Explore the vast range of titles available.

The Jinshan gold deposit, located on the southern flank of the Keguqin Mountains in the western Tianshan orogen, is a typical low-grade, large to super-large epithermal system within a continental volcanic terrain. Although its genesis is linked to Late Palaeozoic volcanic-intrusive activity, controversies over ore-controlling structures have constrained deep and peripheral exploration. Through detailed field and outcrop observations, this study identifies multiple Carboniferous palaeo-volcanic edifices (pipes, depressions, necks), overprinted by NS-trending normal faults and conjugate NNW- and NE-trending strike-slip faults. Mineralisation is shown to be jointly controlled by these volcanic edifices, regional fault systems and the unconformity between Ordovician limestone and Carboniferous volcanic-clastic rocks – termed the ‘silica-calcite interface’. A corresponding ore-controlling model highlights favourable exploration targets at this unconformity within structural intersections of subsidiary vents and regional/ring/radial fractures. Subsequent drilling not only confirmed high-grade, thick orebodies (e.g. 6 m @ 3.56 g/t, peak 56.3 g/t) in predicted areas but also revealed anticipated mineralisation types in unexplored zones south of the mine. The study provides a validated structural model for epithermal exploration in similar volcanic terrains worldwide.

Metabolic plasticity sustains glioblastoma (GBM) survival under nutrient stress, yet how fructolytic adaptation compensates for glucose deprivation remains unclear. Here, we identify glycerate kinase 2 (GLYCTK2) as a glucose-sensing metabolic checkpoint that maintains GBM cell viability through ERK1-mediated phosphorylation. Mechanistically, glucose deprivation-activated ERK1 phosphorylates GLYCTK2 at serine 220 directly, which prevents STUB1 (ubiquitin E3 ligase) binding, thereby abrogating the ubiquitination and degradation of GLYCTK2. Importantly, Functional studies demonstrated that fructose supplementation rescues glucose deprivation-induced death in wild-type GBM cells, but fails to protect GLYCTK2-depleted cells, establishing GLYCTK2 as the gatekeeper of fructolytic salvage pathways. These findings demonstrate an important mechanism by which GBM cells rewire glucose metabolism to fructose metabolism via phosphorylating and stabilizing GLYCTK2 to maintain GBM cell survival under glucose deprivation condition, underscoring the potential to target GLYCTK2 for the treatment of patients with GBM.

Mitochondrial dynamics can regulate Major Histocompatibility Complex (MHC)-I antigen expression by cancer cells and their immunogenicity in mice and in patients with malignancies. A crucial role in the mitochondrial fragmentation connection with immunogenicity is played by the IRE1α-XBP-1s axis. XBP-1s is a transcription factor for aminopeptidase TPP2, which inhibits MHC-I complex cell surface expression likely by degrading tumor antigen peptides. Mitochondrial fission inhibition with Mdivi-1 upregulates MHC-I expression on cancer cells and enhances the efficacy of adoptive T cell therapy in patient-derived tumor models. Therefore mitochondrial fission inhibition might provide an approach to enhance the efficacy of T cell-based immunotherapy. Cancer cells downregulate surface expression of major histocompatibility complex I (MHC-I) for immune evasion. Here, the authors show that rapid mitochondrial fission activates the ER-stress response leading to reduced MHC-I complex formation and cell surface expression in solid cancer cells; moreover inhibition of mitochondrial fission increases the immune-mediated anticancer response in murine models.

