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"H. Jung"
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Outward and upward mobilities : international students in Canada, their families, and structuring institutions
\"People move out to move up. Like other migrant groups, student mobility is a form of social mobility, and one that requires access from a host state. But there are multiple institutions with which students interact and that influence the processes of social mobility. Outward and Upward Mobilities investigates the connection between student and institution. The collection features work by key scholars in the field and considers international students from across Canada regardless of legal status. Exploring how international students and their families fare in local ethnic communities, educational and professional institutions, and the labour market, this volume demonstrates the need to ask more critical questions about the short- and long-term effects of temporary legal status, how student and family experiences differ by educational level and region of settlement, the barriers to and facilitators of adaptation and integration, and ultimately, to what extent individual, familial, institutional, and state goals function in harmony and in discord.\"-- Provided by publisher.
Book
Collinear and TMD quark and gluon densities from parton branching solution of QCD evolution equations
A
bstract
We study parton-branching solutions of QCD evolution equations and present a method to construct both collinear and transverse momentum dependent (TMD) parton densities from this approach. We work with next-to-leading-order (NLO) accuracy in the strong coupling. Using the unitarity picture in terms of resolvable and non-resolvable branchings, we analyze the role of the soft-gluon resolution scale in the evolution equations. For longitudinal momentum distributions, we find agreement of our numerical calculations with existing evolution programs at the level of better than 1% over a range of five orders of magnitude both in evolution scale and in longitudinal momentum fraction. We make predictions for the evolution of transverse momentum distributions. We perform fits to the high-precision deep inelastic scattering (DIS) structure function measurements, and we present a set of NLO TMD distributions based on the parton branching approach.
Journal Article
Thymic development of gut-microbiota-specific T cells
Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection
1
. Maintaining this relationship requires a careful immune balance to contain commensal microorganisms within the lumen while limiting inflammatory anti-commensal responses
1
,
2
. Antigen-specific recognition of intestinal microorganisms by T cells has previously been described
3
,
4
. Although the local environment shapes the differentiation of effector cells
3
–
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it is unclear how microbiota-specific T cells are educated in the thymus. Here we show that intestinal colonization in early life leads to the trafficking of microbial antigens from the intestine to the thymus by intestinal dendritic cells, which then induce the expansion of microbiota-specific T cells. Once in the periphery, microbiota-specific T cells have pathogenic potential or can protect against related pathogens. In this way, the developing microbiota shapes and expands the thymic and peripheral T cell repertoire, allowing for enhanced recognition of intestinal microorganisms and pathogens.
In young mice, antigens from the gut microbiota are trafficked by CX3CR1
+
dendritic cells from the gut to the thymus, where they induce the expansion of T cells that are specific to commensal microorganisms.
Journal Article
Incidence of subsequent osteoporotic fractures after distal radius fractures and mortality of the subsequent distal radius fractures: a retrospective analysis of claims data of the Korea National Health Insurance Service
SummaryA better understanding of the features of subsequent fractures after distal radius fracture (DRF) is important for the prevention of further osteoporotic fractures. This study found that the cumulative incidence of subsequent osteoporotic fractures in South Korea increased over time and that the mortality rates of subsequent DRFs were lower than those of first-time DRFs.IntroductionWe examined the incidence of osteoporotic fractures following distal radius fractures (DRFs) and the mortality rate after subsequent DRFs using claims data from the Korea National Health Insurance (KNHI) Service.MethodsWe identified records for 41,417 patients with first-time DRFs in 2012. The occurrence of osteoporotic fractures of the spine, hip, wrist, and humerus at least 6 months after the index DRF was tracked through 2016. All fractures were identified by specific diagnosis and procedure codes. One-year mortality rates and standardized mortality ratios (SMRs) for initial and subsequent DRFs were calculated for all patients.ResultsThe 4-year cumulative incidence of all subsequent osteoporotic fractures was 14.74% (6105/41,417; 9.47% in men, 15.9% in women). The number of associated subsequent fractures was 2850 for the spine (46.68%), 2271 for the wrist (37.2%), 708 for the hip (11.6%), and 276 for the humerus (4.52%). The cumulative mortality rate 1 year after the first-time and subsequent DRF was 1.47% and 0.71%, respectively, and the overall SMR was 1.48 (95% CI: 1.37–1.61) and 0.71 (95% CI: 0.42−1.21), respectively.ConclusionThe cumulative incidence of osteoporotic fractures following DRFs increased over the study period and was higher among women. The cumulative mortality rates and SMRs of subsequent DRFs were lower than those of first-time DRFs at the 1-year follow-up. Given the increasing incidence rate of DRFs, the incidence of subsequent osteoporotic fractures may also increase.
