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In a seminal paper now a decade old, it was shown that dark matter detectors geared at probing interactions with nucleons could also be used to probe dark matter interactions with electrons. In this work, we show that new detector concepts designed to probe dark matter-electron interactions at low masses can similarly be used to probe new parameter space for dark matter-nucleon interactions. We demonstrate the power of this approach by using existing data from superconducting detectors to place new limits on the interactions of nuclei with MeV-scale dark matter. Further, we show that advances in detector technology that have been anticipated for electronic interactions will automatically extend sensitivity deep into uncharted territory for nuclear interactions. This doubles the effective science output of future low-threshold experiments.

In a seminal paper now a decade old, it was shown that dark matter detectors geared at probing interactions with nucleons could also be used to probe dark matter interactions with electrons. In this work, we show that new detector concepts designed to probe dark matter-electron interactions at low masses can similarly be used to probe new parameter space for dark matter-nucleon interactions. We demonstrate the power of this approach by using existing data from superconducting detectors to place new limits on the interactions of nuclei with MeV-scale dark matter. Further, we show that advances in detector technology that have been anticipated for electronic interactions will automatically extend sensitivity deep into uncharted territory for nuclear interactions. This doubles the effective science output of future low-threshold experiments.

We propose the use of transition-edge sensor (TES) single-photon detectors as a simultaneous target and sensor for direct dark matter searches, and report results from the first search of this kind. We perform a 489 h science run with a TES device optimized for the detection of 1064 nm photons, with a mass of ~0.2 ng and an energy threshold of ~0.3 eV, and set new limits on dark matter interactions with both electrons and nucleons for dark matter with mass below the MeV scale. With their excellent energy resolution, TESs enable search strategies that are complementary to recent results from superconducting nanowire single-photon detectors and kinetic inductance detectors. We show that next-generation TES arrays hold promise to probe new regions of light dark matter parameter space.

We propose the use of transition-edge sensor (TES) single-photon detectors as a simultaneous target and sensor for direct dark matter searches, and report results from the first search of this kind. We perform a 489 h science run with a TES device optimized for the detection of 1064 nm photons, with a mass of ~0.2 ng and an energy threshold of ~0.3 eV, and set new limits on dark matter interactions with both electrons and nucleons for dark matter with mass below the MeV scale. With their excellent energy resolution, TESs enable search strategies that are complementary to recent results from superconducting nanowire single-photon detectors and kinetic inductance detectors. We show that next-generation TES arrays hold promise to probe new regions of light dark matter parameter space.

We present the first results from the Quantum Resolution-Optimized Cryogenic Observatory for Dark matter Incident at Low Energy (QROCODILE). The QROCODILE experiment uses a microwire-based superconducting nanowire single-photon detector (SNSPD) as a target and sensor for dark matter scattering and absorption, and is sensitive to energy deposits as low as 0.11 eV. We introduce the experimental configuration and report new world-leading constraints on the interactions of sub-MeV dark matter particles with masses as low as 30 keV. The thin-layer geometry of the system provides anisotropy in the interaction rate, enabling directional sensitivity. In addition, we leverage the coupling between phonons and quasiparticles in the detector to simultaneously constrain interactions with both electrons and nucleons. We discuss the potential for improvements to both the energy threshold and effective volume of the experiment in the coming years.

We present the first results from the Quantum Resolution-Optimized Cryogenic Observatory for Dark matter Incident at Low Energy (QROCODILE). The QROCODILE experiment uses a microwire-based superconducting nanowire single-photon detector (SNSPD) as a target and sensor for dark matter scattering and absorption, and is sensitive to energy deposits as low as 0.11 eV. We introduce the experimental configuration and report new world-leading constraints on the interactions of sub-MeV dark matter particles with masses as low as 30 keV. The thin-layer geometry of the system provides anisotropy in the interaction rate, enabling directional sensitivity. In addition, we leverage the coupling between phonons and quasiparticles in the detector to simultaneously constrain interactions with both electrons and nucleons. We discuss the potential for improvements to both the energy threshold and effective volume of the experiment in the coming years.

Elevated osteoclast (OC) activity is a major contributor to inflammatory bone loss (IBL) during chronic inflammatory diseases. However, the specific OC precursors (OCPs) responding to inflammatory cues and the underlying mechanisms leading to IBL are poorly understood. We identified two distinct OCP subsets: Ly6C CD11b inflammatory OCPs (iOCPs) induced during chronic inflammation, and homeostatic Ly6C CD11b OCPs (hOCPs) which remained unchanged. Functional and proteomic characterization revealed that while iOCPs were rare and displayed low osteoclastogenic potential under normal conditions, they expanded during chronic inflammation and generated OCs with enhanced activity. In contrast, hOCPs were abundant and manifested high osteoclastogenic potential under normal conditions but generated OCs with low activity and were unresponsive to the inflammatory environment. Osteoclasts derived from iOCPs expressed higher levels of resorptive and metabolic proteins than those generated from hOCPs, highlighting that different osteoclast populations are formed by distinct precursors. We further identified the TNF-α and S100A8/A9 proteins as key regulators that control the iOCP response during chronic inflammation. Furthermore, we demonstrated that the response of iOCPs but not that of hOCPs was abrogated in tnf-α mice, in correlation with attenuated IBL. Our findings suggest a central role for iOCPs in IBL induction. iOCPs can serve as potential biomarkers for IBL detection and possibly as new therapeutic targets to combat IBL in a wide range of inflammatory conditions.

QT interval prolongation is prevalent among patients with Takotsubo cardiomyopathy (TC), whereas torsades de pointes (TdP) has rarely been reported in these patients. We studied all peer-reviewed reports on TC-associated QT interval prolongation and all peer-reviewed reports on TC-associated TdP to characterize the clinical circumstances leading to TdP in patients with TC. The literature search yielded 14 reports on TC-associated TdP and 26 reports on TC-associated QT interval prolongation. Overall, 15 patients with TC-associated TdP and 86 patients with TC-associated QT interval prolongation were reported. We systematically reviewed each report and recorded the risk factors for TdP as well as the clinical circumstances of TC. The prevalence of the male sex was higher among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (26.7% vs 5.8%; P = .01). There was a trend in the mean maximal corrected QT interval being longer among patients with TC-associated TdP relative to patients with TC-associated QT interval prolongation (679.9 ± 230.6 vs 555.9 ± 63.8 milliseconds; P = .06). There were no differences between patients with TC-associated TdP and patients with TC-associated QT interval prolongation in mean age, maximal troponin levels, and lowest ejection fraction. Overall, 12 (80.0%) patients with TC-associated TdP had risk factors for TdP other than the female sex and systolic dysfunction, including suspicion of congenital long QT syndrome, bradycardia, hypokalemia, recent conversion from atrial fibrillation to sinus rhythm, and using QT prolonging agents. Men with TC-associated QT interval prolongation are at risk for TdP. Most patients with TC-associated TdP have risk factors for TdP other than the female sex and systolic dysfunction.