Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
173
result(s) for
"Gruber, Eva"
Sort by:
Task‐induced deactivation dysfunction during reward processing is associated with low self‐esteem in a possible subtype of major depression
Introduction Low self‐esteem is a frequent symptom in major depressive disorder (MDD). This functional magnetic resonance imaging study investigated whether MDD patients with low self‐esteem show a distinct neural pathophysiology. Previous studies linked low self‐esteem to reduced task‐induced deactivation of the pregenual anterior cingulate cortex (pgACC) as a part of the default mode network, and to reduced connectivity between pgACC and reward system. Goya‐Maldonado et al. identified an MDD subtype with pgACC and ventral striatal overactivations during reward processing. We hypothesized that this subtype might be characterized by low self‐esteem. Methods Eighty‐three MDD patients performed the desire–reason dilemma task and completed the Rosenberg Self‐Esteem Scale (RSES). Brain activity during bottom‐up reward processing was regressed upon the RSES scores, controlling for depression severity measured by the Montgomery–Åsberg Depression Rating Scale. To corroborate the findings, we compared self‐esteem scores between patient subgroups with impaired task‐induced deactivation (n = 31) and with preserved task‐induced deactivation (n = 31) of the pgACC. Results Consistent with our a priori hypothesis, activity in a bilateral fronto‐striatal network including pgACC and ventral striatum correlated negatively with RSES scores, also when controlling for depression severity. In the additional analysis, patients with impaired task‐induced pgACC deactivation showed lower self‐esteem (t (52.82) = −2.27; p = .027, d = 0.58) compared to those with preserved task‐induced pgACC deactivation. Conclusions We conclude that low self‐esteem in MDD patients is linked to a task‐induced deactivation dysfunction of the pgACC. Our findings suggest that a previously described possible subtype of MDD with pgACC and ventral striatal overactivations during reward processing is clinically characterized by low self‐esteem. Self‐esteem in patients with major depressive disorder (MDD) correlated negatively with reward‐related activity changes in the pregenual anterior cingulate cortex (pgACC) and the ventral striatum. This suggests that a previously described MDD subtype with reward‐related overactivations in pgACC and ventral striatum is clinically characterized by low self‐esteem.
Journal Article
Gained ground : perspectives on Canadian and comparative North American studies
\"Since the elections of Donald Trump and Justin Trudeau, unprecedented international attention is being drawn to the differences between the United States and Canada. This timely volume takes a close comparative look at the national imaginaries of the two countries. In its analyses of the two countries' cultural productions--literature, but also film, opera, and even theme parks--it follows the approach of Comparative North American Studies, which has been significantly advanced by Reingard M. Nischik's work over recent decades\"-- Provided by publisher.
Book
Accuracy and usability of a diagnostic decision support system in the diagnosis of three representative rheumatic diseases: a randomized controlled trial among medical students
Background
An increasing number of diagnostic decision support systems (DDSS) exist to support patients and physicians in establishing the correct diagnosis as early as possible. However, little evidence exists that supports the effectiveness of these DDSS. The objectives were to compare the diagnostic accuracy of medical students, with and without the use of a DDSS, and the diagnostic accuracy of the DDSS system itself, regarding the typical rheumatic diseases and to analyze the user experience.
Methods
A total of 102 medical students were openly recruited from a university hospital and randomized (unblinded) to a control group (CG) and an intervention group (IG) that used a DDSS (Ada – Your Health Guide) to create an ordered diagnostic hypotheses list for three rheumatic case vignettes. Diagnostic accuracy, measured as the presence of the correct diagnosis first or at all on the hypothesis list, was the main outcome measure and evaluated for CG, IG, and DDSS.
Results
The correct diagnosis was ranked first (or was present at all) in CG, IG, and DDSS in 37% (40%), 47% (55%), and 29% (43%) for the first case; 87% (94%), 84% (100%), and 51% (98%) in the second case; and 35% (59%), 20% (51%), and 4% (51%) in the third case, respectively. No significant benefit of using the DDDS could be observed. In a substantial number of situations, the mean probabilities reported by the DDSS for incorrect diagnoses were actually higher than for correct diagnoses, and students accepted false DDSS diagnostic suggestions. DDSS symptom entry greatly varied and was often incomplete or false. No significant correlation between the number of symptoms extracted and diagnostic accuracy was seen. It took on average 7 min longer to solve a case using the DDSS. In IG, 61% of students compared to 90% in CG stated that they could imagine using the DDSS in their future clinical work life.
