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Care, uncertainty and intergenerational ethics
Our capacity to reshape the future has never been more powerful. Yet our ability to foresee the consequences of what we do has not kept pace. Is the idea that we have responsibilities to future generations therefore meaningful? This book argues that it is, with the aid of a unique reading of the care ethics tradition.
Book
Principles of GNSS, Inertial, and Multisensor Integrated Navigation Systems
Navigation systems engineering is a red-hot area. More and more technical professionals are entering the field and looking for practical, up-to-date engineering know-how. This single-source reference answers the call, providing both an introduction to overall systems operation and an in-depth treatment of architecture, design, and component integration. This book explains how satellite, on-board, and other navigation technologies operate, and it gives practitioners insight into performance issues such as processing chains and error sources. Providing solutions to systems designers and engineers, the book describes and compares different integration architectures, and explains how to diagnose errors. Moreover, this hands-on book includes appendices filled with terminology and equations for quick referencing.
eBook
Wartime for the district nurses
\"Alice Lake and her friend Edith have had everything thrown at them in their first year as district nurses in the London district of Hackney. From babies born out of wedlock to battered wives, they've had plenty to keep them occupied. Now the lives of every Londoner are about to change forever as Hitler and the Luftwaffe rain down their bombs on the people of the city. The girls find themselves caught up in the terrible aftermath of the raids and run into danger themselves. Amidst the upheaval, there is still time for love, though with the men away fighting for King and Country, the girls have their fair share of heartache and anguish to contend with. It's up to them to keep up the Spirit of the Blitz -and everyone is counting on them...\"--Publisher.
Book
Is it time to reassess the BDNF hypothesis of depression?
The brain-derived neurotrophic factor (BDNF) hypothesis of depression postulates that a loss of BDNF is directly involved in the pathophysiology of depression, and that its restoration may underlie the therapeutic efficacy of antidepressant treatment. While this theory has received considerable experimental support, an increasing number of studies have generated evidence which is not only inconsistent, but also directly contradicts the hypothesis. This article provides a critical review of the clinical and preclinical studies which have been responsible for this controversy, outlining pharmacological, behavioural and genetic evidence which demonstrates the contrasting role of BDNF in regulating mood and antidepressant effects throughout the brain. I will also review key studies, both human and animal, which have investigated the association of a BDNF single-nucleotide polymorphism (Val66Met) with depression pathogenesis, and detail the number of inconsistencies which also afflict this novel area of BDNF research. The article will conclude by discussing why now is a critical time to reassess the original BDNF hypothesis of depression, and look towards the formation of new models that can provide a more valid account of the complex relationships between growth factors, mood disorders and their treatment.
Journal Article
Extreme weather and climate change : a reference handbook
\"A guide to understanding the linkages that have been found between climate change and the growing severity and frequency of extreme weather events such as hurricanes, floods, droughts, and wildfires around the world\"-- Provided by publisher.
BOOK
Principles of GNSS, inertial, and multisensor integrated navigation systems, second edition
This newly revised edition offers you a current and comprehensive understanding of satellite navigation, inertial navigation, terrestrial radio navigation, dead reckoning, and environmental feature matching. It provides both an introduction to navigation systems and an in-depth treatment of INS/GNSS and multisensor integration. The second edition offers a wealth of added and updated material, including a brand new chapter on the principles of radio positioning and a chapter devoted to important applications in the field. Other updates include expanded treatments of map matching, image-based navigation, attitude determination, acoustic positioning, pedestrian navigation, advanced GNSS techniques, and several terrestrial and short-range radio positioning technologies. It shows how satellite, inertial, and other navigation technologies work, and focuses on processing chains and error sources. --
eBook
Changes in gene body methylation do not correlate with changes in gene expression in Anthozoa or Hexapoda
Background
As human activity alters the planet, there is a pressing need to understand how organisms adapt to environmental change. Of growing interest in this area is the role of epigenetic modifications, such as DNA methylation, in tailoring gene expression to fit novel conditions. Here, we reanalyzed nine invertebrate (Anthozoa and Hexapoda) datasets to validate a key prediction of this hypothesis: changes in DNA methylation in response to some condition correlate with changes in gene expression.
Results
In accord with previous observations, baseline levels of gene body methylation (GBM) positively correlated with transcription, and negatively correlated with transcriptional variation between conditions. Correlations between changes in GBM and transcription, however, were negligible. There was also no consistent negative correlation between methylation and transcription at the level of gene body methylation class (either highly- or lowly-methylated), anticipated under the previously described “seesaw hypothesis”.
Conclusion
Our results do not support the direct involvement of GBM in regulating dynamic transcriptional responses in invertebrates. If changes in DNA methylation regulate invertebrate transcription, the mechanism must involve additional factors or regulatory influences.
Journal Article
Efficient water oxidation catalyzed by homogeneous cationic cobalt porphyrins with critical roles for the buffer base
A series of cationic cobalt porphyrins was found to catalyze electrochemical water oxidation to O ₂ efficiently at room temperature in neutral aqueous solution. Co–5,10,15,20-tetrakis-(1,3-dimethylimidazolium-2-yl)porphyrin, with a highly electron-deficient meso -dimethylimidazolium porphyrin, was the most effective catalyst. The O ₂ formation rate was 170 nmol⋅cm ⁻²⋅min ⁻¹ (k ₒbₛ = 1.4 × 10 ³ s ⁻¹) with a Faradaic efficiency near 90%. Mechanistic investigations indicate the generation of a Co ᴵⱽ-O porphyrin cation radical as the reactive oxidant, which has accumulated two oxidizing equivalents above the Co ᴵᴵᴵ resting state of the catalyst. The buffer base in solution was shown to play several critical roles during the catalysis by facilitating both redox-coupled proton transfer processes leading to the reactive oxidant and subsequent O–O bond formation. More basic buffer anions led to lower catalytic onset potentials, extending below 1 V. This homogeneous cobalt-porphyrin system was shown to be robust under active catalytic conditions, showing negligible decomposition over hours of operation. Added EDTA or ion exchange resin caused no catalyst poisoning, indicating that cobalt ions were not released from the porphyrin macrocycle during catalysis. Likewise, surface analysis by energy dispersive X-ray spectroscopy of the working electrodes showed no deposition of heterogeneous cobalt films. Taken together, the results indicate that Co–5,10,15,20-tetrakis-(1,3-dimethylimidazolium-2-yl)porphyrin is an efficient, homogeneous, single-site water oxidation catalyst.
Journal Article