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Epilepsy is a disease characterized by recurrent, episodic, and transient central nervous system (CNS) dysfunction resulting from an excessive synchronous discharge of brain neurons. It is characterized by diverse etiology, complex pathogenesis, and difficult treatment. In addition, most epileptic patients exhibit social cognitive impairment and psychological impairment. Iron is an essential trace element for human growth and development and is also involved in a variety of redox reactions in organisms. However, abnormal iron metabolism is associated with several neurological disorders, including hemorrhagic post-stroke epilepsy and post-traumatic epilepsy (PTE). Moreover, ferroptosis is also considered a new form of regulation of cell death, which is attributed to severe lipid peroxidation caused by the production of reactive oxygen species (ROS) and iron overload found in various neurological diseases, including epilepsy. Therefore, this review summarizes the study on iron metabolism and ferroptosis in epilepsy, in order to elucidate the correlation between iron and epilepsy. It also provides a novel method for the treatment, prevention, and research of epilepsy, to control epileptic seizures and reduce nerve injury after the epileptic seizure.

PurposeThis article aims to reveal the factors influencing the sustainable development of mobile e-commerce from both user and operational perspectives. It fills the gap in qualitative research on the sustainable development of artificial intelligence (AI) technology in mobile e-commerce based on the grounded theory. This study provides valuable insights and inspiration for sustainable development in this field and lays the theoretical foundation and research reference for future studies.Design/methodology/approachBased on the grounded theory (GT), interview method was used to conduct the study.FindingsThe impact of AI applications on mobile e-commerce is mainly reflected in three stages of the customer shopping process. They are pre-shopping, mid-shopping and after-shopping AI services and each of the three stages has its own separate dimensions that need attention. The study and its persistence aspects are discussed.Practical implicationsThe results of this study can provide forward-looking suggestions and paths for the construction and optimization of future e-commerce platforms, contribute to the sustainable development of e-commerce and contribute to the sustainable and healthy growth of the social economy.Originality/valueThis study proposes sustainable development measures for the application of AI in mobile e-commerce, from operation to supervision, which is an important reference for promoting coordinated and rapid socio-economic development.

Blockchain technology and its applications have recently become a research hotspot. Its three core technologies, distributed ledger, smart contract, and consensus mechanism, provide trust-enhancing features such as tamper-proof records, full traceability, and data decentralization for a wide range of applications. This paper investigates the use of blockchain technology in environmental health. It investigates indicators such as the number of articles published, author collaboration network, research institution network, and keyword co-occurrence in this field between 2014 and 2021. It describes and analyzes the development and connotations of these indicators. Many scholars have conducted in-depth studies on blockchain in various areas. Still, there are few cross-over studies on environmental health and a lack of cross-over studies on technology application in multiple fields. The current study investigates the evolution of research on the application of blockchain technology in environmental health, as well as potential development patterns and research trends, to provide a theoretical foundation for the application and sustainability of blockchain technology in this field.

With the rapid development of e-commerce and the impact of COVID-19, online takeout has become the first choice of more and more consumers. Previous research has indicated that food packaging is of great significance to marketing performance, yet very little is known about the mechanisms through which food packaging pollution risk affects online takeout consumption. This study proposes an expanded model of the Theory of Planned Behavior (TPB) by incorporating the Concept of Perceived Risk (CPR) to analyze the mechanism of consumers’ packaging pollution risk perception (PPRP) on their purchasing intention toward online takeout. Online survey was performed to collect data from 336 valid respondents in China, which was analyzed using structural equation modeling. The research findings verify the effectiveness of the TPB in the context of Chinese online takeout. Notably, the PPRP of online takeout was found to have a significant negative impact on consumers’ attitudes, subjective norms, and perceived behavioral control (PBC). It was also confirmed that consumers’ attitudes, subjective norms, and PBC regarding online takeout partially mediate the negative relationship between PPRP and purchase intention. In addition, the findings corroborate the granular nuances among three groups concerning consumers’ education level. The results do not only provide suggestions to the online takeout industry but also contribute theoretical value and practical significance for the improvement of sustainable food consumption.

With the continuous economic development, the total amount of data in banks is growing bigger and bigger and it is urgent and necessary to manage these data effectively. This paper studied Hadoop-based bank historical data management from the perspective of data migration, and designed and realized a data migration module. Map Reduce data migration was used in the process of structured data migration. An IO load-based scheduling algorithm was also designed. When scheduling, considering the consumption of resources, it is avoided to assign tasks to heavy-loaded IO nodes. An unstructured data migration tool was developed by smartly using FTP to concurrently migrate log files of online service platforms and other data to HDFS specified directories. The final system test results show that the system in this paper can work normally and meet the design requirements.

