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Lung cancer is a leading cause of cancer death in many countries. Notch signaling has been demonstrated to frequently participate in the process of lung carcinogenesis. Delta-like ligand 4 (Dll4) is a vascular-specific ligand of Notch, and has a critical role in the angiogenesis of numerous cancers. However, the role of Dll4 in the cross-talk between endothelial cells (ECs) and tumor cells remains obscure. Herein, our study revealed that Dll4-expressing ECs (EC-Dll4) significantly suppressed the proliferation of neighboring non-small cell lung cancer (NSCLC) cells and attenuated the growth of NSCLC xenograft in nude mice. On the contrary, silencing endothelial Dll4 by its specific interference RNA reversed these effects of Dll4 on NSCLC cell proliferation and tumor formation. Furthermore, activation of Notch1, but not Notch2 or Notch3, was enhanced in NSCLC cells cultured with EC-Dll4, as well as in xenografts induced by a mixture of NSCLC cells and EC-Dll4. Interference of Notch1 significantly attenuated Dll4-mediated suppression of NSCLC cell proliferations, indicating that Dll4/Notch1 signaling negatively modulates the NSCLC growth. Moreover, PTEN expression in NSCLC cells was increased by EC-Dll4 or rhDll4 (recombinant human-Dll4 protein), and the induction was impaired by Notch1 interference suggesting that Dll4 could upregulate PTEN expression by Notch1. Taken together, we conclude that the cross-talk between ECs and NSCLC cells by Dll4/Notch1/PTEN signaling pathway inhibits the growth of NSCLC.

In order to overcome the disadvantages of uncertainty, randomness and intermittency brought by wind and solar energy, different energy storage systems were put forwarded. Liquid air energy storage is an important technology in solving the grid connection problem of large-scale renewable energy. However, the production of liquid air needs a cryogenic liquefaction technology below a temperature of -150°C, which has a high facility cost and cold loss. Therefore a closed hybrid wind-solar-liquid CO2 energy storage (WS-LCES) system was proposed. In the WS-LCES system, wind power was used to liquefy CO2 and the CO2 was stored in liquid phase with different pressures (90 bar and 8 bar) and temperatures (35°C and -45°C) at both energy storage and release stages. Also, the solar power was stored to increase the energy storage efficiency. For the high density of liquid CO2, the system has a large storage capacity and no geographic constraints. A thermodynamic and parametric analysis was conducted to investigate the optimum system performance.

Over the past decades, a variety of different approaches to realize the utilization of liquefied natural gas (LNG) cold energy have been undertaken. By reviewing on the existing LNG cold energy utilization ways and considering the suggestions of taking advantage of the principle of temperature counterpart and cascade utilization, this paper proposes a novel method that LNG cold energy can be used in liquid air energy storage (LAES) system. Because of a high match in temperature between LNG gasification process and air liquefaction stage, LAES system combined with LNG cold energy has an improved efficiency compared with the conventional LAES system. Additionally, the cold energy of LNG can be taken full advantage of.

The study of the simulation of a high-speed train control system has great significance for the realization of a train control system. This paper studied the basic theory of a high-speed train control system in China. Based on the theory and structure of HLA (High Level Architecture), multi-resolution modelling, simulation real-time management methods and the system architecture of a highspeed train control system simulation was studied systematically, and the simulation result of the on-board vehicle and field centre equipment was shown. With the aim of establishing the credibility of simulation, the methods of VV&A, qualitative and quantitative RAMS analysis and system fault injection were studied, which improved the credibility of high-speed train control system simulation.