The quasi-dynamic loads induced by earthquakes, blasting, or impacts can pose severe threats on the safety and stability of rock engineering at a certain distance to dynamic sources. By utilizing a self-devised quasi-dynamic loading apparatus, we performed uniaxial compressive tests on sandstone samples in combination with an acoustic emission (AE) monitoring system and investigated their mechanical properties and AE behaviours in the range of 10 −2  ~ 10 0 s −1 strain rate. During the millisecond-level period of quasi-dynamic tests, the apparatus enables to apply the quasi-dynamic loads with stable strain rates and a positive correlation between the strain rate and dynamic strength was prominently obtained. The increasing strain rate would result in the enhancement of AE characteristics per signal, e.g., AE counts, duration time, AE energy, and amplitude. However, the total number of AE signals displays a decreasing trend, as well as the total AE counts and b value. The decreasing b-value elucidates that the rock failure becomes more violent, accompanied by the increase in the percentage of AE signals with large amplitudes. Based on the analysis of AE waveforms, three types of AE signals were observed, i.e., type I, II, and III signals. The type II and III AE signals might result from the superposition by two or more type I signals, inducing that the AE counts, energy, and amplitude of the above types of AE signals generally follow the relation: type III > type II > type I. The percentage of type I signals recoded in experiments illustrates a decline trend with respect to the strain rate, while the variation of type III signals is inverse. Therefore, the superposition of AE signals might be the intrinsic mechanism for the effect of strain rate on the AE behaviours in quasi-dynamic tests. Highlights Acoustic emission characteristics in quasi-dynamic tests are considerably impacted by strain rate. Three types of acoustic emission signals are determined based on waveform characteristics. Signal superposition might be the mechanism for rate-dependent acoustic emission behaviours.

At present, China's foreign trade volume of cross-border e-commerce is still relatively small, the targeted legal system has not been established, and the industry access threshold is relatively low. The development of cross-border e-commerce faces many risks. Relying on data mining technology, data docking and risk control. At the data level, the risk of cross-border e-commerce transaction is processed and analyzed, and the potential risk is predicted, and more targeted risk control methods are proposed to reduce the risk of cross-border e-commerce transaction business. Aiming at this problem, this paper establishes the risk data analysis of cross-border e-commerce transactions based on data mining. In order to further verify the data accuracy of data mining technology, this paper analyzes the test values of neural network algorithm, seizure rate and inspection rate. When the misclassification loss parameter value is increased from 1 to 4, the detection rate of the model increases and the detection rate decreases. When the misclassification loss value is higher than 4, the detection rate increases, but the seizure rate decreases significantly. Therefore, the target inspection rate of the model can be changed by adjusting the misclassification loss parameter value of the model. If we set the parameter value of misclassification loss reasonably, we can achieve the goal of preventing and controlling the maximum risk with the lowest data mining cost. Through the analysis, the research in this paper has achieved ideal results, and made a contribution to data mining in cross-border e-commerce transaction risk data analysis.

Investigating the rate-dependent behaviours of cracked rocks under quasi-dynamic loads is crucial to understand the instability and failure mechanisms of rock engineering threatened by dynamic disturbances. To carry out the quasi-dynamic tests under uniaxial compression, a self-devised loading apparatus was employed in this study, and the quasi-dynamic behaviours of cracked sandstone were investigated by using digital image correlation method and acoustic emission (AE) technique, including the mechanical, fracturing and AE characteristics. Based on the experimental results, the quasi-dynamic tests are transient, and the testing time dramatically decreases from several seconds to several milliseconds as the loading velocity increases from 0.1 to 100 mm/s. The uniaxial compressive strength of cracked sandstone under quasi-dynamic loads shows rate dependency, and the increasing crack angle would lead to an increase in the quasi-dynamic strength as well. By analysing the distribution and evolution of strain localization zones (SLZs) around the crack, the increasing strain rate would result in the occurrence of SLZ bifurcation phenomena, implying that the fracturing and failure behaviours of cracked rocks become more violent. In contrast, the rising crack angle would lead to the difficulty in forming the SLZs and bifurcation phenomena. In terms of the AE characteristics, the increase in strain rate induces the decreasing number of AE signals recorded in the quasi-dynamic tests, resulting in the decreasing total AE counts. By dividing the AE characteristics with the number of AE signals, the positive correlations were identified between the strain rate and AE behaviours per signal (i.e., AE counts per signal, AE amplitude per signal and AE energy per signal), which might be the reason why the sample failure become more violent with the increasing strain rate.

