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A bstract Black holes display universal behavior near extremality. One such feature is the late-time blowup of derivatives of linearized perturbations across the horizon. For generic initial data, this instability is regulated by backreaction, and the final state is a near-extremal black hole. The aim of this paper is to study the late time behavior of such black holes analytically using the weakly broken conformal symmetry of their near-horizon region. In particular, gravitational backreaction is accounted for within the Jackiw-Teitelboim model for near-horizon, near-extremal dynamics coupled to bulk matter.

A bstract We study the SL(2) transformation properties of spherically symmetric perturbations of the Bertotti-Robinson universe and identify an invariant μ that characterizes the backreaction of these linear solutions. The only backreaction allowed by Birkhoff’s theorem is one that destroys the AdS 2 × S 2 boundary and builds the exterior of an asymptotically flat Reissner-Nordström black hole with Q = M 1 − μ / 4 . We call such backreaction with boundary condition change an anabasis . We show that the addition of linear anabasis perturbations to Bertotti-Robinson may be thought of as a boundary condition that defines a connected AdS 2 ×S 2 . The connected AdS 2 is a nearly- AdS 2 with its SL(2) broken appropriately for it to maintain connection to the asymptotically flat region of Reissner-Nordström. We perform a backreaction calculation with matter in the connected AdS 2 × S 2 and show that it correctly captures the dynamics of the asymptotically flat black hole.

A bstract Linear perturbations of extremal black holes exhibit the Aretakis instability, in which higher derivatives of a scalar field grow polynomially with time along the event horizon. This suggests that higher derivative corrections to the classical equations of motion may become large, indicating a breakdown of effective field theory at late time on the event horizon. We investigate whether or not this happens. For extremal Reissner-Nordstrom we argue that, for a large class of theories, general covariance ensures that the higher derivative corrections to the equations of motion appear only in combinations that remain small compared to two derivative terms so effective field theory remains valid. For extremal Kerr, the situation is more complicated since backreaction of the scalar field is not understood even in the two derivative theory. Nevertheless we argue that the effects of the higher derivative terms will be small compared to the two derivative terms as long as the spacetime remains close to extremal Kerr.

A bstract Dynamics in the throat of rapidly rotating Kerr black holes is governed by an emergent near-horizon conformal symmetry. The throat contains unstable circular orbits at radii extending from the ISCO down to the light ring. We show that they are related by conformal transformations to physical plunges and osculating trajectories. These orbits have angular momentum arbitrarily higher than that of ISCO. Using the conformal symmetry we compute analytically the radiation produced by the physical orbits. We also present a simple formula for the full self-force on such trajectories in terms of the self-force on circular orbits.

The Event Horizon Telescope (EHT) Collaboration recently published the first images of the supermassive black holes in the cores of the Messier 87 and Milky Way galaxies. These observations have provided a new means to study supermassive black holes and probe physical processes occurring in the strong-field regime. We review the prospects of future observations and theoretical studies of supermassive black hole systems with the next-generation Event Horizon Telescope (ngEHT) project, which will greatly enhance the capabilities of the existing EHT array. These enhancements will open up several previously inaccessible avenues of investigation, thereby providing important new insights into the properties of supermassive black holes and their environments. This review describes the current state of knowledge for five key science cases, summarising the unique challenges and opportunities for fundamental physics investigations that the ngEHT will enable.

Mammalian social organizations require the ability to recognize and remember individual conspecifics. This social recognition memory (SRM) can be examined in rodents using their innate tendency to investigate novel conspecifics more persistently than familiar ones. Here we used the SRM paradigm to examine the influence of housing conditions on the social memory of adult rats. We found that acute social isolation caused within few days a significant impairment in acquisition of short-term SRM of male and female rats. Moreover, SRM consolidation into long-term memory was blocked following only one day of social isolation. Both impairments were reversible, but with different time courses. Furthermore, only the impairment in SRM consolidation was reversed by systemic administration of arginine-vasopressin (AVP). In contrast to SRM, object recognition memory was not affected by social isolation. We conclude that acute social isolation rapidly induces reversible changes in the brain neuronal and molecular mechanisms underlying SRM, which hamper its acquisition and completely block its consolidation. These changes occur via distinct, AVP sensitive and insensitive mechanisms. Thus, acute social isolation of rats swiftly causes changes in their brain and interferes with their normal social behavior.

Oxytocin is a peptide hormone, well known for its role in labor and suckling, and most recently for its involvement in mammalian social behavior. All central and peripheral actions of oxytocin are mediated through the oxytocin receptor, which is the product of a single gene. Transcription of the oxytocin receptor is subject to regulation by gonadal steroid hormones, and is profoundly elevated in the uterus and mammary glands during parturition. DNA methylation is a major epigenetic mechanism that regulates gene transcription, and has been linked to reduced expression of the oxytocin receptor in individuals with autism. Here, we hypothesized that transcription of the mouse oxytocin receptor is regulated by DNA methylation of specific sites in its promoter, in a tissue-specific manner. Hypothalamus-derived GT1-7, and mammary-derived 4T1 murine cell lines displayed negative correlations between oxytocin receptor transcription and methylation of the gene promoter, and demethylation caused a significant enhancement of oxytocin receptor transcription in 4T1 cells. Using a reporter gene assay, we showed that methylation of specific sites in the gene promoter, including an estrogen response element, significantly inhibits transcription. Furthermore, methylation of the oxytocin receptor promoter was found to be differentially correlated with oxytocin receptor expression in mammary glands and the uterus of virgin and post-partum mice, suggesting that it plays a distinct role in oxytocin receptor transcription among tissues and under different physiological conditions. Together, these results support the hypothesis that the expression of the mouse oxytocin receptor gene is epigenetically regulated by DNA methylation of its promoter.

A bstract Most extreme-mass-ratio-inspirals of small compact objects into supermassive black holes end with a fast plunge from an eccentric last stable orbit. For rapidly rotating black holes such fast plunges may be studied in the context of the Kerr/CFT correspondence because they occur in the near-horizon region where dynamics are governed by the infinite dimensional conformal symmetry. In this paper we use conformal transformations to analytically solve for the radiation emitted from fast plunges into near-extreme Kerr black holes. We find perfect agreement between the gravity and CFT computations.

The Event Horizon Telescope (EHT) Collaboration recently published the first images of the supermassive black holes in the cores of the Messier 87 and Milky Way galaxies. These observations have provided a new means to study supermassive black holes and probe physical processes occurring in the strong-field regime. We review the prospects of future observations and theoretical studies of supermassive black hole systems. Current ground-based very-long-baseline interferometry (VLBI) arrays like the EHT and proposed future extensions like the next-generation Event Horizon Telescope will greatly enhance the capabilities of black-hole imaging interferometry. These enhancements will open up several previously inaccessible avenues of investigation, thereby providing important new insights into the properties of supermassive black holes and their environments. This review describes the current state of knowledge for five key science cases, summarising the unique challenges and opportunities for fundamental physics investigations that future mm/sub-mm VLBI developments will enable.