Breast cancer is one of the most common malignancies in women worldwide. Traditional Chinese medicine has been used as adjunctive or complementary therapy for breast cancer. Diterpenoids from Euphorbia fischeriana Steud. have been demonstrated to possess anti-breast-cancer activity. This research was aimed to systematically explore the diterpenoids from E. fischeriana and study the multiple mechanisms on breast cancer. The structures of diterpenoids were identified by the integrated strategy of UHPLC-Q-TOF-MS and molecular networking. A total of 177 diterpenoids belonging to 13 types were collected. In silico ADME analysis was performed on these compounds. It indicated that 130 of 177 diterpenoids completely adjusted to Lipinski’s rule. The targets of compounds were obtained from PharmMapper. The targets of breast cancer were collected from GeneCards. Then, 197 compounds-related targets and 544 breast cancer-related targets were identified. After the intersection process, 58 overlapping targets between compounds-related targets and breast cancer-related targets were acquired. The STRING database was applied to predict the protein-protein interactions. The GO and KEGG pathway enrichment analysis were performed by using the KOBAS database. It indicated that these predicted pathways were closely related to breast cancer. The treatment effect of E. fischeriana on breast cancer might be performed through signaling pathways, such as IL-17 signaling pathway, MAPK signaling pathway, and PI3K-Akt signaling pathway. The predicted top genes such as EGFR, ESR, MAPK, SRC, CASP3, CDK2, and KDR were involved in cell proliferation, gene transcription, apoptosis, signal transduction, DNA damage and repair, tumor differentiation, metastasis, and cell cycle, which indicated that E. fischeriana might treat breast cancer comprehensively. A compounds-KEGG pathways-related targets network was built by using cytoHubba to analyze the hub compounds and targets. It concluded that E. fischeriana treated breast cancer not only by the main components but also by the microconstituents, which reflected the overall regulatory role of multicomponents treating breast cancer. To estimate the binding affinities, binding sites, and binding postures, molecular docking simulations between 177 diterpenoids and top 19 targets were carried out. The results are basically in line with expectations. In conclusion, these results can serve as references for researchers studying potential targets of diterpenoids from E. fischeriana on breast cancer in the future.

To observe the clinical efficacy of microplasma radiofrequency in treating post-traumatic pigmentary deposition using VISIA quantitative analysis, an innovative approach not previously emphasized in microplasma radiofrequency studies. Twenty patients with post-traumatic pigmentary deposition, treated at Cangzhou Central Hospital between July 2022 and December 2022, were selected. Pigmented areas were divided into four regions (A: control; B, C, D: treated with increasing energy parameters). Adverse effects (erythema, edema, micro-crusts, pruritus) were monitored at 2, 4, and 6 weeks post-treatment using CTCAE v5.0 criteria. Pigmentary deposition scores and VISIA parameters (spots, ultraviolet spots, red areas, brown spots) were evaluated. At 2, 4, and 6 weeks, Groups B, C, D showed significant reductions in pigment scores and VISIA parameters vs Group A (P < 0.05), with Group D (highest energy) achieving maximal improvement. Transient mild-moderate erythema (60-100%), edema (40-80%), and micro-crusts (20-60%) occurred in treated groups, resolving spontaneously within 14 days; no severe adverse events were observed. Microplasma radiofrequency significantly improves post-traumatic pigmentary deposition, with energy-dependent efficacy. Despite transient side effects at higher energies, its favorable safety profile supports clinical adoption. VISIA quantitative analysis provides robust objective evaluation, advancing standardization in pigment management.

In order to overcome the disadvantages of uncertainty, randomness and intermittency brought by wind and solar energy, different energy storage systems were put forwarded. Liquid air energy storage is an important technology in solving the grid connection problem of large-scale renewable energy. However, the production of liquid air needs a cryogenic liquefaction technology below a temperature of -150°C, which has a high facility cost and cold loss. Therefore a closed hybrid wind-solar-liquid CO 2 energy storage (WS-LCES) system was proposed. In the WS-LCES system, wind power was used to liquefy CO 2 and the CO 2 was stored in liquid phase with different pressures (90 bar and 8 bar) and temperatures (35°C and -45°C) at both energy storage and release stages. Also, the solar power was stored to increase the energy storage efficiency. For the high density of liquid CO 2 , the system has a large storage capacity and no geographic constraints. A thermodynamic and parametric analysis was conducted to investigate the optimum system performance.