Non-coding RNAs, including piwi-interacting RNAs (piRNAs), are known to regulate osteogenic differentiation in bone marrow-derived mesenchymal stem cells (BMSCs); their role in mesenchymal stem cells (MSCs) from diverse origins remains unclear. In this study, we identified piR48444 as a key regulator that is downregulated during the osteogenic differentiation of stem cells from exfoliated deciduous teeth (SHED) but is upregulated in inflamed and aged BMSCs. Functionally, piR48444 inhibited, while its knockdown enhanced osteogenic differentiation across MSCs from multiple sources. Notably, piR48444-depleted MSCs exhibited superior bone defect repair capacity. PiR48444 antagomir promoted bone regeneration in LPS-induced osteolysis mice and aging mice. Mechanistically, we demonstrated that piR48444 targets METTL7A , suppressing BMP2 mRNA m 6 A methylation. Furthermore, we discovered that the METTL7A/eIF4E complex binds to BMP2 mRNA, thereby enhancing its translational efficiency. Our findings establish piR48444 as a negative regulator of MSC osteogenesis through METTL7A-mediated BMP2 m 6 A methylation, highlighting its potential as a therapeutic target to enhance MSC-based bone regeneration strategies. piR48444 targets METTL7A to inhibit BMP2 mRNA m6A methylation and METTL7A/eIF4E complex-mediated BMP2 mRNA stability and translation, ultimately inhibiting osteogenic differentiation of MSCs and bone regeneration.

Based on the abundant surface hydroxyl groups of plant polyphenols and their tendency for complexation with metal ions, a facile and green approach to improve the interfacial interactions between silica and a rubber matrix is proposed. The interface interactions of plant phenols with silica and Zn ions are characterized by attenuated total refraction Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The results suggest that, with the introduction of plant phenols, strong interface interaction between rubber matrix and silica can be formed through hydrogen bonding and chelating effects. The investigation of mechanical performance of the composites indicates that the proposed approach produces remarkable reinforcing effects on the rubber matrix.

R541.4; 目的 研究血清脂蛋白(a)[LP(a)]水平与用药物洗脱支架行经皮冠状动脉介入治疗(PCI)术后支架内再狭窄及冠状动脉非靶病变的关系.方法 收集2013年1月-2017年1月在中山市人民医院心血管内科确诊为冠心病并首次行PCI、术后1±4年内复查冠脉造影或再次置入支架的患者174例,其中31例发生了支架内再狭窄(再狭窄组),143例未发生支架内再狭窄(无再狭窄组).比较两组间的血脂及冠脉病变情况;以Lp(a)水平500 mg/L为界将174例患者分为高Lp(a)组(33例)和低Lp(a)组(141例),比较两组间的冠脉病变情况及非靶病变情况,并采用多因素logistic回归分析支架内再狭窄和非靶病变的危险因素.结果 在置入药物洗脱支架的患者中,再狭窄组的Lp(a)水平高于无狭窄组[(437.57±391.60) mg/L vs.(279.46±288.06)mg/L],差异有统计学意义(P=0.040);高Lp(a)组的三支血管病变和左主干+三支血管病变比例均明显高于低Lp(a)组(P=0.022).logistic回归分析结果显示,Lp(a)高水平和置入支架数量多是行药物洗脱支架术患者支架内再狭窄的独立危险因素.高Lp(a)组的非靶病变例数占比、支架内再狭窄率、最小管腔直径和支架内晚期管腔丢失均明显高于低Lp(a)组,差异有统计学意义(P＜0.05);logistic回归分析显示,Lp(a)高水平是非靶病变的独立危险因素(P=0.001).结论 Lp(a)水平升高是支架内再狭窄以及非靶病变的独立危险因素,与冠心病再发及进展显著相关.

P237; 船载三维激光扫描技术在海洋测绘中具有重要的理论意义和实用价值.安置参数标定作为船载三维激光扫描系统测量的重要步骤,是当前亟待解决的问题.本文提出了一种无地面控制点的船载三维激光扫描系统安置参数标定方法.该方法在船载三维激光扫描数据时空配准模型的基础上,根据扫描测线重叠区域内的同名特征点,推导扫描系统安置参数标定模型,最后采用差分最小二乘算法求解参数最优值.试验验证了本文方法的合理性和有效性,能够显著提高扫描数据的质量.