Catalogue Search | MBRL
Are you sure you want to remove the book from the shelf?
{{itemTitle}}
2,094
result(s) for
"Gu, Ning"
Sort by:
Adaptive iron-based magnetic nanomaterials of high performance for biomedical applications
With unique physicochemical properties and biological effects, magnetic nanomaterials (MNMs) play a crucial role in the biomedical field. In particular, magnetic iron oxide nanoparticles (MIONPs) are approved by the United States Food and Drug Administration (FDA) for clinical applications at present due to their low toxicity, biocompatibility, and biodegradability. Despite the unarguable effectiveness, massive space for improving such materials’ performance still needs to be filled. Recently, many efforts have been devoted to improving the preparation methods based on the materials’ biosafety. Besides, researchers have successfully regulated the performance of magnetic nanoparticles (MNPs) by changing their sizes, morphologies, compositions; or by aggregating as-synthesized MNPs in an orderly arrangement to meet various clinical requirements. The rise of cloud computing and artificial intelligence techniques provides novel ways for fast material characterization, automated data analysis, and mechanism demonstration. In this review, we summarized the studies that focused on the preparation routes and performance regulations of high-quality MNPs, and their special properties applied in biomedical detection, diagnosis, and treatment. At the same time, the future development of MNMs was also discussed.
Journal Article
العمارة الصينية : بناء الجمال بالطوب والحجارة : السحر الأزلي
فن العمارة الصينية قديمة العهد كالحضارة الصينية. من كل مصدر للمعلومات الأدبية والرسمية والمثالية، هناك أدلة قوية تدل على أن الصينيين كانوا يتمتعون دائما بنظام بناء السكان الأصليين الذي احتفظ بخصائصه الرئيسية من عصور ما قبل التاريخ حتى يومنا هذا. على مساحة واسعة من تركستان الصينية إلى اليابان، من منشوريا إلى النصف الشمالي من الهند الصينية الفرنسية، نفس نظام البناء هو السائد. هذا هو مجال التأثير الثقافي الصيني. أن هذا النظام من البناء يمكن أن يظل موجودا لأكثر من أربعة آلاف سنة على مثل هذا الإقليم الشاسع ولاتزال البنية الحية، محافظة على خصائصها الرئيسية على الرغم من الغزوات الأجنبية المتكررة العسكرية والعقلية والروحية، هي ظاهرة قابلة للمقارنة فقط لاستمرارية الحضارة التي تشكل جزءا لا يتجزأ منها.»ليانغ، سو-شونغ، 1984، 1984 خلال القرن العشرين حاول المهندسون المعماريون الصينيون المدربون من الغرب الجمع بين التصاميم الصينية التقليدية في الهندسة المعمارية الحديثة (عادة الحكومة) مع نجاح كبير علاوة على ذلك فإن الضغط من أجل التنمية الحضرية في جميع أنحاء الصين المعاصرة يتطلب سرعة أعلى من البناء ونسبة مساحة الطابق الأعلى، مما يعني أنه في المدن الكبرى الطلب على المباني الصينية التقليدية، والتي هي عادة أقل من 3 مستويات ورفض لصالح العمارة الحديثة. مع ذلك، فإن المهارات التقليدية للهندسة المعمارية الصينية، بما في ذلك النجارة الرئيسية والثانوية والبناء والحجارة لا تزال تطبق على بناء العمارة العامية في المنطقة الريفية الشاسعة في الصين.
BOOK
Depletable peroxidase-like activity of Fe3O4 nanozymes accompanied with separate migration of electrons and iron ions
As pioneering Fe
3
O
4
nanozymes, their explicit peroxidase (POD)-like catalytic mechanism remains elusive. Although many studies have proposed surface Fe
2+
-induced Fenton-like reactions accounting for their POD-like activity, few have focused on the internal atomic changes and their contribution to the catalytic reaction. Here we report that Fe
2+
within Fe
3
O
4
can transfer electrons to the surface via the Fe
2+
-O-Fe
3+
chain, regenerating the surface Fe
2+
and enabling a sustained POD-like catalytic reaction. This process usually occurs with the outward migration of excess oxidized Fe
3+
from the lattice, which is a rate-limiting step. After prolonged catalysis, Fe
3
O
4
nanozymes suffer the phase transformation to γ-Fe
2
O
3
with depletable POD-like activity. This self-depleting characteristic of nanozymes with internal atoms involved in electron transfer and ion migration is well validated on lithium iron phosphate nanoparticles. We reveal a neglected issue concerning the necessity of considering both surface and internal atoms when designing, modulating, and applying nanozymes.