Conclusions
The diagnostic accuracy of medical students was superior to the DDSS, and its usage did not significantly improve students’ diagnostic accuracy. DDSS usage was time-consuming and may be misleading due to prompting wrong diagnoses and probabilities.
Trial registration
DRKS.de,
DRKS00024433
. Retrospectively registered on February 5, 2021.
Journal Article
The Groot Effect: Plant facilitation and desert shrub regrowth following extensive damage
Deserts are increasing in extent globally, but existing deserts are decreasing in health. The basic biology and ecology of foundation plant species in deserts are limited. This is a direct study that provides an estimate of the capacity for a locally dominant foundation shrub species in California to recover from damage. Desert shrubs are cleared and damaged by humans for many purposes including agriculture, oil and gas production, and sustainable energy developments; we need to know whether foundation species consistently facilitate the abundance and diversity of other plants in high‐stress ecosystems and whether they can recover. A total of 20 Ephedra californica shrubs were clipped to the ground at a single site and systematically resampled for regrowth 2 years later. These shrubs were damaged once and regrew rapidly, and relatively, larger shrubs were not more resilient. This study provides evidence for what we termed the “Groot Effect” because smaller individuals of this shrub species can recover from significant aboveground damage and continue to have positive effects on other plant species (similar to the popular culture reference to a benefactor tree species). The density of other plant species was consistently facilitated while effects on diversity varied with season. These findings confirm that E. californica is a foundation species that can be an important restoration tool within the deserts of California in spite of extreme cycles of drought and physical damage to its canopy. Desert shrubs are ecological foundation species. We need to test their recovery and functions to better understand resilience and change in these high‐stress ecosystems. Here, we show that even relatively smaller individuals can regenerate and have positive effects on other plants.
Journal Article
Histological assessment of optogenetic tools to study fronto-visual and fronto-parietal cortical networks in the rhesus macaque
Optogenetics offers unprecedented possibilities to investigate cortical networks. Yet, the number of successful optogenetic applications in non-human primates is still low, and the consequences of opsin expression in the primate brain are not well documented. We assessed histologically if we can target cerebrocortical networks with three common optogenetic constructs (AAV2/5-CaMKIIα-eNpHR3.0-mCherry, -ChR2-eYFP, -C1V1-mCherry). The frontal eye field or the dorsal premotor area of rhesus macaques were virally injected, and the resulting transduction spread, expression specificity, and opsin trafficking into axons projecting to parietal and visual areas were examined. After variable periods (2–24 months), expression was robust for all constructs at the injection sites. The CaMKIIα promoter driven-expression was predominant, but not exclusive, in excitatory neurons. In the case of eNpHR3.0-mCherry and ChR2-eYFP, opsins were present in axonal projections to target areas, in which sparse, retrogradely transduced neurons could also be found. Finally, the intracellular distribution of opsins differed: ChR2-eYFP had almost exclusive membrane localization, while eNpHR3.0-mCherry and C1V1-mCherry showed additional intracellular accumulations, which might affect neuronal survival in the long-term. Results indicate that all three constructs can be used for local neuronal modulation, but axonal stimulation and long-term use require additional considerations of construct selection and verification.
Journal Article
Analyzing efficacy, stability, and safety of AAV-mediated optogenetic hearing restoration in mice
AAV-mediated optogenetic neural stimulation has become a clinical approach for restoring function in sensory disorders and feasibility for hearing restoration has been indicated in rodents. Nonetheless, long-term stability and safety of AAV-mediated channelrhodopsin (ChR) expression in spiral ganglion neurons (SGNs) remained to be addressed. Here, we used longitudinal studies on mice subjected to early postnatal administration of AAV2/6 carrying fast gating ChR f-Chrimson under the control of the human synapsin promoter unilaterally to the cochlea. f-Chrimson expression in SGNs in both ears and the brain was probed in animals aged 1 mo to 2 yr. f-Chrimson was observed in SGNs at all ages indicating longevity of ChR-expression. SGN numbers in the AAV-injected cochleae declined with age faster than in controls. Investigations were extended to the brain in which viral transduction was observed across the organ at varying degrees irrespective of age without observing viral spread-related pathologies. No viral DNA or virus-related histopathological findings in visceral organs were encountered. In summary, our study demonstrates life-long (24 mo in mice) expression of f-Chrimson in SGNs upon single AAV-dosing of the cochlea.