Invasive candidiasis (IC), a life-threatening fungal infection prevalent among hospitalized patients, has highly variable regional epidemiology. We conducted a multicenter surveillance study to investigate recent trends in species distribution and antifungal susceptibility patterns among IC-associated spp. in Beijing, China, from 2016 to 2017. A total of 1496 non-duplicate isolates, recovered from blood and other sterile body fluids of IC patients, were identified using matrix-assisted laser desorption/ionization time of flight mass spectrometry combined with ribosomal DNA internal transcribed spacer (ITS) region sequencing. Broth microdilution-based susceptibility testing using six antifungal agents was also conducted. was the most frequently isolated species (49.9%), followed by (15.5%), (14.7%) and (14.2%). No significant differences in species distribution were observed when compared with a 2012-2013 dataset. Overall, the rates of susceptibility to fluconazole and voriconazole were high among (98% and 97.2%, respectively) and species complex (91.1% and 92%, respectively) isolates but low among (81.5% and 81.1%, respectively) isolates. In addition, the rate of azole resistance among isolates increased significantly (1.8-fold, <0.05) compared with that observed in 2012-2013, while micafungin resistance rates were <5% for all tested species. Our results suggest that species distribution has remained stable among IC-associated isolates in Beijing. Resistance to micafungin was rare, but increased azole resistance among isolates was noted. Our study provides information on local epidemiology that will be important for the selection of empirical antifungal agents and contributes to global assessments of antifungal resistance.

Magnetic reversal processes of a FePt/{\\alpha}-Fe/FePt trilayer system with in-plane easy axes have been investigated within a micromagnetic approach. It is found that the magnetic reversal process consists of three steps: nucleation of a prototype of domain wall in the soft phase, the evolution as well as the motion of the domain wall from the soft to the hard phase and finally, the magnetic reversal of the hard phase. For small soft layer thickness Ls, the three steps are reduced to one single step, where the magnetizations in the two phases reverse simultaneously and the hysteresis loops are square with nucleation as the coercivity mechanism. As Ls increases, both nucleation and pinning fields decrease. In the meantime, the single-step reversal expands to a standard three-step one and the coercivity mechanism changes from nucleation to pinning. The critical thickness where the coercivity mechanism alters, could be derived analytically, which is found to be inversely proportional to the square root of the crystalline anisotropy of the hard phase. Further increase of Ls leads to the change of the coercivity mechanism from pinning to nucleation.

is a rare fungal species that has not been described in human invasive infections. In this study, we investigated two isolates from patients with invasive infections in two hospitals in China, as part of the China Hospital Invasive Fungal Surveillance Net (CHIF-NET) program. Both patients were under immunocompromised conditions. On chromogenic agar, isolates were dark blue, similar to the color of , but the characteristic moist colony appearance was quite different from that of . The two isolates were misidentified as and by the VITEK 2 YST system. The rDNA internal transcribed spacer (ITS) region and the D1/D2 domain sequences of the two isolates were 100% identical to type strain CBS10761 . The sequence of the intergenic spacer region-1 also clearly distinguished the species. Of the three matrix-assisted laser desorption/ionization time-of-flight mass spectrometry systems, Bruker Biotyper and Autobio MS correctly identified the two isolates to species level, whereas Vitek MS systems misidentified them as or . Echinocandins exhibited no in vitro activities against the two isolates. In addition, the isolates exhibited intermediate susceptibility to fluconazole (with minimal inhibitory concentrations [MICs] of 8 and 16 µg/mL) and itraconazole, voriconazole, and posaconazole (MICs of 0.25-1 µg/mL). demonstrated susceptibility to amphotericin B with MIC of 1 µg/mL. The MICs of fluconazole and voriconazole in our study were higher than the MIC of 62 for isolates (4 and 0.064 µg/mL) in the CHIF-NET program. This case study points to a possible emergence of as an opportunistic human invasive fungal pathogen, and the reduced susceptibility should be noted.