The mechanism of peroxidase-like Fe
3
O
4
nanozymes remains elusive. Here, the authors show the electron transfer mechanism of Fe(II) ions to regenerate surface Fe(II) and the related phase transformation and depletion of activity.
Journal Article
Advances in Atherosclerosis Theranostics Harnessing Iron Oxide‐Based Nanoparticles
Atherosclerosis, a multifaceted chronic inflammatory disease, has a profound impact on cardiovascular health. However, the critical limitations of atherosclerosis management include the delayed detection of advanced stages, the intricate assessment of plaque stability, and the absence of efficacious therapeutic strategies. Nanotheranostic based on nanotechnology offers a novel paradigm for addressing these challenges by amalgamating advanced imaging capabilities with targeted therapeutic interventions. Meanwhile, iron oxide nanoparticles have emerged as compelling candidates for theranostic applications in atherosclerosis due to their magnetic resonance imaging capability and biosafety. This review delineates the current state and prospects of iron oxide nanoparticle‐based nanotheranostics in the realm of atherosclerosis, including pivotal aspects of atherosclerosis development, the pertinent targeting strategies involved in disease pathogenesis, and the diagnostic and therapeutic roles of iron oxide nanoparticles. Furthermore, this review provides a comprehensive overview of theranostic nanomedicine approaches employing iron oxide nanoparticles, encompassing chemical therapy, physical stimulation therapy, and biological therapy. Finally, this review proposes and discusses the challenges and prospects associated with translating these innovative strategies into clinically viable anti‐atherosclerosis interventions. In conclusion, this review offers new insights into the future of atherosclerosis theranostic, showcasing the remarkable potential of iron oxide‐based nanoparticles as versatile tools in the battle against atherosclerosis. This review mainly focuses on the advances and prospects in the iron oxide nanoparticles‐based atherosclerosis theranostics, which may simultaneously possess targeting, diagnostic, and therapeutic functions. A comprehensive and detailed summary of related researches are provided according to three therapeutic strategies, encompassing the chemical therapy, physical stimulation therapy, and biologic therapy.
Journal Article
Drug delivery system based on nanobubbles
Ultrasound (US) medical technology is widely used due to its advantages of safety, speed, and low cost. With the rapid development of biomedical nanotechnology, micro/nanobubbles, as US contrast agents, are not only valuable in US imaging diagnosis but also show broad application prospects in drug delivery. Nanobubbles (NBs) have more advantages as drug delivery systems (DDSs) due to their smaller size and longer circulation time compared with microbubbles. In this review, the fundamentals of NBs, including classification, stability mechanism, and preparation methods are summarized. Then, the strategies of a DDS based on NBs, including direct delivery, codelivery, target delivery, and stimuli‐responsive delivery are reviewed and discussed. The three main applications of NBs‐based DDSs, namely tumor theranostics, brain drug delivery, and vascular disease theranostics were highlighted. The challenges and future directions of the NBs‐based DDSs are also considered and discussed. Based on a comprehensive overview of the nanobubbles (NBs) fundamentals, the strategies using NBs for novel drug delivery are discussed. Applications, including tumor theranostics through enhanced permeability and retention, brain drug delivery by blood−brain barrier opening, and vascular theranostics are presented. Current challenges in the combination of NBs and ultrasound for drug delivery and the corresponding mechanisms that need to be addressed are proposed.
Journal Article
Micro/nano-bubble-assisted ultrasound to enhance the EPR effect and potential theranostic applications
Drug delivery for tumor theranostics involves the extensive use of the enhanced permeability and retention (EPR) effect. Previously, various types of nanomedicines have been demonstrated to accumulate in solid tumors via the EPR effect. However, EPR is a highly variable phenomenon because of tumor heterogeneity, resulting in low drug delivery efficacy in clinical trials. Because ultrasonication using micro/nanobubbles as contrast agents can disrupt blood vessels and enhance the specific delivery of drugs, it is an effective approach to improve the EPR effect for the passive targeting of tumors. In this review, the basic thermal effect, acoustic streaming, and cavitation mechanisms of ultrasound, which are characteristics that can be utilized to enhance the EPR effect, are briefly introduced. Second, micro/nanobubble-enhanced ultrasound imaging is discussed to understand the validity and variability of the EPR effect. Third, because the tumor microenvironment is complicated owing to elevated interstitial fluid pressure and the deregulated extracellular matrix components, which may be unfavorable for the EPR effect, few new trends in smart bubble drug delivery systems, which may improve the accuracy of EPR-mediated passive drug targeting, are summarized. Finally, the challenging and major concerns that should be considered in the next generation of micro/nanobubble-contrast-enhanced ultrasound theranostics for EPR-mediated passive drug targeting are also discussed.
