Explore the vast range of titles available.

Introduction: We evaluated the effects of repeated ketamine, propofol, and ketamine + propofol administration on cognitive functions and brain tissue of elderly rat models with streptozotocin-induced Alzheimer’s disease. Materials and Methods: Thirty elderly male Wistar Albino rats were divided into five groups: control (Group C), Alzheimer’s (Group A), Alzheimer’s + ketamine (Group AK), Alzheimer’s + propofol (Group AP), and Alzheimer’s + propofol + ketamine (Group APK). Alzheimer’s disease was induced in Groups A, AK, AP, and APK via intracerebroventricular streptozotocin. Four weeks after surgery, ketamine, propofol, and ketamine + propofol were administered intraperitoneally for 3 days to Groups AK, AP, and APK, respectively. The radial arm maze test (RAMT) was performed in the initial, 1st, 2nd, 3rd, and 4th weeks after surgery and daily following anaesthesia. Blood and brain tissue samples were obtained. Results: The RAMT results of Groups A, AK, AP, and APK decreased compared to Group C 2 weeks after Alzheimer’s disease onset. Compared to Group A, the RAMT results increased in Groups AK and APK after the first anaesthesia, and in Group AP after the second anaesthesia. Brain tissue paraoxonase-1 (PON-1) and catalase (CAT) activities were low, and the thiobarbituric acid reactive substance (TBARS) level was high in Group A compared to Group C. TBARS levels of Groups AP and APK were lower than Group A, while CAT activity was higher. PON-1 activity was higher in Groups AK, AP, and APK than in Group A. Histopathological changes decreased in Groups AP and AK. A decrease in p53 was found in Group C compared to Group A. Ketamine and propofol were found to be effective at Bcl-2 immunoexpression, but a decrease in Caspase-3 was observed in Group APK. GFAP immunoexpression increased in Group A compared to Group C and in Group AP compared to Group AK. Conclusions: Repetitive anaesthesia application was found to positively affect cognitive functions. This was supported by histopathological and biochemical markers.

The current semi-experimental pilot study was conducted to investigate the effects of dance and movement therapy methods (DMTM) on compassion satisfaction, burnout, and compassion fatigue in nurses using a pre-/posttest design. Nurses ( N = 8) with low compassion satisfaction, high burnout, and high compassion fatigue participated in eight sessions of DMTM. Upon completion of the program, average compassion satisfaction levels increased, and burnout and compassion fatigue levels decreased. Although further testing with larger samples is necessary, preliminary results indicate DMTM is effective for addressing compassion satisfaction, burnout, and compassion fatigue in nurses. [ Journal of Psychosocial Nursing and Mental Health Services, 58 (4), 43–51.]

Alzheimer’s disease (AD) is the most common form of dementia that occurs in the brain. This is a chronic neurodegenerative disease which is valid in 60–70% of all dementia patients. Boron, regarded as a potential antioxidant, has the effect of reducing oxidative stress. Taurine, as one of the thiol-containing amino acids, exists at different concentrations in both the neurons and glial cells of the central nervous system. It plays an important role in the protective and adjuvant therapies as an antioxidant due to its characteristics of maintaining the oxidant-antioxidant balance of the body as well as cell integrity and increasing body resistance. Based on this information, our objective was to reveal the effect of boron alone, taurine alone plus co-administration of taurine and boron application on brain tissue protein carbonyls (PC) and serum advanced oxidation protein products (AOPP) levels in the experimental Alzheimer’s model. For this purpose, 5 groups were formed in our study which consisted of 30 Wistar albino male rats. The rats were given a single dose of STZ stereotaxically. At the end of this period, the rats were decapitated, plus their brain tissues and blood were removed. Our findings suggested that taurine alone and co-administration of boron and taurine had a decreasing effect on AOPP and PC levels of the experimental Alzheimer model of the rats.

Objective: Hypoxic preconditioning allows cells to gain resistance to hypoxic damage. There are a limited number of studies suggesting that hypoxic preconditioning increases antioxidant capacity in the lung. In this study, we aimed to evaluate effects of hypoxic preconditioning on oxidant/antioxidant systems in rat lung. Material and Methods: Rats were divided into 4 groups: control, preconditioning (PC) (10% O2), severe hypoxia (SH) (7% O2) and PC + SH. The parameters related to oxidative stress and antioxidant defense mechanisms, which are malondialdehyde (MDA) levels, total oxidant system (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), superoxide dismutase (SOD) and glutathione (GSH) activity, were measured. Results were evaluated using the One-Way ANOVA and t-test; p0.05 was considered significant. Results: Compared with the control group, MDA levels decreased in all hypoxic groups; decrements in PC and SH groups were statistically significant. Compared with the control group, levels of TOS showed a significant increase in the PC+SH group. OSI of PC+SH group was significantly higher than other groups. There was no significant difference in TAC levels between the groups. Compared to other groups, SOD activity showed a significant decrease in the PC+SH group. GSH levels showed a significant decrease in PC+SH group compared to both control and PC group. Conclusion: Our findings suggest that hypoxic preconditioning does not have an effect on antioxidant defense systems in lungs, but severe hypoxia does affect oxidant/antioxidant systems.