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The skid resistance and pavement texture can vary a lot for different lane paths, meaning that the lateral shift of the vehicle driving in the lane section can affect the safety significantly. On the other hand, a varying skid resistance across a lane section provides the opportunity to influence vehicles to run in lateral positions where the tire/road friction has not yet been reduced by wear; thus, improving safety. This measure would be useful only if the distribution of skid resistance and pavement texture in the lane sections are investigated at frequent intervals. This study focused on four test sections on in-service urban roads. A friction measuring device known as the T2GO system was used to test the skid resistance performance of pavements for both dry and wet conditions. A high-precision 3D-scanner was used to capture the pavement macrotexture, and a microscope was employed to investigate the pavement abrasion. Subsequently, the effect of the lateral variation across the lane of friction and texture was discussed. The feasibility of displacing the vehicles to run in tracks with better skid resistance was explored in terms of the measured friction and the texturedependent drainage capacity. The results indicated that driving closer to the lanes' right side means that better values of friction, texture, and drainage parameters of the unworn pavement surface can be utilized. A 0.3 m or more lateral displacement would create improved friction, in a range between 13% and 14% for 1.5 m track width and between 8% and 11% for 1.65 m track width. Furthermore, the results are useful in studying the vehicles' sideslip.

Background To observe the effect and mechanism of alpha-adrenergic receptor inhibitor phentolamine (PTL) in a rabbit model of acute pulmonary embolism (APE) combined with shock. Methods Twenty-four New Zealand rabbits were randomly divided into sham operation group (S group, n  = 8), model group (M group, n  = 8) and PTL group ( n  = 8), the model of APE combined with shock was established. Mean pulmonary arterial pressure (MPAP), peripheral mean arterial pressure (MAP) and pulmonary circulation time were evaluated. The expression levels of α 1 receptor, α 2 receptor and their downstream molecules in pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions lung tissues were detected and compared, respectively. Results In M group, α receptor-related signaling pathways were significantly activated in both PE and non-PE areas as expressed by up-regulated α 1 , α 2 receptor and phospholipase C (PLC); the expression level of phosphorylated protein kinase A (p-PKA) was significantly down-regulated; myosin light chain kinase (MLCK) and α-smooth muscle actin (α-SMA) levels were up-regulated. PTL treatment significantly improved pulmonary as well as systemic circulation failure: decreased MPAP, restored blood flow in non-PE area, shortened pulmonary circulation time, increased MAP, and restored the circulation failure. PTL induced significantly down-regulated expression of α 1 receptor and its downstream molecule PLC in both PE and non-PE area, the expression level of α 2 receptor was also down-regulated, the expression level of p-PKA was significantly up-regulated. PTL treatment can inhibit both α 1 and α 2 receptor-related signaling pathways in whole lung tissues, and inhibit Ca 2+ signaling pathways. The expression level of MLCK and α-SMA were significantly down-regulated. Compared with PE area, the changes of expression levels of α receptor and its downstream molecules were more significant in the non-PE region. Conclusion In this model of APE combined with shock, the sympathetic nerve activity was enhanced in the whole lung, α 1 and α 2 receptor and their downstream signaling activation might mediate blood flow failure in the whole lung. PTL treatment can effectively restore pulmonary blood flow in non-PE area and improve pulmonary as well as systemic circulation failure possibly through down-regulating α 1 and α 2 receptor and their downstream signaling pathways.