Journal Article
Autograft bone grafting via surgical hip dislocation for collapsed necrotic femoral head: a mid-term retrospective study
Objective
To investigate the mid-term outcomes of surgical hip dislocation combined with bone graft impacting and non-vascularized iliac crest bone flap implanting in the treatment of post-collapse osteonecrosis of femoral head (ONFH).
Methods
From October 2014 and April 2020, 111 patients (121 hips) with ONFH were retrospectively reviewed. Assessment parameters included the Visual analog scale (VAS) pain scores and Harris hip score (HHS). Follow-up end points were set as total hip arthroplasty (THA). Conversion to THA was selected as the definitive endpoint, representing an objective clinical failure requiring intervention, whereas radiologic re-collapse lacks standardized definition and may not consistently correlate with symptomatic progression or necessitate revision surgery. Therefore, it was not used in this study. Kaplan–Meier survival analysis was used to examine the survival rate. Multivariate Cox regression analysis was used to investigate the risk factors associated with conversion to THA, including age, etiology, duration of pain, combined preserved angle (CPA), and hip joint medial space ratio (MSR). Pre- and postoperative variables of HHS in the different groups were assessed.
Results
The average follow-up time was 53.82 ± 25.36 months. The mean VAS score and HHS were significantly improved at the final follow-up compared with preoperative values (
p
< 0.001). By the time of the last follow-up, 19 hips failed and reached the end point of observation. The overall survival rate was 84.30% at 60 months. Multivariate Cox regression analysis revealed that CPA and MSR were independent factor associated with conversion to THA. These findings establish CPA and MSR as crucial preoperative prognostic indicators and patient selection tools. Clinical outcomes was affected by age, duration of pain, JIC classification, combined preserved angle (CPA), and hip joint medial space ratio (MSR).
Conclusions
Surgical hip dislocation combined with non-vascularized iliac crest bone flap bone grafting is an effective treatment on post-collapse ONFH with satisfactory mid-term results, particularly when patients are selected based on favorable preoperative CPA (> 118.73°) and MSR (≤ 20.35%) values. Multicenter studies with longer follow-up are needed to further validate the efficacy of this procedure in post-collapse ONFH.
Journal Article
Sodium‑glucose co-transporter‑2 inhibitors in the treatment of diabetes with heart failure
2022 AHA/ACC/HFSA guideline for the management of heart failure, which is valuable for clinical decision-making, was recently released. This guideline recommended patients with heart failure with type 2 diabetes sodium‑glucose co-transporter‑2 inhibitors for the management of hyperglycemia and to reduce heart failure-related morbidity and mortality (Class 1, Level A). It is important to note that the source of evidence based on this recommendation is from EMPEROR-Reduced, DAPA-HF, and DECLARE-TIMI 58 and does not include newly published PRESERVED-HF, CHIEF-HF, and EMPEROR-Preserved. Here we reviewed these important trials in order to provide more clinical references for patients with diabetes and heart failure, especially heart failure with preserved ejection fraction.
Journal Article
Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma
Radiotherapy performs an important function in the treatment of cancer, but resistance of tumor cells to radiation still remains a serious concern. More research on more effective radiosensitizers is urgently needed to overcome such resistance and thereby improve the treatment outcome. The goal of this study was to evaluate and compare the radiosensitizing efficacies of gold nanoparticles (AuNPs) and silver nanoparticles (AgNPs) on glioma at clinically relevant megavoltage energies. Both AuNPs and AgNPs potentiated the in vitro and in vivo antiglioma effects of radiation. AgNPs showed more powerful radiosensitizing ability than AuNPs at the same mass and molar concentrations, leading to a higher rate of apoptotic cell death. Furthermore, the combination of AgNPs with radiation significantly increased the levels of autophagy as compared with AuNPs plus radiation. These findings suggest the potential application of AgNPs as a highly effective nano-radiosensitizer for the treatment of glioma.
Journal Article