Journal Article
Humor in Contemporary Native North American Literature
In contrast to the popular cliché of the \"stoic Indian,\" humor has always been important in Native North American cultures. Recent Native literature testifies to the centrality of this tradition. Yet literary criticism has so far largely neglected these humorous aspects, instead frequently choosing to concentrate on representations of trauma and cultural disruption, at the risk of reducing Native characters and Native cultures to the position of the tragic victim. This first comprehensive study explores the use of humor in today's Native writing, focusing on a wide variety of texts spanning all genres. It combines concepts from cultural studies and humor studies with approaches by Native thinkers and critics, analyzing the possible effects of humorous forms of representation on the self-image and identity formation of Native individuals and Native cultures. Humor emerges as an indispensable tool for engaging with existing stereotypes: Native writers subvert degrading clichés of \"the Indian\" from within, reimagining Nativeness in a celebration of laughing survivors, \"decolonizing\" the minds of both Native and non-native readers, and contributing to a renewal of Native cultural identity. This book will be of interest to scholars and students of Native Studies both literary and cultural. Due to its encompassing approach, it will also provide a point of entry for the wider readership interested in contemporary Native writing. Eva Gruber is assistant professor in the American Studies section of the Department of Literature at the University of Konstanz, Germany.
eBook
Glowing in the light: fluorescence of bill plates in the Crested Auklet (Aethia cristatella)
We examined the fluorescence of ornaments among three auklet species: Least Auklets (Aethia pusilla), Crested Auklets (Aethia cristatella), and Parakeet Auklets (Aethia psittacula) on Gareloi Island, Alaska during the 2015 breeding season. We found that the ornamental bill plates of Crested Auklets fluoresced, but bill ornaments of Least Auklets and bills of Parakeet Auklets did not. We also found that none of the feathers in these three species exhibited fluorescence. We suggest that differences in ornamentation and fluorescence may be related to life-history strategies associated with sexual selection and predator avoidance.
Journal Article
Sourcing high tissue quality brains from deceased wild primates with known socio‐ecology
The selection pressures that drove dramatic encephalisation processes through the mammal lineage remain elusive, as does knowledge of brain structure reorganisation through this process. In particular, considerable structural brain changes are present across the primate lineage, culminating in the complex human brain that allows for unique behaviours such as language and sophisticated tool use. To understand this evolution, a diverse sample set of humans' closest relatives with varying socio‐ecologies is needed. However, current brain banks predominantly curate brains from primates that died in zoological gardens. We try to address this gap by establishing a field pipeline mitigating the challenges associated with brain extractions of wild primates in their natural habitat. The success of our approach is demonstrated by our ability to acquire a novel brain sample of deceased primates with highly variable socio‐ecological exposure and a particular focus on wild chimpanzees. Methods in acquiring brain tissue from wild settings are comprehensively explained, highlighting the feasibility of conducting brain extraction procedures under strict biosafety measures by trained veterinarians in field sites. Brains are assessed at a fine‐structural level via high‐resolution MRI and state‐of‐the‐art histology. Analyses confirm that excellent tissue quality of primate brains sourced in the field can be achieved with a comparable tissue quality of brains acquired from zoo‐living primates. Our field methods are noninvasive, here defined as not harming living animals, and may be applied to other mammal systems than primates. In sum, the field protocol and methodological pipeline validated here pose a major advance for assessing the influence of socio‐ecology on medium to large mammal brains, at both macro‐ and microstructural levels as well as aiding with the functional annotation of brain regions and neuronal pathways via specific behaviour assessments.
Journal Article