To the Editor: Coronary heart disease (CHD) continues to be a predominant cause of mortality in China even after recommended optimal management. The results of Cox regression showed an increasing risk for the four groups of patients and a significantly higher risk of MACCE for patients with persistent high RIR (HR = 1.80, 95% CI: 1.11–2.92, P = 0.016) [Supplementary Table 7, http://links.lww.com/CM9/C676]. Since the median level of NLR at 1-month was 2.4 and the 1-month NLR ≥2.4 predicted MACCE (HR = 1.55, 95% CI: 1.06–2.26, P = 0.023) [Supplementary Figure 2, http://links.lww.com/CM9/C676], we used 1-month hsCRP and NLR to categorize the participants into four groups: Funding This work was supported by grants from the Noncommunicable Chronic Diseases—National Science and Technology Major Project (No. 2025ZD0548400), the National Key Research and Development Program (No. 2022YFC2503501), Chinese Society of Cardiology’s Foundation (No. Dr. Libby is on the Board of Directors of XBiotech, Inc. Dr. Libby has a financial interest in Xbiotech, a company developing therapeutic human antibodies, in TenSixteen Bio, a company targeting somatic mosaicism and clonal hematopoiesis of indeterminate potential (CHIP) to discover and develop novel therapeutics to treat age-related diseases, and in Soley Therapeutics, a biotechnology company that is combining artificial intelligence with molecular and cellular response detection for discovering and developing new drugs, currently focusing on cancer therapeutics.

In this article, we show that every pair of large even integers satisfying some necessary conditions can be represented in the form of a pair of one prime, one prime squares, two prime cubes, and 187 powers of 2.

In this paper, we study the average behaviour of the representations of n = p 1 2 + p 2 4 + p 3 4 + p 4 k over short intervals for k ≥ 4 , where p 1 , p 2 , p 3 , p 4 are prime numbers. This improves the previous results.

Background We recently showed that intravenous sodium nitroprusside treatment (SNP) could relieve the pulmonary vasospasm of pulmonary embolism (PE) and non-pulmonary embolism (non-PE) regions in a rabbit massive pulmonary embolism (MPE) model associated with shock. The present study explored the potential role of cardiopulmonary sympathetic activity on the pathogenesis and the impact of vasodilators on cardiopulmonary sympathetic activity in this model. Methods Rabbits were randomly divided into sham operation group (S group, n  = 8), model group (M, equal volume of saline intravenously, n  = 11), SNP group (3.5 μg/kg/min intravenously, n  = 10) and diltiazem group (DLZ, 6.0 μg/kg/min intravenously, n = 10). Results MPE resulted in reduced mean arterial pressure and increased mean pulmonary arterial pressure as well as reduced PaO 2 in the M, SNP and DLZ groups. Tyrosine hydroxylase (TH), neuropeptide Y (NPY) and endothelin-1 (ET-1) expression levels were significantly increased, while nitric oxide (NO) levels were reduced in both PE and non-PE regions in the M group. Both SNP and DLZ decreased mean pulmonary arterial pressure, reversed shock status, downregulated the expression of TH, NPY and ET-1, and increased NO levels in PE and non-PE regions. Conclusion Present results indicate that upregulation of the sympathetic medium transmitters TH and NPY in whole lung tissues serves one of the pathological features of MPE. The vasodilators SNP and DLZ could relieve pulmonary vasospasm in both embolization and non-embolization regions and reverse circulatory shock, thereby indirectly downregulating the sympathetic activation of the whole lung tissues and breaking a vicious cycle related to sympathetic activation in this model.

The a priori procedure was designed as a pre-data procedure whereby researchers could find the sample sizes necessary to ensure that sample statistics to be obtained are within particular distances of corresponding population parameters with known probabilities. Researchers specify desired precisions (distances of sample statistics from corresponding population parameters) and desired confidences (probabilities of being within desired distances), and this procedure provides necessary sample sizes to meet precision and confidence specifications. Although the a priori procedure has been devised for a variety of experimental paradigms, these have all been simple. The present article constitutes its extension to analysis of variance models. A fortunate side effect of the equations to be proposed is an improvement in efficiency even for a paradigm that fits a previously published article.

