obtain these results, we used data from existing facilities that have been constructed and operated with the aim of detecting weakly interacting slim particles, pointing out that these facilities are also sensitive to gravitational waves by graviton to photon conversion in the presence of a magnetic field. The principle applies to all experiments of this kind, with prospects of constraining (or detecting), for example, gravitational waves from light primordial black-hole evaporation in the early universe.

The world-wide network of km-scale laser interferometers is aiming at the detection of gravitational waves of astrophysical origin. The second generation of these instruments, called advanced detectors has been, or is in the process of being completed, and a first observational run with the Advanced LIGO interferometers has been performed late in 2015. The basic functionality of advanced detectors is discussed, along with specific features and status updates of the individual projects.

The aim of the study was to characterize the interendothelial junctions in tumor microvessels of five cases of human glioblastoma multiforme. In addition to morphological analysis, tumors were screened for the expression of junctional proteins, such as occludin, claudin-1, ZO-1 and catenins. The expression of the tight junction protein claudin-1 was lost in the majority of tumor microvessels, whereas claudin-5 and occludin were significantly down-regulated only in hyperplastic vessels. As shown by freeze-fracture analysis, under the conditions of tumor growth tight junction particles of endothelial cells were almost exclusively associated with the exocytoplasmic fracture face, providing evidence for a switch of the particles from the protoplasmic to the external leaflet of the endothelial membrane. These results suggest a relationship between claudin-1 suppression and the alteration of tight junction morphology, which is likely to correlate with the increase of endothelial permeability. Underlining the undifferentiated state of tumor microvessels, plakoglobin, a crucial protein for mature endothelial junctions, was not detectable in most microvessels, whereas beta-catenin was abundantly labeled. In this context, it is of particular interest that the majority of microvascular pericytes were negative for alpha-smooth muscle actin, which is a marker of differentiated pericytes, although pericytes were frequently found in electron micrographs. In conclusion, the data suggest that the increase in microvascular permeability in human gliomas, contributing to the clinically severe symptoms of brain edema, is a result of a dysregulation of junctional proteins.

In the central nervous system (CNS) complex endothelial tight junctions (TJs) form a restrictive paracellular diffusion barrier, the blood-brain barrier (BBB). During inflammation, BBB properties are frequently lost, resulting in brain edema. To investigate whether BBB leakiness correlates with molecular changes at BBB TJs, we performed immunofluorescence stainings for TJ molecules in a mouse model of experimental autoimmune encephalomyelitis (EAE) and in human tissue with glioblastoma multiforme (GBM). In TJs of healthy CNS vessels in both mouse and man we detected occludin, ZO-1, claudin-5 and claudin-3. In EAE brain and spinal cord sections we observed the selective loss of claudin-3 immunostaining from TJs of venules surrounded by inflammatory cuffs, whereas the localization of the other TJ proteins remained unchanged. In addition, selective loss of claudin-3 immunostaining was also observed in altered cerebral microvessels of human GBM. Our data demonstrate the selective loss of claudin-3 from BBB TJs under pathological conditions such as EAE or GBM when the integrity of the BBB is compromised, and therefore suggest that claudin-3 is a central component determining the integrity of BBB TJs in vivo.

The quality of the blood-brain barrier (BBB), represented mainly by endothelial tight junctions (TJ), is now believed to be dependent on the brain microenvironment and influenced by the basal lamina of the microvessels. In the highly vascularized glioblastoma multiforme (GBM), a dramatic increase in the permeability of blood vessels is observed but the nature of basal lamina involvement remains to be determined. Agrin, a heparan sulfate proteoglycan, is a component of the basal lamina of BBB microvessels, and growing evidence suggests that it may be important for the maintenance of the BBB. In the present study, we provide first evidence that agrin is absent from basal lamina of tumor vessels if the TJ molecules occludin, claudin-5 and claudin-1 were lacking in the endothelial cells. If agrin was expressed, occludin was always localized at the TJ, claudin-5 was frequently detected, whereas claudin-1 was absent from almost all vessels. Furthermore, despite a high variability of vascular phenotypes, the loss of agrin strongly correlated with the expression of tenascin, an extracellular matrix molecule which has been described previously to be absent in mature non-pathological brain tissue and to accumulate in the basal lamina of tumor vessels. These results support the view that in human GBM, BBB breakdown is reflected by the changes of the molecular compositions of both the endothelial TJ and the basal lamina.

International financial centres used to be stable economic clusters held together by the centripetal forces emanating from physical exchanges. However, given near complete 'virtualisation', these 'anchors' have gradually disappeared. As this article demonstrates, this has had telling consequences for second-tier financial centres like Amsterdam and Frankfurt. Empirically, the article adds cases of financial centre decline to the existing collection of case descriptions. Theoretically, the article assesses the explanatory capacity of the combination of two complementary theoretical perspectives, New Economic Geography and Comparative Political Economy, by determining to what extent they fit the two case studies.

This article traces the location of foreign banks in Germany from 1949 to 2006. As suggested by New Economic Geography models, we find an inverted 'U'-shaped concentration of foreign banks in Germany. Only after a competition between several cities, Frankfurt has emerged as the pre-eminent financial centre, triggered by the 'historical event' of setting up the German central bank in Frankfurt. After a strong increase, Frankfurt's share in the location of foreign banks in Germany decreases slowly but significantly since the mid-1980s. We conclude that there will be a lesser role in Europe for second-tier financial centres in the future.

The German/ British gravitational wave detector GEO 600 is in the process of being upgraded. The upgrading process of GEO 600, called GEO-HF, will concentrate on the improvement of the sensitivity for high frequency signals and the demonstration of advanced technologies. In the years 2009 to 2011 the detector will undergo a series of upgrade steps, which are described in this paper.

Patients consistently report that vomiting and nausea are among the most unpleasant and distressing aspects of chemotherapy. 1 Vomiting due to anticancer drugs reduces the quality of life 2 and may cause patients to delay or refuse potentially curative therapy. 3 The severity and pattern of chemotherapy-induced emesis depend on the specific agents used, the dose, and the regimen. 4 Cisplatin is most commonly associated with profound nausea and vomiting, which follow a distinct pattern of an acute phase (within 24 hours after chemotherapy) and a delayed phase (on days 2 to 5). 5 Severe acute emesis occurs in virtually all patients who receive doses . . .

Modulated differential wavefront sensing (MDWS) is an alignment control scheme in the regime of beams with strong higher order transversal modes (HOMs). It is based on the differential wavefront sensing (DWS) technique. MDWS represents a significant upgrade over conventional techniques used in the presence of high HOM content as it allows for higher control bandwidths while eliminating the need of auxiliary alignment modulations, that otherwise cause loss of applied squeezing. The output port of gravitational wave (GW) interferometers (IFO) is one such place where a lot of HOMs are present. These are filtered out by a cavity called the output mode cleaner (OMC), whose alignment gets challenging due to the presence of HOMs. In this paper, we present the first demonstration of the MDWS scheme for aligning the fundamental mode from the IFO to the OMC at the gravitational wave detector-GEO 600.