Journal Article
Enhancing the Motivational Affordance of Information Systems: The Effects of Real-Time Performance Feedback and Goal Setting in Group Collaboration Environments
Increasing globalization has created tremendous opportunities and challenges for organizations and societies. Consequently, a broad range of information technologies to better support the collaboration of diverse, and increasingly distributed, sets of participants is ever more utilized. Arguably, the success of such technology-mediated collaboration is dependent upon the quality of each individual's contributions; however, although individuals' motivations to do their best could be significantly influenced by the design of a system's human-computer interface, this area has received little attention within the context of group collaboration environments. We fill this gap by integrating research from human-computer interaction, motivation, and technology-supported group work to theoretically derive mechanisms for increasing each individual's motivation within a collective setting. Specifically, we manipulate the interface of a computer-mediated idea generation system (a widely used collaboration tool) to enhance the system's motivational affordance, i.e., the system's properties that fulfill users' motivational needs. Results from two studies demonstrate that by embedding the theoretically derived mechanisms \"providing feedback\" and \"designing for optimal challenge\" into the collaboration environment, significant performance gains were realized. The results suggest that even slight manipulations of the human-computer interface can contribute significantly to the successful design of a wide variety of group collaboration environments.
Journal Article
Toward unification of the multiscale modeling of the atmosphere
As far as the representation of deep moist convection is concerned, only two kinds of model physics are used at present: highly parameterized as in the conventional general circulation models (GCMs) and explicitly simulated as in the cloud-resolving models (CRMs). Ideally, these two kinds of model physics should be unified so that a continuous transition of model physics from one kind to the other takes place as the resolution changes. With such unification, the GCM can converge to a global CRM (GCRM) as the grid size is refined. This paper suggests two possible routes to achieve the unification. ROUTE I continues to follow the parameterization approach, but uses a unified parameterization that is applicable to any horizontal resolutions between those typically used by GCMs and CRMs. It is shown that a key to construct such a unified parameterization is to eliminate the assumption of small fractional area covered by convective clouds, which is commonly used in the conventional cumulus parameterizations either explicitly or implicitly. A preliminary design of the unified parameterization is presented, which demonstrates that such an assumption can be eliminated through a relatively minor modification of the existing mass-flux based parameterizations. Partial evaluations of the unified parameterization are also presented. ROUTE II follows the \"multi-scale modeling framework (MMF)\" approach, which takes advantage of explicit representation of deep moist convection and associated cloud-scale processes by CRMs. The Quasi-3-D (Q3-D) MMF is an attempt to broaden the applicability of MMF without necessarily using a fully three-dimensional CRM. This is accomplished using a network of cloud-resolving grids with large gaps. An outline of the Q3-D algorithm and highlights of preliminary results are reviewed.
Journal Article
Intestinal Microbes in Autoimmune and Inflammatory Disease
Autoimmune diseases and chronic inflammatory disorders are characterized by dysregulated immune responses resulting in excessive and uncontrolled tissue inflammation. Multiple factors including genetic variation, environmental stimuli, and infection are all thought to contribute to continued inflammation and pathology. Current evidence supports the microbiota as one such factor with emerging data linking commensal organisms to the onset and progression of disease. In this review, we will discuss links between the microbiota and specific diseases as well as highlight common pathways that link intestinal microbes with multiple autoimmune and inflammatory diseases.
Journal Article