Purpose: The present study aimed to evaluate the oncologic outcomes of patients 80 years or older compared with younger patients, and we then further investigated the efficacy of chemotherapy in individuals 80 years or older.Methods: A retrospective analysis was conducted using the Surveillance, Epidemiology and End Results database. The χ2 test was used to analyze the different clinicopathologic and demographic variables between 65- and 79-year and ≥80-year groups. Kaplan–Meier analysis and log-rank testing were used to compare colorectal cancer (CRC)–specific survival (CCSS) curves between different groups. Multivariate and univariate Cox proportional hazards models with hazard ratios (HRs) and 95% confidence intervals (CIs) were also used to assess CCSS and OS.Results: A total of 189,926 patients were included in our study. Compared with 65- to 79-year-old patients, age 80 years or older was associated with 48.4% increased CRC-specific mortality (HR = 1.484, 95% CI = 1.453–1.516, P < 0.0001; using 65–79 years old as the reference). Moreover, not receiving chemotherapy was significantly associated with an increased risk of CRC-related death, independent of other prognostic factors (HR = 0.615, 95% CI = 0.589–0.643, P < 0.0001) in individuals 80 years or older.Conclusions: This large population-based study showed that older age was associated with worse oncologic outcomes compared to younger age. Chemotherapy could offer survival benefit for very old patients diagnosed with CRC, and we strongly believed that very old patients were undertreated in the present medical practices.

Introduction Immediate postmastectomy reconstruction for breast cancer has been widely used due to its unique esthetic and psychological effects. However, no other population‐based study has investigated the effects of different reconstruction types on the survival in patients with triple negative breast cancer (TNBC). Methods We selected patients who met the eligibility criteria from the Surveillance, Epidemiology, and End Results cancer registry (N = 9760). We then assessed the effect of different reconstructive surgical approaches (implant, autologous, implant and autologous combined reconstruction) on the overall survival (OS) and breast cancer‐specific survival (BCSS) by using the Kaplan–Meier survival curve and Cox proportional hazard regression analyses. The nomograms were used to predict OS and BCSS. And the competitive risk model was used to assess breast cancer‐specific death (BCSD) and non‐breast cancer‐specific death (NBCSD). Results Statistical analysis suggested that the three reconstruction methods had better OS and BCSS with lower hazard than mastectomy alone (log‐rank test, p < 0.05). Multivariate stratified analysis showed that patients aged 40–60 years had the greatest improvement in OS (Adjusted hazard ratio [AHR], 0.646; 95% Confidence Interval [CI], 0.439–0.950; p = 0.026) with combined reconstruction. BCSS could be improved only by implant reconstruction (AHR, 0.672; 95% CI, 0.514–0.878; p = 0.004). In addition, autologous reconstruction (AHR, 0.570; 95% CI, 0.350–0.929; p = 0.024) and implant reconstruction (AHR, 0.538; 95% CI, 0.339–0.853; p = 0.008) improved OS in patients >60 years of age. The survival prediction model quantified the survival benefits of TNBC patients undergoing different surgeries. Moreover, the C‐indexes showed the good predictive ability of the nomograms. Conclusions Our results suggest that for TNBC patients, there is a survival benefit of immediate postmastectomy reconstruction compared with mastectomy alone. Among them, implant reconstruction has the most obvious advantage. Kaplan–Meier survival curves and log‐rank tests were used to evaluate the effect of different reconstruction methods (implant, autologous, implant and autologous combined reconstruction) on the overall survival (OS) of triple negative breast cancer patients. All three reconstruction methods had higher OS and lower risk than mastectomy alone (p < 0.0001). Among the three reconstruction methods, autologous reconstruction has the lowest survival rate and the highest risk.

Long-term anti-skid performance plays a vital role on the road life cycle and driving safety. Therefore, the CVS was proposed, which can perform full-size polishing on the rutting slabs. The CVS system was used to simulate the long-term anti-skid attenuation law of five kinds of asphalt mixture with different BOF steel slag contents, and the influence of different BOF steel slag contents on the road anti-skid performance was comprehensively analyzed by using pendulum friction value. With the increase of BOF steel slag volume, the long-term anti-skid performance of asphalt mixture increases first and then decreases. Especially, the asphalt mixture with 50% BOF steel slag content has the best long-term anti-skid performance.