Background: entrepreneurial self-efficacy is the level of confidence that entrepreneurs can complete various entrepreneurial tasks. It can significantly predict entrepreneurial effectiveness, entrepreneurial motivation and entrepreneurial ability. This study explores the mechanism of entrepreneurial environment on college students’ entrepreneurial self-efficacy and analyzes the role of entrepreneurial competence and entrepreneurial education in the relationship between entrepreneurial competence and entrepreneurial education. Methods: a questionnaire survey was conducted among 1100 college students from 10 colleges and universities in Guangdong Province, and the survey results were statistically analyzed. Results: the results show that: (1) entrepreneurial education and entrepreneurship practice have a significant positive impact on college students’ self-efficacy; (2) entrepreneurial environment and entrepreneurial competence have a significant positive predictive effect on entrepreneurial self-efficacy; (3) entrepreneurial competence plays a mediating role in the influence of entrepreneurial environment on entrepreneurial self-efficacy; (4) entrepreneurial education plays a moderating role between entrepreneurial environment and entrepreneurial self-efficacy. Conclusion: present study found that entrepreneurial environment, entrepreneurial competence and entrepreneurial education play a positive role in college students’ entrepreneurial self-efficacy. Therefore, this paper suggests the promotion of an entrepreneurial education by creating a good innovative and entrepreneurial environment, establishing a talent training model based on entrepreneurial competence model, and building a high-quality entrepreneurial education system.

Value: As an attempt to enrich the extant literature, this study considers both the impact of technology on improving medical services' sustainable development and the influence factor that motivates enterprises or related institutions to choose medical services with technology. This research is an exploration of blockchain technology in the sustainable development of medical services through the rich expansion of technical theory and practice. It also points out the security issues that need to be addressed in sustainable applications, and discusses their solutions in a preliminary way.

3-benzyl-5-((2-nitrophenoxy) methyl)-dihydrofuran-2(3 H)-one (3BDO) is a mTOR agonist that inhibits autophagy. The main purpose of this study is to investigate the effects of 3BDO on seizure and cognitive function by autophagy regulation in pentylenetetrazol (PTZ)-kindled epileptic mice model. The PTZ-kindled epileptic mice model was used in study. The behavioral changes and electroencephalogram (EEG) of the mice in each group were observed. The cognitive functions were tested by Morris water maze test. The loss of hippocampal neurons was detected by hematoxylin-eosin (HE) staining and immunofluorescence analysis. Immunohistochemistry, western blot and q-PCR were employed to detect the expression of autophagy-related proteins and mTOR in the hippocampus and cortex. Less seizures, increased hippocampal neurons and reduced astrocytes of hippocampus were observed in the 3BDO-treated epileptic mice than in the PTZ-kindled epileptic mice. Morris water maze test results showed that 3BDO significantly improved the cognitive function of the PTZ-kindled epileptic mice. Western blot analyses and q-PCR revealed that 3BDO inhibited the expression of LC3, Beclin-1, Atg5, Atg7 and p-ULK1/ULK1, but increased that of p-mTOR/mTOR, p-P70S6K/P70S6K in the hippocampus and temporal lobe cortex of epileptic mice. Immunohistochemistry and immunofluorescence also showed 3BDO inhibited the LC3 expression and increased the mTOR expression in the hippocampus of epileptic mice. In addition, the autophagy activator EN6 reversed the decrease in the 3BDO-induced autophagy and aggravated the seizures and cognitive dysfunction in the epileptic mice. 3BDO regulates autophagy by activating the mTOR signaling pathway in PTZ-kindled epileptic mice model, thereby alleviating hippocampus neuronal loss and astrocytes proliferation, reducing seizures and effectively improving cognitive function. Therefore, 3BDO may have potential value in the treatment of epilepsy.

In today’s society, consumers’ food needs can be satisfied by catering e-commerce platforms. However, the plastic pollution of tableware and packaging caused by a large number of catering orders every day has always been an unsolved environmental problem. (1) Background: At present, China’s three largest catering platforms, Meituan, Eleme and Baidu, receive 20 million takeout orders daily and consume about 60 million plastic products. Plastic pollution will have a sustained impact on the environment. (2) Methods: In this study, we use literature research and case analysis. We use Meituan’s takeout food as an example. We studied the takeout business growth, status of online takeout in the treatment of plastic packaging, harm to environment, humans and animals, as well as specific solutions. (3) Results: There are four main reasons which contribute to the plastic packaging pollution (i.e., high recycling cost, difficulty to deal with mixed plastic packaging, low effectiveness of collecting plastic packing, and immature technology and treatment to incinerate and landfill catering plastic waste). (4) Conclusion: Our findings suggest that regulators, takeout platforms and consumers, which have corresponding responsibilities in the environmental protection consumption of online food, are supposed to work together to get rid of the online takeout pollution for achieving sustainable consumption. Not only is government legislation needed to improve the waste management system and encourage the exploration of new intelligent waste classification tools, but platforms, businesses and users should enhance the environmental awareness of online takeout packaging pollution as well. Theoretical contributions and managerial implications are also discussed.